nach oben

Head and Neck Pathology

Erschienen in:

01.06.2012 | Original Paper

Metastatic Papillary Thyroid Carcinoma to the Maxilla: Case Report and Literature Review

verfasst von: Nikolaos G. Nikitakis, Angeliki Polymeri, Antonis Polymeris, Alexandra Sklavounou

Erschienen in: Head and Neck Pathology | Ausgabe 2/2012

Einloggen, um Zugang zu erhalten

Abstract

Metastatic tumors to the oral cavity are uncommon and a thyroid origin is considered exceedingly rare. A case of metastatic papillary thyroid carcinoma (PTC) presenting as a painful swelling in the right posterior maxilla of a 63-year-old male is reported here. The patient had been diagnosed with PTC 2 years ago and treated with thyroidectomy and radioactive iodine treatment. Radiographically, the metastatic lesion presented as a poorly-defined radiolucent lesion around an impacted maxillary third molar in the right maxilla. Histopathologic examination revealed features of PTC which was immunohistochemically positive for pancytokeratin, keratin 19 and thyroglobulin. Imaging studies revealed the presence of residual maxillary and neck disease as well as additional metastatic lesions in the sternum, ribs, and left tibia. A thorough review of the English language literature revealed only 36 previously published cases of thyroid cancer metastases to the oral cavity, the demographic and clinicopathologic features of which are summarized.

Hodak SP, Burman KD. Thyroid carcinoma. Metastases to bone. In: Wartofsky L, Van Nostrand D, editors. Thyroid cancer A. Comprehensive guide to clinical management. 2nd ed. Totowa: Humana Press Inc; 2006. p. 497.

DeGroot LJ, Sridama V. Thyroid neoplasia. In: DeGroot LJ, editor. Endocrinology. 2nd ed. Philadelphia: W.B. Saunders Company; 1989. p. 766–7.

Wood WJ, Singletary SE, Hickey RC. Current results of treatment for distant metastatic well-differentiated thyroid carcinoma. Arch Surg. 1989;124:1374–7.PubMedCrossRef

Larsen PR, Davies TF, Hay DI. The thyroid gland. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR, editors. Williams textbook of endocrinology. 9th ed. Philadelphia: W.B. Saunders Company; 1998. p. 487.

Grebe SK, Hay ID. Follicular thyroid cancer. Endocrinol Metab Clin North Am. 1995;24:761–801.PubMed

Pittas AG, Adler M, Fazzari M, et al. Bone metastases from thyroid carcinoma: clinical characteristics and prognostic variables in one hundred forty-six patients. Thyroid. 2000;10:261–8.PubMedCrossRef

Meyer I, Shklar G. Malignant tumors metastatic to mouth and jaws. Oral Surg Oral Med Oral Pathol. 1965;20:350–62.PubMedCrossRef

Zachariades N, Koumoura F, Vairaktaris E, et al. Metastatic tumors to the jaws: a report of seven cases. J Oral Maxillofac Surg. 1989;47:991–6.PubMedCrossRef

Vural E, Hanna E. Metastatic follicular thyroid carcinoma to the mandible: a case report and review of the literature. Am J Otoralyngol. 1998;19:198–202.CrossRef

10.

Hirshberg A, Leibovich P, Buchner A. Metastatic tumors to the jawbones: analysis of 390 cases. J Oral Pathol Med. 1994;23:337–41.PubMedCrossRef

11.

D’Silva NJ, Summerlin DJ, Cordell KG, et al. Metastatic tumors in the jaws: a retrospective study of 114 cases. Am Dent Assoc. 2006;137:1667–72.

12.

van der Waal RI, Buter J, van der Waal I. Oral metastases: report of 24 cases. Br J Oral Maxillofac Surg. 2003;41:3–6.PubMedCrossRef

13.

Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, et al. Metastatic tumours to the oral cavity—pathogenesis and analysis of 673 cases. Oral Oncol. 2008;44:743–52.PubMedCrossRef

14.

Clausen F, Poulsen H. Metastatic carcinoma to the jaws. Acta Pathol Microbiol Immunol Scand. 1963;57:361–74.CrossRef

15.

Erdag T, Bilgen C, Ceryan K. Metastatic thyroid carcinoma of the mandibule. Rev Laryngol Otol Rhinol (Bord). 1999;120:31–4.

16.

McDaniel RK, Luna MA, Stimson PG. Metastatic tumors in the jaws. Oral Surg. 1971;31:380–6.PubMedCrossRef

17.

Al-Ani S. Metastatic tumors to the mouth: report of two cases. J Oral Surg. 1973;31:120–2.PubMed

18.

Ripp GA, Wendth AJ Jr, Vitale P. Metastatic thyroid carcinoma of the mandible mimicking an arteriovenous malformation. J Oral Surg. 1977;35:743–5.PubMed

19.

Draper BW, Precious DS, Priddy RW, et al. Clinicopathological conference. Case 29, part 2. Follicular thyroid carcinoma metastatic to the mandible. J Oral Surg. 1979;37:736–9.PubMed

20.

Stypulkowska J, Bartkowski S, Pana’s M, et al. Metastatic tumors to the jaws and oral cavity. Oral Surg. 1979;37:805–8.

21.

Osguthorpe JD, Bratton JR. Occult thyroid carcinoma appearing as a single mandibular metastasis. Otolaryngol Head Neck Surg. 1982;90:674–5.PubMed

22.

Nishimura Y, Nakajima T, Yakata H, et al. Metastatic thyroid carcinoma of the mandible. J Oral Maxillofac Surg. 1982;40:221–5.PubMedCrossRef

23.

Parichatikanond P, Parichatikanond P, Damrongvadha P, et al. Jaw metastasis from follicular carcinoma of thyroid gland simulating ameloblastoma. J Med Assoc Thai. 1984;67:362–7.PubMed

24.

Tovi F, Leiberman A, Hirsch M. Uncommon clinical manifestations in a case of thyroid carcinoma. Head Neck Surg. 1984;6:974–7.PubMedCrossRef

25.

Markitziu A, Fisher D, Marmary Y. Thyroid papillary carcinoma presenting as jaw and parotid gland metastases. Int J Oral Maxillofac Surg. 1986;15:648–53.PubMedCrossRef

26.

Kahn MA, McCord PT. Metastatic thyroid carcinoma of the mandible: case report. J Oral Maxillofac Surg. 1989;47:1314–6.PubMedCrossRef

27.

Whitaker B, Robinson K, Hewan-Lowe K, et al. Thyroid metastasis to the oral soft tissues: case report of a diagnostic dilemma. J Oral Maxillofac Surg. 1993;51:588–93.PubMedCrossRef

28.

Agarwal A, Mishra SK, Jain M. Follicular thyroid carcinoma with metastasis to the mandible. J Indian Med Assoc. 1998;96:354–5.PubMed

29.

Anil S, Lal PM, Gill DS, et al. Metastasis of thyroid carcinoma to the mandible. Case report Aust Dent J. 1999;44:56–7.CrossRef

30.

Piattelli A, Fioroni M, Rubini C. Gingival metastasis from a medullary thyroid carcinoma: case report. J Periodontol. 2000;71:112–6.PubMedCrossRef

31.

Colella G, Capone R, Cappabianca S. Mandibular metastasis from papillary thyroid carcinoma—a case report. Tumori. 2003;89:452–4.PubMed

32.

Ostrosky A, Mareso EA, Klurfan FJ, et al. Mandibular metastasis of follicular thyroid carcinoma. Case Report Med Oral. 2003;8:224–7.

33.

Bodner L, Sion-Vardy N, Geffen DB, et al. Metastatic tumors to the jaws: a report of eight new cases. Med Oral Patol Oral Cir Bucal. 2006;11:E132–5.PubMed

34.

Liu L, Venkataraman G, Salhadar A. Follicular variant of papillary thyroid carcinoma with unusual late metastasis to the mandible and the scapula. Pathol Int. 2007;57:296–8.PubMedCrossRef

35.

Tamiolakis D, Tsamis I, Thomaidis V, et al. Jaw bone metastases: four cases. Acta Dermatovenerol Alp Panonica Adriat. 2007;16:21–5.PubMed

36.

Kaveri H, Punnya VA, Tayaar AS. Metastatic thyroid carcinoma to the mandible. J Oral Maxillofac Pathol. 2007;11:32–4.CrossRef

37.

Antunes AA, Antunes AP. Gnathic bone metastasis: a retrospective study of 10 cases. Braz J Otorhinolaryngol. 2008;74:561–5.PubMed

38.

Ismail SB, Abraham MT, Zaini ZB, et al. Metastatic follicular thyroid carcinoma to the mandible: a case report. Cases J. 2009;2:6533.PubMedCrossRef

39.

Algahtani M, Alqudah M, Alshehri S, et al. Pathologic fracture of the mandible caused by metastatic follicular thyroid carcinoma. J Can Dent Assoc. 2009;75:457–60.PubMed

40.

Nishikawa H, Nakashiro K, Sumida T, et al. Mandibular osteoblastic metastasis of poorly differentiated carcinoma of the thyroid gland. Int J Oral Maxillofac Surg. 2010;39:301–4.PubMedCrossRef

41.

Kumar RV, Chakravarthy C, Sekhar GR, et al. Metastatic thyroid carcinoma presenting as hypervascular lesion of the mandible: a case report and review of literature. J Oral Maxillofac Surg. 2010;68:2613–6.PubMedCrossRef

42.

Daley T, Darling MR. Metastases to the mouth and jaws: a contemporary Canadian experience. J Can Dent Assoc. 2011;77:b67.PubMed

43.

Marcocci C, Pacini F, Elisei R, et al. Clinical and biologic behavior of bone metastases from differentiated thyroid carcinoma. Surgery. 1989;106:960–6.PubMed

44.

Schlumberger M, Tubiana M, De Vathaire F, et al. Long-term results of treatment of 283 patients with lung and bone metastases from differentiated thyroid carcinoma. J Clin Endocrinol Metab. 1986;63:960–7.PubMedCrossRef

Titel: Metastatic Papillary Thyroid Carcinoma to the Maxilla: Case Report and Literature Review
verfasst von: Nikolaos G. Nikitakis
Angeliki Polymeri
Antonis Polymeris
Alexandra Sklavounou
Publikationsdatum: 01.06.2012
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 2/2012
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-011-0323-6

Neu im Fachgebiet Pathologie

01.04.2024 | Forensische Traumatologie | CME

Springer Medizin

Metastatic Papillary Thyroid Carcinoma to the Maxilla: Case Report and Literature Review

Abstract

Neu im Fachgebiet Pathologie

Theoretische Grundlagen von Explosionen und Explosionsverletzungen

Auswirkungen vorgeschalteter Laborprozesse auf die Digitalisierung histologischer Schnittpräparate

Knochenmarkhistologie bei Zytopenien

Herausforderungen der Automation bei der quantitativen Auswertung von Leberbiopsien

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2012

Sinonasal Myospherulosis and Paraffin Retention Cysts Suggested by CT: Report of a Case

Angiosarcoma Arising from the Tongue of an 11-Year-Old Girl with Xeroderma Pigmentosum

Prognostic Significance of Regulators of Cell Cycle and Apoptosis, p16INK4a, p53, and bcl-2 in Primary Mucosal Melanomas of the Head and Neck

Epithelial Salivary Gland Tumors in Two Distant Geographical Locations, Finland (Helsinki and Oulu) and Israel (Tel Aviv): A 10-Year Retrospective Comparative Study of 2,218 Cases

External Auditory Osteoma

Lip Ulceration Associated with Intravenous Administration of Zoledronic Acid: Report of a Case

Neu im Fachgebiet Pathologie

Theoretische Grundlagen von Explosionen und Explosionsverletzungen

Auswirkungen vorgeschalteter Laborprozesse auf die Digitalisierung histologischer Schnittpräparate

Knochenmarkhistologie bei Zytopenien

Herausforderungen der Automation bei der quantitativen Auswertung von Leberbiopsien