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Head and Neck Pathology
Erschienen in: Head and Neck Pathology 3/2015

01.09.2015 | Review Paper

Functional Histology of Salivary Gland Pleomorphic Adenoma: An Appraisal

verfasst von: Asterios Triantafyllou, Lester D. R. Thompson, Kenneth O. Devaney, Diana Bell, Jennifer L. Hunt, Alessandra Rinaldo, Vincent Vander Poorten, Alfio Ferlito

Erschienen in: Head and Neck Pathology | Ausgabe 3/2015

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Abstract

The complex microstructure of salivary gland pleomorphic adenoma is examined in relation to function. Events related to secretion of macromolecules and absorption, responses to the altered microenvironment and controversies concerning epithelial–mesenchymal transition versus modified myoepithelial differentiation are explored. Their effects on tumor cell phenotypes and arrangements are emphasized. Heterotopic differentiation and attempts at organogenesis are also considered. The approach allows interpreting microstructure independently of histogenetic perceptions, envisaging the tumor cells as a continuum, endorsing luminal structures as the principal components, and defining pleomorphic adenoma as a benign epithelial tumour characterized by variable epithelial–mesenchymal transition, secretion/differentiation and metaplasia.
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Metadaten
Titel
Functional Histology of Salivary Gland Pleomorphic Adenoma: An Appraisal
verfasst von
Asterios Triantafyllou
Lester D. R. Thompson
Kenneth O. Devaney
Diana Bell
Jennifer L. Hunt
Alessandra Rinaldo
Vincent Vander Poorten
Alfio Ferlito
Publikationsdatum
01.09.2015
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 3/2015
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-014-0581-1

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