Background
Materials and methods
Results
Variable | Mean (±SD) | Minimum | Maximum | |
---|---|---|---|---|
Age (years) | 36.35 ± 7.33 | 22.00 | 50.00 | |
Duration of marriage (years) | 15.07 ± 8.55 | 0.16 | 33.00 | |
Disease duration (years) | 7.37 ± 5.40 | 0.02 | 26 | |
Age at diagnosis (years) | 27.92 ± 7.57 | 11.00 | 49.50 | |
EDSS | 2.06 ± 1.85 | 0.00 | 7.50 | |
Fatigue | 3.65 ± 1.57 | 1.00 | 7.00 | |
Anxiety | 13.18(9.18) | 0 | 20 | |
Depression | 13.46(9.57) | 0 | 28 | |
Stress | 19.59(10.03) | 0 | 34 | |
QOL | Physical health composite score | 62.66 ± 19.15 | 15.42 | 96.24 |
Mental health composite score | 60.75 ± 19.99 | 9.07 | 97.34 | |
Education N (%) | Secondary school or below | 74 (24.7) | ||
High school | 132 (44.0) | |||
University | 94 (31.3) | |||
Occupation N (%) | Housewife | 258 (86.0) | ||
Employed | 33 (11.0) | |||
Retired | 9 (3.0) | |||
Disease pattern N (%) | Relapsing-Remitting MS (RRMS) | 243 (81.0) | ||
Progressive MS | 39 (13.0) | |||
Clinically Isolated Syndrome (CIS) | 18 (6.0) | |||
Taking medications N (%) | No | 30 (10.0) | ||
Yes 270 (90.0) | Disease Modifying Therapy (DMT) | 141 (47.0) | ||
Anticholinergic drugs | 51 (17.0) | |||
Psychiatric drugs | 8 (2.7) | |||
Antidepressants drugs | 56(18.7) | |||
Benzodiazepines drugs | 18(6.0) | |||
Anticonvulsants drugs | 50(16.7) | |||
Beta blockers drugs | 17 (5.7) | |||
Antispasmodic drugs (baclofen,tizanidine, Methocarbamol) | 38(12.7) | |||
Complementary drugs | 183 (61.0) |
Domain | Cut-Off Point | N (%) < Cut-Off Point | Mean (±SD) | Max/Min |
---|---|---|---|---|
Desire | 3.3 | 116 (38.7) | 3.41 (1.05) | 6.00/1.20 |
Arousal | 3.4 | 116 (38.3) | 3.61 (1.18) | 6.00/1.20 |
Lubrication | 3.7 | 104 (34.7) | 4.28 (1.28) | 6.00/1.20 |
Orgasm | 3.4 | 112 (37.3) | 3.76 (1.27) | 6.00/1.20 |
Satisfaction | 3.8 | 69 (23.0) | 4.57 (1.16) | 6.00/1.20 |
Pain | 3.8 | 52 (17.3) | 4.99 (1.18) | 6.00/1.20 |
Total | 28 | 211 (70.3) | 24.64 (5.11) | 34.40/7.20 |
FSFI Domain | Desire | Arousal | Lubrication | Orgasm | Satisfaction | Pain | Total Sexual Dysfunction | |
---|---|---|---|---|---|---|---|---|
Age | r | −0.212** | −0.238** | −0.119* | − 0.156** | − 0.154** | 0.153** | − 0.166** |
p | < 0.001 | < 0.001 | 0.040 | 0.007 | 0.008 | 0.008 | 0.004 | |
Duration of marriage (years) | r | −0.171** | − 0.237** | − 0.150** | − 0.169** | −0.141* | 0.153** | −0.166** |
p | 0.003 | < 0.001 | 0.009 | 0.003 | 0.015 | 0.008 | 0.004 | |
Fatigue | r | −0.173** | −0.226** | −0.261** | − 0.234** | −0.252** | − 0.195** | −0.313** |
p | 0.003 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | 0.001 | < 0.001 | |
Age at diagnosis | r | −0.107 | − 0.137* | 0.021 | − 0.049 | −0.041 | 0.195** | −0.024 |
p | 0.065 | 0.018 | 0.711 | 0.397 | 0.475 | 0.001 | 0.673 | |
Anxiety | r | 0.070 | −0.094 | 0.009 | − 0.105 | −0.093 | 0.008 | −0.054 |
p | 0.229 | 0.104 | 0.879 | 0.069 | 0.109 | 0.887 | 0.349 | |
Depression | r | 0.007 | −0.200** | −0.066 | −0.147* | − 0.118* | −0.043 | − 0.135* |
p | 0.900 | < 0.001 | 0.252 | 0.011 | 0.040 | 0.453 | 0.020 | |
Stress | r | 0.114* | −0.076 | 0.028 | −0.075 | − 0.060 | −0.043 | − 0.029 |
p | 0.048 | 0.189 | 0.627 | 0.195 | 0.301 | 0.454 | 0.613 | |
Disease duration (years) | r | −0.069 | −0.041 | −0.147* | − 0.173** | −0.101 | − 0.044 | −0.106 |
p | 0.235 | 0.483 | 0.011 | 0.003 | 0.082 | 0.450 | 0.068 | |
EDSS | r | −0.071 | −0.148* | −0.127* | − 0.173** | −0.154** | − 0.024 | −0.164** |
p | 0.219 | 0.010 | 0.028 | 0.003 | 0.008 | 0.676 | 0.004 | |
Physical health composite score | r | 0.257** | 0.368** | 0.319** | 0.323** | 0.365** | 0.195** | 0.427** |
p | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | 0.001 | < 0.001 | |
Mental health composite score | r | 0.225** | 0.300** | 0.212** | 0.290** | 0.303** | 0.193** | 0.354** |
p | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | 0.001 | < 0.001 | |
MS Pattern Mean (SD) | ||||||||
CIS | 18 | 3.46(0.76) | 3.58(1.14) | 5.01(0.86) | 3.51(1.40) | 4.97(1.18) | 5.20(0.87) | 25.75(4.18) |
RRMS | 243 | 3.42(1.06) | 3.66(1.16) | 4.27(1.26) | 3.84(1.26) | 4.57(1.13) | 4.94(1.20) | 24.73(5.17) |
Progressives | 39 | 3.35(1.09) | 3.28(1.26) | 4.02(1.47) | 3.37(1.13) | 4.35(1.29) | 5.16(1.12) | 23.56(5.02) |
ANOVA | F | 0.093 | 1.760 | 3.819 | 2.750 | 1.755 | 0.871 | 1.337 |
P | 0.911 | 0.174 | 0.023 | 0.066 | 0.175 | 0.420 | 0.264 | |
Education Mean (SD) | ||||||||
Secondary school or below | 74 | 3.29(1.21) | 3.25(1.28) | 3.98(1.50) | 3.46(1.36) | 4.37(1.27) | 5.23(1.18) | 23.58(5.72) |
High school | 132 | 3.43(0.996) | 3.72(1.21) | 4.40(1.19) | 3.89(1.23) | 4.57(1.18) | 4.95(1.15) | 24.95(5.14) |
University | 94 | 3.50(.990) | 3.74(0.99) | 4.37(1.20) | 3.82(1.21) | 4.74(1.02) | 4.86(1.22) | 25.04(4.46) |
ANOVA | F | 0.811 | 4.685 | 2.844 | 2.866 | 2.029 | 2.097 | 2.113 |
P | 0.445 | 0.010 | 0.060 | 0.058 | 0.133 | 0.125 | 0.123 |
Characteristic | Unadjusted odds ratio (95% CI) | P | Adjusted odds ratio (95% CI) | P* |
---|---|---|---|---|
Age (years) | 1.032 (0.997 to 1.069) | 0.073 | 1.133 (0.933 to 1.306) | 0.085 |
Marriage duration (years) | 1.020 (0.990 to 1.050) | 0.193 | 0.981 (0.918 to 1.047) | 0. 559 |
Fatigue | 1.254 (1.064 to 1.478) | 0.007 | 1.228 (1.003 to 1.504) | 0.047 |
EDSS* | 1.101 (0.957 to 1.267) | 0.177 | 0.987 (0.788 to 1.235) | 0.907 |
BMI** | 1.071(1.004 to 1.143) | 0.037 | 1.071 (0.998 to 1.149) | 0.055 |
Depression | 1.013 (0.986 to 1.040) | 0.355 | 1.023 (0.973 to 1.076) | 0.367 |
Anxiety | 1.008 (0.981 to 1.036) | 0.572 | 1.012 (0.962 to 1.065) | 0. 638 |
Stress | 0.999 (0.975 to 1.024) | 0.938 | 0.971 (0.925 to 1.019) | 0. 230 |
Disease duration(years) | 1.015 (0.969 to 1.063) | 0.540 | 0.916 (0.803 to 1.046) | 0.195 |
Age at diagnosis(years) | 1.011(9.979 to 1.045) | 0.532 | 0.920(0.813 to 1.041) | 0.184 |
Disease Modifying Therapy(DMT) | 1.149(0.700–1.887) | 0.583 | 1.002(0.574 to 1.749) | 0.994 |
Antidepressants drugs | 0.520(0.255–1.060 | 0.072 | 0.641(0.294 to 1.398) | 0.264 |
Anticonvultion drugs | 0.541(0.258 to 1.137) | 0. 105 | 0.708(0.311 to 1.609) | 0.410 |
Antispasmodic drugs | 0.827(0.384 to 1.785) | 0.629 | 1.099(0.440 to 2.745) | 0.840 |
Course disease | ||||
Relapsing remitting | 0.878 (9.302 to 2.553) | 0.812 | 0.806 (0. 328 to 1.979) | 0. 638 |
Progressive | 1.115 (.317 to 3.921) | 0.865 | 0.807 (0.420 to 1.551) | 0.520 |
CIS*** | Ref | |||
education | ||||
Secondary school or below | 1.145(0.582–2.255) | 0.694 | 0.806(0.328 to 1.979) | 0.638 |
High school | 0.942(0.530–1.674) | 0.838 | 0.807(0.420 to 1.551) | 0.520 |
University | Ref |
QOL Domain | Without SD (FSFI > 28) | with SD (FSFI < 28) | t | P |
---|---|---|---|---|
Mean (SD) | Mean (SD) | |||
Physical function | 71.85 (28.69) | 60.68 (29.78( | 2.998 | 0.003 |
Role limitation due to physical problems | 54.49 (44.36) | 43.36 (43.75) | 2.004 | 0.046 |
Role limitation due to emotional problems | 51.31 (47.95) | 40.91 (45.37) | 1.742 | 0.083 |
Pain | 83.85 (21.30) | 69.49 (24.72) | 5.079 | < 0.001 |
Emotional well-being | 65.52 (18.61) | 57.59 (21.13) | 3.072 | 0.002 |
Energy | 55.55 (20.32) | 49.04 (21.15) | 2.460 | 0.014 |
Health perceptions | 60.84 (20.17) | 55.59 (20.47) | 2.038 | 0.042 |
Social function | 82.49 (16.95) | 72.59 (22.01) | 4.212 | < 0.001 |
Cognitive function | 80.00(21.63) | 70.40 (25.48) | 3.323 | 0.001 |
Health distress | 75.00 (23.60) | 68.10 (27.47) | 2.067 | 0.040 |
Sexual function | 93.70 (13.70) | 62.48 (26.09) | 13.346 | < 0.001 |
Change in health | 51.40 (29.03) | 47.81 (26.15) | 1.046 | 0.297 |
Satisfaction with sexual function | 85.17 (21.13) | 55.76 (30.44) | 9.466 | < 0.001 |
Overall QOL | 72.05 (15.69) | 64.40 (18.40) | 3.430 | 0.001 |
Physical health composite score | 69.97 (17.02) | 59.63 (19.20) | 4.336 | < 0.001 |
Mental health composite score | 66.78 (19.13) | 58.21 (19.85) | 3.455 | 0.001 |