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Erschienen in: Der Kardiologe 4/2013

01.08.2013 | Leitlinien

Kommentar zu den neuen Leitlinien (2012) der Europäischen Gesellschaft für Kardiologie zur kardiovaskulären Prävention

verfasst von: Prof. Dr. G.C. Schuler, W. Koenig, V. Adams, H. Gohlke

Erschienen in: Die Kardiologie | Ausgabe 4/2013

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Zusammenfassung

Die neuen europäischen Leitlinien für die Prävention kardiovaskulärer (CV) Erkrankungen werden von 9 medizinischen Fachgesellschaften getragen. Sie sind neu strukturiert, kürzer gefasst und besser lesbar: Kernaussagen werden jedem Unterkapitel vorangestellt, Empfehlungen werden mit ihrem Evidenzgrad aufgeführt. Am Ende eines jeden Unterkapitels werden die neuesten Informationen benannt und ebenfalls Bereiche mit unzureichender Studienlage für weiteren Forschungsbedarf aufgeführt. Eine der wichtigsten Neuerungen ist sicherlich die Unterteilung des 10-jährigen Risikos für kardiovaskulären Tod in 4 Risikogruppen: geringes (<1%), mittleres (1% bis <5%), hohes (5% bis <10%) und sehr hohes Risiko (10% und mehr). Alle Patienten mit CV-Erkrankung werden der höchsten Risikogruppe zugeordnet mit entsprechenden Konsequenzen z. B. für den Lipidzielwert: LDL-Cholesterin von <70 mg/dl (1,8 mmol/l). Eine Therapieadhärenz und Verhaltensänderung können am ehesten mit motivierenden Gesprächen erreicht werden, die Zeit beanspruchen; auf die ärztliche Verantwortung, klare Empfehlungen im Entlassungsbrief nach Krankenhausaufenthalt zu formulieren und Hilfen bei der Umsetzung anzubieten, wird besonders eingegangen.
Literatur
1.
Zurück zum Zitat Graham I, Atar D, Borch-Johnsen K et al (2007) European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Eur Heart J 28:2375–2414PubMedCrossRef Graham I, Atar D, Borch-Johnsen K et al (2007) European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Eur Heart J 28:2375–2414PubMedCrossRef
2.
Zurück zum Zitat Graham I, Atar D, Borch-Johnsen K et al (2007) Fourth Joint Task Force of the European Society of Cardiology and other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur J Cardiovasc Prev Rehabil 14:S1–S113PubMedCrossRef Graham I, Atar D, Borch-Johnsen K et al (2007) Fourth Joint Task Force of the European Society of Cardiology and other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur J Cardiovasc Prev Rehabil 14:S1–S113PubMedCrossRef
3.
Zurück zum Zitat Perk J, De Backer G, Gohlke H et al (2012) European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur Heart J 33:1635–1701PubMedCrossRef Perk J, De Backer G, Gohlke H et al (2012) European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur Heart J 33:1635–1701PubMedCrossRef
4.
Zurück zum Zitat Perk J, De Backer G, Gohlke H et al (2012) European guidelines on cardiovascular disease prevention in clinical practice (version 2012): the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur J Prev Cardiol 19:585–667CrossRef Perk J, De Backer G, Gohlke H et al (2012) European guidelines on cardiovascular disease prevention in clinical practice (version 2012): the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur J Prev Cardiol 19:585–667CrossRef
5.
Zurück zum Zitat Perk J, De Backer G, Gohlke H et al (2012) European guidelines on cardiovascular disease prevention in clinical practice (version 2012): the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Atherosclerosis 223:1–68PubMedCrossRef Perk J, De Backer G, Gohlke H et al (2012) European guidelines on cardiovascular disease prevention in clinical practice (version 2012): the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Atherosclerosis 223:1–68PubMedCrossRef
6.
Zurück zum Zitat Perk J, Backer G, Gohlke H et al (2012) European guidelines on cardiovascular disease prevention in clinical practice (version 2012): the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice. Int J Behav Med (Epub ahead of print) Perk J, Backer G, Gohlke H et al (2012) European guidelines on cardiovascular disease prevention in clinical practice (version 2012): the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice. Int J Behav Med (Epub ahead of print)
7.
Zurück zum Zitat Guyatt GH, Oxman AD, Vist GE et al (2008) GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336:924–926PubMedCrossRef Guyatt GH, Oxman AD, Vist GE et al (2008) GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336:924–926PubMedCrossRef
8.
Zurück zum Zitat Mente A, Koning L de, Shannon HS et al (2009) A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch intern med 169:659–669PubMedCrossRef Mente A, Koning L de, Shannon HS et al (2009) A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch intern med 169:659–669PubMedCrossRef
9.
Zurück zum Zitat Howard BV, Van Horn L, Hsia J et al (2006) Low-fat dietary pattern and risk of cardiovascular disease: the women’s health initiative randomized controlled dietary modification trial. JAMA 295:655–666PubMedCrossRef Howard BV, Van Horn L, Hsia J et al (2006) Low-fat dietary pattern and risk of cardiovascular disease: the women’s health initiative randomized controlled dietary modification trial. JAMA 295:655–666PubMedCrossRef
10.
Zurück zum Zitat Berrington de Gonzalez A, Hartge P, Cerhan JR et al (2010) Body-mass index and mortality among 1.46 million white adults. N Engl J Med 363:2211–2219CrossRef Berrington de Gonzalez A, Hartge P, Cerhan JR et al (2010) Body-mass index and mortality among 1.46 million white adults. N Engl J Med 363:2211–2219CrossRef
11.
Zurück zum Zitat Pischon T, Boeing H, Hoffmann K et al (2008) General and abdominal adiposity and risk of death in Europe. New N Engl J Med 359:2105–2120CrossRef Pischon T, Boeing H, Hoffmann K et al (2008) General and abdominal adiposity and risk of death in Europe. New N Engl J Med 359:2105–2120CrossRef
12.
Zurück zum Zitat Astrup A, Dyerberg J, Elwood P et al (2011) The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010? Am J Clin Nutr 93:684–688PubMedCrossRef Astrup A, Dyerberg J, Elwood P et al (2011) The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010? Am J Clin Nutr 93:684–688PubMedCrossRef
13.
Zurück zum Zitat Singer MV, Teyssen S (2001) Alkoholassozierte Organschäden. Dtsch Ärtzebl 98:A2109–A2120 Singer MV, Teyssen S (2001) Alkoholassozierte Organschäden. Dtsch Ärtzebl 98:A2109–A2120
14.
Zurück zum Zitat Bibbins-Domingo K, Chertow GM, Coxson PG et al (2010) Projected effect of dietary salt reductions on future cardiovascular disease. N Engl J Med 362:590–599PubMedCrossRef Bibbins-Domingo K, Chertow GM, Coxson PG et al (2010) Projected effect of dietary salt reductions on future cardiovascular disease. N Engl J Med 362:590–599PubMedCrossRef
15.
Zurück zum Zitat Mozaffarian D, Rimm EB (2006) Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA 296:1885–1899PubMedCrossRef Mozaffarian D, Rimm EB (2006) Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA 296:1885–1899PubMedCrossRef
16.
Zurück zum Zitat Estruch R, Ros E, Salas-Salvado J et al (2013) Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med (in press) Estruch R, Ros E, Salas-Salvado J et al (2013) Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med (in press)
18.
Zurück zum Zitat World Health Organization (1998) Obesity: preventing and managing the global epidemic. Report of a WHO Consultation World Health Organization (1998) Obesity: preventing and managing the global epidemic. Report of a WHO Consultation
19.
Zurück zum Zitat Whitlock G, Lewington S, Sherliker P et al (2009) Body-mass index and cause-specific mortality in 900.000 adults: collaborative analyses of 57 prospective studies. Lancet 373:1083–1096PubMedCrossRef Whitlock G, Lewington S, Sherliker P et al (2009) Body-mass index and cause-specific mortality in 900.000 adults: collaborative analyses of 57 prospective studies. Lancet 373:1083–1096PubMedCrossRef
20.
Zurück zum Zitat Zheng W, McLerran DF, Rolland B et al (2011) Association between body-mass index and risk of death in more than 1 million Asians. N Engl J Med 364:719–729PubMedCrossRef Zheng W, McLerran DF, Rolland B et al (2011) Association between body-mass index and risk of death in more than 1 million Asians. N Engl J Med 364:719–729PubMedCrossRef
21.
Zurück zum Zitat Drew BS, Dixon AF, Dixon JB (2007) Obesity management: update on orlistat. Vasc Health Risk Manag 3:817–821PubMed Drew BS, Dixon AF, Dixon JB (2007) Obesity management: update on orlistat. Vasc Health Risk Manag 3:817–821PubMed
22.
Zurück zum Zitat Poirier P, Cornier MA, Mazzone T et al (2011) Bariatric surgery and cardiovascular risk factors. Circulation 123:1683–1701PubMedCrossRef Poirier P, Cornier MA, Mazzone T et al (2011) Bariatric surgery and cardiovascular risk factors. Circulation 123:1683–1701PubMedCrossRef
23.
Zurück zum Zitat Vanhees L, McGee H, Dugmore D et al (2002) A representative study of cardiac rehabilitation activities in European Union Member States: the Carinex survey. J Cardiopulm Rehabil 22:264–272PubMedCrossRef Vanhees L, McGee H, Dugmore D et al (2002) A representative study of cardiac rehabilitation activities in European Union Member States: the Carinex survey. J Cardiopulm Rehabil 22:264–272PubMedCrossRef
24.
Zurück zum Zitat Wen CP, Wai JPM, Tsai MK et al (2011) Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. Lancet 378:1244–1253PubMedCrossRef Wen CP, Wai JPM, Tsai MK et al (2011) Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. Lancet 378:1244–1253PubMedCrossRef
25.
Zurück zum Zitat Heran BS, Chen JM, Ebrahim S et al (2011) Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev 6:CD001800 Heran BS, Chen JM, Ebrahim S et al (2011) Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev 6:CD001800
26.
Zurück zum Zitat Franklin BA (2005) Cardiovascular events associated with exercise. The risk-protection paradox. J Cardiopulm Rehabil 25:189–195PubMedCrossRef Franklin BA (2005) Cardiovascular events associated with exercise. The risk-protection paradox. J Cardiopulm Rehabil 25:189–195PubMedCrossRef
27.
Zurück zum Zitat Piepoli MF, Davos C, Francis DP et al (2004) Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH). BMJ 328:189–192PubMedCrossRef Piepoli MF, Davos C, Francis DP et al (2004) Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH). BMJ 328:189–192PubMedCrossRef
28.
Zurück zum Zitat O’Connor CM, Whellan DJ, Lee KL et al (2009) Efficacy and safety of exercise training in patients with chronic heart failure: HF-action randomized controlled trial. JAMA 301:1439–1450CrossRef O’Connor CM, Whellan DJ, Lee KL et al (2009) Efficacy and safety of exercise training in patients with chronic heart failure: HF-action randomized controlled trial. JAMA 301:1439–1450CrossRef
29.
Zurück zum Zitat Gielen S, Schuler G, Adams V (2010) Cardiovascular effects of exercise training: molecular mechanisms. Circulation 122:1221–1238PubMedCrossRef Gielen S, Schuler G, Adams V (2010) Cardiovascular effects of exercise training: molecular mechanisms. Circulation 122:1221–1238PubMedCrossRef
30.
Zurück zum Zitat Raupach T, Gohlke H (2012) Epidemiologie und Bedeutung tabakassoziierter kardiovaskulärer Erkrankungen. Pneumologe 9:185–190CrossRef Raupach T, Gohlke H (2012) Epidemiologie und Bedeutung tabakassoziierter kardiovaskulärer Erkrankungen. Pneumologe 9:185–190CrossRef
31.
Zurück zum Zitat John U, Hanke M (2002) Tobacco smoking- and alcohol drinking-attributable cancer mortality in Germany. Eur J Cancer Prev 11:11–17PubMedCrossRef John U, Hanke M (2002) Tobacco smoking- and alcohol drinking-attributable cancer mortality in Germany. Eur J Cancer Prev 11:11–17PubMedCrossRef
32.
Zurück zum Zitat Prescott E, Hippe M, Schnohr P et al (1998) Smoking and risk of myocardial infarction in women and men: longitudinal population study. BMJ 316:1043–1047PubMedCrossRef Prescott E, Hippe M, Schnohr P et al (1998) Smoking and risk of myocardial infarction in women and men: longitudinal population study. BMJ 316:1043–1047PubMedCrossRef
33.
Zurück zum Zitat Rusanen M, Kivipelto M, Quesenberry CP et al (2011) Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia. Arch intern med 171:333–339PubMedCrossRef Rusanen M, Kivipelto M, Quesenberry CP et al (2011) Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia. Arch intern med 171:333–339PubMedCrossRef
34.
Zurück zum Zitat Tan CE, Glantz SA (2012) Association between smoke-free legislation and hospitalizations for cardiac, cerebrovascular, and respiratory diseases/clinical perspective. Circulation 126:2177–2183PubMedCrossRef Tan CE, Glantz SA (2012) Association between smoke-free legislation and hospitalizations for cardiac, cerebrovascular, and respiratory diseases/clinical perspective. Circulation 126:2177–2183PubMedCrossRef
35.
Zurück zum Zitat Sargent JD, Demidenko E, Malenka DJ et al (2012) Smoking restrictions and hospitalization for acute coronary events in Germany. Clin Res Cardiol 101:227–235PubMedCrossRef Sargent JD, Demidenko E, Malenka DJ et al (2012) Smoking restrictions and hospitalization for acute coronary events in Germany. Clin Res Cardiol 101:227–235PubMedCrossRef
36.
Zurück zum Zitat Breitling LP, Rothenbacher D, Vossen CY et al (2011) Validated smoking cessation and prognosis in patients with stable coronary heart disease. J Am Coll Cardiol 58:196–197PubMedCrossRef Breitling LP, Rothenbacher D, Vossen CY et al (2011) Validated smoking cessation and prognosis in patients with stable coronary heart disease. J Am Coll Cardiol 58:196–197PubMedCrossRef
37.
Zurück zum Zitat Batra A (2011) Therapie der Tabakabhängigkeit. Dtsch Ärtzebl Int 108:555–564 Batra A (2011) Therapie der Tabakabhängigkeit. Dtsch Ärtzebl Int 108:555–564
38.
Zurück zum Zitat Heatherton TF, Kozlowski LT, Frecker RC et al (1991) The Fagerström test for nicotine dependence: a revision of the Fagerström tolerance questionnaire. Br J Addict 86:1119–1127PubMedCrossRef Heatherton TF, Kozlowski LT, Frecker RC et al (1991) The Fagerström test for nicotine dependence: a revision of the Fagerström tolerance questionnaire. Br J Addict 86:1119–1127PubMedCrossRef
39.
Zurück zum Zitat Tonne C, Schwartz J, Mittleman M et al (2005) Long-term survival after acute myocardial infarction is lower in more deprived neighborhoods. Circulation 111:3063–3070PubMedCrossRef Tonne C, Schwartz J, Mittleman M et al (2005) Long-term survival after acute myocardial infarction is lower in more deprived neighborhoods. Circulation 111:3063–3070PubMedCrossRef
40.
Zurück zum Zitat Albert MA, Glynn RJ, Buring J et al (2006) Impact of traditional and novel risk factors on the relationship between socioeconomic status and incident cardiovascular events. Circulation 114:2619–2626PubMedCrossRef Albert MA, Glynn RJ, Buring J et al (2006) Impact of traditional and novel risk factors on the relationship between socioeconomic status and incident cardiovascular events. Circulation 114:2619–2626PubMedCrossRef
41.
Zurück zum Zitat Nicholson A, Kuper H, Hemingway H (2006) Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146GÇà538 participants in 54 observational studies. Eur Heart J 27:2763–2774PubMedCrossRef Nicholson A, Kuper H, Hemingway H (2006) Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146GÇà538 participants in 54 observational studies. Eur Heart J 27:2763–2774PubMedCrossRef
42.
Zurück zum Zitat Denollet J, Schiffer AA, Spek V (2010) A general propensity to psychological distress affects cardiovascular outcomes: evidence from research on the type D (distressed) personality profile. Circ Cardiovasc Qual Outcomes 3:546–557PubMedCrossRef Denollet J, Schiffer AA, Spek V (2010) A general propensity to psychological distress affects cardiovascular outcomes: evidence from research on the type D (distressed) personality profile. Circ Cardiovasc Qual Outcomes 3:546–557PubMedCrossRef
43.
Zurück zum Zitat Barter PJ, Caulfield M, Eriksson M et al (2007) Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med 357:2109–2122PubMedCrossRef Barter PJ, Caulfield M, Eriksson M et al (2007) Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med 357:2109–2122PubMedCrossRef
44.
Zurück zum Zitat Schwartz GG, Olsson AG, Abt M et al (2012) Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med 367:2089–2099PubMedCrossRef Schwartz GG, Olsson AG, Abt M et al (2012) Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med 367:2089–2099PubMedCrossRef
45.
Zurück zum Zitat AIM-HIGH Investigators, Boden WE, Probstfield JL et al (2011) Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med 365:2255–2267CrossRef AIM-HIGH Investigators, Boden WE, Probstfield JL et al (2011) Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med 365:2255–2267CrossRef
46.
Zurück zum Zitat Cholesterol Treatment Trialists‘ (CTT) Collaboration, Baigent C, Blackwell L et al (2010) Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 376:1670–1681CrossRef Cholesterol Treatment Trialists‘ (CTT) Collaboration, Baigent C, Blackwell L et al (2010) Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 376:1670–1681CrossRef
47.
Zurück zum Zitat Nicholls SJ, Ballantyne CM, Barter PJ et al (2011) Effect of two intensive statin regimens on progression of coronary disease. N Engl J Med 365:2078–2087PubMedCrossRef Nicholls SJ, Ballantyne CM, Barter PJ et al (2011) Effect of two intensive statin regimens on progression of coronary disease. N Engl J Med 365:2078–2087PubMedCrossRef
48.
Zurück zum Zitat Koenig W, Marx N, Thiery J et al (2012) Kommentar zu den neuen Leitlinien (2011) der Europäischen Gesellschaft für Kardiologie zum Management von Dyslipidämien. Kardiologe 6:210–216CrossRef Koenig W, Marx N, Thiery J et al (2012) Kommentar zu den neuen Leitlinien (2011) der Europäischen Gesellschaft für Kardiologie zum Management von Dyslipidämien. Kardiologe 6:210–216CrossRef
49.
Zurück zum Zitat Kamstrup PR, Tybjaerg-Hansen A, Steffensen R et al (2009) Genetically elevated lipoprotein(a) and increased risk of myocardial infarction. JAMA 301:2331–2339PubMedCrossRef Kamstrup PR, Tybjaerg-Hansen A, Steffensen R et al (2009) Genetically elevated lipoprotein(a) and increased risk of myocardial infarction. JAMA 301:2331–2339PubMedCrossRef
50.
Zurück zum Zitat Nordestgaard BG, Chapman MJ, Ray K et al (2010) Lipoprotein(a) as a cardiovascular risk factor: current status. Eur Heart J 31:2844–2853PubMedCrossRef Nordestgaard BG, Chapman MJ, Ray K et al (2010) Lipoprotein(a) as a cardiovascular risk factor: current status. Eur Heart J 31:2844–2853PubMedCrossRef
51.
Zurück zum Zitat Antithrombotic Trialists (ATT) Collaboration, Baigent C, Blackwell L et al (2009) Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 373:1849–1860CrossRef Antithrombotic Trialists (ATT) Collaboration, Baigent C, Blackwell L et al (2009) Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 373:1849–1860CrossRef
52.
Zurück zum Zitat Macchia A, Laffaye N, Comignani PD et al (2012) Statins but not aspirin reduce thrombotic risk assessed by thrombin generation in diabetic patients without cardiovascular events: the RATIONAL trial. PLoS One 7:e32894PubMedCrossRef Macchia A, Laffaye N, Comignani PD et al (2012) Statins but not aspirin reduce thrombotic risk assessed by thrombin generation in diabetic patients without cardiovascular events: the RATIONAL trial. PLoS One 7:e32894PubMedCrossRef
53.
Zurück zum Zitat Giorgia DB, Michele S, Giovanni FMS et al (2009) Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trials. BMJ 339:b4531CrossRef Giorgia DB, Michele S, Giovanni FMS et al (2009) Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trials. BMJ 339:b4531CrossRef
54.
Zurück zum Zitat Diener HC, Bogousslavsky J, Brass LM et al (2004) Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 364:331–337PubMedCrossRef Diener HC, Bogousslavsky J, Brass LM et al (2004) Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 364:331–337PubMedCrossRef
55.
Zurück zum Zitat Authors/Task force Members, Camm AJ, Lip GY et al (2012) 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation * Developed with the special contribution of the European Heart Rhythm Association. Eur Heart J 33:2719–2747CrossRef Authors/Task force Members, Camm AJ, Lip GY et al (2012) 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation * Developed with the special contribution of the European Heart Rhythm Association. Eur Heart J 33:2719–2747CrossRef
56.
Zurück zum Zitat Greenland P, Alpert JS, Beller GA et al (2010) 2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults: a Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the American Society of Echocardiography, American Society of Nuclear Cardiology, Society of Atherosclerosis Imaging and Prevention, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance. J Am Coll Cardiol 56:e50–e103PubMedCrossRef Greenland P, Alpert JS, Beller GA et al (2010) 2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults: a Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the American Society of Echocardiography, American Society of Nuclear Cardiology, Society of Atherosclerosis Imaging and Prevention, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance. J Am Coll Cardiol 56:e50–e103PubMedCrossRef
57.
Zurück zum Zitat Emerging Risk factors Collaboration, Kaptoge S, Di Angelantonio E et al (2012) C-Reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med 367:1310–1320CrossRef Emerging Risk factors Collaboration, Kaptoge S, Di Angelantonio E et al (2012) C-Reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med 367:1310–1320CrossRef
58.
Zurück zum Zitat Ridker PM, Danielson E, Fonseca FAH et al (2008) Rosuvastatin to prevent vascular events in men and women with elevated C-Reactive protein. N Engl J Med 359:2195–2207PubMedCrossRef Ridker PM, Danielson E, Fonseca FAH et al (2008) Rosuvastatin to prevent vascular events in men and women with elevated C-Reactive protein. N Engl J Med 359:2195–2207PubMedCrossRef
59.
Zurück zum Zitat Homocysteine Study Coolaboration (2002) Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 288:2015–2022CrossRef Homocysteine Study Coolaboration (2002) Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 288:2015–2022CrossRef
60.
Zurück zum Zitat Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group, Armitage JM, Bowman L et al (2010) Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. JAMA 303:2486–2494CrossRef Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group, Armitage JM, Bowman L et al (2010) Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. JAMA 303:2486–2494CrossRef
61.
62.
Metadaten
Titel
Kommentar zu den neuen Leitlinien (2012) der Europäischen Gesellschaft für Kardiologie zur kardiovaskulären Prävention
verfasst von
Prof. Dr. G.C. Schuler
W. Koenig
V. Adams
H. Gohlke
Publikationsdatum
01.08.2013
Verlag
Springer Berlin Heidelberg
Erschienen in
Die Kardiologie / Ausgabe 4/2013
Print ISSN: 2731-7129
Elektronische ISSN: 2731-7137
DOI
https://doi.org/10.1007/s12181-013-0507-2

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