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01.06.2012 | Original Paper

Cytoplasmic Ezrin and Moesin Correlate with Poor Survival in Head and Neck Squamous Cell Carcinoma

verfasst von: Nicolas F. Schlecht, Margaret Brandwein-Gensler, Richard V. Smith, Nicole Kawachi, Darcy Broughel, Juan Lin, Christian E. Keller, Paul A. Reynolds, Frank J. Gunn-Moore, Thomas Harris, Geoffrey Childs, Thomas J. Belbin, Michael B. Prystowsky

Erschienen in: Head and Neck Pathology | Ausgabe 2/2012

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Abstract

Members of the 4.1 superfamily of proteins, including ezrin, moesin, merlin, and willin regulate many normal physiologic processes such as cellular shape, motility, and proliferation. In addition, they contribute both to tumor development and tumor progression. We reported previously that strong cytoplasmic ezrin expression was independently associated with poorer patient survival. One hundred and thirty-one histologically confirmed primary head and neck squamous cell carcinomas were examined prospectively for cancer progression and survival at a large health care center in the Bronx, NY, USA. Immunohistochemical analysis of ezrin, moesin, merlin, and willin expression in tissue microarray samples of primary head and neck squamous cell carcinoma revealed a significant association of increased cytoplasmic ezrin with poor cancer survival. Global RNA analyses suggest that cancers with high cytoplasmic ezrin have a more invasive phenotype. This study supports our previous findings associating cytoplasmic ezrin with more aggressive behavior and poorer outcome and indicates the need for a multi-institutional study to validate the use of cytoplasmic ezrin as a biomarker for treatment planning in head and neck squamous cell carcinoma.

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Titel: Cytoplasmic Ezrin and Moesin Correlate with Poor Survival in Head and Neck Squamous Cell Carcinoma
verfasst von: Nicolas F. Schlecht
Margaret Brandwein-Gensler
Richard V. Smith
Nicole Kawachi
Darcy Broughel
Juan Lin
Christian E. Keller
Paul A. Reynolds
Frank J. Gunn-Moore
Thomas Harris
Geoffrey Childs
Thomas J. Belbin
Michael B. Prystowsky
Publikationsdatum: 01.06.2012
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 2/2012
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-011-0328-1

Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Springer Medizin

Cytoplasmic Ezrin and Moesin Correlate with Poor Survival in Head and Neck Squamous Cell Carcinoma

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Springer Medizin

Abstract

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