Erschienen in:
01.06.2011 | Case Report
CD20-negative Epstein–Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia
verfasst von:
Hideki Muramatsu, Yoshiyuki Takahashi, Yoshie Shimoyama, Sayoko Doisaki, Nobuhiro Nishio, Yoshinori Ito, Asahito Hama, Akira Shimada, Hiroshi Yagasaki, Masafumi Ito, Seiji Kojima
Erschienen in:
International Journal of Hematology
|
Ausgabe 6/2011
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Abstract
Epstein–Barr virus-associated post-transplant lymphoproliferative disease (EBV-PTLD) is a life-threatening complication following allogeneic hematopoietic stem cell transplantation (HSCT). Monitoring of EBV DNA in high-risk patients with subsequent pre-emptive rituximab treatment is highly effective, and can prevent EBV-associated disease following HSCT. Here, we report a 10-year-old girl with aplastic anemia who developed CD20 negative EBV-PTLD after unrelated bone marrow transplantation that was refractory to rituximab treatment. Similar to other types of lymphoma, the absence of CD20 antigen is likely to be characteristic of rituximab-refractory EBV-PTLD.