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Head and Neck Pathology

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01.07.2012 | Invited Review

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

verfasst von: Tatyana Isayeva, Yufeng Li, Daniel Maswahu, Margaret Brandwein-Gensler

Erschienen in: Head and Neck Pathology | Sonderheft 1/2012

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Abstract

Perhaps one of the most important developments in head and neck oncology of the past decade is the demonstration that patients with human papillomavirus (HPV)-mediated oropharyngeal cancers have significantly improved outcomes, compared to HPV-negative counterpart patients. This has become the basis for clinical trials investigating the impact on “treatment deintensification” for patients with HPV-mediated oropharyngeal cancers. Unfortunately, the significance of HPV in non-oropharyngeal head and neck cancers is much less certain. Our goal is to systematically review the published data regarding the role HPV in carcinomas of the oral cavity, larynx, sinonasal tract and nasopharynx with respect to HPV detection frequency, viral activity, and association with outcome. We also present preliminary data on HPV16/18 transcriptional status in oral cavity carcinomas, as well as salivary gland neoplasia, as determined by nested reverse transcription PCR for HPV E6/E7 RNA. The weighted prevalence (WP) of HPV DNA detection in 4,195 oral cavity cancer patients is 20.2 %, (95 % CI 16.0 %, 25.2 %). HPV16 is the most common type detected. Importantly, no data currently demonstrates a significant association between the presence of HPV DNA and improved outcome. The WP of HPV DNA in 1,712 laryngeal cancer patients is 23.6 %, (95 % CI 18.7 %, 29.3 %). Similarly, no association has yet been demonstrated between HPV DNA status and outcome. The WP of HPV DNA detection in 120 sinonasal cancer patients is 29.6 % (95 % CI 17.8 %, 44.9 %), and in 154 nasopharyngeal carcinoma patients is 31.1 %, (95 % CI 20.3 %, 44.5 %). Recent preliminary data also suggests an association between HPV and certain salivary gland neoplasms. The clinical significance of these findings is unclear. The published data strongly support the need for studies on patients with oral and laryngeal carcinomas that will be powered to find any differences in clinical outcome with respect to HR-HPV and p16 overexpression.

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Titel: Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review
verfasst von: Tatyana Isayeva
Yufeng Li
Daniel Maswahu
Margaret Brandwein-Gensler
Publikationsdatum: 01.07.2012
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe Sonderheft 1/2012
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-012-0368-1

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Open Access 15.04.2024 | Biomarker | Schwerpunkt: Next Generation Pathology

Springer Medizin

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Abstract

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Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

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Springer Medizin

Abstract

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Weitere Artikel der Sonderheft 1/2012

Morphologic Features of Conventional Squamous Cell Carcinoma of the Oropharynx: ‘Keratinizing’ and ‘Nonkeratinizing’ Histologic Types as the Basis for a Consistent Classification System

Radiographic Imaging of Human Papillomavirus Related Carcinomas of the Oropharynx

Epidemiology and Clinical Aspects of HPV in Head and Neck Cancers

HPV Specific Testing: A Requirement for Oropharyngeal Squamous Cell Carcinoma Patients

Biology of Human Papillomavirus Infections in Head and Neck Carcinogenesis

HPV Detection Methods in Head and Neck Cancer

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie