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Clinical Reviews in Allergy & Immunology

Erschienen in:

01.10.2008

Antiendothelial Cells Autoantibodies in Vasculitis-Associated Systemic Diseases

verfasst von: Philippe Guilpain, Luc Mouthon

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 1-2/2008

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Abstract

Antiendothelial cell antibodies (AECA) have been detected in healthy individuals, as well as in autoimmune and systemic inflammatory diseases, including systemic vasculitides. AECA have been reported in large vessel vasculitides such as giant cell arteritis and Takayasu arteritis; medium-sized vessel vasculitides, such as polyarteritis nodosa related to hepatitis B virus infection and Kawasaki disease; and small-sized vessel vasculitides, such as Wegener’s granulomatosis, microscopic polyangiitis, and Henoch–Schonlein purpura. In Takayasu arteritis and antineutrophil cytoplasm antibody-positive vasculitides, AECA have been reported to correlate with disease activity. A cell-based enzyme-linked immunosorbent assay (ELISA) using cultured human umbilical vein endothelial cells (HUVEC) represent one of the reference techniques for AECA detection, although flow cytometry and immunobloting have also been proposed. AECA might contribute to the pathogenesis of systemic vasculitides and vasculitis-associated diseases through (1) activation of endothelial cells (EC), (2) direct cytotoxic effect due to complement-dependent cytotoxicity or indirect cytotoxic effect secondary to antibody-dependent cytotoxicity, (3) induction of coagulation, (4) induction of apoptosis through the binding of phospholipids or heat-shock protein 60, and (5) induction of EC activation. None of the identified target antigens of AECA is specific for EC, and EC-specific target antigens of AECA remain to be identified in systemic vasculitides.

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Titel: Antiendothelial Cells Autoantibodies in Vasculitis-Associated Systemic Diseases
verfasst von: Philippe Guilpain
Luc Mouthon
Publikationsdatum: 01.10.2008
Verlag: Humana Press Inc
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 1-2/2008
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-007-8069-3

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Antiendothelial Cells Autoantibodies in Vasculitis-Associated Systemic Diseases

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