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Breast Cancer Research

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01.12.2006 | Review

Measuring proliferation in breast cancer: practicalities and applications

verfasst von: Mark J Beresford, George D Wilson, Andreas Makris

Erschienen in: Breast Cancer Research | Ausgabe 6/2006

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Abstract

Various methods are available for the measurement of proliferation rates in tumours, including mitotic counts, estimation of the fraction of cells in S-phase of the cell cycle and immunohistochemistry of proliferation-associated antigens. The evidence, advantages and disadvantages for each of these methods along with other novel approaches is reviewed in relation to breast cancer. The potential clinical applications of proliferative indices are discussed, including their use as prognostic indicators and predictors of response to systemic therapy.

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Titel: Measuring proliferation in breast cancer: practicalities and applications
verfasst von: Mark J Beresford
George D Wilson
Andreas Makris
Publikationsdatum: 01.12.2006
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 6/2006
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr1618

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Measuring proliferation in breast cancer: practicalities and applications

Abstract

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