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Erschienen in: Current HIV/AIDS Reports 2/2014

01.06.2014 | The Global Epidemic (S Vermund, Section Editor)

Review of HIV in the Caribbean: Significant Progress and Outstanding Challenges

verfasst von: J. Peter Figueroa

Erschienen in: Current HIV/AIDS Reports | Ausgabe 2/2014

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Abstract

This paper reviews the recent literature on HIV in the Caribbean and discusses the challenges faced. HIV incidence in the Caribbean has declined by 49 % in the past decade, coverage of persons living with HIV among those eligible for antiretroviral treatment as per national guidelines was 70 % in 2012, and some countries are meeting the target of virtual elimination of mother-to-child transmission. HIV prevalence in the Caribbean is 1 % with features of both a generalized and concentrated HIV epidemic. HIV prevalence among female sex workers has declined but remains unacceptably high among men who have sex with men. Social and cultural factors, gender norms, and strong stigma associated with HIV and homosexuality contribute to the continued spread of HIV. Caribbean countries and their partners have invested significant resources, creative effort and impressive research in strengthening the HIV response nationally and regionally. However, in order to control the HIV epidemic, leaders at all levels, and the people, must address fundamental structural barriers in society that deny marginalized persons their rights, undermine public health goals, and impede universal access to HIV prevention, treatment, and care.
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Zurück zum Zitat Figueroa JP, Jones-Cooper C. Attitudes towards male circumcision among attendees of a sexually transmitted infection clinic in Kingston, Jamaica. West Indian Med J. 2010;59(4):351–5.PubMed Figueroa JP, Jones-Cooper C. Attitudes towards male circumcision among attendees of a sexually transmitted infection clinic in Kingston, Jamaica. West Indian Med J. 2010;59(4):351–5.PubMed
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Zurück zum Zitat Carter M, Gallo M, Anderson C, Snead MC, Wiener J, Costenbader E, et al. Intraviginal Cleansing among Women Attending a Sexually Transmitted Infection Clinic in Kingston, Jamaica. West Indian Med J. 2013;62(1):56–61.PubMed Carter M, Gallo M, Anderson C, Snead MC, Wiener J, Costenbader E, et al. Intraviginal Cleansing among Women Attending a Sexually Transmitted Infection Clinic in Kingston, Jamaica. West Indian Med J. 2013;62(1):56–61.PubMed
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Zurück zum Zitat Foster TM, Lee MG, McGaw CD, Frankson MA. Prevalence of Needlestick Injuries and other High Risk Exposures among Healthcare Workers in Jamaica. West Indian Med J. 2010;59(2):153–8.PubMed Foster TM, Lee MG, McGaw CD, Frankson MA. Prevalence of Needlestick Injuries and other High Risk Exposures among Healthcare Workers in Jamaica. West Indian Med J. 2010;59(2):153–8.PubMed
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Zurück zum Zitat Duncan J, Grant Y, Clarke TR, Harvey KM, Gibson RC, Barrow G, et al. Sociodemographics and clinical presentation of HIV in Jamaica over 20 years. A comparative analysis of surveillance data. West Indian Med J. 2010;59(4):409–17.PubMed Duncan J, Grant Y, Clarke TR, Harvey KM, Gibson RC, Barrow G, et al. Sociodemographics and clinical presentation of HIV in Jamaica over 20 years. A comparative analysis of surveillance data. West Indian Med J. 2010;59(4):409–17.PubMed
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Zurück zum Zitat Koenig SP, Rodriguez LA, Bartholomew C, Edwards A, Carmichael TE, Barrow G, et al. Long-term antiretroviral treatment outcomes in seven countries in the Caribbean. J Acquir Immune Defic Syndr. 2012;59(4):e60–71. doi:10.1097/QAI.0b013e318245d3c1. HIV treatment outcomes for 8,203 patients starting ART from 1998 to 2008 were studied in 7 Caribbean countries. Mortality was 13% overall with 75% of patients alive and in-care at the end of the study period.PubMedCentralPubMedCrossRef Koenig SP, Rodriguez LA, Bartholomew C, Edwards A, Carmichael TE, Barrow G, et al. Long-term antiretroviral treatment outcomes in seven countries in the Caribbean. J Acquir Immune Defic Syndr. 2012;59(4):e60–71. doi:10.​1097/​QAI.​0b013e318245d3c1​. HIV treatment outcomes for 8,203 patients starting ART from 1998 to 2008 were studied in 7 Caribbean countries. Mortality was 13% overall with 75% of patients alive and in-care at the end of the study period.PubMedCentralPubMedCrossRef
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Zurück zum Zitat Halpern M, Lachmansingh B, Minior T, Hasbrouck LM, Persaud N, Foo A. Implementation of a standardized HIV patient monitoring system in Guyana. Rev Panam Salud Publ. 2010;28(2):107–13.CrossRef Halpern M, Lachmansingh B, Minior T, Hasbrouck LM, Persaud N, Foo A. Implementation of a standardized HIV patient monitoring system in Guyana. Rev Panam Salud Publ. 2010;28(2):107–13.CrossRef
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Zurück zum Zitat Landis RC, Branch-Beckles SL, Crichlow S, Hambleton IR, Best A. Ten Year Trends in Community Viral Load n Barbados: Implications for Treatment as Prevention. PLoS One. 2013;8(3):e58590. Analysis of viral load trends in Barbados showed a significant improvement in viral load suppression in the past decade; from 33.6% of clients achieving the 200 copies/ml threshold in 2002 to 70.3% in 2011 (p<0.001) (80). This translated into an estimated 26.2% viral load suppression at a population level at the end of 2010, which is similar to reports in developed countries that used similar methods.PubMedCentralPubMedCrossRef Landis RC, Branch-Beckles SL, Crichlow S, Hambleton IR, Best A. Ten Year Trends in Community Viral Load n Barbados: Implications for Treatment as Prevention. PLoS One. 2013;8(3):e58590. Analysis of viral load trends in Barbados showed a significant improvement in viral load suppression in the past decade; from 33.6% of clients achieving the 200 copies/ml threshold in 2002 to 70.3% in 2011 (p<0.001) (80). This translated into an estimated 26.2% viral load suppression at a population level at the end of 2010, which is similar to reports in developed countries that used similar methods.PubMedCentralPubMedCrossRef
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Zurück zum Zitat Harvey K, Carrington D, Duncan D, Figueroa J, Hirshorn L, Manning D. Evaluation of adherence to highly active antiretroviral therapy in adults in Jamaica. West Indian Med J. 2008;57:293–7.PubMed Harvey K, Carrington D, Duncan D, Figueroa J, Hirshorn L, Manning D. Evaluation of adherence to highly active antiretroviral therapy in adults in Jamaica. West Indian Med J. 2008;57:293–7.PubMed
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Zurück zum Zitat Duke N, Aboh S, Bosivert N. Analysis of Resistance Testing in Trinidad. West Indian Med J. 2010;59:400–2.PubMed Duke N, Aboh S, Bosivert N. Analysis of Resistance Testing in Trinidad. West Indian Med J. 2010;59:400–2.PubMed
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Zurück zum Zitat Barrow G, Hylton-Kong T, Rodriguez N, Yamamura Y, Figueroa JP. HIV-1 Drug Resistance Testing in Treatment Naïve, Chronically Infected Patients in Jamaica. Antivir Ther. 2013. doi:10.3851/IMP2869.PubMed Barrow G, Hylton-Kong T, Rodriguez N, Yamamura Y, Figueroa JP. HIV-1 Drug Resistance Testing in Treatment Naïve, Chronically Infected Patients in Jamaica. Antivir Ther. 2013. doi:10.​3851/​IMP2869.PubMed
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88.
Zurück zum Zitat Hamilton CL, Eyzaguirre LM, Amarakoon II, Figueroa P, Duncan J, Carr JK, et al. Analysis of protease and reverse transcriptase genes of HIV for antiretroviral drug resistance in Jamaican adults. AIDS Res Hum Retrovir. 2012;28(8):923–7.PubMedCrossRef Hamilton CL, Eyzaguirre LM, Amarakoon II, Figueroa P, Duncan J, Carr JK, et al. Analysis of protease and reverse transcriptase genes of HIV for antiretroviral drug resistance in Jamaican adults. AIDS Res Hum Retrovir. 2012;28(8):923–7.PubMedCrossRef
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Zurück zum Zitat Collins-Fairclough AM, Charurat M, Nadai Y, Pando M, Avila MM, Blattner WA, et al. Significantly longer envelope V2 loops are characteristic of heterosexually transmitted subtype B HIV-1 in Trinidad. PLoS One. 2011;6(6):e19995.PubMedCentralPubMedCrossRef Collins-Fairclough AM, Charurat M, Nadai Y, Pando M, Avila MM, Blattner WA, et al. Significantly longer envelope V2 loops are characteristic of heterosexually transmitted subtype B HIV-1 in Trinidad. PLoS One. 2011;6(6):e19995.PubMedCentralPubMedCrossRef
90.•
Zurück zum Zitat Barrow C, Barrow G. HIV Treatment as Prevention in Jamaica and Barbados: Magic Bullet or Sustainable Response? JIAPAC 2013. J Int Assoc Provid AIDS Care 2013 Dec 30. [Epub ahead of print]. This paper discusses the potential and challenges of ARV treatment as prevention in the context of Jamaica and Barbados. Barrow C, Barrow G. HIV Treatment as Prevention in Jamaica and Barbados: Magic Bullet or Sustainable Response? JIAPAC 2013. J Int Assoc Provid AIDS Care 2013 Dec 30. [Epub ahead of print]. This paper discusses the potential and challenges of ARV treatment as prevention in the context of Jamaica and Barbados.
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Zurück zum Zitat Figueroa JP. Turning the Tide toward an AIDS Free Generation: Is It Within Our Reach? West Indian Med J. 2013;62(4):279–81. Figueroa JP. Turning the Tide toward an AIDS Free Generation: Is It Within Our Reach? West Indian Med J. 2013;62(4):279–81.
Metadaten
Titel
Review of HIV in the Caribbean: Significant Progress and Outstanding Challenges
verfasst von
J. Peter Figueroa
Publikationsdatum
01.06.2014
Verlag
Springer US
Erschienen in
Current HIV/AIDS Reports / Ausgabe 2/2014
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-014-0199-7

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