Background
Methods
Transition probabilities
Transition Matrix Intervention (No-intervention) * | |||
---|---|---|---|
To
From
|
NGT
|
IGT
|
T2D
|
NGT
| 0.848 (0.837) | 0.152 (0.163) | - |
IGT
| 0.177 (0.162) | 0.794 (0.775) | 0.03 (0.06) |
T2D
| - | 0.005 (0.005) | 0.995 (0.995) |
Duration of expected effects
Mortality
Mr[age]
T2d2d
Health care cost in different states
cNGT
cIGT
cT2D
Cost of the Intervention Course and Follow-up Mentoring
Screening (per participant) |
EUR113.32
|
---|---|
Mailing informational folders | EUR 113.32 |
52 TN/244 folders = 21.3%, one folder = EUR24.15
| |
Course (per person)
|
EUR109.16
|
Phone hotline | EUR3.80 |
Email mentoring | EUR3.80 |
Newsletter | (8 × EUR1.75) EUR14.00 |
Journal | (2 × EUR1.68) EUR3.36 |
Collection of medical data | (2 × EUR0.15) EUR0.30 |
Postage | (2 × EUR0.35) EUR0.70 |
Prevention managers (contact hours + preparation) | (26 h × EUR32/10 persons) EUR83.20 |
Follow-up mentoring
(per person per year)
|
EUR183.93
|
Phone hotline | (2 × EUR3.80) EUR7.60 |
Email mentoring | (2 × EUR3.80) EUR7.60 |
Newsletter | (12 × EUR0.90) EUR10.80 |
Journal | (4 × EUR1.49) EUR5.96 |
Collection of medical data | (2 × EUR0.15) EUR0.30 |
Postage | (4 × EUR0.35) EUR1.40 |
Events, 10 person group, 2 times per year | (2 × EUR45/10 persons) EUR18.00 |
Prevention managers (contact hours + preparation) | (41.33 × EUR32/10 persons) EUR132.27 |
Other costs to be considered
| |
Driving to educational locations, one round-trip | (2 × 5 km × EUR0.30/km) EUR3.00 |
Summary
| |
Screening
|
EUR113.32
|
Intervention, including transportation costs
|
EUR133.16
|
Follow-up, including transportation costs
|
EUR143.95
|
Total cost of year 1
|
EUR390.43
|
Total cost of follow-up for year 2 and each following year
|
EUR189.93
|
Utility weights
Men (SE) | Women (SE) | |
---|---|---|
health utility value for NGT (uNGT)
| 0.772 (0.004) | 0.747 (0.004) |
health utility value for IGT (uIGT)
| 0.764 (0.006) | 0.740 (0.006) |
health utility value for T2D (uT2D)
| 0.724 (0.010) | 0.701 (0.010) |
uNGT
uIGT
uT2D
Parameter1
| Deterministic value | Standard Error | Distribution | Alpha | Beta |
---|---|---|---|---|---|
Ngt2igt
| 0.163 | 0.037 | Beta | 16.28 | 83.72 |
Igt2ngt
| 0.162 | 0.037 | Beta | 16.23 | 83.77 |
Igt2t2d
| 0.062 | 0.024 | Beta | 6.23 | 93.77 |
T2d2igt
| 0.005 | 0.007 | Beta | 0.50 | 99.50 |
cNGT
| EUR1,744.21.00 | EUR1,744.21 | Gamma | 1.00 | 1744.21 |
cIGT
| EUR2,696.48 | EUR2,696.48 | Gamma | 1.00 | 2696.48 |
cT2D
| EUR 5,896.48 | EUR5,861.92 | Gamma | 1.00 | 5861.92 |
Cost of intervention
| EUR230.03 | EUR230.03 | Gamma | 1.00 | 230.03 |
Mean
|
Methods of moments
| ||||
uNGT, men
| 0.772 | 0.004 | Beta | 7067.38 | 2087.26 |
uNGT, women
| 0.747 | 0.004 | Beta | 7342.67 | 2486.87 |
uIGT, men
| 0.764 | 0.006 | Beta | 3458.69 | 1066.73 |
uIGT, women
| 0.740 | 0.006 | Beta | 3578.37 | 1260.34 |
uT2D, men
| 0.724 | 0.010 | Beta | 1400.32 | 533.82 |
uT2D, women
| 0.701 | 0.010 | Beta | 1422.19 | 606.61 |
Results
ICER
| |||||
---|---|---|---|---|---|
Age | Sex | ||||
Men | Women | ||||
30 | -25,164 € | -31 407 € | |||
50 | -15,108 € | -21,215 € | |||
70 | 27,546 € | 19,433 € | |||
QALYs gained
| |||||
Age | Sex | ||||
Men | Women | Men, intervention | Women, intervention | ||
30 | 17.44 | 18.07 | 17.46 | 18.10 | |
50 | 13.24 | 14.06 | 13.27 | 14.08 | |
70 | 6.04 | 6.96 | 6.06 | 6.98 | |
Cost
| |||||
Age | Sex | ||||
Men | Women | Men, intervention | Women, intervention | ||
30 | 76 270 € | 83,277 € | 75,670 € | 82,587 € | |
50 | 52,652 € | 59,236 € | 52,308 € | 58,787 € | |
70 | 20,686 € | 25,611 € | 21,021 € | 25,849 € |
Sensitivity analysis
ICER (deterministic) in Euros per QALY gained | |||
---|---|---|---|
Discount rate
| |||
0%
|
3%
|
5%
| |
Man, 30 years
| -34,749 | -25,164 | -15,736 |
Women, 30 years
| -43,831 | -31,407 | -20,212 |
Man, 50 years
| -23,032 | -15,108 | -7,738 |
Woman, 50 years
| -30,831 | -21,215 | -12,746 |
Man, 70 years
| 15,796 | 27,546 | 35,863 |
Woman, 70 years
| 5,935 | 19,443 | 29,074 |
Effectiveness of intervention
| |||
3 years
|
7 years
|
20 years
| |
Man, 30 years
| 54,644 | -25,164 | -52,186 |
Woman, 30 years
| 55,441 | -31,407 | -61,140 |
Man, 50 years
| 65,552 | -15,108 | -39,813 |
Woman, 50 years
| 67,048 | -21,215 | -48,969 |
Man, 70 years
| 146,654 | 27,546 | -13,294 |
Woman, 70 years
| 147,153 | 19,443 | -24,960 |