Background
Methods
Objectives
Ethics
Methods
Statistics
Results
Population
Number | |||
---|---|---|---|
Age (years) | 116 | 41.8 ± 17.5 | [15-84; 39.5] |
BMI (kg/m2) | 116 | 23.4 ± 4.7 | [15.2-40.2; 22.3] |
Males | 51 | 44.0 % | |
Females | 65 | 56.0 % | |
Living alone | 22 | 19.0 % | |
School of professional occupation | 66/115 | 57.4 % |
N = 116 | |||
---|---|---|---|
Age at PID diagnosis (years) | 31.6 ± 20.3 | [0–79.6; 32.4] | |
Time from PID diagnosis (years) | 10.2 ± 9.9 | [0.4–50.6; 6.6] | |
Type of PID | |||
• Agammaglobulinemia | 1 | 0.9 % | |
• X-linked agammaglobulinemia | 5 | 4.3 % | |
• Hypogammaglobulinemia | 9 | 7.8 % | |
• Common variable immune deficiency | 76 | 65.5 % | |
• Severe combined immuno-deficiency | 4 | 3.5 % | |
• IgG subclass deficiency with recurrent infections | 12 | 10.3 % | |
• Other PID | 9 | 7.8 % | |
At least one severe infection within the previous 12 months | 6 | 5.2 % |
N = 116 | |||
---|---|---|---|
Age at start of IgRT (years) | 115a
| 33.34 ± 20.17 | [0–79.7; 33.6] |
Duration of IgRT (years) | 115a
| 8.5 ± 8.4 | [0.2–38.5; 5.6] |
History of at least one switch from IVIg to SCIg | 49 | 42.2 % | |
History of at least one switch from SCIg to IVIg | 14 | 12.1 % | |
Route of IgRT at enrollment | |||
• IVIg at hospital | 46 | 39.7 % | |
• IVIg at home | 13 | 11.2 % | |
• SCIg at home | 57 | 49.1 %) | |
Switch from IVIg to SCIg after enrollment | 11 | 9.5 % | |
Switch from SCIg to IVIg after enrollment | 2 | 1.7 % | |
Switch from hospital-based to home-based IgRT | 12 | 10.3 % | |
Switch from home-based to hospital-based IgRT | 2 | 1.7 % |
Ig replacement therapy
Satisfaction regarding IgRT
LQI Factor I | LQI Factor II | LQI Factor III | |
---|---|---|---|
Hospital-based IVIg | 81.2 ± 2.5 | 85.8 ± 2.3 | 82.3 ± 2.5 |
Home-based IVIg | 72.8 ± 4.7 | 79.5 ± 4.1 | 86.9 ± 4.5 |
Home-based SCIg | 85.6 ± 2.3 | 85.6 ± 1.9 | 91.5 ± 2.2 |
Hospital-based IVIg vs home based IVIg | [-2.3 to 19.0]
P = 0.12 | [-2.8 to 15.5]
P = 0.17 | [14.8 to 5.5
P = 0.37 |
Hospital-based IVIg vs home based SCIg | [-11.1 to 2.2]
P = 0.19 | [-5.5 to 6.0]
P = 0.93 | [-15.5 to -2.8]
P = 0.005 |
Home-based IVIg vs home based SCIg | [-23.3 to -2.3]
P = 0.02 | [-15.1 to 2.9]
P = 0.18 | [-14.6 to 5.4]
P = 0.37 |
Quality of life
Hospital-based IVIg N = 46 | Home-based IVIg N = 13 | Home-based SCIg N = 57 |
p
| |
---|---|---|---|---|
Physical functioning | 47.61 ± 9.78 | 48.79 ± 12.74 | 49.11 ± 9.97 | 0.76 |
Role physical | 44.66 ± 10.04 | 48.54 ± 8.91 | 45.24 ± 11.39 | 0.56 |
Bodily pain | 47.13 ± 10.63 | 49.63 ± 11.62 | 46.75 ± 13.81 | 0.78 |
General health | 37.39 ± 10.35 | 34.34 ± 10.04 | 37.70 ± 10.38 | 0.61 |
Vitality | 44.11 ± 11.03 | 48.69 ± 10.02 | 45.38 ± 10.19 | 0.43 |
Social functioning | 43.15 ± 11.25 | 40.98 ± 11.03 | 43.52 ± 13.51 | 0.83 |
Role emotional | 41.28 ± 14.29 | 40.33 ± 11.53 | 44.29 ± 13.89 | 0.47 |
Mental health | 42.19 ± 12.56 | 42.07 ± 13.78 | 40.58 ± 12.36 | 0.81 |
Physical component score | 46.25 ± 9.39 | 49.41 ± 9.04 | 46.94 ± 10.48 | 0.64 |
Mental component score | 40.93 ± 13.70 | 39.51 ± 13.01 | 41.42 ± 12.98 | 0.91 |