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Current Psychiatry Reports

Erschienen in:

01.09.2013 | Complex Medical-Psychiatric Issues (MB Riba, Section Editor)

The Comorbidity between Depression and Diabetes

verfasst von: Bibilola D. Oladeji, Oye Gureje

Erschienen in: Current Psychiatry Reports | Ausgabe 9/2013

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Abstract

Comorbidity of depression and diabetes is common, and each disorder has a negative impact on the outcome of the other. The direction of causality is not certain as each disorder seems to act as both a risk factor and consequence for the other in longitudinal studies. This bidirectional association is possibly mediated by shared environmental and genetic risk factors. Comorbid depression is associated with reduced adherence to medication and self-care management, poor glycaemic control, increased health care utilization, increased costs and elevated risk of complications, as well as mortality in patients with diabetes. Psychological and pharmacological interventions are shown to be effective in improving depression symptoms; however, collaborative care programs that simultaneously manage both disorders seem to be most effective in improving diabetes-related outcomes.

Harter M, Baumeister H, Reuter K, et al. Increased 12-month prevalence rates of mental disorders in patients with chronic somatic diseases. Psychother Psychosom. 2007;76:354–60.PubMedCrossRef

Gili M, Comas A, Garcia-Garcia M, et al. Comorbidity between common mental disorders and chronic somatic disease in primary care patients. Gen Hosp Psychiatry. 2010;32:240–5.PubMedCrossRef

International Diabetes Federation. Diabetes Atlas 5th ed. In. Brussels: International Diabetes Federation; 2012.

World Health Organization. WHO Global status report on noncommunicable diseases 2010: description of the global burden of NCDs, their risk factors and determinants. In. Geneva: World Health Organization; 2011.

Roy T, Lloyd CE. Epidemiology of depression and diabetes: A systematic review. J Affect Disord. 2012;142(S1):S8–S21.PubMedCrossRef

Nouwen A, Winkley K, Twisk J, et al. Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia. 2010;53(12):2480–6.PubMedCrossRef

•• Chen PC, Chan YT, Chen HF, Ko MC, Li CY. Population-Based Cohort Analyses of the Bidirectional Relationship Between Type 2 Diabetes and Depression. Diabetes Care. 2013;36:376–82. Prospective cohort study demostrated bidirectional associations between diabetes and depression.PubMedCrossRef

Golden SH, Lazo M, Carnethon M, et al. Examining a Bidirectional Association Between Depressive Symptoms and Diabetes. JAMA. 2008;299:2751–9.PubMedCrossRef

Murray CJL, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2197–223.PubMedCrossRef

10.

Egede LE, Ellis C. Diabetes and depression: Global perspectives. Diabetes Res Clin Pract. 2010;87:302–12.PubMedCrossRef

11.

Park M, Katon WJ, Wolf FM. Depression and risk of mortality in individuals with diabetes: a meta-analysis and systematic review. Gen Hosp Psychiatry. 2013;35:217–25.PubMedCrossRef

12.

Scott KM. The joint association of mental and physical conditions with disability. In: von Korff M, Scott KM, Gureje O, editors. Global Perspectives on Mental-Physical Comorbidity in the WHO World Mental Health Surveys. Cambridge: Cambridge University Press; 2009.

13.

Gonzalez JS, Peyrot M, McCarl LA, et al. Depression and diabetes treatment nonadherence: a meta-analysis. Diabetes Care. 2008;31(12):2398–403.PubMedCrossRef

14.

Lloyd CE, Hermanns N, Nouwen A, et al. The epidemiology of depression and diabetes. In: Katon W, Maj M, Sartorius N, editors. Depression and Diabetes. UK: Wiley-Blackwell; 2010.

15.

Molosankwe I, Patel A, Gagliardino JJ, Knapp M, McDaid D. Economic aspects of the association between diabetes and depression: A systematic review. J Affect Disord. 2012;142(S1):S42–55.PubMedCrossRef

16.

Shrestha SS, Zhang P, Li R, et al. Medical expenditures associated with major depressive disorder among privately insured working-age adults with diagnosed diabetes in the United States, 2008. Diabetes Res Clin Pract. 2013;100(1):102–10.PubMedCrossRef

17.

Pan A, Lucas M, Sun Q, et al. Bidirectional association between depression and type 2 diabetes mellitus in women. Arch Intern Med. 2010;170(21):1884–91.PubMedCrossRef

18.

Shehatah A, Rabie MA, Al-Shahry A. Prevalence and correlates of depressive disorders in elderly with type 2 diabetes in primary health care settings. J Affect Disord. 2010;123:197–201.PubMedCrossRef

19.

Barnard KD, Skinner TC, Peveler R. The prevalence of co-morbid depression in adults with Type 1 diabetes: systematic literature review. Diabet Med. 2006;23:445–8.PubMedCrossRef

20.

Gendelman N, Snell-Bergeon JK, Mcfann K, et al. Prevalence and correlates of depression in individuals with and without Type 1 diabetes. Diabetes Care. 2009;32:575–9.PubMedCrossRef

21.

Collins MM, Corcoran P, Perry IJ. Anxiety and depression symptoms in patients with diabetes. Diabet Med. 2009;26(2):153–61.PubMedCrossRef

22.

• Pouwer F, Geelhoed-Duijvestijn PH, Tack CJ, et al. Prevalence of comorbid depresssion is high in out-patients with type 1 or type 2 diabetes mellitus. Results from three out-patient clinics in the Netherlands. Diabet Med. 2010;27(2):217–24. Even though the rates of depression were similar in types 1 and 2 diabetes, the risk factors associated with depression were different in patients with type 1 and 2 diabetes.PubMedCrossRef

23.

Engum A, Mykletun A, Midthjell K, Holen A, Dahl AA. A large population-based study of sociodemographic, lifestyle, and clinical factors associated with depresssion in type 1 and type 2 diabetes. Diabetes Care. 2005;28:1904–9.PubMedCrossRef

24.

Ali S, Davies MJ, Taub NA, Stone MA, Khunti K. Prevalence of diagnosed depression in South Asian and white European people with type 1 and type 2 diabetes mellitus in a UK secondary care population. Postgrad Med J. 2009;85(1003):238–43.PubMedCrossRef

25.

Moussavi S, Chatterji S, Verdes E, et al. Depression, chronic diseases, and decrements in health: results from the World Health Surveys. Lancet. 2007;370:851–8.PubMedCrossRef

26.

Li C, Ford ES, Strine TW, Mokdad AH. Prevalence of depression among US adults with diabetes: findings from the 2006 behavioural risk factor surveillance system. Diabetes Care. 2008;31(1):105–7.PubMedCrossRef

27.

Lloyd CE, Roy T, Nouwen A, Chauhan AM. Epidemiology of depression in diabetes: International and cross-cultural issues. J Affect Disord. 2012;142(S1):S22–9.PubMedCrossRef

28.

Al-Amer RM, Sobeh MM, Zayed AA, Al-Domi HA. Depression among adults with diabetes in Jordan: risk factors and relationship to blood sugar control. J Diabetes Compl. 2011;25:247–52.CrossRef

29.

Chien IC, Wu EL, Lin CH, Chou P. Prevalence of diabetes in patients with major depression: a population based study. Comp Psychaitry. 2012;53:569–75.CrossRef

30.

Asghar S, Hussain A, Ali SM, Khan AK, Magnusson A. Prevalence of depression and diabetes: a population-based study from rural Bangladesh. Diabet Med. 2007;24(8):872–7.PubMedCrossRef

31.

Holt RIG, Phillips DIW, Jameson KA, et al. The Hertfordshire Cohort Study G: The relationship between depression and diabetes mellitus: findings from the Hertfordshire Cohort Study. Diabetic Med. 2009;26(6):641–8.PubMedCrossRef

32.

Khamseh ME, Baradaran HR, Rajabali H. Depression and diabetes in Iranian patients: a comparative study. Int J Psychiatry Med. 2007;37(1):81–6.PubMedCrossRef

33.

Rotella F, Mannucci E. Diabetes mellitus as a risk factor for depression. A meta-analysis of longitudinal studies. Diabetes Res Clin Pract. 2013;99:98–104.PubMedCrossRef

34.

Rotella F, Mannucci E. Depression as a risk factor for diabetes: a meta-analysis of longitudinal studies. J Clin Psychiatry. 2013;74(1):31–7.PubMedCrossRef

35.

Gureje O. The pattern and nature of mental physical comorbidity: Specific or general. In: von Korff M, Scott KM, Gureje O, editors. Global Perspectives on Mental-Physical Comorbidity In the WHO World Mental Health Surveys. Cambridge: Cambridge University Press; 2009.

36.

Leone T, Coast E, Narayanan S, de Graft Aikins A. Diabetes and depression comorbidity and socio-economic status in low and middle income countries (LMICs): a mapping of the evidence. Globalization and Health. 2012;8(1):39.PubMedCrossRef

37.

Mast BT, Miles T, Penninx BW, et al. Vascular Disease and Future Risk of Depressive Symptomatology in Older Adults: Findings from the Health, Aging, and Body Composition Study. Biol Psychiatry. 2008;64(4):320–6.PubMedCrossRef

38.

Katon W, Russo J, Lin EH, et al. Depression and diabetes: factors associated with major depression at five-year follow-up. Psychosomatics. 2009;50:570–9.PubMed

39.

• Mantyselka P, Korniloff K, Saaristo T, et al. Association of depressive symptoms with impaired glucose regulation, screen-detected, and previously known Type 2 diabetes. Diabetes Care. 2011;34:71–6. Patients with previous diagnosis of depression had significantly higher rates of depression compared to those with normal glucose levels or previously undiagnosed diabetes.PubMedCrossRef

40.

Mezuk B, Lee H, Abdou CM, et al. Is ignorance bliss? Depression, antidepresants, and the diagnosis of prediabetes and type 2 diabetes. Health Psychol. 2013;32(3):254–63.PubMedCrossRef

41.

Roy T, Lloyd CE, Parvin M, Mohiuddin KG, Rahman M. Prevalence of co-morbid depression in out-patients with type 2 diabetes mellitus in Bangladesh. BMC Psychiatry. 2012;12(1):123.PubMedCrossRef

42.

Mezuk B, Eaton WW, Albrecht S, Golden SH. Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care. 2008;31(12):2383–90.PubMedCrossRef

43.

Campayo A, de Jonge P, Roy JF, et al. Depressive disorder and incident diabetes mellitus: the effect of characteristics of depression. Am J Psychiatry. 2010;167(5):580–8.PubMedCrossRef

44.

Sambamoorthi U, Ma Y, Findley PA, Rust G. Antidepressant use, depression, and new-onset diabetes among elderly Medicare beneficiaries. J Diabetes. 2012;23. doi: 10.1111/1753-0407.12014.

45.

Renn BN, Feliciano L, Segal DL. The bidirectional relationship of depression and diabetes: A systematic review. Clin Psychol Rev. 2011;31(8):1239–46.PubMedCrossRef

46.

Kan C, Silva N, Golden SH, et al. Systematic Review and Meta-analysis of the Association Between Depression and Insulin Resistance. Diabetes Care. 2013;36(2):480–9.PubMedCrossRef

47.

Katon W, Russo J, Lin EHB, et al. Diabetes and Poor Disease Control: Is Comorbid Depression Associated With Poor Medication Adherence or Lack of Treatment Intensification? Psychosomatic Med. 2009;71(9):965–72.CrossRef

48.

Andersohn F, Schade R, Suissa S, Garbe E. Long-Term Use of Antidepressants for Depressive Disorders and the Risk of Diabetes Melitus. Am J Psychiatry. 2009;166:591–8.PubMedCrossRef

49.

Deuschle M. Effects of antidepressants on glucose metabolism and diabetes mellitus type 2 in adults. Curr Opin Psychiatry. 2013;26:60–5.PubMedCrossRef

50.

Owens MJ, Nemeroff CB. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem. 1994;40(2):288–95.PubMed

51.

Manjarrez G, Herrera R, Leon M, Hernandez-R J. A Low Brain Serotonergic Neurotransmission in Children With Type 1 Diabetes Detected Through the Intensity Dependence of Auditory-Evoked Potentials. Diabetes Care. 2006;29(1):73–7.PubMedCrossRef

52.

Kloiber S, Kohli MA, Brueckl T, et al. Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression. Mol Psychiatry. 2010;15(7):736–47.PubMedCrossRef

53.

Lara C. Early-Life Psychosocial Factors and Adult-Onset Diabetes. In: von Korff M, Scott KM, Gureje O, editors. Global Perspectives on Mental-Physical Comorbidity. Cambridge: Cambridge University Press; 2009. p. 136–53.

54.

Scott KM, Von Korff M, Angermeyer MC, et al. Association of childhood adversities and early-onset mental disorders with adult-onset chronic physical conditions. Arch Gen Psychiatry. 2011;68(8):838–44.PubMedCrossRef

55.

Renzaho AMN, Houng B, Oldroyd J et al. Stressful life events and the onset of chronic diseases among Australian adults: findings from a longitudinal survey. Eur J Public Health. 2013 Feb 8. [Epub ahead of print].

56.

Knol MJ, Heerdink ER, Egberts ACG, et al. Depressive Symptoms in Subjects With Diagnosed and Undiagnosed Type 2 Diabetes. Psychosomatic Med. 2007;69(4):300–5.CrossRef

57.

Nouwen A, Nefs G, Caramlau I, et al. Prevalence of Depression in Individuals With Impaired Glucose Metabolism or Undiagnosed Diabetes. Diabetes Care. 2011;34:752–62.PubMedCrossRef

58.

Katon WJ, Russo JE, Heckbert SR, et al. The relationship between changes in depression symptoms and changes in health risk behaviors in patients with diabetes. Int J Geriatric Psychiatry. 2010;25(5):466–75.CrossRef

59.

Gale CR, Kivimaki M, Lawlor DA, et al. Fasting Glucose, Diagnosis of Type 2 Diabetes, and Depression: The Vietnam Experience Study. Biol Psychiatry. 2010;67(2):189–92.PubMedCrossRef

60.

Champaneri S, Wand GS, Malhotra SS, Casagrande SS, Golden SH. Biological Basis of Depression in Adults with Diabetes. Curr Diab Rep. 2010;10(6):396–405.PubMedCrossRef

61.

Schmidt HD, Shelton RC, Duman RS. Functional Biomarkers of Depression: Diagnosis, Treatment, and Pathophysiology. Neuropsychopharmacology. 2011;36(12):2375–94.PubMedCrossRef

62.

Gragnoli C. Depression and type 2 diabetes: Cortisol pathway implication and investigational needs. J Cell Physiol. 2012;227(6):2318–22.PubMedCrossRef

63.

Pan A, Keum N, Okereke OI, et al. Bidirectional Association Between Depression and Metabolic Syndrome: A systematic review and meta-analysis of epidemiological studies. Diabetes Care. 2012;35(5):1171–80.PubMedCrossRef

64.

Stuart MJ, Baune BT. Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity. NeurosciBiobehav Rev. 2012;36(1):658–76.

65.

Maes M. Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(3):664–75.PubMedCrossRef

66.

Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011;11(2):98–107.PubMedCrossRef

67.

Hood KK, Lawrence JM, Anderson A, et al. Metabolic and Inflammatory Links to Depression in Youth With Diabetes. Diabetes Care. 2012;35(12):2443–6.PubMedCrossRef

68.

Richardson LK, Egede LE, Mueller M, Echols CL, Gebregziabher M. Longitudinal effects of depression on glycemic control in veterans with type 2 diabetes. Gen Hosp Psychiatry. 2008;30(6):509–14.PubMedCrossRef

69.

Aikens JE, Perkins DW, Lipton B, Piette JD. Longitudinal Analysis of Depressive Symptoms and Glycemic Control in Type 2 Diabetes. Diabetes Care. 2009;32(7):1177–81.PubMedCrossRef

70.

de Groot M, Jacobson AM, Samson JA, Welch G. Glycemic control and major depression in patients with type 1 and type 2 diabetes mellitus. J Psychosomatic Res. 1999;46(5):425–35.CrossRef

71.

Sacco WP, Bykowski CA. Depression and haemoglobin A1c in type 1 and type 2 diabetes: the role of self-efficacy. Diabetes Res Clin Pract. 2010;90:141–6.PubMedCrossRef

72.

Melin EO, Thunander M. Depression, obesity and smoking were independently associated with inadequate glycaemic control in patients with type I diabetes. Eur J Endrocrinol. 2013;168(6):861–9.CrossRef

73.

van Bastelaar KM, Pouwer F, Geelhoed-Duijvestijn PH, et al. Diabetes-specific emotional distress mediates the association betweeen depressive symptoms and glycaemic control in type 1 and type 2 diabetes. Diabet Med. 2010;27:798–803.PubMedCrossRef

74.

van Steenbergen-Weijenburg KM, van Puffelen AL, Horn EK, et al. More co-morbid depression in patients with Type 2 diabetes with multiple complications. An observational study at a specialized outpatient clinic. Diabetic Med. 2011;28(1):86–9.PubMedCrossRef

75.

van Dooren FEP, Nefs G, Schram MT, et al. Depression and Risk of Mortality in People with Diabetes Mellitus: A Systematic Review and Meta-Analysis. PLoS ONE. 2013;8(3):e57058.PubMedCrossRef

76.

Coleman SM, Katon W, Lin E, Von Korff M. Depression and Death in Diabetes; 10-Year Follow-Up of All-Cause and Cause-Specific Mortality in a Diabetic Cohort. Psychosomatics. 2013. doi: 10.1016/j.psym.2013.02.015.

77.

Sullivan MD, O’Connor P, Feeney P, et al. Depression Predicts All-Cause Mortality: Epidemiological evaluation from the ACCORD HRQL substudy. Diabetes Care. 2012;35(8):1708–15.PubMedCrossRef

78.

Ahola AJ, Harjutsalo V, Saraheimo M, Forsblom C, Groop PH. Purchase of antidepressant agents by patients with type 1 diabetes is associated with increased mortality rates in women but not in men. Diabetologia. 2012;55(1):73–9.PubMedCrossRef

79.

Chereches RM, Litan CM, Zlati AM, Bloom JR. Does co-morbid depression impact diabetes related costs? Evidence from a cross-sectional survey in a low-income country. J Ment Health Policy Econ. 2012;15(3):127–38.PubMed

80.

Le TK, Curtis B, Kahle-Wrobleski K, et al. Treatment patterns and resource use among patients with comorbid diabetes mellitus and major depressive disorder. J Med Econ. 2011;14(4):440–7.PubMed

81.

Das-Munshi J, Stewart R, Ismail K, et al. Diabetes, Common Mental Disorders, and Disability: Findings From the UK National Psychiatric Morbidity Survey. Psychosomatic Med. 2007;69(6):543–50.CrossRef

82.

Dismuke CE, Egede LE. Association between major depression, depressive symptoms and personal income in US adults with diabetes. Gen Hosp Psychiatry. 2010;32(5):484–91.PubMedCrossRef

83.

•• Baumeister H, Hutter N, Bengel J. Psychological and pharmacological intervention for depression in patients with diabetes mellitus and depression. Cochrane Database Syst Rev. 2012;12. Psychological and pharmacological interventions are effective in treating depression symptoms in patients with diabetes. While pharmacological interventions improve glycaemic control, the effects of psychological interventiions on glycaemic control is inconclusive.

84.

Markowitz SM, Gonzalez JS, Wilkinson JL, Safren SA. A Review of Treating Depression in Diabetes: Emerging Findings. Psychosomatics. 2011;52(1):1–18.PubMedCrossRef

85.

Lustman PJ, Clouse RE, Nix BD, et al. Sertraline for prevention of depression recurrence in diabetes mellitus: A randomized, double-blind, placebo-controlled trial. Arch Gen Psychiatry. 2006;63(5):521–9.PubMedCrossRef

86.

Lustman PJ, Williams MM, Sayuk GS, Nix BD, Clouse RE. Factors influencing glycemic control in type 2 diabetes during acute- and maintenance-phase treatment of major depressive disorder with bupropion. Diabetes Care. 2007;30(3):459–66.PubMedCrossRef

87.

Katon WJ, Lin EHB, Von Korff M, et al. Collaborative Care for Patients with Depression and Chronic Illnesses. New Engl J Med. 2010;363(27):2611–20.PubMedCrossRef

88.

Coleman SM, Katon W. Treatment implication for comorbid diabetes mellitus and depression. IPsychiatry Times. 2013;30:1–5.

Titel: The Comorbidity between Depression and Diabetes
verfasst von: Bibilola D. Oladeji
Oye Gureje
Publikationsdatum: 01.09.2013
Verlag: Springer US
Erschienen in: Current Psychiatry Reports / Ausgabe 9/2013
Print ISSN: 1523-3812
Elektronische ISSN: 1535-1645
DOI: https://doi.org/10.1007/s11920-013-0390-3

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