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Current Nutrition Reports

Erschienen in:

01.06.2014 | Cardiovascular Disease (JH Goedecke, Section Editor)

Genetic Variants in the FADS Gene: Implications for Dietary Recommendations for Fatty Acid Intake

verfasst von: Rasika A. Mathias, Vrindarani Pani, Floyd H. Chilton

Erschienen in: Current Nutrition Reports | Ausgabe 2/2014

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Abstract

Unequivocally, genetic variants within the fatty acid desaturase (FADS) cluster are determinants of long chain polyunsaturated fatty acid (LC-PUFA) levels in circulation, cells, and tissues. A recent series of papers have addressed these associations in the context of ancestry; evidence clearly supports that the associations are robust to ethnicity. However, ~80 % of African Americans carry two copies of the alleles associated with increased levels of arachidonic acid compared with only ~45 % of European Americans, raising important questions of whether gene-PUFA interactions induced by a modern western diet are differentially driving the risk of diseases of inflammation in diverse populations, and are these interactions leading to health disparities. We highlight an important aspect thus far missing in the debate regarding dietary recommendations; we contend that current evidence from genetics strongly suggest that an individual’s, or at the very least the population from which an individual is sampled, genetic architecture must be factored into dietary recommendations currently in place.

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Titel: Genetic Variants in the FADS Gene: Implications for Dietary Recommendations for Fatty Acid Intake
verfasst von: Rasika A. Mathias
Vrindarani Pani
Floyd H. Chilton
Publikationsdatum: 01.06.2014
Verlag: Springer US
Erschienen in: Current Nutrition Reports / Ausgabe 2/2014
Elektronische ISSN: 2161-3311
DOI: https://doi.org/10.1007/s13668-014-0079-1

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