Background
MiRNAs and drug resistance
MiRNAs and ADR resistance
MiRNAs | Expression1 | Genes and Pathways | References |
---|---|---|---|
miR-27a | ↑ | P-gp, cyclin D1, p21 | [54] |
miR-135a-5p | ↑ | AP-2α | [55] |
miR-BART20-5p | ↑ | Bad | [56] |
miR-19a/b | ↑ | PTEN | [57] |
miR-501 | ↑ | BLID | |
miR-20a | ↑ | EGR2 | [60] |
miR-21-5p | ↑ | PTEN,TIMP3 | [61] |
miR-633 | ↑ | FADD | [62] |
miR-520h | ↑ | HDAC1 | [63] |
miR-129-5p | ↓ | ABCB1, ABCC5, ABCG1 | [64] |
miR-508-5p | ↓ | ABCB1, ZNRD1 | [65] |
miR-103/107 | ↓ | cav-1, P-gp | [66] |
miR-27b, miR-508-5p | ↓ | ABCB1, CCNG1, ZNRD1 | [67] |
miR-140 | ↓ | ABCC1, ABCG2, SOX4 | [68] |
miR-107 | ↓ | P-gp, cyclin D1, c-myc | [69] |
miR-15b, miR-16 | ↓ | Bcl-2 | [70] |
miR-181b | ↓ | Bcl-2 | [71] |
miR-497 | ↓ | Bcl-2 | [72] |
miR-200bc/429 | ↓ | Bcl-2, XIAP | [73] |
miR-34 | ↓ | Bcl-2, Notch, HMGA2 | [74] |
miR-200c | ↓ | E-cadherin, Bax, Bcl-2 | [75] |
miR-185 | ↓ | ARC | [76] |
miR-126 | ↓ | EZH2 | [77] |
miR-218 | ↓ | SMO | [78] |
miR-494 | ↓ | PDE4D | [79] |
MiRNAs and resistance to platinum drugs
MiRNAs | Expression1 | Genes and Pathways | Drugs | Reference |
---|---|---|---|---|
miR-20a | ↑ | EGR2 | cisplatin | [60] |
CYLD | [83] | |||
miR-106a | ↑ | PTEN/Akt | cisplatin | [84] |
RUNX | [85] | |||
miR-21 | ↑ | PTEN/Akt | cisplatin | [86] |
miR-25 | ↑ | FOXO3a | cisplatin | [87] |
miR-141 | ↑ | KEAP1 | cisplatin | [88] |
miR-223 | ↑ | FBXW7 | cisplatin | [89] |
miR-99a, miR-491 | ↑ | CAPNS1 | cisplatin | [90] |
miR-421 | ↑ | E-cadherin, caspase-3 | cisplatin | [91] |
miR-135b-5p | ↑ | KLF4 | cisplatin | [92] |
miR-135b | ↑ | MST1, MAPK | cisplatin | [93] |
miR-17-5p | ↑ | p21 | cisplatin | [94] |
miR-193a-3p | ↑ | SRSF2 | cisplatin | [28] |
miR-4295 | ↑ | LRIG1 | cisplatin | [95] |
miR-3174 | ↑ | ARHGAP10 | cisplatin | [96] |
miR-27a | ↑ | P-gp, LRP, Bcl-2 | oxaliplatin | [97] |
miR-135a | ↑ | E2F1, DAPK2 | oxaliplatin | [98] |
miR-27b, miR-508-5p | ↓ | ABCB1, CCNG1, ZNRD1 | cisplatin | [67] |
miR-129-5p | ↓ | ABCB1, ABCC5, ABCG1 | cisplatin | [64] |
miR-508-5p | ↓ | ABCB1, ZNRD1 | cisplatin | [65] |
miR-129 | ↓ | P-gp | cisplatin | [99] |
miR-107 | ↓ | P-gp, cyclin D1, c-myc | oxaliplatin | [69] |
miR-15b, miR-16 | ↓ | Bcl-2 | cisplatin | [70] |
miR-181b | ↓ | Bcl-2 | cisplatin | [71] |
miR-497 | ↓ | Bcl-2 | cisplatin | [72] |
miR-200bc/429 cluster | ↓ | Bcl-2, XIAP | cisplatin | [73] |
miR-34 | ↓ | Bcl-2, Notch, HMGA2 | cisplatin | [74] |
miR-449a | ↓ | Bcl-2, CCDN1 | cisplatin | [100] |
miR-1271 | ↓ | IGF1R, IRS1, mTOR, Bcl-2 | cisplatin | [101] |
miR-143 | ↓ | IGF1R, Bcl-2 | cisplatin | [102] |
miR-503 | ↓ | IGF1R, Bcl-2 | cisplatin | [103] |
miR-23b-3p | ↓ | ATG12, HMGB2 | cisplatin | [104] |
miR-181a | ↓ | ATG5 | cisplatin | [105] |
miR-30 | ↓ | LC3-II | cisplatin | [106] |
miR-148a-3p | ↓ | RAB12, mTOR1, AKAP1 | cisplatin | [107] |
miR-200c | ↓ | E-cadherin | cisplatin | [75] |
RhoE | [108] | |||
ZEB2 | [109] | |||
miR-101 | ↓ | ANXA2 | cisplatin | [110] |
VEGF-C | [111] | |||
miR-218 | ↓ | mTOR | cisplatin | [112] |
SMO | oxaliplatin | [78] | ||
miR-185 | ↓ | ARC | cisplatin | [76] |
miR-34a | ↓ | MET | cisplatin | [113] |
miR-26a | ↓ | NRAS, E2F2 | cisplatin | [114] |
miR-149 | ↓ | FoxM1 | cisplatin | [115] |
miR-524-5p | ↓ | SOX9 | cisplatin | [116] |
miR-362-5p | ↓ | SUZ12 | cisplatin | [117] |
miR-198 | ↓ | FGFR1 | cisplatin | [118] |
miR-574-3p | ↓ | ZEB1 | cisplatin | [119] |
miR-876-3p | ↓ | TMED3 | cisplatin | [120] |
miR-874 | ↓ | ATG16L1 | cisplatin | [121] |
let-7b | ↓ | AURKB | cisplatin | [122] |
miR-122 | ↓ | ERCC1 | cisplatin | [123] |
miR-138-5p | ↓ | ERCC1, ERCC4 | cisplatin | [48] |
miR-192-5p | ↓ | ERCC3, ERCC4 | cisplatin | [124] |
MiRNAs and 5-FU resistance
MiRNAs | Expression1 | Genes and Pathways | Reference |
---|---|---|---|
miR-BART20-5p | ↑ | BAD | [56] |
miR-193-3p | ↑ | PTEN | [127] |
miR-147 | ↑ | PTEN | [128] |
miR-17 | ↑ | DEDD | [129] |
miR-129-5p | ↓ | ABCB1, ABCC5, ABCG1 | [64] |
miR-508-5p | ↓ | ABCB1, ZNRD1 | [65] |
miR-27b, miR-508-5p | ↓ | ABCB1, CCNG1, ZNRD1 | [67] |
miR-107 | ↓ | P-gp, cyclin D1, c-myc, | [69] |
miR-181b | ↓ | Bcl-2 | [71] |
miR-429 | ↓ | Bcl-2 | [130] |
miR-200c | ↓ | E-cadherin | [75] |
miR-218 | ↓ | SMO | [78] |
miR-23b-3p | ↓ | ATG12, HMGB2 | [104] |
miR-31 | ↓ | RhoA | [131] |
ZH2 | [132] | ||
E2F6, SMUG1 | [133] | ||
miR-197 | ↓ | MAPK1 | [134] |
miR-BART15-3p | ↓ | TAX1BP1 | [135] |
miR-195-5p | ↓ | ZNF139 | [136] |
miR-204 | ↓ | TGFBR2 | [137] |
miR-623 | ↓ | CCND1 | [138] |
miR-939 | ↓ | SLC34A2/Raf/MEK/ERK | [139] |
miR-124 | ↓ | EZH2 | [140] |
MiRNAs and VCR resistance
MiRNAs | Expression1 | Genes and Pathways | Reference |
---|---|---|---|
miR-19a/b | ↑ | PTEN | [57] |
miR-129-5p | ↓ | ABCB1, ABCC5, ABCG1 | [64] |
miR-508-5p | ↓ | ABCB1, ZNRD1 | [65] |
miR-27b, miR-508-5p | ↓ | CCNG1, ABCB1, ZNRD1 | [67] |
miR-15b, miR-16 | ↓ | Bcl-2 | [70] |
miR-181b | ↓ | Bcl-2 | [71] |
miR-497 | ↓ | Bcl-2 | [72] |
miR-200bc/429 cluster | ↓ | Bcl-2, XIAP | [73] |
miR-126 | ↓ | EZH2 | [77] |
miR-647 | ↓ | ANK2 | [141] |
miR-1284 | ↓ | EIF4A1 | [142] |
miR-23b-3p | ↓ | ATG12, HMGB2 | [104] |
miR-101 | ↓ | ANXA2 | [110] |
MiRNAs and PTX resistance
MiRNAs and resistance to targeted therapy drugs
MiRNAs | Expression1 | Genes and Pathways | Drugs | Reference |
---|---|---|---|---|
miR-21 | ↑ | PTEN | trastuzumab | [154] |
miR-125b | ↑ | trastuzumab | [155] | |
miR-223 | ↑ | FBXW7 | trastuzumab | [156] |
miR-200c | ↓ | ZEB1, ZEB2 | trastuzumab | [157] |
miR-16 | ↓ | CCNJ, FUBP1 | trastuzumab, lapatinib | [158] |
miR-494 | ↓ | FGFR2 | lapatinib | [159] |
MiRNAs and resistance to other drugs
MiRNAs | Expression1 | Genes and Pathways | Drugs | Reference |
---|---|---|---|---|
miR-15b, miR-16 | ↓ | Bcl-2 | etoposide, mitomycin | [70] |
miR-181b | ↓ | Bcl-2 | etoposide | [71] |
miR-497 | ↓ | Bcl-2 | etoposide | [72] |
miR-200bc/429 cluster | ↓ | Bcl-2, XIAP | etoposide | [73] |
miR-17-92 cluster | ↑ | oxaliplatin/capecitabine | [160] |
LncRNAs and chemoresistance
LncRNAs and resistance to platinum drugs
LncRNAs | Expression1 | Genes and Pathways | Drugs | Reference |
---|---|---|---|---|
PCAT-1 | ↑ | EZH2, PTEN | cisplatin | [161] |
miR-128/ZEB1 | [162] | |||
DANCR | ↑ | MDR1, MRP1 | cisplatin | [163] |
SNHG5 | ↑ | Bax, MDR1, MRP1, Bcl-2 | cisplatin | [164] |
GHET1 | ↑ | Bax, Bcl-2, MDR1, MRP1 | cisplatin | [165] |
AK022798 | ↑ | MRP1, P-gp | cisplatin | [166] |
ANRIL | ↑ | MDR1, MRP1 | cisplatin | [167] |
UCA1 | ↑ | miR-27b | cisplatin | [168] |
HULC | ↑ | cisplatin | [169] | |
HOTAIR | ↑ | miR-126/PI3K/AKT/MRP1 | cisplatin | [170] |
miR-34a, PI3K/Akt,Wnt/β-catenin | cisplatin | [171] | ||
XLOC_006753 | ↑ | PI3K/AKT/mTOR | cisplatin | [172] |
ZFAS1 | ↑ | Wnt/β-catenin | cisplatin | [173] |
BCAR4 | ↑ | Wnt | cisplatin | [174] |
MALAT1 | ↑ | miR-23b-3p/ATG12 | cisplatin | [175] |
PVT-1 | ↑ | MDR1, MRP, mTOR, HIF-1α | cisplatin | [176] |
BLACAT1 | ↑ | miR-361/ABCB1 | oxaliplatin | [179] |
CASC2 | ↓ | miR-19a | cisplatin | [180] |
CRAL | ↓ | miR-505/CYLD/AKT | cisplatin | [181] |
LncRNAs and ADR resistance
LncRNAs and 5-FU resistance
LncRNAs and PTX resistance
CircRNAs and chemoresistance in gastric cancer
CircRNAs | Expression1 | Genes and Pathways | Related drug | Reference |
---|---|---|---|---|
circAKT3 | ↑ | miR-198/ PIK3R1 | cisplatin | [200] |
hsa_circ_0081143 | ↑ | miR-646/CDK6 | cisplatin | [201] |
circFN1 | ↑ | miR-182-5p | cisplatin | [202] |
circ-PVT1 | ↑ | miR-124-3p/ZEB1 | paclitaxel | [23] |
circ MTHFD2 | ↑ | miR-124/FDZ5/MDR-1 | pemetrexed | [203] |