As the incidence of GCT of the frontal bone is extremely rare, the majority of studies in the literature have been case reports [
5‐
7]. The World Health Organization recognizes three distinct types of GCTs arising from the bone, tendon sheath, or soft tissue [
8]. GCT most frequently occurs in the epiphyses of long bones and rarely occur in the orbit [
9]. Radiographic features of GCT include an osteolytic lesion that is radiolucent and results in bony erosions with sharp margins on CT scan. MRI shows a well-circumscribed lesion that exhibits isointensity on T1-weighted images and hypointensity on T2-weighted images. Typically, the lesion enhances with contrast on both imaging modalities [
10,
11]. Histologically, GCT arising from bone are composed of stromal mononuclear cells and giant cells whose histogenesis is controversial. The mononuclear cell represents the true neoplastic component, while the multinucleated giant cells have an osteoclast-like phenotype and express histocytic lineage markers. The histologic differential diagnosis of GCT include other processes in which multinucleated giant cells can be found, such as giant cell granuloma, “brown tumor” of hyperparathyroidism, non-ossifying fibroma, osteoblastoma, aneurysmal bone cyst, and Langerhans cell histiocytosis [
12,
13]. While GCT is generally considered a benign tumor, it has the potential for malignant transformation [
3,
4,
11]; therefore, careful observation is essential. The lesion often grows slowly and can cause significant bone destruction. The current treatment goal is for total surgical resection of the tumor without adjuvant radiation therapy, which has been shown to have the lowest recurrence rate. Indeed, Kamoshima et al. described a 2-year-old female patient with recurrent GCT of the frontal bone that underwent two partial surgical removals of the tumor with recurrence before total resection of the lesion, surrounding bone, and frontal base dura mater was curative [
14]. The reported incidence in the literature of non-recurrence after total resection of a frontal bone lesion has been up to 30 months [
15]. If total resection cannot be achieved, the combination of subtotal resection and radiation therapy shows a similar low recurrence. Other therapeutic strategies may lead to increased recurrence rates [
16]. Continued long-term follow-up will be important in the ongoing management of our patient.