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03.09.2019 | Meta-Analysis

Association between nonalcoholic fatty liver disease and cardiac function and structure—a meta-analysis

verfasst von: Marta Borges-Canha, João Sérgio Neves, Diogo Libânio, Madalena Von-Hafe, Catarina Vale, Miguel Araújo-Martins, Ana Rita Leite, Pedro Pimentel-Nunes, Davide Carvalho, Adelino Leite-Moreira

Erschienen in: Endocrine | Ausgabe 3/2019

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Abstract

Purpose

Nonalcoholic fatty liver disease is increasingly recognized as the hepatic counterpart of metabolic syndrome. It is hypothesized that structural and functional cardiac changes may be associated with this metabolic disease. We aimed to gather the existing information on the association of nonalcoholic fatty liver disease with cardiac alterations, and to evaluate a possible correlation between them.

Methods

Systematic review of Medline searching results for original articles studying NAFLD and cardiac parameters until August 2018. A meta-analysis was conducted to each parameter of cardiac structure and function selected, using Review Manager 5.3 software. This study was conducted according to preferred reporting items for systematic reviews and meta-analysis (PRISMA).

Results

A total of 16 studies met the eligibility criteria and were included in the meta-analysis. There was a significant association between nonalcoholic fatty liver disease and (1) higher left ventricle mass and ratios between left ventricle mass and both height and body surface area; (2) higher LVEDD; (3) higher left atrium diameter and ratio between left atrial volume and body surface area; (4) higher posterior wall and septum thickness; (5) lower E/A wave ratio; (6) higher E/E’ ratio; (7) longer deceleration time and (8) longer relaxation time.

Conclusion

NAFLD associates with adverse structural alterations and cardiac dysfunction. Our results highlight the importance of identifying NAFLD in patients with metabolic dysfunction as this may represent an additional contributor to cardiovascular risk.

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Titel: Association between nonalcoholic fatty liver disease and cardiac function and structure—a meta-analysis
verfasst von: Marta Borges-Canha
João Sérgio Neves
Diogo Libânio
Madalena Von-Hafe
Catarina Vale
Miguel Araújo-Martins
Ana Rita Leite
Pedro Pimentel-Nunes
Davide Carvalho
Adelino Leite-Moreira
Publikationsdatum: 03.09.2019
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 3/2019
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-019-02070-0

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Association between nonalcoholic fatty liver disease and cardiac function and structure—a meta-analysis