Erschienen in:
01.08.2020 | Brief Report
Hyponatremia, IL-6, and SARS-CoV-2 (COVID-19) infection: may all fit together?
verfasst von:
A. Berni, D. Malandrino, G. Parenti, M. Maggi, L. Poggesi, A. Peri
Erschienen in:
Journal of Endocrinological Investigation
|
Ausgabe 8/2020
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Excerpt
Hyponatremia is the most common electrolyte disorder encountered in clinical practice and is associated with an increased risk of overall mortality in in-patients [
1]. The most common cause of hyponatremia is the syndrome of inappropriate antidiuresis (SIAD), which accounts for up to 40–50% of cases, but the prevalence may be higher in some pathological conditions, such as subarachnoid haemorrhage, traumatic brain injury, and pneumonia [
2]. Besides infectious diseases, several inflammatory conditions may be complicated by SIAD. In these situations, interleukin-6 (IL-6), released by monocytes and macrophages, plays a pathogenic role in causing electrolyte impairment by inducing the non-osmotic release of vasopressin [
3]. …