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The Cerebellum
Erschienen in: The Cerebellum 2/2017

01.04.2017 | Consensus paper

Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia

verfasst von: Vikram G. Shakkottai, Amit Batla, Kailash Bhatia, William T Dauer, Christian Dresel, Martin Niethammer, David Eidelberg, Robert S. Raike, Yoland Smith, H. A. Jinnah, Ellen J. Hess, Sabine Meunier, Mark Hallett, Rachel Fremont, Kamran Khodakhah, Mark S. LeDoux, Traian Popa, Cécile Gallea, Stéphane Lehericy, Andreea C. Bostan, Peter L. Strick

Erschienen in: The Cerebellum | Ausgabe 2/2017

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Abstract

A role for the cerebellum in causing ataxia, a disorder characterized by uncoordinated movement, is widely accepted. Recent work has suggested that alterations in activity, connectivity, and structure of the cerebellum are also associated with dystonia, a neurological disorder characterized by abnormal and sustained muscle contractions often leading to abnormal maintained postures. In this manuscript, the authors discuss their views on how the cerebellum may play a role in dystonia. The following topics are discussed:
  • The relationships between neuronal/network dysfunctions and motor abnormalities in rodent models of dystonia.
  • Data about brain structure, cerebellar metabolism, cerebellar connections, and noninvasive cerebellar stimulation that support (or not) a role for the cerebellum in human dystonia.
  • Connections between the cerebellum and motor cortical and sub-cortical structures that could support a role for the cerebellum in dystonia.
Overall points of consensus include:
  • Neuronal dysfunction originating in the cerebellum can drive dystonic movements in rodent model systems.
  • Imaging and neurophysiological studies in humans suggest that the cerebellum plays a role in the pathophysiology of dystonia, but do not provide conclusive evidence that the cerebellum is the primary or sole neuroanatomical site of origin.
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Metadaten
Titel
Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia
verfasst von
Vikram G. Shakkottai
Amit Batla
Kailash Bhatia
William T Dauer
Christian Dresel
Martin Niethammer
David Eidelberg
Robert S. Raike
Yoland Smith
H. A. Jinnah
Ellen J. Hess
Sabine Meunier
Mark Hallett
Rachel Fremont
Kamran Khodakhah
Mark S. LeDoux
Traian Popa
Cécile Gallea
Stéphane Lehericy
Andreea C. Bostan
Peter L. Strick
Publikationsdatum
01.04.2017
Verlag
Springer US
Erschienen in
The Cerebellum / Ausgabe 2/2017
Print ISSN: 1473-4222
Elektronische ISSN: 1473-4230
DOI
https://doi.org/10.1007/s12311-016-0825-6

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