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Arthritis Research & Therapy
Erschienen in: Arthritis Research & Therapy 6/2012

01.12.2012 | Review

Inflammatory lesions in the bone marrow of rheumatoid arthritis patients: a morphological perspective

verfasst von: Serena Bugatti, Antonio Manzo, Roberto Caporali, Carlomaurizio Montecucco

Erschienen in: Arthritis Research & Therapy | Ausgabe 6/2012

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Abstract

The synovial tissue stands at the epicenter of joint pathology in rheumatoid arthritis (RA). As a primary target of the disease, studies on the synovium have provided invaluable insights into the mechanisms involved in disease pathogenesis. Recent work has, however, revealed the importance of a previously unseen anatomic compartment in direct contact with the joint space, namely the subchondral bone marrow. Bone marrow edema (BME) visible on magnetic resonance imaging (MRI) is clinically meaningful in both early and late RA as it associates with future development of bone erosions and poor functional outcomes. Although the histopathologic correlates of MRI-based BME in early RA remain obscure, studies in advanced disease are consistent in describing lymphocytic inflammatory infiltrates within the subchondral marrow cavity of affected joints. In this review, we discuss the nature of bone marrow lesions in patients with RA, analyze their relationship with synovitis, and explore their potential contribution to the pathological processes of the disease.
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Metadaten
Titel
Inflammatory lesions in the bone marrow of rheumatoid arthritis patients: a morphological perspective
verfasst von
Serena Bugatti
Antonio Manzo
Roberto Caporali
Carlomaurizio Montecucco
Publikationsdatum
01.12.2012
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 6/2012
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar4115

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