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Current Hypertension Reports
Erschienen in: Current Hypertension Reports 2/2013

01.04.2013 | Pathogenesis of Hypertension (R Agarwal, Section Editor)

Sympathetic Hyperactivity in Chronic Kidney Disease: Pathophysiology and (New) Treatment Options

verfasst von: Eva E. Vink, Rosa L. de Jager, Peter J. Blankestijn

Erschienen in: Current Hypertension Reports | Ausgabe 2/2013

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Abstract

Abundant evidence shows that chronic kidney disease (CKD) is a disease state characterized by increased sympathetic activation. Kidney injury (ischemia) plays a central role in this pathogenesis. Sympathetic excitation is associated with an increased risk of cardiovascular morbidity and mortality. Several pharmacologic strategies are developed to decrease sympathetic activity. However, these medications have limitations. Percutaneous catheter-based renal denervation has the potential to become a new treatment option for CKD. This current report focuses on the effects of sympathetic hyperactivity in CKD, and gives an overview in experimental as well as clinical evidence for a central role of the kidneys in the pathophysiology of sympathetic hyperactivity. Moreover, the effect of pharmacologic treatment and the potential beneficial effect of renal denervation will be discussed.
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Metadaten
Titel
Sympathetic Hyperactivity in Chronic Kidney Disease: Pathophysiology and (New) Treatment Options
verfasst von
Eva E. Vink
Rosa L. de Jager
Peter J. Blankestijn
Publikationsdatum
01.04.2013
Verlag
Current Science Inc.
Erschienen in
Current Hypertension Reports / Ausgabe 2/2013
Print ISSN: 1522-6417
Elektronische ISSN: 1534-3111
DOI
https://doi.org/10.1007/s11906-013-0328-5

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