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Erschienen in: The Journal of Obstetrics and Gynecology of India 4/2011

01.08.2011 | Original Article

LEEP Verses Cryotherapy in CIN

verfasst von: Abha Singh, Bhavna Arthur, Vivek Agarwal

Erschienen in: The Journal of Obstetrics and Gynecology of India | Ausgabe 4/2011

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Abstract

Objective

To compare the effectiveness and safety profile of LEEP (Loop Electrosurgical Excision Procedure) verses cryotherapy in the treatment of CIN.

Material and Method

Women with abnormal pap smears were subjected to VIA and VILLI followed by colposcopy. A total of 200 cases were included in this prospective study. Once the diagnosis of CIN was confirmed on histopathology, the women were subjected to either cryotherapy or LEEP randomly. They were follow up at 1, 6 and 12 months. At 12 months follow up, cervix was subjected to VIA, VILLI and colposcopy. Chi square test was used to analyze the data.

Observations

The efficacy of cryotherapy was found to be 88% and that of LEEP was 94% which is not significantly different. The overall cure rate of symptoms was 82 and 79% in cryosurgery and LEEP group, respectively.

Conclusion

Although LEEP was associated with higher cure rates but the difference is not significant statistically. Either method if used appropriately gives good results in treatment of CIN lesions, however, LEEP seems to have an edge over cryotherapy when used on severe lesions.
Literatur
1.
Zurück zum Zitat Saraiya UB, Miniello G. Significance of human papilloma virus infection in cervical carcinogenesis. J Obstet Gynecol India. 2007;57:486–92. Saraiya UB, Miniello G. Significance of human papilloma virus infection in cervical carcinogenesis. J Obstet Gynecol India. 2007;57:486–92.
2.
Zurück zum Zitat Kerkar A, Rajendra A, Kulkarni YV. Screening for cervical cancer: an overview. J Obstet Gynecol India. 2006;56:115–22. Kerkar A, Rajendra A, Kulkarni YV. Screening for cervical cancer: an overview. J Obstet Gynecol India. 2006;56:115–22.
3.
Zurück zum Zitat Dietsch E, Gibb H, Francis K. Abnormal pap test results and the rurality factor. Aust J Rural Health. 2003;11(2):50–6.PubMedCrossRef Dietsch E, Gibb H, Francis K. Abnormal pap test results and the rurality factor. Aust J Rural Health. 2003;11(2):50–6.PubMedCrossRef
4.
Zurück zum Zitat Pandey K, Bhagoliwal A. Cancer cervix—need for mass surveillance programme specially in rural areas. J Obstet Gynecol. 2005;55(5):436–9. Pandey K, Bhagoliwal A. Cancer cervix—need for mass surveillance programme specially in rural areas. J Obstet Gynecol. 2005;55(5):436–9.
5.
Zurück zum Zitat Ashrafunnessa, Mohammad K. Cervical intraepithelial neoplasia & its relationship with hormonal contraceptive methods. Bangladesh Med Res Counc Bull. 2008;34:33–8.PubMedCrossRef Ashrafunnessa, Mohammad K. Cervical intraepithelial neoplasia & its relationship with hormonal contraceptive methods. Bangladesh Med Res Counc Bull. 2008;34:33–8.PubMedCrossRef
6.
Zurück zum Zitat Parrazzani F, Chatenoud L, Vecchia LC, et al. Determinants of risk of invasive cervical cancer in young women. Br J Cancer. 1998;77(5):838–41.CrossRef Parrazzani F, Chatenoud L, Vecchia LC, et al. Determinants of risk of invasive cervical cancer in young women. Br J Cancer. 1998;77(5):838–41.CrossRef
7.
Zurück zum Zitat Misra JS, Das V, Singh U, et al. Comparative risk assessment of age and parity in cervical carcinogenesis. J. Obstet Gynecol India. 2007;57(5):422–5. Misra JS, Das V, Singh U, et al. Comparative risk assessment of age and parity in cervical carcinogenesis. J. Obstet Gynecol India. 2007;57(5):422–5.
8.
Zurück zum Zitat Munoz N, Franceschi S, Bosetti C, et al. Role of parity & HPV in cervical cancer: the IARC multicentric case-control study. Lancet. 2002;159:1093–101.CrossRef Munoz N, Franceschi S, Bosetti C, et al. Role of parity & HPV in cervical cancer: the IARC multicentric case-control study. Lancet. 2002;159:1093–101.CrossRef
9.
Zurück zum Zitat Melissa S, Miller J, Masuk M, et al. Contraceptive & reproductive risk factor for cervical intra epithelial neoplasia in American Indian woman. Int J Epidemiol. 2000;29:983–98.CrossRef Melissa S, Miller J, Masuk M, et al. Contraceptive & reproductive risk factor for cervical intra epithelial neoplasia in American Indian woman. Int J Epidemiol. 2000;29:983–98.CrossRef
10.
Zurück zum Zitat Rivoire WA, Monego HL, Reis RD, et al. Comparison of loop electrosurgical Conizatio with one or two passes in high grade cervical intraepithelial neoplasias. Gynecol Obstet Invest. 2009;67:228–35.PubMedCrossRef Rivoire WA, Monego HL, Reis RD, et al. Comparison of loop electrosurgical Conizatio with one or two passes in high grade cervical intraepithelial neoplasias. Gynecol Obstet Invest. 2009;67:228–35.PubMedCrossRef
11.
Zurück zum Zitat Dhaubhadel P, Vaidya A, Choudhary P. Early detection of precursors of cervical cancer with cervical cytology and visual inspection of cervix with acetic acid. J Nepal Med Assoc. 2008;47(170):71–6. Dhaubhadel P, Vaidya A, Choudhary P. Early detection of precursors of cervical cancer with cervical cytology and visual inspection of cervix with acetic acid. J Nepal Med Assoc. 2008;47(170):71–6.
12.
Zurück zum Zitat Chirenje ZM, Rusakaniko S, Akino V, et al. A randomised clinical trial of loop electrosurgical excision procedure (LEEP) versus cryotherapy in the treatment of cervical intraepithelial neoplasia. J obstet Gynaecol. 2001;21((5)):617–21.PubMed Chirenje ZM, Rusakaniko S, Akino V, et al. A randomised clinical trial of loop electrosurgical excision procedure (LEEP) versus cryotherapy in the treatment of cervical intraepithelial neoplasia. J obstet Gynaecol. 2001;21((5)):617–21.PubMed
13.
Zurück zum Zitat Kehrli LD, Cordola DM. Cervical dysplasia recurrence rates among university women: cryosurgery compared with loop excisional electrical procedure. Northridge: California State University. Kehrli LD, Cordola DM. Cervical dysplasia recurrence rates among university women: cryosurgery compared with loop excisional electrical procedure. Northridge: California State University.
Metadaten
Titel
LEEP Verses Cryotherapy in CIN
verfasst von
Abha Singh
Bhavna Arthur
Vivek Agarwal
Publikationsdatum
01.08.2011
Verlag
Springer-Verlag
Erschienen in
The Journal of Obstetrics and Gynecology of India / Ausgabe 4/2011
Print ISSN: 0971-9202
Elektronische ISSN: 0975-6434
DOI
https://doi.org/10.1007/s13224-011-0048-1

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