nach oben

Head and Neck Pathology

Erschienen in:

01.06.2008 | Symposia

Intraoperative Consultation (IOC) in Mucosal Lesions of the Upper Aerodigestive Tract

verfasst von: Bruce M. Wenig

Erschienen in: Head and Neck Pathology | Ausgabe 2/2008

Einloggen, um Zugang zu erhalten

Abstract

Intraoperative consultation (frozen section) plays an important part in the treatment of the head and neck cancer patient. The appropriate use of intraoperative consultations (frozen sections) usually results in a definitive diagnosis with immediate therapeutic impact while the patient is in the operating room. Among the determinations made by frozen section analysis include the evaluation of adequacy of surgical margins of resection; the differentiation between nonneoplastic, benign and malignant proliferations; the evaluation of lymph nodes for the presence of metastatic disease; the determination of specimen identification and specimen adequacy, including the verification of such organs as the parathyroid glands; and the determination of whether a given case requires special diagnostic testing best performed on frozen material, such as for lymphomas. This paper focuses on intraoperative consultation of mucosal lesions of the upper aerodigestive tract, including epithelial dysplasia and squamous cell carcinoma. Other issues that often not diagnosed or at issue at the time of surgery, including the diagnosis of microinvasive carcinoma and differentiating inflammatory lesions from neoplastic lesions are included for completion.

Dehner LP, Rosai J. Frozen section examination in surgical pathology. Minn Med. 1977;60:83–94.PubMed

Ferreiro JA, Myers JL, Bostwick DG. Accuracy of frozen section diagnosis in surgical pathology: review of 1-year experience with 24,880 cases at Mayo Clinic Rochester. Mayo Clin Proc. 1995;70:1137–41.PubMed

Holaday WJ, Assor D. Ten thousand consecutive frozen section. A retrospective study focusing on accuracy and quality control. Am J Clin Pathol. 1974;61:769–77.PubMed

Howanitz PJ, Hoffman GG, Zarbo RJ. The accuracy of frozen-section diagnosis in 34 hospitals. Arch Pathol Lab Med. 1990;114:355–9.PubMed

Kaufman Z, Lew S, Giffel B, Dinbar A. Frozen-section diagnosis in surgical pathology. A prospective analysis of 526 frozen sections. Cancer. 1986;57:377–9.PubMedCrossRef

Rogers C, Klatt EC, Chandrasoma P. Accuracy of frozen-section diagnosis in a teaching hospital. Arch Pathol Lab Med. 1987;111:514–7.PubMed

Saltzstein SL, Nahum AM. Frozen section diagnosis: accuracy and errors; uses and abuses. Laryngoscope. 1973;83:1128–43.PubMedCrossRef

Sawady J, Berner JJ, Siegler EE. Accuracy of and reason for frozen sections: a correlative, retrospective study. Hum Pathol. 1988;19:1019–23.PubMedCrossRef

Zarbo RJ, Hoffman GG, Howanitz PJ. Interinstituional comparison of frozen-section consultation: a College of American Pathologists q-probe study of 79,647 consultations in 297 North American institutions. Arch Pathol Lab Med. 1991;115:1187–94.PubMed

10.

Dinardo L, Lin J, Carageore L, Powers CN. Accuracy, utility, and cost of frozen section margins in head and neck cancer surgery. Laryngoscope. 2000;110:1773–6.PubMedCrossRef

11.

Gandour-Edwards R, Donald PJ, Wiese D. The accuracy and clinical utility of frozen section in head and neck surgery. Evidence at a university medical center. Head Neck. 1993;15:33–8.PubMedCrossRef

12.

Gandour-Edwards RF, Donald PJ, Lie JT. Clinical utility of intraoperative frozen section diagnosis in head and neck surgery. A quality assurance perspective. Head Neck. 1993;15:373–6.PubMedCrossRef

13.

Ranchod M. Upper aserodigestive tract. In: Ranchod M (ed) Intraoperative consultations in surgical pathology: state of the art reviews. California Society of Pathologists; 1996, vol 3(2). p. 299–304.

14.

Byers RM, Bland KL, Borlase B, Luna M. Prognostic and therapeutic value of frozen section determination in the surgical treatment of squamous carcinoma of the head and neck. Am J Surg. 1978;136:525–8.PubMedCrossRef

15.

Bähr W, Stoll P. Intraoperative histological evaluation of tumor resection borders without prolonging surgery. Int J Oral Maxillofac Surg. 1992;21:90–1.PubMedCrossRef

16.

Spiro RH, Guillamondegui O, Paulino AF, Huvos AG. Pattern of invasion and margin assessment in patients with oral tongue cancer. Head Neck. 1999;21:408–13.PubMedCrossRef

17.

Cooley ML, Hoffman HT, Robinson RA. Discrepancies in frozen section mucosal margin tissue in laryngeal squamous cell carcinoma. Head Neck. 2002;24:262–7.PubMedCrossRef

18.

Batsakis JG. Surgical excision margins: a pathologist’s perspective. Adv Anat Pathol 1999;6:140–8.PubMed

19.

Barnes L. Diseases of the larynx, hypopharynx, and esophagus. In: Barnes L, editor. Surgical pathology of the head and neck. Second edition, revised and expanded. Marcel Dekker, Inc.; New York. 2001:127–237.

20.

Looser KG, Shah JP, Strong EW. The significance of “positive” margins in surgically resected epidermoid carcinomas. Head Neck Surg. 1978;1:107–11.PubMedCrossRef

21.

Mantravadi RV, Haas RE, Leibner EJ, Skolnik EM, Applebaum EL. Postoprative radiotherapy for persistent tumor at the surgical margin in head and neck cancers. Laryngoscope 1983;93:1337–40.PubMed

22.

Brandwein-Gensler M, Teixeira MS, Lewis CM, et al. Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. Am J Surg Pathol. 2005;29:167–78.PubMedCrossRef

23.

Jacobs JR, Ahmad K, Casiano R, et al. Implications of positive surgical margins. Laryngoscope. 1993;103:64–8.PubMedCrossRef

24.

Scholl P, Byers RM, Batsakis JG, et al. Microscopic cut-through of cancer in the surgical treatment of squamous carcinoma of the tongue. Prognostic and therapeutic implications. Am J Surg. 1986;152:354–60.PubMedCrossRef

25.

Loree TR, Strong EW. Significance of “positive” margins in oral squamous cell carcinoma. Am J Surg. 1990;160:410–4.PubMedCrossRef

26.

Batsakis JG. Surgical margins in squamous cell carcinoma. Ann Otol Rhinol Laryngol 1988;97:213–4.PubMed

27.

Beitler JJ, Smith RV, Silver CE, et al. Close or positive margins after surgical resection for head and neck cancer patient: the addition of brachytherapy improves local control. Int J Radiat Oncol Biol Phys. 1998;40:313–7.PubMed

28.

van Es RJJ, Amerongen N, Slootweg PJ, Egyedi P. Resection margin as a predictor of recurrence at the primary site for T1 and T2 oral cancers. Evaluation of histopathologic variables. Arch Otolaryngol Head Neck Surg. 1996;122:521–5.PubMed

29.

Bauer WC, Lesinski SG, Ogura JH. The significance of positive margins in hemilaryngectomy specimens. Laryngoscope. 1975;85:1–13.PubMedCrossRef

30.

McGregor AD, MacDonald DG. Routes of entry of squamous cell carcinoma to the mandible. Head Neck Surg. 1988;10:294–301.PubMedCrossRef

31.

McGregor AD, MacDonald DG. Patterns of spread of squamous cell carcinoma within the mandible. Head Neck. 1989;11:457–61.PubMedCrossRef

32.

Cleary KR, Batsakis JG. Oral squamous cell carcinoma and the mandible. Ann Otol Rhinol Laryngol. 1995;104:977–9.PubMed

33.

Weisman RA, Kimmelman CP. Bone scanning in the assessment of mandibular invasion by oral cavity carcinoma. Laryngoscope. 1982;92:1–4.PubMedCrossRef

34.

Forest LA, Shuller DE, Lucas JG, Sullivan MI. Rapid analysis of mandibular margins. Laryngoscope. 1995;105:475–7.CrossRef

35.

Dubner S, Heller KS. Local control of squamous cell carcinoma following marginal segmented mandibulectomy. Head Neck. 1993;15:29–32.PubMedCrossRef

36.

Beaumont DG, Hains JD. Changes in surgical margins in vivo following resection and after fixation. Aust J Otolaryngol. 1992;1:51–2.

37.

Johnson RE, Sigman JD, Funk GF, Robinson RA, Hoffman HT. Quantification of surgical margin shrinkage in the oral cavity. Head Neck. 1997;19:281–6.PubMedCrossRef

38.

Sondenaa K, Kjellvold KH. A prospective study of the length of the distal margin after low anterior resection for rectal cancer. Int J Colorectal Dis. 1990;5:103–5.PubMedCrossRef

39.

Goldstein NS, Soman A, Sacksner J. Disparate surgical margin lengths of colorectal resection specimens between in vivo and in vitro measurements. The effects of surgical resection and formalin fixation on organ shrinkage. Am J Clin Pathol. 1999;111:349–51.PubMed

40.

Gardner ES, Sumner WT, Cook JL. Predictable tissue shrinkage during frozen section histopathologic processing for Mohs micrographic surgery. Dermatologic Surg. 2001;27:813–8.CrossRef

41.

Silverman MK. Golomb FM, Kopf AW, et al. Verification of a formula for determination of preexcision surgical margins from fixed-tissue melanoma specimens. J Am Acad Dermatol. 2002;27:214–9.

42.

Fajardo LF. Radiation injury. In: Barnes L, editors. Surgical pathology of the head and neck. Second edition, revised and expanded. Marcel Dekker, Inc.: New York; 2001. p. 2171–90.

43.

Matsusaka S, Nagareda T, Yamasaki H, et al. Immunohistochemical evaluation for intraoperative rapid pathological assessment of the gastric margin. World J Surg. 2003;27:715–8.PubMedCrossRef

44.

Brennan JA, Mao L, Hruban RH, et al. Molecular assessment of histopathological staging in squamous-cell carcinoma of the head and neck. N Engl J Med. 1995;332:429–35.PubMedCrossRef

45.

Ball VA, Righi PD, Tejada E, et al. P53 immunostaining of surgical margins as a predictor of local recurrence in squamous cell carcinoma of the oral cavity and oropharynx. Ear Nose Throat J. 1997;76:818–23.PubMed

46.

Franklin S, Pho T, Abreo FW, et al. Detection of the protoncogene eIF4E in larynx and hypopharynx cancers. Arch Otolaryngol Head Neck Surg. 1999;125:177–82.PubMed

47.

Ord RA, Aisner S. Accuracy of frozen sections in assessing margins in oral cancer resection. J Oral Maxillofac Surg. 1997;55:663–9.PubMedCrossRef

48.

Remsen KA, Lucente FE, Biller HF. Reliability of frozen section diagnosis in head and neck neoplasms. Laryngoscope. 1984;94:519–24.PubMedCrossRef

49.

Gnepp DR. Frozen sections. In: Gnepp DR, editor. Pathology of the head and neck. New York: Churchill Livingstone; 1988. p. 1–24.

50.

Rassekh CH, Johnson JT, Myers EN. Accuracy of intraoperative staging of the N0 neck in squamous cell carcinoma. Laryngoscope. 1995;105:1334–6.PubMedCrossRef

51.

Manni JJ, van den Hoogen FJA. Supraomohyoid neck dissection with frozen section biopsy as a staging procedure in the clinically node-negative neck in carcinoma of the oral cavity. Am J Surg. 1991;162:373–6.PubMedCrossRef

52.

Shoaib T, Soutar DS, MacDonald DG, et al. The accuracy of head and neck carcinoma sentinel lymph node biopsy in the clinically N0 neck. Cancer 2001;91:2077–83.PubMedCrossRef

53.

Pitman KT, Johnson JT, Brown ML, Myers EN. Sentinel lymph node biopsy in head and neck squamous cell carcinoma. Laryngoscope. 2002;112:2101–13.PubMedCrossRef

54.

Ross GL, Soutar DS, Shoaib T, et al. The ability of lymphoscintigraphy to direct sentinel node biopsy in the clinically N0 neck for patients with head and neck squamous cell carcinoma. Br J Radiol. 2002;75:950–8.PubMed

55.

Asthana S, Deo SV, Shukla NK, et al. Intraoperative neck staging using sentinel node biopsy and imprint cytology in oral cancer. Head Neck. 2003;25:368–72.PubMedCrossRef

56.

Civantos FJ, Gomez C, Duque C, et al. Sentinel node biopsy in oral cavity cancer correlation with PET scan and immunohistochemistry. Head Neck. 2003;25:1–9.PubMedCrossRef

57.

Loree TR. Sentinel lymph node biopsy for early stage clinical N0 squamous cell carcinoma of the oral cavity. Ann Surg Oncol. 2004;11:725–6.PubMedCrossRef

Titel: Intraoperative Consultation (IOC) in Mucosal Lesions of the Upper Aerodigestive Tract
verfasst von: Bruce M. Wenig
Publikationsdatum: 01.06.2008
Verlag: Humana Press Inc
Erschienen in: Head and Neck Pathology / Ausgabe 2/2008
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-008-0053-6

Neu im Fachgebiet Pathologie

Open Access 15.04.2024 | Biomarker | Schwerpunkt: Next Generation Pathology

Springer Medizin

Intraoperative Consultation (IOC) in Mucosal Lesions of the Upper Aerodigestive Tract

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2008

Molecular Diagnosis in Head and Neck: What a Surgical Pathologist Must Know

Juvenile Hemangioma of the Parotid Gland

Langerhans Cell Histiocytosis of the Temporal Bone

Angiocentric Lesions of the Head and Neck

Sinonasal Renal Cell-like Adenocarcinoma: A Report on Four Patients

The Role of the Human Papillomavirus in the Pathogenesis of Schneiderian Inverted Papillomas: An Analytic Overview of the Evidence

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie