Skip to main content
Erschienen in: Current Neurology and Neuroscience Reports 3/2013

01.03.2013 | Neurotrauma (J Levine, Section Editor)

Physiological Monitoring of the Severe Traumatic Brain Injury Patient in the Intensive Care Unit

verfasst von: Peter Le Roux

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 3/2013

Einloggen, um Zugang zu erhalten

Abstract

Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide. Despite encouraging animal research, pharmacological agents and neuroprotectants have disappointed in the clinical environment. Current TBI management therefore is directed towards identification, prevention, and treatment of secondary cerebral insults that are known to exacerbate outcome after injury. This strategy is based on a variety of monitoring techniques that include the neurological examination, imaging, laboratory analysis, and physiological monitoring of the brain and other organ systems used to guide therapeutic interventions. Recent clinical series suggest that TBI management informed by multimodality monitoring is associated with improved patient outcome, in part because care is provided in a patient-specific manner. In this review we discuss physiological monitoring of the brain after TBI and the emerging field of neurocritical care bioinformatics.
Literatur
1.
Zurück zum Zitat • Maas AI, Menon DK, Lingsma HF, et al. Re-orientation of clinical research in traumatic brain injury: report of an international workshop on comparative effectiveness research. J Neurotrauma. 2011;29:32–46. This is a summary from an international workshop that describes the limitations of randomized trials in TBI, highlights priorities for future research, and describes the value of systems biology, high-quality clinical databases, and comparative effectiveness research.PubMed • Maas AI, Menon DK, Lingsma HF, et al. Re-orientation of clinical research in traumatic brain injury: report of an international workshop on comparative effectiveness research. J Neurotrauma. 2011;29:32–46. This is a summary from an international workshop that describes the limitations of randomized trials in TBI, highlights priorities for future research, and describes the value of systems biology, high-quality clinical databases, and comparative effectiveness research.PubMed
2.
Zurück zum Zitat Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet. 1974;2:81–4.PubMed Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet. 1974;2:81–4.PubMed
3.
Zurück zum Zitat Wijdicks EF, Bamlet WR, Maramattom BV, Manno EM, McClelland RL. Validation of a new coma scale: the FOUR score. Ann Neurol. 2005;58:585–93.PubMed Wijdicks EF, Bamlet WR, Maramattom BV, Manno EM, McClelland RL. Validation of a new coma scale: the FOUR score. Ann Neurol. 2005;58:585–93.PubMed
4.
Zurück zum Zitat Ely EW, Margolin R, Francis J, May L, Truman B, Dittus R, Speroff T, Gautam S, Bernard GR, Inouye SK. Evaluation of delirium in critically ill patients: validation of the confusion assessment method for the intensive care unit (CAM-ICU). Crit Care Med. 2001;29:1370–9.PubMed Ely EW, Margolin R, Francis J, May L, Truman B, Dittus R, Speroff T, Gautam S, Bernard GR, Inouye SK. Evaluation of delirium in critically ill patients: validation of the confusion assessment method for the intensive care unit (CAM-ICU). Crit Care Med. 2001;29:1370–9.PubMed
5.
Zurück zum Zitat Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y. Intensive care delirium screening checklist: evaluation of a new screening tool. Intensive Care Med. 2001;27:859–64.PubMed Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y. Intensive care delirium screening checklist: evaluation of a new screening tool. Intensive Care Med. 2001;27:859–64.PubMed
6.
Zurück zum Zitat Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. VI. Indications for intracranial pressure monitoring. J Neurotrauma. 2007;24 Suppl 1:S37–44.PubMed Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. VI. Indications for intracranial pressure monitoring. J Neurotrauma. 2007;24 Suppl 1:S37–44.PubMed
7.
Zurück zum Zitat Bouzat P, Francony G, Fauvage B, Payen JF. Transcranial Doppler pulsatility index for initial management of brain-injured patients. Neurosurgery. 2010;67:E1863–4.PubMed Bouzat P, Francony G, Fauvage B, Payen JF. Transcranial Doppler pulsatility index for initial management of brain-injured patients. Neurosurgery. 2010;67:E1863–4.PubMed
8.
Zurück zum Zitat • Rajajee V, Vanaman M, Fletcher JJ, Jacobs TL. Optic nerve ultrasound for the detection of raised intracranial pressure. Neurocrit Care. 2011;15:506–15. This is a prospective observational study in 65 patients with acute brain injury of various causes. An optic nerve sheath diameter of 0.48 cm or greater was associated with an ICP greater than 20 mmHg.PubMed • Rajajee V, Vanaman M, Fletcher JJ, Jacobs TL. Optic nerve ultrasound for the detection of raised intracranial pressure. Neurocrit Care. 2011;15:506–15. This is a prospective observational study in 65 patients with acute brain injury of various causes. An optic nerve sheath diameter of 0.48 cm or greater was associated with an ICP greater than 20 mmHg.PubMed
9.
Zurück zum Zitat Smith M. Monitoring intracranial pressure in traumatic brain injury. Anesth Analg. 2008;106:240–8.PubMed Smith M. Monitoring intracranial pressure in traumatic brain injury. Anesth Analg. 2008;106:240–8.PubMed
10.
Zurück zum Zitat Ehtisham A, Taylor S, Bayless L, et al. Placement of external ventricular drains and intracranial pressure monitors by neurointensivists. Neurocrit Care. 2009;10:241–7.PubMed Ehtisham A, Taylor S, Bayless L, et al. Placement of external ventricular drains and intracranial pressure monitors by neurointensivists. Neurocrit Care. 2009;10:241–7.PubMed
11.
Zurück zum Zitat Timofeev I, Dahyot-Fizelier C, Keong N, Nortje J, Al-Rawi PG, Czosnyka M, Menon DK, Kirkpatrick PJ, Gupta AK, Hutchinson PJ. Ventriculostomy for control of raised ICP in acute traumatic brain injury. Acta Neurochir Suppl. 2008;102:99–104.PubMed Timofeev I, Dahyot-Fizelier C, Keong N, Nortje J, Al-Rawi PG, Czosnyka M, Menon DK, Kirkpatrick PJ, Gupta AK, Hutchinson PJ. Ventriculostomy for control of raised ICP in acute traumatic brain injury. Acta Neurochir Suppl. 2008;102:99–104.PubMed
12.
Zurück zum Zitat Birch AA, Eynon CA, Schley D. Erroneous intracranial pressure measurements from simultaneous pressure monitoring and ventricular drainage catheters. Neurocrit Care. 2006;5:51–4.PubMed Birch AA, Eynon CA, Schley D. Erroneous intracranial pressure measurements from simultaneous pressure monitoring and ventricular drainage catheters. Neurocrit Care. 2006;5:51–4.PubMed
13.
Zurück zum Zitat • Exo J, Kochanek PM, Adelson PD, Greene S, Clark RS, Bayir H, Wisniewski SR, Bell MJ. Intracranial pressure-monitoring systems in children with traumatic brain injury: Combining therapeutic and diagnostic tools. Pediatr Crit Care Med. 2011;12(5):560–5. This is a retrospective review of children with severe TBI who had an EVD and an intraparenchymal ICP monitor. EVD and intraparenchymal measurements of ICP correlated, but intermittent EVD ICP measurements may fail to identify ICP events when draining CSF.PubMed • Exo J, Kochanek PM, Adelson PD, Greene S, Clark RS, Bayir H, Wisniewski SR, Bell MJ. Intracranial pressure-monitoring systems in children with traumatic brain injury: Combining therapeutic and diagnostic tools. Pediatr Crit Care Med. 2011;12(5):560–5. This is a retrospective review of children with severe TBI who had an EVD and an intraparenchymal ICP monitor. EVD and intraparenchymal measurements of ICP correlated, but intermittent EVD ICP measurements may fail to identify ICP events when draining CSF.PubMed
14.
Zurück zum Zitat Lozier AP, Sciacca RR, Romagnoli MF, Connolly Jr ES. Ventriculostomy-related infections: a critical review of the literature. Neurosurgery. 2002;51(1):170–81. discussion 181-2.PubMed Lozier AP, Sciacca RR, Romagnoli MF, Connolly Jr ES. Ventriculostomy-related infections: a critical review of the literature. Neurosurgery. 2002;51(1):170–81. discussion 181-2.PubMed
15.
Zurück zum Zitat Beer R, Lackner P, Pfausler B, Schmutzhard E. Nosocomial ventriculitis and meningitis in neurocritical care patients. J Neurol. 2008;255:1617–24.PubMed Beer R, Lackner P, Pfausler B, Schmutzhard E. Nosocomial ventriculitis and meningitis in neurocritical care patients. J Neurol. 2008;255:1617–24.PubMed
16.
Zurück zum Zitat Marshall LF, Smith RW, Shapiro HM. The outcome with aggressive treatment in severe head injuries. Part I: the significance of intracranial pressure monitoring. J Neurosurg. 1979;50(1):20–5.PubMed Marshall LF, Smith RW, Shapiro HM. The outcome with aggressive treatment in severe head injuries. Part I: the significance of intracranial pressure monitoring. J Neurosurg. 1979;50(1):20–5.PubMed
17.
Zurück zum Zitat Narayan RK, Kishore PR, Becker DP, et al. Intracranial pressure: to monitor or not to monitor? A review of our experience with severe head injury. J Neurosurg. 1982;56:650–9.PubMed Narayan RK, Kishore PR, Becker DP, et al. Intracranial pressure: to monitor or not to monitor? A review of our experience with severe head injury. J Neurosurg. 1982;56:650–9.PubMed
18.
Zurück zum Zitat Marmarou A, Anderson RL, Ward JD, et al. Impact of ICP instability and hypotension on outcome in patients with severe head trauma. J Neurosurg. 1991;75(Suppl):S159–S66. Marmarou A, Anderson RL, Ward JD, et al. Impact of ICP instability and hypotension on outcome in patients with severe head trauma. J Neurosurg. 1991;75(Suppl):S159–S66.
19.
Zurück zum Zitat Vik A, Nag T, Fredriksli OA, Skandsen T, Moen KG, Schirmer-Mikalsen K, Manley GT. Relationship of “dose” of intracranial hypertension to outcome in severe traumatic brain injury. J Neurosurg. 2008;109(4):678–84.PubMed Vik A, Nag T, Fredriksli OA, Skandsen T, Moen KG, Schirmer-Mikalsen K, Manley GT. Relationship of “dose” of intracranial hypertension to outcome in severe traumatic brain injury. J Neurosurg. 2008;109(4):678–84.PubMed
20.
Zurück zum Zitat • Stein DM, Hu PF, Brenner M, Sheth KN, Liu KH, Xiong W, Aarabi B, Scalea TM. Brief episodes of intracranial hypertension and cerebral hypoperfusion are associated with poor functional outcome after severe traumatic brain injury. J Trauma. 2011;71(2):364–74. Thus is a prospective study of 60 patients. The number of brief 5-min episodes of increased ICP or cerebral hypoperfusion was associated with poor outcome.PubMed • Stein DM, Hu PF, Brenner M, Sheth KN, Liu KH, Xiong W, Aarabi B, Scalea TM. Brief episodes of intracranial hypertension and cerebral hypoperfusion are associated with poor functional outcome after severe traumatic brain injury. J Trauma. 2011;71(2):364–74. Thus is a prospective study of 60 patients. The number of brief 5-min episodes of increased ICP or cerebral hypoperfusion was associated with poor outcome.PubMed
21.
Zurück zum Zitat Treggiari MM, Schutz N, Yanez ND, Romand JA. Role of intracranial pressure values and patterns in predicting outcome in traumatic brain injury: a systematic review. Neurocrit Care. 2007;6:104–12.PubMed Treggiari MM, Schutz N, Yanez ND, Romand JA. Role of intracranial pressure values and patterns in predicting outcome in traumatic brain injury: a systematic review. Neurocrit Care. 2007;6:104–12.PubMed
22.
Zurück zum Zitat Stein SC, Georgoff P, Meghan S, et al. Relationship of aggressive monitoring and treatment to improved outcomes in severe traumatic brain injury. J Neurosurg. 2010;112:1105–12.PubMed Stein SC, Georgoff P, Meghan S, et al. Relationship of aggressive monitoring and treatment to improved outcomes in severe traumatic brain injury. J Neurosurg. 2010;112:1105–12.PubMed
23.
Zurück zum Zitat Cremer OL, van Dijk GW, van Wensen E, Brekelmans GJ, Moons KG, Leenen LP, Kalkman CJ. Effect of intracranial pressure monitoring and targeted intensive care on functional outcome after severe head injury. Crit Care Med. 2005;33(10):2207–13.PubMed Cremer OL, van Dijk GW, van Wensen E, Brekelmans GJ, Moons KG, Leenen LP, Kalkman CJ. Effect of intracranial pressure monitoring and targeted intensive care on functional outcome after severe head injury. Crit Care Med. 2005;33(10):2207–13.PubMed
24.
Zurück zum Zitat Shafi S, Diaz-Arrastia R, Madden C, Gentilello L. Intracranial pressure monitoring in brain-injured patients is associated with worsening of survival. J Trauma. 2008;64(2):335–40.PubMed Shafi S, Diaz-Arrastia R, Madden C, Gentilello L. Intracranial pressure monitoring in brain-injured patients is associated with worsening of survival. J Trauma. 2008;64(2):335–40.PubMed
25.
Zurück zum Zitat Forsyth RJ, Wolny S, Rodrigues B. Routine intracranial pressure monitoring in acute coma. Cochrane Database Syst Rev. 2010(2):CD002043. Forsyth RJ, Wolny S, Rodrigues B. Routine intracranial pressure monitoring in acute coma. Cochrane Database Syst Rev. 2010(2):CD002043.
26.
Zurück zum Zitat • Katsnelson M, Mackenzie L, Frangos S, Oddo M, Levine JM, Pukenas B, Faerber J, Dong C, Andrew Kofke W, le Roux PD. Are initial radiographic and clinical scales associated with subsequent intracranial pressure and brain oxygen levels after severe traumatic brain injury? Neurosurgery. 2012;70(5):1095–105. One hundred and one patients with severe TBI were studied using mixed-effects models and logistic regression. The APACHE score and Marshall and Rotterdam CT grades (P < 0.001) were associated with mortality. There was no relationship between GCS score, Injury Severity Score, Marshall score, or Rotterdam score and subsequent ICP or PbtO 2 . The APACHE II score was inversely associated with median and minimum PbtO 2 and the amount of time of reduced PbtO 2 .PubMed • Katsnelson M, Mackenzie L, Frangos S, Oddo M, Levine JM, Pukenas B, Faerber J, Dong C, Andrew Kofke W, le Roux PD. Are initial radiographic and clinical scales associated with subsequent intracranial pressure and brain oxygen levels after severe traumatic brain injury? Neurosurgery. 2012;70(5):1095–105. One hundred and one patients with severe TBI were studied using mixed-effects models and logistic regression. The APACHE score and Marshall and Rotterdam CT grades (P < 0.001) were associated with mortality. There was no relationship between GCS score, Injury Severity Score, Marshall score, or Rotterdam score and subsequent ICP or PbtO 2 . The APACHE II score was inversely associated with median and minimum PbtO 2 and the amount of time of reduced PbtO 2 .PubMed
27.
Zurück zum Zitat Le Roux P, Lam AM, Newell DW, Grady MS, Winn HR. Cerebral arteriovenous difference of oxygen: a predictor of cerebral infarction and outcome in severe head injury. J Neurosurg. 1997;87:1–8.PubMed Le Roux P, Lam AM, Newell DW, Grady MS, Winn HR. Cerebral arteriovenous difference of oxygen: a predictor of cerebral infarction and outcome in severe head injury. J Neurosurg. 1997;87:1–8.PubMed
28.
Zurück zum Zitat Stiefel MF, Udoetek J, Spiotta A, Gracias VH, Goldberg AH, Maloney-Wilensky E, Bloom S, Le Roux P. Conventional neurocritical care and cerebral oxygenation after traumatic brain injury. J Neurosurgery. 2006;105:568–75. Stiefel MF, Udoetek J, Spiotta A, Gracias VH, Goldberg AH, Maloney-Wilensky E, Bloom S, Le Roux P. Conventional neurocritical care and cerebral oxygenation after traumatic brain injury. J Neurosurgery. 2006;105:568–75.
29.
Zurück zum Zitat Menon DK, Coles JP, Gupta AK, Fryer TD, Smielewski P, Chatfield DA, Aigbirhio F, Skepper JN, Minhas PS, Hutchinson PJ, Carpenter TA, Clark JC, Pickard JD. Diffusion limited oxygen delivery following head injury. Crit Care Med. 2004;32:1384–90.PubMed Menon DK, Coles JP, Gupta AK, Fryer TD, Smielewski P, Chatfield DA, Aigbirhio F, Skepper JN, Minhas PS, Hutchinson PJ, Carpenter TA, Clark JC, Pickard JD. Diffusion limited oxygen delivery following head injury. Crit Care Med. 2004;32:1384–90.PubMed
30.
Zurück zum Zitat Vespa PM, O’Phelan K, McArthur D, Miller C, Eliseo M, Hirt D, Glenn T, Hovda DA. Pericontusional brain tissue exhibits persistent elevation of lactate/pyruvate ratio independent of cerebral perfusion pressure. Crit Care Med. 2007;35(4):1153–60.PubMed Vespa PM, O’Phelan K, McArthur D, Miller C, Eliseo M, Hirt D, Glenn T, Hovda DA. Pericontusional brain tissue exhibits persistent elevation of lactate/pyruvate ratio independent of cerebral perfusion pressure. Crit Care Med. 2007;35(4):1153–60.PubMed
31.
Zurück zum Zitat •• Oddo M, Levine JM, Mackenzie L, Frangos S, Feihl F, Kasner SE, Katsnelson M, Pukenas B, Macmurtrie E, Maloney-Wilensky E, Kofke WA, LeRoux PD. Brain hypoxia is associated with short-term outcome after severe traumatic brain injury independently of intracranial hypertension and low cerebral perfusion pressure. Neurosurgery. 2011;69(5):1037–45. discussion 1045. An observational cohort of 103 severe TBI patients was monitored with ICP and PbtO 2 for more than 24 h. After ICP, CPP, age, GCS score, Marshall CT grade, and APACHE II score had been controlled for, brain hypoxia was independently associated with poor prognosis (adjusted odds ratio for favorable outcome, 0.89 per hour of brain hypoxia; 95 % confidence interval, 0.79-0.99; P = 0.04).PubMed •• Oddo M, Levine JM, Mackenzie L, Frangos S, Feihl F, Kasner SE, Katsnelson M, Pukenas B, Macmurtrie E, Maloney-Wilensky E, Kofke WA, LeRoux PD. Brain hypoxia is associated with short-term outcome after severe traumatic brain injury independently of intracranial hypertension and low cerebral perfusion pressure. Neurosurgery. 2011;69(5):1037–45. discussion 1045. An observational cohort of 103 severe TBI patients was monitored with ICP and PbtO 2 for more than 24 h. After ICP, CPP, age, GCS score, Marshall CT grade, and APACHE II score had been controlled for, brain hypoxia was independently associated with poor prognosis (adjusted odds ratio for favorable outcome, 0.89 per hour of brain hypoxia; 95 % confidence interval, 0.79-0.99; P = 0.04).PubMed
32.
Zurück zum Zitat Maloney-Wilensky E, Gracias V, Itkin A, Hoffman K, Bloom S, Yang W, Christian S, Le Roux P. Brain tissue oxygen and outcome after severe traumatic brain injury: a systematic review. Crit Care Med. 2009;37(6):2057–63.PubMed Maloney-Wilensky E, Gracias V, Itkin A, Hoffman K, Bloom S, Yang W, Christian S, Le Roux P. Brain tissue oxygen and outcome after severe traumatic brain injury: a systematic review. Crit Care Med. 2009;37(6):2057–63.PubMed
33.
Zurück zum Zitat Oddo M, Le Roux P. What is the etiology, pathogenesis and pathophysiology of elevated intracranial pressure? In: Neligan P, Deutschman CS, editors. The evidenced based practice of critical care. Philadelphia: Elsevier Science; 2009. p. 399–405. Oddo M, Le Roux P. What is the etiology, pathogenesis and pathophysiology of elevated intracranial pressure? In: Neligan P, Deutschman CS, editors. The evidenced based practice of critical care. Philadelphia: Elsevier Science; 2009. p. 399–405.
34.
Zurück zum Zitat Miller JD. Volume and pressure in the craniospinal axis. Clin Neurosurg. 1975;22:76–105.PubMed Miller JD. Volume and pressure in the craniospinal axis. Clin Neurosurg. 1975;22:76–105.PubMed
35.
Zurück zum Zitat Marmarou A, Shulman K, LaMorgese J. Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system. J Neurosurg. 1975;43(5):523–34.PubMed Marmarou A, Shulman K, LaMorgese J. Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system. J Neurosurg. 1975;43(5):523–34.PubMed
36.
Zurück zum Zitat Czosnyka M, Guazzo E, Whitehouse M, et al. Significance of intracranial pressure waveform analysis after head injury. Acta Neurochir. 1996;138:531–41. discussion 41–42.PubMed Czosnyka M, Guazzo E, Whitehouse M, et al. Significance of intracranial pressure waveform analysis after head injury. Acta Neurochir. 1996;138:531–41. discussion 41–42.PubMed
37.
Zurück zum Zitat Balestreri M, Czosnyka M, Steiner LA, et al. Association between outcome, cerebral pressure reactivity and slow ICP waves following head injury. Acta Neurochir Suppl. 2005;95:25–8.PubMed Balestreri M, Czosnyka M, Steiner LA, et al. Association between outcome, cerebral pressure reactivity and slow ICP waves following head injury. Acta Neurochir Suppl. 2005;95:25–8.PubMed
38.
Zurück zum Zitat Maset AL, Marmarou A, Ward JD, et al. Pressure-volume index in head injury. J Neurosurg. 1987;67:832–40.PubMed Maset AL, Marmarou A, Ward JD, et al. Pressure-volume index in head injury. J Neurosurg. 1987;67:832–40.PubMed
39.
Zurück zum Zitat Czosnyka M, Smielewski P, Kirkpatrick P, Laing RJ, Menon D, Pickard JD. Continuous assessment of the cerebral vasomotor reactivity in head injury. Neurosurgery. 1997;41(1):11–7. discussion 17-9.PubMed Czosnyka M, Smielewski P, Kirkpatrick P, Laing RJ, Menon D, Pickard JD. Continuous assessment of the cerebral vasomotor reactivity in head injury. Neurosurgery. 1997;41(1):11–7. discussion 17-9.PubMed
40.
Zurück zum Zitat Czosnyka M, Smielewski P, Kirkpatrick P, Menon DK, Pickard JD. Monitoring of cerebral autoregulation in head-injured patients. Stroke. 1996;27(10):1829–34.PubMed Czosnyka M, Smielewski P, Kirkpatrick P, Menon DK, Pickard JD. Monitoring of cerebral autoregulation in head-injured patients. Stroke. 1996;27(10):1829–34.PubMed
41.
Zurück zum Zitat Steiner LA, Czosnyka M, Piechnik SK, et al. Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury. Crit Care Med. 2002;30:733–8.PubMed Steiner LA, Czosnyka M, Piechnik SK, et al. Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury. Crit Care Med. 2002;30:733–8.PubMed
42.
Zurück zum Zitat Czosnyka M, Brady K, Reinhard M, Smielewski P, Steiner LA. Monitoring of cerebrovascular autoregulation: facts, myths, and missing links. Neurocrit Care. 2009;10:373–86.PubMed Czosnyka M, Brady K, Reinhard M, Smielewski P, Steiner LA. Monitoring of cerebrovascular autoregulation: facts, myths, and missing links. Neurocrit Care. 2009;10:373–86.PubMed
43.
Zurück zum Zitat Jaeger M, Dengl M, Meixensberger J, Schuhmann MU. Effects of cerebrovascular pressure reactivity- guided optimization of cerebral perfusion pressure on brain tissue oxygenation after traumatic brain injury. Crit Care Med. 2010;38:1343–7.PubMed Jaeger M, Dengl M, Meixensberger J, Schuhmann MU. Effects of cerebrovascular pressure reactivity- guided optimization of cerebral perfusion pressure on brain tissue oxygenation after traumatic brain injury. Crit Care Med. 2010;38:1343–7.PubMed
44.
Zurück zum Zitat • Kosty JA, Kumar M, Park S, Le Roux P, Kofke WA. Comparison of Clinician Practices in Measuring Cerebral Perfusion Pressure (CPP): A Literature Review and Multidisciplinary Survey. Proceedings of the Neurocritical Care Society Annual Meeting, Montreal, Canada, 2011. This is a review of citations in the third edition of the guidelines for the management of severe TBI, meta-analyses on CPP published by the Cochrane Library, and survey results from 241 members of the Neurocritical Care Society. There was variability in both clinical practice and research reports in how MABP is measured to determine CPP. Among survey responders, 59 % referenced the heart and 41 % referenced the midbrain. • Kosty JA, Kumar M, Park S, Le Roux P, Kofke WA. Comparison of Clinician Practices in Measuring Cerebral Perfusion Pressure (CPP): A Literature Review and Multidisciplinary Survey. Proceedings of the Neurocritical Care Society Annual Meeting, Montreal, Canada, 2011. This is a review of citations in the third edition of the guidelines for the management of severe TBI, meta-analyses on CPP published by the Cochrane Library, and survey results from 241 members of the Neurocritical Care Society. There was variability in both clinical practice and research reports in how MABP is measured to determine CPP. Among survey responders, 59 % referenced the heart and 41 % referenced the midbrain.
45.
Zurück zum Zitat Czosnyka M, Matta BF, Smielewski P, et al. Cerebral perfusion pressure in head-injured patients: a noninvasive assessment using transcranial Doppler ultrasonography. J Neurosurg. 1998;88(5):802–8.PubMed Czosnyka M, Matta BF, Smielewski P, et al. Cerebral perfusion pressure in head-injured patients: a noninvasive assessment using transcranial Doppler ultrasonography. J Neurosurg. 1998;88(5):802–8.PubMed
46.
Zurück zum Zitat Czosnyka M, Smielewski P, Kirkpatrick P, et al. Continuous monitoring of cerebrovascular pressure-reactivity in head injury. Acta Neurochir Suppl. 1998;71:74–7.PubMed Czosnyka M, Smielewski P, Kirkpatrick P, et al. Continuous monitoring of cerebrovascular pressure-reactivity in head injury. Acta Neurochir Suppl. 1998;71:74–7.PubMed
47.
Zurück zum Zitat Robertson CS, Valadka AB, Hannay HJ, et al. Prevention of secondary ischemic insults after severe head injury. Crit Care Med. 1999;27(10):2086–95.PubMed Robertson CS, Valadka AB, Hannay HJ, et al. Prevention of secondary ischemic insults after severe head injury. Crit Care Med. 1999;27(10):2086–95.PubMed
48.
Zurück zum Zitat Vespa P. What is the optimal threshold for cerebral perfusion pressure following traumatic brain injury? Neurosurg Focus. 2003;15(6):E4.PubMed Vespa P. What is the optimal threshold for cerebral perfusion pressure following traumatic brain injury? Neurosurg Focus. 2003;15(6):E4.PubMed
49.
Zurück zum Zitat Nordstrom CH, Reinstrup P, Xu W, et al. Assessment of the lower limit for cerebral perfusion pressure in severe head injuries by bedside monitoring of regional energy metabolism. Anesthesiology. 2003;98(4):809–14.PubMed Nordstrom CH, Reinstrup P, Xu W, et al. Assessment of the lower limit for cerebral perfusion pressure in severe head injuries by bedside monitoring of regional energy metabolism. Anesthesiology. 2003;98(4):809–14.PubMed
50.
Zurück zum Zitat •• Aries MJ, Czosnyka M, Budohoski KP, Steiner LA, Lavinio A, Kolias AG, Hutchinson PJ, Brady KM, Menon DK, Pickard JD, Smielewski P. Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury. Crit Care Med. 2012;40(8):2456–63. An automated curve fitting method was used to determine CPP at the minimum value of the PRx (CPP opt ) in 327 patients with severe TBI. Patients with a median CPP close to CPP opt were more likely to have a favorable outcome.PubMed •• Aries MJ, Czosnyka M, Budohoski KP, Steiner LA, Lavinio A, Kolias AG, Hutchinson PJ, Brady KM, Menon DK, Pickard JD, Smielewski P. Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury. Crit Care Med. 2012;40(8):2456–63. An automated curve fitting method was used to determine CPP at the minimum value of the PRx (CPP opt ) in 327 patients with severe TBI. Patients with a median CPP close to CPP opt were more likely to have a favorable outcome.PubMed
51.
Zurück zum Zitat Chieregato A, Sabia G, Tanfani A, Compagnone C, Tagliaferri F, Targa L. Xenon-CT and transcranial Doppler in poor-grade or complicated aneurysmatic subarachnoid hemorrhage patients undergoing aggressive management of intracranial hypertension. Intensive Care Med. 2006;32:1143–50.PubMed Chieregato A, Sabia G, Tanfani A, Compagnone C, Tagliaferri F, Targa L. Xenon-CT and transcranial Doppler in poor-grade or complicated aneurysmatic subarachnoid hemorrhage patients undergoing aggressive management of intracranial hypertension. Intensive Care Med. 2006;32:1143–50.PubMed
52.
Zurück zum Zitat • Washington CW, Zipfel GJ. Detection and monitoring of vasospasm and delayed cerebral ischemia: a review and assessment of the literature. Neurocrit Care. 2011;15:312–7. This is a literature review of English-language articles describing the use of TCD ultrasonography, CT angiography, and CTP in evaluation of vasospasm and delayed cerebral ischemia after SAH.PubMed • Washington CW, Zipfel GJ. Detection and monitoring of vasospasm and delayed cerebral ischemia: a review and assessment of the literature. Neurocrit Care. 2011;15:312–7. This is a literature review of English-language articles describing the use of TCD ultrasonography, CT angiography, and CTP in evaluation of vasospasm and delayed cerebral ischemia after SAH.PubMed
53.
Zurück zum Zitat Carrera E, Schmidt JM, Oddo M, Fernandez L, Claassen J, Seder D, Lee K, Badjatia N, Connolly Jr ES, Mayer SA. Transcranial Doppler for predicting delayed cerebral ischemia after subarachnoid hemorrhage. Neurosurgery. 2009;65:316–23.PubMed Carrera E, Schmidt JM, Oddo M, Fernandez L, Claassen J, Seder D, Lee K, Badjatia N, Connolly Jr ES, Mayer SA. Transcranial Doppler for predicting delayed cerebral ischemia after subarachnoid hemorrhage. Neurosurgery. 2009;65:316–23.PubMed
54.
Zurück zum Zitat Jahromi BS, MacDonald RL. Vasospasm: diagnosis and medical management. In: Le Roux P, Winn HR, Newell DW, editors. Management of cerebral aneurysms. Philadelphia: Elsevier; 2004. p. 455–87. Jahromi BS, MacDonald RL. Vasospasm: diagnosis and medical management. In: Le Roux P, Winn HR, Newell DW, editors. Management of cerebral aneurysms. Philadelphia: Elsevier; 2004. p. 455–87.
55.
Zurück zum Zitat Homburg AM, Jakobsen M, Enevoldsen E. Transcranial Doppler recordings in raised intracranial pressure. Acta Neurol Scand. 1993;87:488–93.PubMed Homburg AM, Jakobsen M, Enevoldsen E. Transcranial Doppler recordings in raised intracranial pressure. Acta Neurol Scand. 1993;87:488–93.PubMed
56.
Zurück zum Zitat Molina CA, Alexandrov AV. Transcranial ultrasound in acute stroke: from diagnosis to therapy. Cerebrovasc Dis. 2007;24 Suppl 1:1–6.PubMed Molina CA, Alexandrov AV. Transcranial ultrasound in acute stroke: from diagnosis to therapy. Cerebrovasc Dis. 2007;24 Suppl 1:1–6.PubMed
57.
Zurück zum Zitat Figaji AA, Zwane E, Fieggen AG, et al. Pressure autoregulation, intracranial pressure, and brain tissue oxygenation in children with severe traumatic brain injury. J Neurosurg Pediatr. 2009;4:420–8.PubMed Figaji AA, Zwane E, Fieggen AG, et al. Pressure autoregulation, intracranial pressure, and brain tissue oxygenation in children with severe traumatic brain injury. J Neurosurg Pediatr. 2009;4:420–8.PubMed
58.
Zurück zum Zitat Kincaid MS. Transcranial Doppler ultrasonography: a diagnostic tool of increasing utility. Curr Opin Anaesthesiol. 2008;21:552–9.PubMed Kincaid MS. Transcranial Doppler ultrasonography: a diagnostic tool of increasing utility. Curr Opin Anaesthesiol. 2008;21:552–9.PubMed
59.
Zurück zum Zitat Stolz E, Cioli F, Allendoerfer J, et al. Can early neurosonology predict outcome in acute stroke? A metaanalysis of prognostic clinical effect sizes related to the vascular status. Stroke. 2008;39:3255–61.PubMed Stolz E, Cioli F, Allendoerfer J, et al. Can early neurosonology predict outcome in acute stroke? A metaanalysis of prognostic clinical effect sizes related to the vascular status. Stroke. 2008;39:3255–61.PubMed
60.
Zurück zum Zitat Rigamonti A, Ackery A, Baker AJ. Transcranial Doppler monitoring in subarachnoid hemorrhage: a critical tool in critical care. Can J Anaesth. 2008;55:112–23.PubMed Rigamonti A, Ackery A, Baker AJ. Transcranial Doppler monitoring in subarachnoid hemorrhage: a critical tool in critical care. Can J Anaesth. 2008;55:112–23.PubMed
61.
Zurück zum Zitat Martin KK, Wigginton JB, Babikian VL, et al. Intraoperative cerebral high intensity transient signals and postoperative cognitive function: a systematic review. Am J Surg. 2009;197:55–63.PubMed Martin KK, Wigginton JB, Babikian VL, et al. Intraoperative cerebral high intensity transient signals and postoperative cognitive function: a systematic review. Am J Surg. 2009;197:55–63.PubMed
62.
Zurück zum Zitat Poppert H, Sadikovic S, Sander K, et al. Embolic signals in unselected stroke patients: prevalence and diagnostic benefit. Stroke. 2006;37:2039–43.PubMed Poppert H, Sadikovic S, Sander K, et al. Embolic signals in unselected stroke patients: prevalence and diagnostic benefit. Stroke. 2006;37:2039–43.PubMed
63.
Zurück zum Zitat • Sharma D, Souter MJ, Moore AE, Lam AM. Clinical experience with transcranial Doppler ultrasonography as a confirmatory test for brain death: a retrospective analysis. Neurocrit Care. 2011;14(3):370–6. TCD ultrasonography confirmed brain death diagnosis in 51 patients (57 %) and was inconclusive in 38 patients (43 %).PubMed • Sharma D, Souter MJ, Moore AE, Lam AM. Clinical experience with transcranial Doppler ultrasonography as a confirmatory test for brain death: a retrospective analysis. Neurocrit Care. 2011;14(3):370–6. TCD ultrasonography confirmed brain death diagnosis in 51 patients (57 %) and was inconclusive in 38 patients (43 %).PubMed
64.
Zurück zum Zitat Lee SC, Chen JF, Lee ST. Continuous regional cerebral blood flow monitoring in the neurosurgical intensive care unit. J Clin Neurosci. 2005;12:520–3.PubMed Lee SC, Chen JF, Lee ST. Continuous regional cerebral blood flow monitoring in the neurosurgical intensive care unit. J Clin Neurosci. 2005;12:520–3.PubMed
65.
Zurück zum Zitat Gaines C, Carter LP, Crowell RM. Comparison of local cerebral blood flow determined by thermal and hydrogen clearance. Stroke. 1983;14:66–9.PubMed Gaines C, Carter LP, Crowell RM. Comparison of local cerebral blood flow determined by thermal and hydrogen clearance. Stroke. 1983;14:66–9.PubMed
66.
Zurück zum Zitat Vajkoczy P, Roth H, Horn P, et al. Continuous monitoring of regional cerebral blood flow: experimental and clinical validation of a novel thermal diffusion microprobe. J Neurosurg. 2000;93:265–74.PubMed Vajkoczy P, Roth H, Horn P, et al. Continuous monitoring of regional cerebral blood flow: experimental and clinical validation of a novel thermal diffusion microprobe. J Neurosurg. 2000;93:265–74.PubMed
67.
Zurück zum Zitat Vajkoczy P, Horn P, Thome C, et al. Regional cerebral blood flow monitoring in the diagnosis of delayed ischemia following aneurysmal subarachnoid hemorrhage. J Neurosurg. 2003;98:1227–34.PubMed Vajkoczy P, Horn P, Thome C, et al. Regional cerebral blood flow monitoring in the diagnosis of delayed ischemia following aneurysmal subarachnoid hemorrhage. J Neurosurg. 2003;98:1227–34.PubMed
68.
Zurück zum Zitat Sioutos PJ, Orozco JA, Carter LP, Weinand ME, Hamilton AJ, Williams FC. Continuous regional cerebral cortical blood flow monitoring in head-injured patients. Neurosurgery. 1995;36(5):943–9.PubMed Sioutos PJ, Orozco JA, Carter LP, Weinand ME, Hamilton AJ, Williams FC. Continuous regional cerebral cortical blood flow monitoring in head-injured patients. Neurosurgery. 1995;36(5):943–9.PubMed
69.
Zurück zum Zitat Miller JI, Chou MW, Capocelli A, et al. Continuous intracranial multimodality monitoring comparing local cerebral blood flow, cerebral perfusion pressure, and microvascular resistance. Acta Neurochir Suppl. 1998;71:82–4.PubMed Miller JI, Chou MW, Capocelli A, et al. Continuous intracranial multimodality monitoring comparing local cerebral blood flow, cerebral perfusion pressure, and microvascular resistance. Acta Neurochir Suppl. 1998;71:82–4.PubMed
70.
Zurück zum Zitat • Rosenthal G, Sanchez-Mejia RO, Phan N, et al. Incorporating a parenchymal thermal diffusion cerebral blood flow probe in bedside assessment of cerebral autoregulation and vasoreactivity in patients with severe traumatic brain injury. J Neurosurg. 2011;114:62–70. Twenty patients with severe TBI were studied. CAR and CO 2 vasoreactivity can be assessed using a Hemedex probe.PubMed • Rosenthal G, Sanchez-Mejia RO, Phan N, et al. Incorporating a parenchymal thermal diffusion cerebral blood flow probe in bedside assessment of cerebral autoregulation and vasoreactivity in patients with severe traumatic brain injury. J Neurosurg. 2011;114:62–70. Twenty patients with severe TBI were studied. CAR and CO 2 vasoreactivity can be assessed using a Hemedex probe.PubMed
71.
Zurück zum Zitat Bonner RF, Nossal R. Principles of laser-Doppler flowmetry. In: Shepherd AP, Oberg PA, editors. Laser Doppler flowmetry. Boston: Kluwer; 1990. p. 17–45. Bonner RF, Nossal R. Principles of laser-Doppler flowmetry. In: Shepherd AP, Oberg PA, editors. Laser Doppler flowmetry. Boston: Kluwer; 1990. p. 17–45.
72.
Zurück zum Zitat Bolognese P, Miller JI, Heger IM, et al. Laser Doppler flowmetry in neurosurgery. J Neurosurg Anesthesiol. 1993;5:151–8.PubMed Bolognese P, Miller JI, Heger IM, et al. Laser Doppler flowmetry in neurosurgery. J Neurosurg Anesthesiol. 1993;5:151–8.PubMed
73.
Zurück zum Zitat Bhatia A, Gupta AK. Neuromonitoring in the intensive care unit. I. Intracranial pressure and cerebral blood flow monitoring. Intensive Care Med. 2007;33:1263–71.PubMed Bhatia A, Gupta AK. Neuromonitoring in the intensive care unit. I. Intracranial pressure and cerebral blood flow monitoring. Intensive Care Med. 2007;33:1263–71.PubMed
74.
Zurück zum Zitat DeGeorgia MA, Deogaonkar A. Multimodal monitoring in the neurological intensive care unit. Neurologist. 2005;11:45–54. DeGeorgia MA, Deogaonkar A. Multimodal monitoring in the neurological intensive care unit. Neurologist. 2005;11:45–54.
75.
Zurück zum Zitat Klaessens JHGM, Kolkman RGM, Hopman JCW, et al. Monitoring cerebral perfusion using near-infrared spectroscopy and laser Doppler flowmetry. Physiol Meas. 2003;24:N35–40.PubMed Klaessens JHGM, Kolkman RGM, Hopman JCW, et al. Monitoring cerebral perfusion using near-infrared spectroscopy and laser Doppler flowmetry. Physiol Meas. 2003;24:N35–40.PubMed
76.
Zurück zum Zitat Wright WL. Multimodal monitoring in the ICU: when could it be useful? J Neurol Sci. 2007;261:10–5.PubMed Wright WL. Multimodal monitoring in the ICU: when could it be useful? J Neurol Sci. 2007;261:10–5.PubMed
77.
Zurück zum Zitat Eyre JA, Essex TJH, Flecknell PA, et al. A comparison of measurements of cerebral blood flow in the rabbit using laser Doppler spectroscopy and radionuclide labelled microspheres. Clin Phys Physiol Meas. 1988;9:65–74.PubMed Eyre JA, Essex TJH, Flecknell PA, et al. A comparison of measurements of cerebral blood flow in the rabbit using laser Doppler spectroscopy and radionuclide labelled microspheres. Clin Phys Physiol Meas. 1988;9:65–74.PubMed
78.
Zurück zum Zitat Fakuda O, Endo S, Kuwayama N, et al. The characteristics of laser-Doppler flowmetry for the measurement of regional cerebral blood flow. Neurosurgery. 1995;36:358–64. Fakuda O, Endo S, Kuwayama N, et al. The characteristics of laser-Doppler flowmetry for the measurement of regional cerebral blood flow. Neurosurgery. 1995;36:358–64.
79.
Zurück zum Zitat Frerichs KU, Feuerstein GZ. Laser-Doppler flowmetry. A review of its application for measuring cerebral and spinal cord blood flow. Mol Chem Neuropathol. 1990;12:55–70.PubMed Frerichs KU, Feuerstein GZ. Laser-Doppler flowmetry. A review of its application for measuring cerebral and spinal cord blood flow. Mol Chem Neuropathol. 1990;12:55–70.PubMed
80.
Zurück zum Zitat Kirkpatrick PJ, Smielweski P, Czosnyka, et al. Continuous monitoring of cortical perfusion by laser Doppler flowmetry in ventilated patients with head injury. J Neurolog Neurosurg Psychiatry. 1994;57:1382–88. Kirkpatrick PJ, Smielweski P, Czosnyka, et al. Continuous monitoring of cortical perfusion by laser Doppler flowmetry in ventilated patients with head injury. J Neurolog Neurosurg Psychiatry. 1994;57:1382–88.
81.
Zurück zum Zitat Kirkpatrick PJ, Smielweski P, Piechnik, et al. Early effects of mannitol in patients with head injuries assessed using bedside multimodality monitoring. Neurosurgery. 1996;39:714–20.PubMed Kirkpatrick PJ, Smielweski P, Piechnik, et al. Early effects of mannitol in patients with head injuries assessed using bedside multimodality monitoring. Neurosurgery. 1996;39:714–20.PubMed
82.
Zurück zum Zitat Lam JMK, Hsiang JNK, Poon WS. Monitoring of autoregulation using laser Doppler flowmetry in patients with head injury. J Neurosurg. 1997;86:438–45.PubMed Lam JMK, Hsiang JNK, Poon WS. Monitoring of autoregulation using laser Doppler flowmetry in patients with head injury. J Neurosurg. 1997;86:438–45.PubMed
83.
Zurück zum Zitat Smielewski P, Czosnyka M, Kirkpatrick P, et al. Evaluation of the transient hyperemic response test in head injured patients. J Neurosurg. 1997;86:773–8.PubMed Smielewski P, Czosnyka M, Kirkpatrick P, et al. Evaluation of the transient hyperemic response test in head injured patients. J Neurosurg. 1997;86:773–8.PubMed
84.
Zurück zum Zitat Powers WJ, Zazulia AR. PET in cerebrovascular disease. PET Clin. 2010;5(1):83106.PubMed Powers WJ, Zazulia AR. PET in cerebrovascular disease. PET Clin. 2010;5(1):83106.PubMed
85.
Zurück zum Zitat • Heiss WD. PET in coma and in vegetative state. Eur J Neurol. 2012;19(2):207–11. This is a review on the use of PET.PubMed • Heiss WD. PET in coma and in vegetative state. Eur J Neurol. 2012;19(2):207–11. This is a review on the use of PET.PubMed
86.
Zurück zum Zitat Johnston AJ, Steiner LA, Coles JP, et al. Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury. Crit Care Med. 2005;33(1):189–95.PubMed Johnston AJ, Steiner LA, Coles JP, et al. Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury. Crit Care Med. 2005;33(1):189–95.PubMed
87.
Zurück zum Zitat Hutchinson PJ, Gupta AK, Fryer TF, et al. Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study. J Cereb Blood Flow Metab. 2002;22(6):735–45.PubMed Hutchinson PJ, Gupta AK, Fryer TF, et al. Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study. J Cereb Blood Flow Metab. 2002;22(6):735–45.PubMed
88.
Zurück zum Zitat Stocchetti N, Paparella A, Brindelli F, Bacchi M, Piazza P, Zuccoli P. Cerebral venous oxygen saturation studied with bilateral samples in the internal jugular veins. Neurosurgery. 1994;34:38–44.PubMed Stocchetti N, Paparella A, Brindelli F, Bacchi M, Piazza P, Zuccoli P. Cerebral venous oxygen saturation studied with bilateral samples in the internal jugular veins. Neurosurgery. 1994;34:38–44.PubMed
89.
Zurück zum Zitat Ketty SS, Schmidt CF. The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J Clin Invest. 1948;27:476–83. Ketty SS, Schmidt CF. The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J Clin Invest. 1948;27:476–83.
90.
Zurück zum Zitat Matta BF, Lam AM, Mayberg TS, Shapira Y, Winn HR. A critique of the intraoperative use of jugular venous bulb catheters during neurosurgical procedures. Anesth Analg. 1994;79:745–50.PubMed Matta BF, Lam AM, Mayberg TS, Shapira Y, Winn HR. A critique of the intraoperative use of jugular venous bulb catheters during neurosurgical procedures. Anesth Analg. 1994;79:745–50.PubMed
91.
Zurück zum Zitat Feldman Z, Robertson CS. Monitoring of cerebral hemodynamics with jugular bulb catheters. Crit Care Clin. 1997;13(1):51–77.PubMed Feldman Z, Robertson CS. Monitoring of cerebral hemodynamics with jugular bulb catheters. Crit Care Clin. 1997;13(1):51–77.PubMed
92.
Zurück zum Zitat Robertson CS, Gopinath SP, Goodman JC, et al. SjvO2 monitoring in head injured patients. J Neurotrauma. 1995;12:891–6.PubMed Robertson CS, Gopinath SP, Goodman JC, et al. SjvO2 monitoring in head injured patients. J Neurotrauma. 1995;12:891–6.PubMed
93.
Zurück zum Zitat Artru F, Dailler F, Burel E, et al. Assessment of jugular blood oxygen and lactate indices for detection of cerebral ischemia and prognosis. J Neurosurg Anesthesiol. 2004;16:226–31.PubMed Artru F, Dailler F, Burel E, et al. Assessment of jugular blood oxygen and lactate indices for detection of cerebral ischemia and prognosis. J Neurosurg Anesthesiol. 2004;16:226–31.PubMed
94.
Zurück zum Zitat Sheinberg GM, Kanter MJ, Robertson CS, et al. Continuous monitoring of jugular venous oxygen saturation in head-injured patients. J Neurosurg. 1992;76:212–7.PubMed Sheinberg GM, Kanter MJ, Robertson CS, et al. Continuous monitoring of jugular venous oxygen saturation in head-injured patients. J Neurosurg. 1992;76:212–7.PubMed
95.
Zurück zum Zitat Gopinath SP, Rogertson CS, Constant CF, et al. Jugular venous desaturation and outcome after head injury. J Neurol Neurosurg Psychiatry. 1994;57:717–23.PubMed Gopinath SP, Rogertson CS, Constant CF, et al. Jugular venous desaturation and outcome after head injury. J Neurol Neurosurg Psychiatry. 1994;57:717–23.PubMed
96.
Zurück zum Zitat Thiagarajan A, Goverdhan P, Chari P, Somasunderam K. The effect of hyperventilation and hyperoxia on cerebral venous oxygen saturation in patients with traumatic brain injury. Anesth Analg. 1998;87:850–3.PubMed Thiagarajan A, Goverdhan P, Chari P, Somasunderam K. The effect of hyperventilation and hyperoxia on cerebral venous oxygen saturation in patients with traumatic brain injury. Anesth Analg. 1998;87:850–3.PubMed
97.
Zurück zum Zitat Goetting MG, Preston G. Jugular bulb catheterization: experience with 123 patients. Crit Care Med. 1990;18(11):1220–3.PubMed Goetting MG, Preston G. Jugular bulb catheterization: experience with 123 patients. Crit Care Med. 1990;18(11):1220–3.PubMed
98.
Zurück zum Zitat Brain Trauma Foundation, American Association of Neurological Surgeons, Congress of Neurological Surgeons, Joint Section on Neurotrauma and Critical Care, AANS/CNS. Guidelines for the management of severe traumatic brain injury. X. Brain oxygen monitoring and thresholds. J Neurotrauma. 2007;24 Suppl 1:S65–70. Brain Trauma Foundation, American Association of Neurological Surgeons, Congress of Neurological Surgeons, Joint Section on Neurotrauma and Critical Care, AANS/CNS. Guidelines for the management of severe traumatic brain injury. X. Brain oxygen monitoring and thresholds. J Neurotrauma. 2007;24 Suppl 1:S65–70.
99.
Zurück zum Zitat Rosenthal G, Hemphill III JC, Sorani M, et al. Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury. Crit Care Med. 2008;36:1917–24.PubMed Rosenthal G, Hemphill III JC, Sorani M, et al. Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury. Crit Care Med. 2008;36:1917–24.PubMed
100.
Zurück zum Zitat Hemphill 3rd JC, Knudson MM, Derugin N, Morabito D, Manley GT. Carbon dioxide reactivity and pressure autoregulation of brain tissue oxygen. Neurosurgery. 2001;48:377–83.PubMed Hemphill 3rd JC, Knudson MM, Derugin N, Morabito D, Manley GT. Carbon dioxide reactivity and pressure autoregulation of brain tissue oxygen. Neurosurgery. 2001;48:377–83.PubMed
101.
Zurück zum Zitat Scheufler K-M, Lehnert A, Rohrborn H-J, et al. Individual values of brain tissue oxygen pressure, microvascular oxygen saturation, cytochrome redox level and energy metabolites in detecting critically reduced cerebral energy state during acute changes in global cerebral perfusion. J Neurosurg Anesthesiol. 2004;16:210–9.PubMed Scheufler K-M, Lehnert A, Rohrborn H-J, et al. Individual values of brain tissue oxygen pressure, microvascular oxygen saturation, cytochrome redox level and energy metabolites in detecting critically reduced cerebral energy state during acute changes in global cerebral perfusion. J Neurosurg Anesthesiol. 2004;16:210–9.PubMed
102.
Zurück zum Zitat Scheufler KM, Rohrborn HJ, Zentner J. Does tissue oxygen-tension reliably reflect cerebral oxygen delivery and consumption? Anesth Analg. 2002;95:1042–48.PubMed Scheufler KM, Rohrborn HJ, Zentner J. Does tissue oxygen-tension reliably reflect cerebral oxygen delivery and consumption? Anesth Analg. 2002;95:1042–48.PubMed
103.
Zurück zum Zitat Maloney-Wilensky E, Le Roux P. The physiology behind direct brain oxygen monitors and practical aspects of their use. Childs Nerv System. 2010;26(4):419–30. Maloney-Wilensky E, Le Roux P. The physiology behind direct brain oxygen monitors and practical aspects of their use. Childs Nerv System. 2010;26(4):419–30.
104.
Zurück zum Zitat Longhi L, Valeriani V, Rossi S, De Marchi M, Egidi M, Stocchetti N. Effects of hyperoxia on brain tissue oxygen tension in cerebral focal lesions. Acta Neurochir Suppl. 2002;81:315–7.PubMed Longhi L, Valeriani V, Rossi S, De Marchi M, Egidi M, Stocchetti N. Effects of hyperoxia on brain tissue oxygen tension in cerebral focal lesions. Acta Neurochir Suppl. 2002;81:315–7.PubMed
105.
Zurück zum Zitat Pennings FA, Schuurman PR, van den Munckhof P, Bouma GJ. Brain tissue oxygen pressure monitoring in awake patients during functional neurosurgery: the assessment of normal values. J Neurotrauma. 2008;25:1173–7.PubMed Pennings FA, Schuurman PR, van den Munckhof P, Bouma GJ. Brain tissue oxygen pressure monitoring in awake patients during functional neurosurgery: the assessment of normal values. J Neurotrauma. 2008;25:1173–7.PubMed
106.
Zurück zum Zitat Hoffman WE, Charbel FT, Edelman G. Brain tissue oxygen, carbon dioxide, and pH in neurosurgical patients at risk for ischemia. Anesth Analg. 1996;82(3):582–6.PubMed Hoffman WE, Charbel FT, Edelman G. Brain tissue oxygen, carbon dioxide, and pH in neurosurgical patients at risk for ischemia. Anesth Analg. 1996;82(3):582–6.PubMed
107.
Zurück zum Zitat Doppenberg EM, Zauner A, Watson JC, et al. Determination of the ischemic threshold for brain oxygen tension. Acta Neurochir Suppl. 1998;71:166–9.PubMed Doppenberg EM, Zauner A, Watson JC, et al. Determination of the ischemic threshold for brain oxygen tension. Acta Neurochir Suppl. 1998;71:166–9.PubMed
108.
Zurück zum Zitat Bardt TF, Unterberg AW, Hartl R, et al. Monitoring of brain tissue PO2 in traumatic brain injury: effect of cerebral hypoxia on outcome. Acta Neurochir Suppl. 1998;71:153–6.PubMed Bardt TF, Unterberg AW, Hartl R, et al. Monitoring of brain tissue PO2 in traumatic brain injury: effect of cerebral hypoxia on outcome. Acta Neurochir Suppl. 1998;71:153–6.PubMed
109.
Zurück zum Zitat Kiening KL, Unterberg AW, Bardt TF, et al. Monitoring of cerebral oxygenation in patients with severe head injuries: brain tissue PO2 versus jugular vein oxygen saturation. J Neurosurg. 1996;85(5):751–7.PubMed Kiening KL, Unterberg AW, Bardt TF, et al. Monitoring of cerebral oxygenation in patients with severe head injuries: brain tissue PO2 versus jugular vein oxygen saturation. J Neurosurg. 1996;85(5):751–7.PubMed
110.
Zurück zum Zitat Chang JJ, Youn TS, Benson D, Mattick H, Andrade N, Harper CR, Moore CB, Madden CJ, Diaz-Arrastia RR. Physiologic and functional outcome correlates of brain tissue hypoxia in traumatic brain injury. Crit Care Med. 2009;37(1):283–90.PubMed Chang JJ, Youn TS, Benson D, Mattick H, Andrade N, Harper CR, Moore CB, Madden CJ, Diaz-Arrastia RR. Physiologic and functional outcome correlates of brain tissue hypoxia in traumatic brain injury. Crit Care Med. 2009;37(1):283–90.PubMed
111.
Zurück zum Zitat Gopinath SP, Valadka AB, Uzura M, Robertson CS. Comparison of jugular venous oxygen saturation and brain tissue PO2 as monitors of cerebral ischemia after head injury. Crit Care Med. 1999;27:2337–45.PubMed Gopinath SP, Valadka AB, Uzura M, Robertson CS. Comparison of jugular venous oxygen saturation and brain tissue PO2 as monitors of cerebral ischemia after head injury. Crit Care Med. 1999;27:2337–45.PubMed
112.
Zurück zum Zitat Dings J, Meixensberger J, Jager A, et al. Clinical experience with 118 brain tissue oxygen partial pressure catheter probes. Neurosurgery. 1998;43:1082–95.PubMed Dings J, Meixensberger J, Jager A, et al. Clinical experience with 118 brain tissue oxygen partial pressure catheter probes. Neurosurgery. 1998;43:1082–95.PubMed
113.
Zurück zum Zitat van Santbrink H, Maas AIR, Avezaat CJJ. Continuous monitoring of partial pressure of brain tissue oxygen in patients with severe head injury. Neurosurgery. 1996;38:21–31.PubMed van Santbrink H, Maas AIR, Avezaat CJJ. Continuous monitoring of partial pressure of brain tissue oxygen in patients with severe head injury. Neurosurgery. 1996;38:21–31.PubMed
114.
Zurück zum Zitat van den Brink WA, van Santbrink H, Steyerberg EW, et al. Brain oxygen tension in severe head injury. Neurosurgery. 2000;46:868–78.PubMed van den Brink WA, van Santbrink H, Steyerberg EW, et al. Brain oxygen tension in severe head injury. Neurosurgery. 2000;46:868–78.PubMed
115.
Zurück zum Zitat •• Ponce LL, Pillai S, Cruz J, Li X, Hannay HJ, Gopinath S, Robertson CS. Position of probe determines prognostic information of brain tissue pO2 in severe traumatic brain injury. Neurosurgery. 2012;70(6):1492–502. Four hundred and five patients who had PbtO 2 monitoring after severe TBI were examined. When the PbtO 2 probe was in abnormal brain, the average PbtO 2 was higher in those patients with a favorable outcome, but a relationship between outcome and PbtO 2 in multivariate analysis was not observed when the probe was in normal-appearing brain.PubMed •• Ponce LL, Pillai S, Cruz J, Li X, Hannay HJ, Gopinath S, Robertson CS. Position of probe determines prognostic information of brain tissue pO2 in severe traumatic brain injury. Neurosurgery. 2012;70(6):1492–502. Four hundred and five patients who had PbtO 2 monitoring after severe TBI were examined. When the PbtO 2 probe was in abnormal brain, the average PbtO 2 was higher in those patients with a favorable outcome, but a relationship between outcome and PbtO 2 in multivariate analysis was not observed when the probe was in normal-appearing brain.PubMed
116.
Zurück zum Zitat Hlatky R, Valadka AB, Goodman JC, Contant CF, Robertson CS. Patterns of energy substrates during ischemia measured in the brain by microdialysis. J Neurotrauma. 2004;21(7):894–906.PubMed Hlatky R, Valadka AB, Goodman JC, Contant CF, Robertson CS. Patterns of energy substrates during ischemia measured in the brain by microdialysis. J Neurotrauma. 2004;21(7):894–906.PubMed
117.
Zurück zum Zitat Rose JC, Neill TA, Hemphill 3rd JC. Continuous monitoring of the microcirculation in neurocritical care: an update on brain tissue oxygenation. Curr Opin Crit Care. 2006;12:97–102.PubMed Rose JC, Neill TA, Hemphill 3rd JC. Continuous monitoring of the microcirculation in neurocritical care: an update on brain tissue oxygenation. Curr Opin Crit Care. 2006;12:97–102.PubMed
118.
Zurück zum Zitat Gracias VH, Guillamondegui OD, Stiefel MF, Wilensky EM, Bloom S, Pryor JP, Reilly PM, Le Roux P, Schwab CW. Cerebral cortical oxygenation: a pilot study. J Trauma. 2004;56:469–74.PubMed Gracias VH, Guillamondegui OD, Stiefel MF, Wilensky EM, Bloom S, Pryor JP, Reilly PM, Le Roux P, Schwab CW. Cerebral cortical oxygenation: a pilot study. J Trauma. 2004;56:469–74.PubMed
119.
Zurück zum Zitat Al-Rawi PG, Hutchinson PJ, Gupta AK, et al. Multiparameter brain tissue monitoring correlation between parameters and identification of CPP thresholds. Zentralbl Neurochir. 2000;61(2):74–9.PubMed Al-Rawi PG, Hutchinson PJ, Gupta AK, et al. Multiparameter brain tissue monitoring correlation between parameters and identification of CPP thresholds. Zentralbl Neurochir. 2000;61(2):74–9.PubMed
120.
Zurück zum Zitat Dohmen C, Bosche B, Graf R, et al. Identification and clinical impact of impaired cerebrovascular autoregulation in patients with malignant middle cerebral artery infarction. Stroke. 2007;38(1):56–61.PubMed Dohmen C, Bosche B, Graf R, et al. Identification and clinical impact of impaired cerebrovascular autoregulation in patients with malignant middle cerebral artery infarction. Stroke. 2007;38(1):56–61.PubMed
121.
Zurück zum Zitat Gupta AK, Hutchinson PJ, Fryer T, et al. Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method. J Neurosurg. 2002;96(2):263–8.PubMed Gupta AK, Hutchinson PJ, Fryer T, et al. Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method. J Neurosurg. 2002;96(2):263–8.PubMed
122.
Zurück zum Zitat Oddo M, Frangos S, Maloney-Wilensky E, Andrew Kofke W, Le Roux P, Levine JM. Effect of Shivering on Brain Tissue Oxygenation During Induced Normothermia in Patients With Severe Brain Injury. Neurocrit Care. 2010;12(1):10–6.PubMed Oddo M, Frangos S, Maloney-Wilensky E, Andrew Kofke W, Le Roux P, Levine JM. Effect of Shivering on Brain Tissue Oxygenation During Induced Normothermia in Patients With Severe Brain Injury. Neurocrit Care. 2010;12(1):10–6.PubMed
123.
Zurück zum Zitat Weiner GM, Lacey MR, Mackenzie L, Shah DP, Frangos SG, Grady MS, Kofke WA, Levine J, Schuster J, Le Roux P. Decompressive craniectomy for elevated intracranial pressure and its effect on the cumulative ischemic burden and therapeutic intensity levels after sever traumatic brain injury. Neurosurgery. 2010;66:1111–9.PubMed Weiner GM, Lacey MR, Mackenzie L, Shah DP, Frangos SG, Grady MS, Kofke WA, Levine J, Schuster J, Le Roux P. Decompressive craniectomy for elevated intracranial pressure and its effect on the cumulative ischemic burden and therapeutic intensity levels after sever traumatic brain injury. Neurosurgery. 2010;66:1111–9.PubMed
124.
Zurück zum Zitat Smith MJ, Maggee S, Stiefel M, Bloom S, Gracias V, Le Roux P. Packed red blood cell transfusion increases local cerebral oxygenation. Crit Care Med. 2005;33:1104–8.PubMed Smith MJ, Maggee S, Stiefel M, Bloom S, Gracias V, Le Roux P. Packed red blood cell transfusion increases local cerebral oxygenation. Crit Care Med. 2005;33:1104–8.PubMed
125.
Zurück zum Zitat Muench E, Horn P, Bauhuf C, Roth H, Philipps M, Hermann P, Quintel M, Schmiedek P, Vajkoczy P. Effects of hypervolemia and hypertension on regional cerebral blood flow, intracranial pressure, and brain tissue oxygenation after subarachnoid hemorrhage. Crit Care Med. 2007;35:1844–51.PubMed Muench E, Horn P, Bauhuf C, Roth H, Philipps M, Hermann P, Quintel M, Schmiedek P, Vajkoczy P. Effects of hypervolemia and hypertension on regional cerebral blood flow, intracranial pressure, and brain tissue oxygenation after subarachnoid hemorrhage. Crit Care Med. 2007;35:1844–51.PubMed
126.
Zurück zum Zitat Spiotta AM, Stiefel MF, Gracias VH, et al. Brain tissue oxygen-directed management and outcome in patients with severe traumatic brain injury. J Neurosurg. 2010;113:571–80.PubMed Spiotta AM, Stiefel MF, Gracias VH, et al. Brain tissue oxygen-directed management and outcome in patients with severe traumatic brain injury. J Neurosurg. 2010;113:571–80.PubMed
127.
Zurück zum Zitat Narotam PK, Morrison JF, Nathoo N. Brain tissue oxygen monitoring in traumatic brain injury and major trauma: outcome analysis of a brain tissue oxygen-directed therapy. J Neurosurg. 2009;111:672–82.PubMed Narotam PK, Morrison JF, Nathoo N. Brain tissue oxygen monitoring in traumatic brain injury and major trauma: outcome analysis of a brain tissue oxygen-directed therapy. J Neurosurg. 2009;111:672–82.PubMed
128.
Zurück zum Zitat Martini RP, Deem S, Yanez ND, et al. Management guided by brain tissue oxygen monitoring and outcome following severe traumatic brain injury. J Neurosurg. 2009;111(4):644–9.PubMed Martini RP, Deem S, Yanez ND, et al. Management guided by brain tissue oxygen monitoring and outcome following severe traumatic brain injury. J Neurosurg. 2009;111(4):644–9.PubMed
129.
Zurück zum Zitat • Nangunoori R, Maloney-Wilensky E, Stiefel M, et al. Brain tissue oxygen-based therapy and outcome after severe traumatic brain injury: a systematic literature review. Neurocrit Care. 2012;17(1):131–8. Seven studies that compared ICP/CPP- and PbtO 2 -based therapy with ICP/CPP-based therapy were identified. Four studies that included 491 evaluable patients were used in the final analysis. Summary results suggested that combined ICP/CPP- and PbtO 2 -based therapy is associated with better outcome after severe TBI than ICP/CPP-based therapy alone.PubMed • Nangunoori R, Maloney-Wilensky E, Stiefel M, et al. Brain tissue oxygen-based therapy and outcome after severe traumatic brain injury: a systematic literature review. Neurocrit Care. 2012;17(1):131–8. Seven studies that compared ICP/CPP- and PbtO 2 -based therapy with ICP/CPP-based therapy were identified. Four studies that included 491 evaluable patients were used in the final analysis. Summary results suggested that combined ICP/CPP- and PbtO 2 -based therapy is associated with better outcome after severe TBI than ICP/CPP-based therapy alone.PubMed
130.
Zurück zum Zitat Misra M, Stark J, Dujovny M, et al. Transcranial cerebral oximetry in random normal subjects. Neurol Res. 1998;20(2):137–41.PubMed Misra M, Stark J, Dujovny M, et al. Transcranial cerebral oximetry in random normal subjects. Neurol Res. 1998;20(2):137–41.PubMed
131.
Zurück zum Zitat Samra SK, Stanley JC, Zelenock GB, Dorje P. An assessment of contributions made by extracranial tissues during cerebral oximetry. J Neurosurg Anaesthesiol. 1999;11(1):1–5. Samra SK, Stanley JC, Zelenock GB, Dorje P. An assessment of contributions made by extracranial tissues during cerebral oximetry. J Neurosurg Anaesthesiol. 1999;11(1):1–5.
132.
Zurück zum Zitat Highton D, Elwell C, Smith M. Noninvasive cerebral oximetry: is there light at the end of the tunnel? Curr Opin Anaesthesiol. 2010;23:576–81.PubMed Highton D, Elwell C, Smith M. Noninvasive cerebral oximetry: is there light at the end of the tunnel? Curr Opin Anaesthesiol. 2010;23:576–81.PubMed
133.
Zurück zum Zitat Hirsch JC, Charpie JR, Ohye RG, Gurney JG. Near infrared spectroscopy (NIRS) should not be standard of care for postoperative management. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2010;13:51–4.PubMed Hirsch JC, Charpie JR, Ohye RG, Gurney JG. Near infrared spectroscopy (NIRS) should not be standard of care for postoperative management. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2010;13:51–4.PubMed
134.
Zurück zum Zitat Lee JK, Kibler KK, Benni PB, et al. Cerebrovascular reactivity measured by near-infrared spectroscopy. Stroke. 2009;40:1820–6.PubMed Lee JK, Kibler KK, Benni PB, et al. Cerebrovascular reactivity measured by near-infrared spectroscopy. Stroke. 2009;40:1820–6.PubMed
135.
Zurück zum Zitat Zweifel C, Lavinio A, Steiner LA, Radolovich D, Smielewski P, Timofeev I, Hiler M, Balestreri M, Kirkpatrick PJ, Pickard JD, Hutchinson P, Czosnyka M. Continuous monitoring of cerebrovascular pressure reactivity in patients with head injury. Neurosurg Focus. 2008;25(4):E2.PubMed Zweifel C, Lavinio A, Steiner LA, Radolovich D, Smielewski P, Timofeev I, Hiler M, Balestreri M, Kirkpatrick PJ, Pickard JD, Hutchinson P, Czosnyka M. Continuous monitoring of cerebrovascular pressure reactivity in patients with head injury. Neurosurg Focus. 2008;25(4):E2.PubMed
136.
Zurück zum Zitat Kirkpatrick PJ, Smielewski P, Czosnyka M, Menon DK, Pickard JD. Near infrared spectroscopy use in patients with head injury. J Neurosurg. 1995;83:963–70.PubMed Kirkpatrick PJ, Smielewski P, Czosnyka M, Menon DK, Pickard JD. Near infrared spectroscopy use in patients with head injury. J Neurosurg. 1995;83:963–70.PubMed
137.
Zurück zum Zitat Leal-Noval SR, Cayuela A, Arellano-Orden V, Marín-Caballos A, Padilla V, Ferrándiz-Millón C, Corcia Y, García-Alfaro C, Amaya-Villar R, Murillo-Cabezas F. Invasive and noninvasive assessment of cerebral oxygenation in patients with severe traumatic brain injury. Intensive Care Med. 2010;36(8):1309–17.PubMed Leal-Noval SR, Cayuela A, Arellano-Orden V, Marín-Caballos A, Padilla V, Ferrándiz-Millón C, Corcia Y, García-Alfaro C, Amaya-Villar R, Murillo-Cabezas F. Invasive and noninvasive assessment of cerebral oxygenation in patients with severe traumatic brain injury. Intensive Care Med. 2010;36(8):1309–17.PubMed
138.
Zurück zum Zitat Adamides AA, Rosenfeldt FL, Winter CD, et al. Brain tissue lactate elevations predict episodes of intracranial hypertension in patients with traumatic brain injury. J Am Coll Surg. 2009;209:531–9.PubMed Adamides AA, Rosenfeldt FL, Winter CD, et al. Brain tissue lactate elevations predict episodes of intracranial hypertension in patients with traumatic brain injury. J Am Coll Surg. 2009;209:531–9.PubMed
139.
Zurück zum Zitat Belli A, Sen J, Petzold A, Russo S, Kitchen N, Smith M. Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study. Acta Neurochir (Wien). 2008;150:461–9. Belli A, Sen J, Petzold A, Russo S, Kitchen N, Smith M. Metabolic failure precedes intracranial pressure rises in traumatic brain injury: a microdialysis study. Acta Neurochir (Wien). 2008;150:461–9.
140.
Zurück zum Zitat Vespa PM, McArthur D, O’Phelan K, et al. Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study. J Cereb Blood Flow Metab. 2003;23(7):865–77.PubMed Vespa PM, McArthur D, O’Phelan K, et al. Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study. J Cereb Blood Flow Metab. 2003;23(7):865–77.PubMed
141.
Zurück zum Zitat Vespa P, Bergsneider M, Hattori N, et al. Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study. J Cereb Blood Flow Metab. 2005;25(6):763–74.PubMed Vespa P, Bergsneider M, Hattori N, et al. Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study. J Cereb Blood Flow Metab. 2005;25(6):763–74.PubMed
142.
Zurück zum Zitat Tisdall MM, Smith M. Cerebral microdialysis: research technique or clinical tool. Br J Anaesth. 2006;97:18–25.PubMed Tisdall MM, Smith M. Cerebral microdialysis: research technique or clinical tool. Br J Anaesth. 2006;97:18–25.PubMed
143.
Zurück zum Zitat • Larach DB, Kofke WA, Le Roux P. Potential non-hypoxic/ischemic causes of increased cerebral interstitial fluid lactate/pyruvate ratio: a review of available literature. Neurocrit Care. 2011;15(3):609–22. This article reviews the potential nonhypoxic/ischemic causes of an increased LPR.PubMed • Larach DB, Kofke WA, Le Roux P. Potential non-hypoxic/ischemic causes of increased cerebral interstitial fluid lactate/pyruvate ratio: a review of available literature. Neurocrit Care. 2011;15(3):609–22. This article reviews the potential nonhypoxic/ischemic causes of an increased LPR.PubMed
144.
Zurück zum Zitat Hutchinson PJ, Al-Rawi PG, O’Connell MT, et al. Head injury monitoring using cerebral microdialysis and Paratrend multiparameter sensors. Zentralbl Neurochir. 2000;61(2):88–94.PubMed Hutchinson PJ, Al-Rawi PG, O’Connell MT, et al. Head injury monitoring using cerebral microdialysis and Paratrend multiparameter sensors. Zentralbl Neurochir. 2000;61(2):88–94.PubMed
145.
Zurück zum Zitat Hutchinson PJ, Al-Rawi PG, O’Connell MT, et al. On-line monitoring of substrate delivery and brain metabolism in head injury. Acta Neurochir Suppl. 2000;76:431–5.PubMed Hutchinson PJ, Al-Rawi PG, O’Connell MT, et al. On-line monitoring of substrate delivery and brain metabolism in head injury. Acta Neurochir Suppl. 2000;76:431–5.PubMed
146.
Zurück zum Zitat Zauner A, Doppenberg EM, Woodward JJ, et al. Continuous monitoring of cerebral substrate delivery and clearance: initial experience in 24 patients with severe acute brain injuries. Neurosurgery. 1997;41(5):1082–91.PubMed Zauner A, Doppenberg EM, Woodward JJ, et al. Continuous monitoring of cerebral substrate delivery and clearance: initial experience in 24 patients with severe acute brain injuries. Neurosurgery. 1997;41(5):1082–91.PubMed
147.
Zurück zum Zitat •• Timofeev I, Carpenter KL, Nortje J, et al. Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients. Brain. 2011;134(Pt 2):484–94. This article considers prospective observational CMD data from 223 patients. In a multivariate logistic regression model, positive predictors of mortality were glucose concentration, LPR, ICP, PRx, and age.PubMed •• Timofeev I, Carpenter KL, Nortje J, et al. Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients. Brain. 2011;134(Pt 2):484–94. This article considers prospective observational CMD data from 223 patients. In a multivariate logistic regression model, positive predictors of mortality were glucose concentration, LPR, ICP, PRx, and age.PubMed
148.
Zurück zum Zitat Peerdeman SM, Girbes AR, Polderman KH, et al. Changes in cerebral interstitial glycerol concentration in head-injured patients; correlation with secondary events. Intensive Care Med. 2003;29(10):1825–8.PubMed Peerdeman SM, Girbes AR, Polderman KH, et al. Changes in cerebral interstitial glycerol concentration in head-injured patients; correlation with secondary events. Intensive Care Med. 2003;29(10):1825–8.PubMed
149.
Zurück zum Zitat Staub F, Graf R, Gabel P, et al. Multiple interstitial substances measured by microdialysis in patients with subarachnoid hemorrhage. Neurosurgery. 2000;47(5):1106–15.PubMed Staub F, Graf R, Gabel P, et al. Multiple interstitial substances measured by microdialysis in patients with subarachnoid hemorrhage. Neurosurgery. 2000;47(5):1106–15.PubMed
150.
Zurück zum Zitat Obrenovitch TP, Urenjak J. Is high extracellular glutamate the key to excitotoxicity in traumatic brain injury? J Neurotrauma. 1997;14(10):677–98.PubMed Obrenovitch TP, Urenjak J. Is high extracellular glutamate the key to excitotoxicity in traumatic brain injury? J Neurotrauma. 1997;14(10):677–98.PubMed
151.
Zurück zum Zitat Hillered L, Vespa PM, Hovda DA. Translational neurochemical research in acute human brain injury: the current status and potential future for cerebral microdialysis. J Neurotrauma. 2005;22(1):3–41.PubMed Hillered L, Vespa PM, Hovda DA. Translational neurochemical research in acute human brain injury: the current status and potential future for cerebral microdialysis. J Neurotrauma. 2005;22(1):3–41.PubMed
152.
Zurück zum Zitat Oddo M, Milby A, Chen I, Frangos S, MacMutrie E, Maloney-Wilensky E, Stiefel MF, Kofke A, Levine JM, Le Roux P. Hemoglobin concentration and cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage: a microdialysis study. Stroke. 2009;40(4):1275–81.PubMed Oddo M, Milby A, Chen I, Frangos S, MacMutrie E, Maloney-Wilensky E, Stiefel MF, Kofke A, Levine JM, Le Roux P. Hemoglobin concentration and cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage: a microdialysis study. Stroke. 2009;40(4):1275–81.PubMed
153.
Zurück zum Zitat Oddo M, Schmidt JM, Carrera C, Badjatia N, Connolly ES, Presciutti M, Ostapkovich ND, Levine JM, Le Roux P, Mayer SA. Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study. Crit Care Med. 2008;36:3233–8.PubMed Oddo M, Schmidt JM, Carrera C, Badjatia N, Connolly ES, Presciutti M, Ostapkovich ND, Levine JM, Le Roux P, Mayer SA. Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study. Crit Care Med. 2008;36:3233–8.PubMed
154.
Zurück zum Zitat Nortje J, Coles JP, Timofeev I, et al. Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings. Crit Care Med. 2008;36(1):273–81.PubMed Nortje J, Coles JP, Timofeev I, et al. Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings. Crit Care Med. 2008;36(1):273–81.PubMed
155.
Zurück zum Zitat Marion DW, Puccio A, Wisniewski SR, et al. Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injury. Crit Care Med. 2002;30(12):2619–25.PubMed Marion DW, Puccio A, Wisniewski SR, et al. Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injury. Crit Care Med. 2002;30(12):2619–25.PubMed
156.
Zurück zum Zitat Goodman JC, Robertson CS. Microdialysis: is it ready for prime time? Curr Opin Crit Care. 2009;15:110–7.PubMed Goodman JC, Robertson CS. Microdialysis: is it ready for prime time? Curr Opin Crit Care. 2009;15:110–7.PubMed
157.
Zurück zum Zitat Bellander BM, Cantais E, Enblad P, et al. Consensus meeting on microdialysis in neurointensive care. Intensive Care Med. 2004;30:2166–9.PubMed Bellander BM, Cantais E, Enblad P, et al. Consensus meeting on microdialysis in neurointensive care. Intensive Care Med. 2004;30:2166–9.PubMed
158.
Zurück zum Zitat Abend NS, Dlugos DJ, Hahn CD, Hirsch LJ, Herman ST. Use of EEG monitoring and management of non-convulsive seizures in critically ill patients: a survey of neurologists. Neurocrit Care. 2010;12(3):382–9.PubMed Abend NS, Dlugos DJ, Hahn CD, Hirsch LJ, Herman ST. Use of EEG monitoring and management of non-convulsive seizures in critically ill patients: a survey of neurologists. Neurocrit Care. 2010;12(3):382–9.PubMed
159.
Zurück zum Zitat Vespa PM, Miller C, McArthur D, Eliseo M, Etchepare M, Hirt D, Glenn TC, Martin N, Hovda D. Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis. Crit Care Med. 2007;35(12):2830–6.PubMed Vespa PM, Miller C, McArthur D, Eliseo M, Etchepare M, Hirt D, Glenn TC, Martin N, Hovda D. Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis. Crit Care Med. 2007;35(12):2830–6.PubMed
160.
Zurück zum Zitat Pandian JD, Cascino GD, So EL, Manno E, Fulgham JR. Digital video-electroencephalographic monitoring in the neurological-neurosurgical intensive care unit: clinical features and outcome. Arch Neurol. 2004;61:1090–4.PubMed Pandian JD, Cascino GD, So EL, Manno E, Fulgham JR. Digital video-electroencephalographic monitoring in the neurological-neurosurgical intensive care unit: clinical features and outcome. Arch Neurol. 2004;61:1090–4.PubMed
161.
Zurück zum Zitat Claassen J, Mayer SA, Kowalski RG, Emerson RG, Hirsch LJ. Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology. 2004;62:1743–8.PubMed Claassen J, Mayer SA, Kowalski RG, Emerson RG, Hirsch LJ. Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology. 2004;62:1743–8.PubMed
162.
Zurück zum Zitat Sundt Jr TM, Sharbrough FW, Anderson RE, Michenfelder JD. Cerebral blood flow measurements and electroencephalograms during carotid endarterectomy. J Neurosurg. 1974;41:310–20.PubMed Sundt Jr TM, Sharbrough FW, Anderson RE, Michenfelder JD. Cerebral blood flow measurements and electroencephalograms during carotid endarterectomy. J Neurosurg. 1974;41:310–20.PubMed
163.
Zurück zum Zitat Sundt Jr TM, Sharbrough FW, Piepgras DG, Kearns TP, Messick Jr JM, O’Fallon WM. Correlation of cerebral blood flow and electroencephalographic changes during carotid endarterectomy: with results of surgery and hemodynamics of cerebral ischemia. Mayo Clin Proc. 1981;56:533–43.PubMed Sundt Jr TM, Sharbrough FW, Piepgras DG, Kearns TP, Messick Jr JM, O’Fallon WM. Correlation of cerebral blood flow and electroencephalographic changes during carotid endarterectomy: with results of surgery and hemodynamics of cerebral ischemia. Mayo Clin Proc. 1981;56:533–43.PubMed
164.
Zurück zum Zitat Claassen J, Hirsch LJ, Kreiter KT, Du EY, Connolly ES, Emerson RG, Mayer SA. Quantitative continuous EEG for detecting delayed cerebral ischemia in patients with poor-grade subarachnoid hemorrhage. Clin Neurophysiol. 2004;115:2699–710.PubMed Claassen J, Hirsch LJ, Kreiter KT, Du EY, Connolly ES, Emerson RG, Mayer SA. Quantitative continuous EEG for detecting delayed cerebral ischemia in patients with poor-grade subarachnoid hemorrhage. Clin Neurophysiol. 2004;115:2699–710.PubMed
165.
Zurück zum Zitat Vespa PM, Nuwer MR, Juhasz C, Alexander M, Nenov V, Martin N, Becker DP. Early detection of vasospasm after acute subarachnoid hemorrhage using continuous EEG ICU monitoring. Electroencephalogr Clin Neurophysiol. 1997;103:607–15.PubMed Vespa PM, Nuwer MR, Juhasz C, Alexander M, Nenov V, Martin N, Becker DP. Early detection of vasospasm after acute subarachnoid hemorrhage using continuous EEG ICU monitoring. Electroencephalogr Clin Neurophysiol. 1997;103:607–15.PubMed
166.
Zurück zum Zitat Hebb MO, McArthur DL, Alger J, Etchepare M, Glenn TC, Bergsneider M, Martin N, Vespa PM. Impaired percent alpha variability on continuous electroencephalography is associated with thalamic injury and predicts poor long-term outcome after human traumatic brain injury. J Neurotrauma. 2007;24:579–90.PubMed Hebb MO, McArthur DL, Alger J, Etchepare M, Glenn TC, Bergsneider M, Martin N, Vespa PM. Impaired percent alpha variability on continuous electroencephalography is associated with thalamic injury and predicts poor long-term outcome after human traumatic brain injury. J Neurotrauma. 2007;24:579–90.PubMed
167.
Zurück zum Zitat Wittman Jr JJ, Hirsch LJ. Continuous electroencephalogram monitoring in the critically ill. Neurocrit Care. 2005;2(3):330–41.PubMed Wittman Jr JJ, Hirsch LJ. Continuous electroencephalogram monitoring in the critically ill. Neurocrit Care. 2005;2(3):330–41.PubMed
168.
Zurück zum Zitat Robinson LR, Micklesen PJ, Tirschwell DL, Lew HL. Predictive value of somatosensory evoked potentials for awakening from coma. Crit Care Med. 2003;31:960–7.PubMed Robinson LR, Micklesen PJ, Tirschwell DL, Lew HL. Predictive value of somatosensory evoked potentials for awakening from coma. Crit Care Med. 2003;31:960–7.PubMed
169.
Zurück zum Zitat • Oddo M, Rossetti AO. Predicting neurological outcome after cardiac arrest. Curr Opin Crit Care. 2011;17:254–9. This is a review of EEG, evoked potentials, and biomarkers to predict outcome after cardiac arrest.PubMed • Oddo M, Rossetti AO. Predicting neurological outcome after cardiac arrest. Curr Opin Crit Care. 2011;17:254–9. This is a review of EEG, evoked potentials, and biomarkers to predict outcome after cardiac arrest.PubMed
170.
Zurück zum Zitat Vos PE, Lamers KJ, Hendriks JC, van Haaren M, Beems T, Zimmerman C, van Geel W, de Reus H, Biert J, Verbeek MM. Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury. Neurology. 2004;62:1303–10.PubMed Vos PE, Lamers KJ, Hendriks JC, van Haaren M, Beems T, Zimmerman C, van Geel W, de Reus H, Biert J, Verbeek MM. Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury. Neurology. 2004;62:1303–10.PubMed
171.
Zurück zum Zitat Anderson RE, Hansson LO, Nilsson O, Dijlai-Merzoug R, Settergren G. High serum S100B levels for trauma patients without head injuries. Neurosurgery. 2001;48(6):1255–8. discussion 1258-60.PubMed Anderson RE, Hansson LO, Nilsson O, Dijlai-Merzoug R, Settergren G. High serum S100B levels for trauma patients without head injuries. Neurosurgery. 2001;48(6):1255–8. discussion 1258-60.PubMed
172.
Zurück zum Zitat Vos PE, Jacobs B, Andriessen TM, Lamers KJ, Borm GF, Beems T, Edwards M, Rosmalen CF, Vissers JL. GFAP and S100B are biomarkers of traumatic brain injury: an observational cohort study. Neurology. 2010;75(20):1786–93.PubMed Vos PE, Jacobs B, Andriessen TM, Lamers KJ, Borm GF, Beems T, Edwards M, Rosmalen CF, Vissers JL. GFAP and S100B are biomarkers of traumatic brain injury: an observational cohort study. Neurology. 2010;75(20):1786–93.PubMed
173.
Zurück zum Zitat Pelinka LE, Kroepfl A, Leixnering M, Buchinger W, Raabe A, Redl H. GFAP versus S100B in serum after traumatic brain injury: relationship to brain damage and outcome. J Neurotrauma. 2004;21:1553–61.PubMed Pelinka LE, Kroepfl A, Leixnering M, Buchinger W, Raabe A, Redl H. GFAP versus S100B in serum after traumatic brain injury: relationship to brain damage and outcome. J Neurotrauma. 2004;21:1553–61.PubMed
174.
Zurück zum Zitat Ost M, Nylen K, Csajbok L, Ohrfelt AO, Tullberg M, Wikkelso C, Nellgard P, Rosengren L, Blennow K, Nellgard B. Initial CSF total tau correlates with 1-year outcome in patients with traumatic brain injury. Neurology. 2006;67:1600–4.PubMed Ost M, Nylen K, Csajbok L, Ohrfelt AO, Tullberg M, Wikkelso C, Nellgard P, Rosengren L, Blennow K, Nellgard B. Initial CSF total tau correlates with 1-year outcome in patients with traumatic brain injury. Neurology. 2006;67:1600–4.PubMed
175.
Zurück zum Zitat Marklund N, Blennow K, Zetterberg H, Ronne-Engstrom E, Enblad P, Hillered L. Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury. J Neurosurg. 2009;110:1227–37.PubMed Marklund N, Blennow K, Zetterberg H, Ronne-Engstrom E, Enblad P, Hillered L. Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury. J Neurosurg. 2009;110:1227–37.PubMed
176.
Zurück zum Zitat • Petzold A, Tisdall MM, Girbes AR, Martinian L, Thom M, Kitchen N, Smith M. In vivo monitoring of neuronal loss in traumatic brain injury: a microdialysis study. Brain. 2011;134:464–83. This reports a CMD study in ten patients. Extracellular fluid neurofilament heavy chain levels were of prognostic value.PubMed • Petzold A, Tisdall MM, Girbes AR, Martinian L, Thom M, Kitchen N, Smith M. In vivo monitoring of neuronal loss in traumatic brain injury: a microdialysis study. Brain. 2011;134:464–83. This reports a CMD study in ten patients. Extracellular fluid neurofilament heavy chain levels were of prognostic value.PubMed
177.
Zurück zum Zitat Pineda JA, Lewis SB, Valadka AB, Papa L, Hannay HJ, Heaton SC, Demery JA, Liu MC, Aikman JM, Akle V, Brophy GM, Tepas JJ, Wang KK, Robertson CS, Hayes RL. Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury. J Neurotrauma. 2007;24:354–66.PubMed Pineda JA, Lewis SB, Valadka AB, Papa L, Hannay HJ, Heaton SC, Demery JA, Liu MC, Aikman JM, Akle V, Brophy GM, Tepas JJ, Wang KK, Robertson CS, Hayes RL. Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury. J Neurotrauma. 2007;24:354–66.PubMed
178.
Zurück zum Zitat Turck N, Vutskits L, Sanchez-Pena P, Robin X, Hainard A, Gex-Fabry M, Fouda C, Bassem H, Mueller M, Lisacek F, Puybasset L, Sanchez JC. A multiparameter panel method for outcome prediction following aneurysmal subarachnoid hemorrhage. Intensive Care Med. 2010;36:107–15.PubMed Turck N, Vutskits L, Sanchez-Pena P, Robin X, Hainard A, Gex-Fabry M, Fouda C, Bassem H, Mueller M, Lisacek F, Puybasset L, Sanchez JC. A multiparameter panel method for outcome prediction following aneurysmal subarachnoid hemorrhage. Intensive Care Med. 2010;36:107–15.PubMed
179.
Zurück zum Zitat Siman R, Toraskar N, Dang A, McNeil E, McGarvey M, Plaum J, Maloney E, Grady MS. A panel of neuron-enriched proteins as markers for traumatic brain injury in humans. J Neurotrauma. 2009;26(11):1867–77.PubMed Siman R, Toraskar N, Dang A, McNeil E, McGarvey M, Plaum J, Maloney E, Grady MS. A panel of neuron-enriched proteins as markers for traumatic brain injury in humans. J Neurotrauma. 2009;26(11):1867–77.PubMed
180.
Zurück zum Zitat • Siman R, Giovannone N, Toraskar N, Frangos S, Stein SC, Levine JM, Kumar MA. Evidence that a panel of neurodegeneration biomarkers predicts vasospasm, infarction, and outcome in aneurysmal subarachnoid hemorrhage. PLoS One. 2011;6(12):e28938. In CSF samples from 14 patients, eight biomarkers for acute brain damage were quantified. This panel predicted lasting brain dysfunction and the pathophysiological processes after SAH.PubMed • Siman R, Giovannone N, Toraskar N, Frangos S, Stein SC, Levine JM, Kumar MA. Evidence that a panel of neurodegeneration biomarkers predicts vasospasm, infarction, and outcome in aneurysmal subarachnoid hemorrhage. PLoS One. 2011;6(12):e28938. In CSF samples from 14 patients, eight biomarkers for acute brain damage were quantified. This panel predicted lasting brain dysfunction and the pathophysiological processes after SAH.PubMed
181.
Zurück zum Zitat Diedler J, Czosnyka M. Merits and pitfalls of multimodality brain monitoring. Neurocrit Care. 2010;12(3):313–6.PubMed Diedler J, Czosnyka M. Merits and pitfalls of multimodality brain monitoring. Neurocrit Care. 2010;12(3):313–6.PubMed
182.
Zurück zum Zitat Piper I, Chambers I, Citerio G, et al. The brain monitoring with Information Technology (BrainIT) collaborative network: EC feasibility study results and future direction. Acta Neurochir (Wien). 2010;152:1859–71. Piper I, Chambers I, Citerio G, et al. The brain monitoring with Information Technology (BrainIT) collaborative network: EC feasibility study results and future direction. Acta Neurochir (Wien). 2010;152:1859–71.
183.
Zurück zum Zitat Sorani MD, Hemphill 3rd JC, Morabito D, et al. New approaches to physiological informatics in neurocritical care. Neurocrit Care. 2007;7:45–52.PubMed Sorani MD, Hemphill 3rd JC, Morabito D, et al. New approaches to physiological informatics in neurocritical care. Neurocrit Care. 2007;7:45–52.PubMed
184.
Zurück zum Zitat • Hemphill JC, Andrews P, De Georgia M. Medscape. Multimodal monitoring and neurocritical care bioinformatics. Nat Rev Neurol. 2011;7(8):451–60. This article reviews the acquisition, storage, and analysis of physiological and other data needed to manage brain injury.PubMed • Hemphill JC, Andrews P, De Georgia M. Medscape. Multimodal monitoring and neurocritical care bioinformatics. Nat Rev Neurol. 2011;7(8):451–60. This article reviews the acquisition, storage, and analysis of physiological and other data needed to manage brain injury.PubMed
185.
Zurück zum Zitat Reinstrup P, Ståhl N, Mellergård P, Uski T, Ungerstedt U, Nordström CH. Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery. Neurosurgery. 2000;47(3):701–9.PubMed Reinstrup P, Ståhl N, Mellergård P, Uski T, Ungerstedt U, Nordström CH. Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery. Neurosurgery. 2000;47(3):701–9.PubMed
186.
Zurück zum Zitat Schulz MK, Wang LP, Tange M, Bjerre P. Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg. 2000;93(5):808–14.PubMed Schulz MK, Wang LP, Tange M, Bjerre P. Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg. 2000;93(5):808–14.PubMed
Metadaten
Titel
Physiological Monitoring of the Severe Traumatic Brain Injury Patient in the Intensive Care Unit
verfasst von
Peter Le Roux
Publikationsdatum
01.03.2013
Verlag
Current Science Inc.
Erschienen in
Current Neurology and Neuroscience Reports / Ausgabe 3/2013
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-012-0331-2

Weitere Artikel der Ausgabe 3/2013

Current Neurology and Neuroscience Reports 3/2013 Zur Ausgabe

Pediatric Neurology (D Nordli, Section Editor)

Latest American and European Updates on Infantile Spasms

Nerve and Muscle (M Hirano and LH Weimer, Section Editors)

Neuromuscular Disorders of Glycogen Metabolism

Nerve and Muscle (M Hirano and LH Weimer, Section Editors)

Update on the Treatment of Duchenne Muscular Dystrophy

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Thrombektomie auch bei großen Infarkten von Vorteil

16.05.2024 Ischämischer Schlaganfall Nachrichten

Auch ein sehr ausgedehnter ischämischer Schlaganfall scheint an sich kein Grund zu sein, von einer mechanischen Thrombektomie abzusehen. Dafür spricht die LASTE-Studie, an der Patienten und Patientinnen mit einem ASPECTS von maximal 5 beteiligt waren.

Schwindelursache: Massagepistole lässt Otholiten tanzen

14.05.2024 Benigner Lagerungsschwindel Nachrichten

Wenn jüngere Menschen über ständig rezidivierenden Lagerungsschwindel klagen, könnte eine Massagepistole der Auslöser sein. In JAMA Otolaryngology warnt ein Team vor der Anwendung hochpotenter Geräte im Bereich des Nackens.

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Viertel reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.