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Immunologic Research
Erschienen in: Immunologic Research 1-2/2012

01.04.2012 | Immunology in Serbia

The potential of interleukin-17 to mediate hematopoietic response

verfasst von: Aleksandra Krstic, Slavko Mojsilovic, Gordana Jovcic, Diana Bugarski

Erschienen in: Immunologic Research | Ausgabe 1-2/2012

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Abstract

It has long been known that T cells have the potential to modulate hematopoietic response in different ways. More recently, the importance of interleukin (IL)-17-secreting Th17 cells in T-cell-mediated regulation of hematopoiesis was indicated by the line of evidence that IL-17 links T-cell function and hematopoiesis through stimulation of granulopoiesis and neutrophil trafficking. Furthermore, our data demonstrated that IL-17 also affects other cells of hematopoietic system, such as erythroid progenitors, as well as mesenchymal stem cells. In order to better understand the regulatory role of IL-17 in hematopoiesis, molecular mechanisms underlying the effects of IL-17 on hematopoietic and mesenchymal stem cells were also studied.
Literatur
1.
Milenkovic P, Ivanovic Z, Kataranovski M, Lukic ML. Stimulator of proliferation of spleen colony-forming cells in T-cell deprived mice treated with cyclophosphamide or irradiation. Cell Prolif. 1991;24:507–15.PubMedCrossRef
2.
Milenkovic P, Stojanovic N, Jovcic G, Lukic M. Regeneration of spleen colony-forming cells and granulocyte-monocyte progenitors in T-cell deprived mice treated with cyclophosphamide. Leuk Res. 1987;11:1099–103.PubMedCrossRef
3.
Milenkovic P, Biljanovic-Paunovic L, Lukic M, Pavlovic-Kentera V. Erythroid-committed progenitors and spleen colony-forming cells in adult thymus-deprived mice. Cell Tissue Kinet. 1983;16:429–40.PubMed
4.
Lord BI, Schofield R. The influence of thymus cells in hemopoiesis: stimulation of hemopoietic stem cells in a syngeneic, in vivo, situation. Blood. 1973;42:395–404.PubMed
5.
Resnitzky P, Zipori D, Trainin N. Effect of neonatal thymectomy on hemopoietic tissue in mice. Blood. 1971;37:634–46.PubMed
6.
Trainin N, Resnitzky P. Influence of neonatal thymectomy on cloning capacity of bone marrow cells in mice. Nature. 1969;221:1154–5.PubMedCrossRef
7.
Bonomo AC, el-Cheikh MC, Borojevic R, Cavalcante LA, DosReis GA: Comparative analysis of splenic cell proliferation induced by interleukin 3 and by syngeneic accessory cells (syngeneic mixed leukocyte reaction): evidence that autoreactive T-cell functioning instructs hematopoietic phenomena. Cell Immunol. 1990;125:210–224.
8.
Sonoda Y, Okuda T, Yokota S, Maekawa T, Shizumi Y, Nishigaki H, Misawa S, Fujii H, Abe T. Actions of human interleukin-4/B-cell stimulatory factor-1 on proliferation and differentiation of enriched hematopoietic progenitor cells in culture. Blood. 1990;75:1615–21.PubMed
9.
Broxmeyer HE, Lu L, Cooper S, Tushinski R, Mochizuki D, Rubin BY, Gillis S, Williams DE. Synergistic effects of purified recombinant human and murine B cell growth factor-1/IL-4 on colony formation in vitro by hematopoietic progenitor cells. Multiple actions. J Immunol. 1988;141:3852–62.PubMed
10.
Greenberger JS, Krensky AM, Messner H, Burakoff SJ, Wandl U, Sakakeeny MA. Production of colony-stimulating factor(s) for granulocyte-macrophage and multipotential (granulocyte/erythroid/megakaryocyte/macrophage) hematopoietic progenitor cells (CFU-GEMM) by clonal lines of human IL-2-dependent T-lymphocytes. Exp Hematol. 1984;12:720–7.PubMed
11.
Bacon ER, Sing AP, Reinish CL. Amplification of granulopoiesis by T cell subpopulations. Exp Hematol. 1983;11:747–56.PubMed
12.
Asquith KL, Ramshaw HS, Hansbro PM, Beagley KW, Lopez AF, Foster PS. The IL-3/IL-5/GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation. J Immunol. 2008;180:1199–206.PubMed
13.
Rådinger M, Sergejeva S, Johansson AK, Malmhäll C, Bossios A, Sjöstrand M, Lee JJ, Lötvall J: Regulatory role of CD8 + T lymphocytes in bone marrow eosinophilopoiesis. Respir Res. 2006;7:83.
14.
Broxmeyer HE, Bruns HA, Zhang S, Cooper S, Hangoc G, McKenzie AN, Dent AL, Schindler U, Naeger LK, Hoey T, Kaplan MH. Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Immunity. 2002;16:815–25.PubMedCrossRef
15.
Young HA, Klinman DM, Reynolds DA, Grzegorzewski KJ, Nii A, Ward JM, Winkler-Pickett RT, Ortaldo JR, Kenny JJ, Komschlies KL. Bone marrow and thymus expression of interferon-gamma results in severe B-cell lineage reduction, T-cell lineage alterations, and hematopoietic progenitor deficiencies. Blood. 1997;89:583–95.PubMed
16.
Fossiez F, Djossou O, Chomarat P, Flores-Romo L, Ait-Yahia S, Maat C, Pin JJ, Garrone P, Garcia E, Saeland S, Blanchard D, Gaillard C, Das Mahapatra B, Rouvier E, Golstein P, Banchereau J, Lebecque S: T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med. 1996;183:2593–2603.
17.
Kelso A, Troutt AB, Maraskovsky E, Gough NM, Morris L, Pech MH, Thomson JA. Heterogeneity in lymphokine profiles of CD4+ and CD8+ T cells and clones activated in vivo and in vitro. Immunol Rev. 1991;123:85–114.PubMedCrossRef
18.
Monteiro JP, Benjamin A, Costa ES, Barcinski MA, Bonomo A. Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells. Blood. 2005;105:1484–91.PubMedCrossRef
19.
20.
Urbieta M, Barao I, Jones M, Jurecic R, Panoskaltsis-Mortari A, Blazar BR, Murphy WJ, Levy RB. Hematopoietic progenitor cell regulation by CD4 + CD25 + T cells. Blood. 2010;115:4934–43.PubMedCrossRef
21.
Fossiez F, Banchereau J, Murray R, Van Kooten C, Garrone P, Lebecque S. Interleukin-17. Int Rev Immunol. 1998;16:541–51.PubMedCrossRef
22.
Schwarzenberger P, La Russa V, Miller A, Ye P, Huang W, Zieske A, Nelson S, Bagby GJ, Stoltz D, Mynatt RL, Spriggs M, Kolls JK. IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines. J Immunol. 1998;161:6383–9.PubMed
23.
Schwarzenberger P, Huang W, Ye P, Oliver P, Manuel M, Zhang Z, Bagby G, Nelson S, Kolls JK. Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis. J Immunol. 2000;164:4783–9.PubMed
24.
Schwarzenberger P, Kolls JK. Interleukin 17: an example for gene therapy as a tool to study cytokine mediated regulation of hematopoiesis. J Cell Biochem Suppl. 2002;38:88–95.PubMedCrossRef
25.
Jovcic G, Bugarski D, Krstic A, Vlaski M, Petakov M, Mojsilovic S, Stojanovic N, Milenkovic P. The effect of interleukin-17 on hematopoietic cells and cytokine release in mouse spleen. Physiol Res. 2007;56:331–9.PubMed
26.
Jovcic G, Bugarski D, Petakov M, Krstic A, Vlaski M, Stojanovic N, Milenkovic P. In vivo effects of interleukin-17 on haematopoietic cells and cytokine release in normal mice. Cell Prolif. 2004;37:401–12.PubMedCrossRef
27.
Jovcic G, Bugarski D, Petakov M, Stankovic J, Stojanovic N, Milenkovic P. Effect of IL-17 on in vitro hematopoietic progenitor cells growth and cytokine release in normal and post-irradiated murine bone marrow. Growth Factors. 2001;19:61–71.PubMedCrossRef
28.
Vlaski M, Krstic AD, Jovcic GS, Bugarski DS, Petakov MD, Stojanovic NN, Milenkovic PB. Effects of IL-17 on functional activity of peripheral blood cells. Acta Vet (Beogr). 2004;54:249–61.CrossRef
29.
Krstic A, Santibanez JF, Okic I, Mojsilovic S, Kocic J, Jovcic G, Milenkovic P, Bugarski D. Combined effect of IL-17 and blockade of nitric oxide biosynthesis on haematopoiesis in mice. Acta Physiol (Oxf). 2010;199:31–41.CrossRef
30.
Krstic A, Vlaski M, Hammoud M, Chevaleyre J, Duchez P, Jovcic G, Bugarski D, Milenkovic P, Bourin P, Boiron JM, Praloran V, Ivanovic Z. Low O2 concentrations enhance the positive effect of IL-17 on the maintenance of erythroid progenitors during co-culture of CD34 + and mesenchymal stem cells. Eur Cytokine Netw. 2009;20:10–6.PubMed
31.
Bugarski D, Krstic A, Vlaski M, Petakov M, Jovcic G, Stojanovic N, Milenkovic P. Interleukine-17-induced inhibitory effect on late stage murine erythroid bone marrow progenitors. Eur Cytokine Netw. 2004;15:247–54.PubMed
32.
Krstic A, Ilic V, Mojsilovic S, Jovcic G, Milenkovic P, Bugarski D. p38 MAPK signaling mediates IL-17-induced nitric oxide synthase expression in bone marrow cells. Growth Factors. 2009;27:79–90.PubMedCrossRef
33.
Towatari M, Ciro M, Ottolenghi S, Tsuzuki S, Enver T. Involvement of mitogen-activated protein kinase in the cytokine-regulated phosphorylation of transcription factor GATA-1. Hematol J. 2004;5:262–72.PubMedCrossRef
34.
Suzuki N, Suwabe N, Ohneda O, Obara N, Imagawa S, Pan X, Motohashi H, Yamamoto M. Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levels. Blood. 2003;102:3575–83.PubMedCrossRef
35.
Tan W, Huang W, Zhong Q, Schwarzenberger P. IL-17 receptor knockout mice have enhanced myelotoxicity and impaired hemopoietic recovery following gamma irradiation. J Immunol. 2006;176:6186–93.PubMed
36.
Ilic V, Krstic A, Katic-Radivojevic S, Jovcic G, Milenkovic P, Bugarski D. Syphacia obvelata modifies mitogen-activated protein kinases and nitric oxide synthases expression in murine bone marrow cells. Parasitol Int. 2010;59:82–8.PubMedCrossRef
37.
Bugarski D, Jovcic G, Katic-Radivojevic S, Petakov M, Krstic A, Stojanovic N, Milenkovic P. Hematopoietic changes and altered reactivity to IL-17 in Syphacia obvelata-infected mice. Parasitol Int. 2006;55:91–7.PubMedCrossRef
38.
Cilloni D, Carlo-Stella C, Falzetti F, Sammarelli G, Regazzi E, Colla S, Rizzoli V, Aversa F, Martelli MF, Tabilio A. Limited engraftment capacity of bone marrow-derived mesenchymal cells following T-cell-depleted hematopoietic stem cell transplantation. Blood. 2000;96:3637–43.PubMed
39.
Vallera DA, Blazar BR. T cell depletion for graft-versus-host-disease prophylaxis. A perspective on engraftment in mice and humans. Transplantation. 1989;47:751–60.PubMedCrossRef
40.
Pontikoglou C, Deschaseaux F, Sensebé L, Papadaki HA. Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoietic stem cell transplantation. Stem Cell Rev. 2011;7:569–89.PubMedCrossRef
41.
Dazzi F, Ramasamy R, Glennie S, Jones SP, Roberts I. The role of mesenchymal stem cells in haemopoiesis. Blood Rev. 2006;20:161–71.PubMedCrossRef
42.
Owen M. Marrow stromal stem cells. J Cell Sci Suppl. 1988;10:63–76.PubMed
43.
Friedenstein AJ, Deriglasova UF, Kulagina NN, Panasuk AF, Rudakowa SF, Luriá EA, Ruadkow IA. Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Exp Hematol. 1974;2:83–92.PubMed
44.
Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation. 1968;6:230–47.PubMedCrossRef
45.
Moseley TA, Haudenschild DR, Rose L, Reddi AH. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 2003;14:155–74.PubMedCrossRef
46.
Rifas L, Avioli LV. A novel T cell cytokine stimulates interleukin-6 in human osteoblastic cells. J Bone Miner Res. 1999;14:1096–103.PubMedCrossRef
47.
Kennedy J, Rossi DL, Zurawski SM, Vega F Jr, Kastelein RA, Wagner JL, Hannum CH, Zlotnik A. Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells. J Interferon Cytokine Res. 1996;16:611–7.PubMedCrossRef
48.
Yao Z, Fanslow WC, Seldin MF, Rousseau AM, Painter SL, Comeau MR, Cohen JI, Spriggs MK. Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity. 1995;3:811–21.PubMedCrossRef
49.
Yao Z, Painter SL, Fanslow WC, Ulrich D, Macduff BM, Spriggs MK, Armitage RJ. Human IL-17: a novel cytokine derived from T cells. J Immunol. 1995;155:5483–6.PubMed
50.
Shen F, Ruddy MJ, Plamondon P, Gaffen SL. Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells. J Leukoc Biol. 2005;77:388–99.PubMedCrossRef
51.
Ruddy MJ, Wong GC, Liu XK, Yamamoto H, Kasayama S, Kirkwood KL, Gaffen SL. Functional cooperation between interleukin-17 and tumor necrosis factor-alpha is mediated by CCAAT/enhancer-binding protein family members. J Biol Chem. 2004;279:2559–67.PubMedCrossRef
52.
Mojsilovic S, Krstic A, Ilic V, Okic-Đorđevic I, Kocic J, Trivanovic D, Santibañez JF, Jovcic G, Bugarski D: IL-17 and FGF signaling involved in mouse mesenchymal stem cell proliferation. Cell Tissue Res. 2011;346:305–16.
53.
Huang H, Kim HJ, Chang EJ, Lee ZH, Hwang SJ, Kim HM, Lee Y, Kim HH. IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling. Cell Death Differ. 2009;16:1332–43.PubMedCrossRef
54.
Silva WA Jr, Covas DT, Panepucci RA, Proto-Siqueira R, Siufi JL, Zanette DL, Santos AR, Zago MA. The profile of gene expression of human marrow mesenchymal stem cells. Stem Cells. 2003;21:661–9.PubMedCrossRef
55.
Huang W, La Russa V, Alzoubi A, Schwarzenberger P. Interleukin-17A: a T-cell-derived growth factor for murine and human mesenchymal stem cells. Stem Cells. 2006;24:1512–8.PubMedCrossRef
56.
Shin JH, Shin DW, Noh M. Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes. Biochem Pharmacol. 2009;77:1835–44.PubMedCrossRef
57.
Lee SJ, Lee EJ, Kim SH, Choi I, Lee DM, Lee HJ, Yoon D, Chun T. IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor γ through CAAT/enhancer binding protein β signaling. Biotechnol Lett. 2011;33:229–35.PubMedCrossRef
58.
Kocić J, Santibañez JF, Krstić A, Mojsilović S, Dorđević IO, Trivanović D, Ilić V, Bugarski D. Interleukin 17 inhibits myogenic and promotes osteogenic differentiation of C2C12 myoblasts by activating ERK1,2. Biochim Biophys Acta. 2012 (in press)
59.
Pappu R, Ramirez-Carrozzi V, Sambandam A. The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases. Immunology. 2011;134:8–16.PubMedCrossRef
60.
Hamada S, Umemura M, Shiono T, Tanaka K, Yahagi A, Begum MD, Oshiro K, Okamoto Y, Watanabe H, Kawakami K, Roark C, Born WK, O’Brien R, Ikuta K, Ishikawa H, Nakae S, Iwakura Y, Ohta T, Matsuzaki G. IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver. J Immunol. 2008;181:3456–63.PubMed
61.
Umemura M, Yahagi A, Hamada S, Begum MD, Watanabe H, Kawakami K, Suda T, Sudo K, Nakae S, Iwakura Y, Matsuzaki G. IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacilli Calmette-Guerin infection. J Immunol. 2007;178:3786–96.PubMed
62.
Lockhart E, Green AM, Flynn JL. IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol. 2006;177:4662–9.PubMed
63.
Stark MA, Huo Y, Burcin TL, Morris MA, Olson TS, Ley K. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity. 2005;22:285–94.PubMedCrossRef
64.
McKenzie BS, Kastelein RA, Cua DJ. Understanding the IL-23-IL-17 immune pathway. Trends Immunol. 2006;27:17–23.PubMedCrossRef
65.
Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005;6:1133–41.PubMedCrossRef
66.
Gaffen SL. Biology of recently discovered cytokines: interleukin-17–a unique inflammatory cytokine with roles in bone biology and arthritis. Arthritis Res Ther. 2004;6:240–7.PubMedCrossRef
67.
Schwarzenberger P, Huang W, Oliver P, Byrne P, La Russa V, Zhang Z, Kolls JK. Il-17 mobilizes peripheral blood stem cells with short- and long-term repopulating ability in mice. J Immunol. 2001;167:2081–6.PubMed
68.
Lemoli RM, D’Addio A. Hematopoietic stem cell mobilization. Haematologica. 2008;93:321–4.PubMedCrossRef
Metadaten
Titel
The potential of interleukin-17 to mediate hematopoietic response
verfasst von
Aleksandra Krstic
Slavko Mojsilovic
Gordana Jovcic
Diana Bugarski
Publikationsdatum
01.04.2012
Verlag
Springer-Verlag
Erschienen in
Immunologic Research / Ausgabe 1-2/2012
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-012-8276-8

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