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06.06.2020 | Original Research

Decrease of miR-125a-5p in Gastritis and Gastric Cancer and Its Possible Association with H. pylori

verfasst von: Mônica Pezenatto dos Santos, Jéssica Nunes Pereira, Roger Willian De Labio, Lilian Carla Carneiro, Jaqueline Correia Pontes, Mônica Santiago Barbosa, Marília De Arruda Cardoso Smith, Spencer Luíz Marques Payão, Lucas Trevizani Rasmussen

Erschienen in: Journal of Gastrointestinal Cancer | Ausgabe 2/2021

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Abstract

Purpose

The aim of this study was to evaluate the expression of miR-125a-5p in patients with dyspeptic symptoms and gastric cancer, correlating them with the development of this cancer and H. pylori.

Methods

Patients were divided in groups according to histopathological analysis (control, gastritis, and cancer groups). Polymerase chain reaction was performed to detect H. pylori and real-time quantitative PCR to determine miR-125a-5p expression.

Results

H. pylori was detected in 44% of the patients, with prevalence in the gastritis and cancer groups. A statistically significant decrease of miR-125a-5p expression was found in the control positive (p = 0.0183*), gastritis positive (p = 0.0380*), and cancer positive (p = 0.0288*) groups when compared with the control negative group.

Conclusion

We suggest that decreased expression of the miRNA-125a-5p associated with the presence of the H. pylori is an important mechanism in gastric diseases and could be a possible marker for early diagnosis of gastric cancer.

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Titel: Decrease of miR-125a-5p in Gastritis and Gastric Cancer and Its Possible Association with H. pylori
verfasst von: Mônica Pezenatto dos Santos
Jéssica Nunes Pereira
Roger Willian De Labio
Lilian Carla Carneiro
Jaqueline Correia Pontes
Mônica Santiago Barbosa
Marília De Arruda Cardoso Smith
Spencer Luíz Marques Payão
Lucas Trevizani Rasmussen
Publikationsdatum: 06.06.2020
Verlag: Springer US
Erschienen in: Journal of Gastrointestinal Cancer / Ausgabe 2/2021
Print ISSN: 1941-6628
Elektronische ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-020-00432-w

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Decrease of miR-125a-5p in Gastritis and Gastric Cancer and Its Possible Association with H. pylori