Anzeige
Erschienen in:
22.10.2021 | Original Research
Effect of Pressurized Intraperitoneal Aerosol Chemotherapy on the Survival Rate of Patients with Peritoneal Carcinomatosis of Gastric Origin
Erschienen in: Journal of Gastrointestinal Cancer | Ausgabe 4/2022
Einloggen, um Zugang zu erhaltenAbstract
Introduction
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new surgical technique for the treatment of initially unresectable peritoneal carcinomatosis (PC). Our objective was to compare the results of PIPAC associated with systemic chemotherapy (PIPAC_CHEM) with those of systemic chemotherapy alone (ONLY_CHEM) in patients with gastric PC without metastasis other than peritoneal, and the WHO performance status < 3.
Methods
This was a retrospective, single center, comparative non-randomized study. Seventeen PIPAC_CHEM patients were compared to 29 ONLY_CHEM patients. The primary endpoint was overall survival at 6 months from diagnosis of PC.
Results
Ninety-eight patients were screened and 46 were included (PIPAC_CHEM, n = 17; ONLY_CHEM, n = 29). The PIPAC_ CHEM population was significantly younger (median 64 years [56; 68] vs 74 years [61; 79]; p = 0.0054). Median PIPAC session per patient is 2 [1–3]. Six-month survival was significantly higher in the PIPAC_CHEM group than in the ONLY_CHEM group 16/17 (94.1% [65–99.2]) vs 19/29 (65.5% [45.4–79.7]), respectively; p = 0.029. Over the entire follow-up, median survival [95% CI] was 12.8 months [7.2–34.3] with PIPAC vs 9.1 months [5.4–11.5] without, p = 0.056.
At 6 months, median length of additional hospitalization was significantly less for PIPAC_CHEM (median 2 days [2–7]) than without PIPAC (median 11 days [3–21]) (p = 0.045).
Conclusion
The overall survival at 6 months after the diagnosis of carcinomatosis was significantly better for PIPAC_CHEM patients. This difference appears to continue until at least 18 months. At 6 months, days of additional hospitalization was significantly less in the PIPAC_CHEM group.
Trial Registration
Clinicaltrials.gov Identifier: NCT 04,879,953