Background
Methods
Microarray data analysis
Quantitative realtime PCR
Results
Gene expression profiles of leiomyomas, keloids and scars
Gene Bank | Symbol | Fold Change | Probability | Function |
---|---|---|---|---|
NM_003478 | CUL5 | 5.06 | 0.0001 | apoptosis |
AB037736 | CASP8AP2 | 4.07 | 0.0021 | apoptosis |
NM_018947 | CYCS | 2.08 | 0.0013 | apoptosis |
AB014517 | CUL3 | 2.07 | 0.00001 | apoptosis |
BC010958 | CCND2 | 5.62 | 0.0041 | cell cycle |
U47413 | CCNG1 | 3.16 | 0.0007 | cell cycle |
AF048731 | CCNT2 | 2.83 | 0.0004 | cell cycle |
NM_001927 | DBS | 61.51 | 0.0022 | cytoskeleton/motility |
AK124338 | ACTG2 | 30.16 | 0.00001 | cytoskeleton/motility |
BC022015 | CNN1 | 27.26 | 0.00001 | cytoskeleton/motility |
NM_006449 | CDC42EP3 | 25.29 | 0.0051 | cytoskeleton/motility |
AB023209 | KIAA0992 | 17.61 | 0.0004 | cytoskeleton/motility |
AF474156 | TPM1 | 14.84 | 0.0029 | cytoskeleton/motility |
BC011776 | TPM2 | 12.04 | 0.00001 | cytoskeleton/motility |
M11315 | COL4A1 | 11.87 | 0.0029 | cytoskeleton/motility |
AK126474 | LMOD1 | 9.49 | 0.00001 | cytoskeleton/motility |
AB062484 | CALD1 | 9.22 | 0.0042 | cytoskeleton/motility |
NM_003186 | TAGLN | 6.68 | 0.00001 | cytoskeleton/motility |
BC017554 | ACTA2 | 5.18 | 0.00001 | cytoskeleton/motility |
AK074048 | FLNA | 5.08 | 0.00001 | cytoskeleton/motility |
NM_016274 | CKIP-1 | 4.44 | 0.002 | cytoskeleton/motility |
BC003576 | ACTN1 | 4.23 | 0.0024 | cytoskeleton/motility |
AF089841 | FLNC | 3.43 | 0.0005 | cytoskeleton/motility |
X05610 | COL4A2 | 7.86 | 0.0017 | extracellular matrix |
BC005159 | COL6A1 | 3.70 | 0.002 | extracellular matrix |
A98730 | CAPN6 | 13.7 | 0.0023 | protease activity |
U41766 | ADAM9 | 4.76 | 0.0021 | protease |
NM_001110 | ADAM10 | 3.2 | 0.00001 | protease |
AF031385 | CYR61 (CCN1) | 9.13 | 0.0035 | growth factor |
M32977 | VEGF | 7.13 | 0.002 | growth factor |
AF035287 | SDFR1 | 4.70 | 0.0001 | chemokine receptor |
X04434 | IGF1R | 3.64 | 0.0017 | growth factor receptor |
AB029156 | HDGFRP3 | 2.89 | 0.0006 | GF receptor activity |
AF056979 | IFNGR1 | 2.72 | 0.0001 | signal transduction |
AB020673 | MYH11 | 53.80 | 0.0006 | signal transduction |
D26070 | ITPR1 | 26.18 | 0.0034 | signal transduction |
AB037717 | SORBS1 | 15.25 | 0.0005 | signal transduction |
AF110225 | ITGB1BP2 | 14.18 | 0.0009 | signal transduction |
AB004903 | SOCS2 | 11.39 | 0.0002 | signal transduction |
B011147 | GREB1 | 11.37 | 0.0025 | signal transduction |
AB000509 | TRAF5 | 7.83 | 0.0032 | signal transduction |
NM_005261 | GEM | 7.48 | 0.0003 | signal transduction |
AF028832 | HSPCA | 4.27 | 0.00001 | signal transduction |
AC006581 | M6PR | 3.85 | 0.0012 | signal transduction |
AF275719 | HSPCB | 3.74 | 0.001 | signal transduction |
AJ242780 | ITPKB | 3.68 | 0.00001 | signal transduction |
AK095866 | GPR125 | 3.62 | 0.0001 | signal transduction |
AF016050 | NRP1 | 3.44 | 0.0011 | signal transduction |
AB015706 | IL6ST | 3.42 | 0.0002 | signal transduction |
AK057120 | HMGB1 | 3.16 | 0.0001 | signal transduction |
NM_006644 | HSPH1 | 3.14 | 0.002 | signal transduction |
AB072923 | BSG | 2.90 | 0.0024 | signal transduction |
AB010881 | FZD7 | 2.62 | 0.0024 | signal transduction |
AF273055 | INPP5A | 2.58 | 0.002 | signal transduction |
AC078943 | TANK | 2.32 | 0.0005 | signal transduction |
AF051344 | LTBP4 | 2.20 | 0.0002 | signal transduction |
AJ404847 | ILK | 4.74 | 0.0002 | protein kinase activity |
AF119911 | CSNK1A1 | 3.40 | 0.0015 | protein kinase activity |
NM_002037 | FYN | 3.30 | 0.0028 | protein kinase activity |
AB058694 | CDC2L5 | 2.37 | 0.0001 | protein kinase activity |
AF415177 | CAMK2G | 2.18 | 0.0008 | protein kinase activity |
NM_005654 | NR2F1 | 12.57 | 0.0039 | transcription factor |
BC062602 | PNN | 9.93 | 0.0001 | transcription factor |
AK098174 | MEIS1 | 9.61 | 0.00001 | transcription factor |
NM_000125 | ESR1 | 9.36 | 0.0004 | transcription factor |
AF249273 | BCLAF1 | 8.62 | 0.0001 | transcription factor |
AF017418 | MEIS2 | 7.46 | 0.0009 | transcription factor |
AF045447 | MADH4 | 6.39 | 0.00001 | transcription factor |
AF162704 | AR | 5.54 | 0.0018 | transcription factor |
NM_001527 | HDAC2 | 4.76 | 0.00001 | transcription factor |
NM_004268 | CRSP6 | 4.76 | 0.0001 | transcription factor |
BC020868 | STAT5B | 4.57 | 0.0003 | transcription factor |
BC002646 | JUN | 3.84 | 0.0042 | transcription factor |
AY347527 | CREB1 | 3.77 | 0.0031 | transcription factor |
AL833643 | MAX | 3.66 | 0.0014 | transcription factor |
NM_021809 | TGIF2 | 3.58 | 0.0014 | transcription factor |
AB007836 | TGFB1I1 | 3.55 | 0.0007 | transcription coactivator |
NM_005760 | CEBPZ | 3.53 | 0.00001 | transcription factor |
AL833268 | MEF2C | 3.49 | 0.0019 | transcription factor |
NM_005903 | MADH5 | 3.10 | 0.0037 | transcription factor |
NM_022739 | SMURF2 | 2.58 | 0.0013 | transcription factor |
NM_003472 | DEK | 2.55 | 0.0001 | transcription factor |
NM_001358 | DHX15 | 2.49 | 0.0029 | transcription factor |
BC029619 | ATF1 | 2.41 | 0.0026 | transcription factor |
AB082525 | TSC22 | 2.26 | 0.0002 | transcription factor |
AL831995 | MEF2A | 2.25 | 0.0024 | transcription factor |
AA765457 | DDX17 | 10.41 | 0.0035 | translation factor |
NM_018951 | HOXA10 | 8.69 | 0.00001 | translation factor |
BC000751 | EIF5A | 4.07 | 0.001 | translation factor |
AF015812 | DDX5 | 2.48 | 0.0004 | translation factor |
AL079283 | EIF1A | 2.35 | 0.0005 | translation factor |
NM_003760 | EIF4G3 | 2.35 | 0.0028 | translation factor |
NM_012218 | ILF3 | 2.29 | 0.0003 | translation factor |
AB018284 | EIF5B | 2.26 | 0.002 | translation factor |
AF155908 | HSPB7 | 9.52 | 0.0002 | protein binding |
AF209712 | MCP | 6.54 | 0.00001 | complement activation |
AL833430 | SPARCL1 | 5.12 | 0.00001 | calcium ion binding |
AF297048 | PTGIS | 4.26 | 0.0004 | catalytic activity |
AF288537 | FSTL1 | 4.11 | 0.001 | calcium ion binding |
AB034951 | HSPA8 | 3.13 | 0.001 | protein binding |
NM_001155 | ANXA6 | 2.85 | 0.0014 | calcium ion binding |
NM_003642 | HAT1 | 2.81 | 0.00001 | catalytic activity |
NM_002267 | KPNA3 | 2.55 | 0.0031 | protein transporter |
AK124769 | XPO1 | 2.46 | 0.0002 | protein transporter |
AJ238248 | CENTB2 | 2.37 | 0.0045 | GTPase activator activity |
AF072928 | MTMR6 | 2.17 | 0.002 | phosphatase activity |
Gene Bank | Symbol | Fold Change | Probability | Function |
---|---|---|---|---|
AF004709 | MAPK13 | 0.06 | 0.0002 | apoptosis |
AF010316 | PTGES | 0.09 | 0.0003 | apoptosis |
NM_014430 | CIDEB | 0.21 | 0.0014 | apoptosis |
AJ307882 | TRADD | 0.26 | 0.0007 | apoptosis |
BC041689 | CASP1 | 0.31 | 0.0009 | apoptosis |
NM_014922 | NALP1 | 0.31 | 0.0025 | apoptosis |
AF159615 | FRAG1 | 0.33 | 0.0044 | apoptosis |
BC019307 | BCL2L1 | 0.42 | 0.0027 | apoptosis |
NM_016426 | GTSE1 | 0.43 | 0.0033 | apoptosis |
AK027080 | LTBR | 0.50 | 0.0047 | apoptosis |
M92287 | CCND3 | 0.48 | 0.0028 | cell cycle |
AJ242501 | MAP7 | 0.2 | 0.0001 | structural molecule |
AF381029 | LMNA | 0.3 | 0.00001 | structural molecule |
X83929 | DSC3 | 0.009 | 0.0035 | cell adhesion |
AB025105 | CDH1 | 0.01 | 0.0009 | cell adhesion |
AJ246000 | SELL | 0.21 | 0.002 | cell adhesion |
NM_003568 | ANXA9 | 0.22 | 0.0031 | cell adhesion |
AF281287 | PECAM1 | 0.36 | 0.0017 | cell adhesion |
J00124 | KRT14 | 0.0001 | 0.0003 | cytoskeleton/motility |
BC034535 | KRT6B | 0.005 | 0.0043 | cytoskeleton/motility |
M19156 | KRT10 | 0.018 | 0.001 | cytoskeleton/motility |
AJ551176 | SDC1 | 0.039 | 0.0038 | cytoskeleton/motility |
NM_006478 | GAS2L1 | 0.22 | 0.0016 | cytoskeleton/motility |
M34225 | KRT8 | 0.26 | 0.0029 | cytoskeleton/motility |
NM_005886 | KATNB1 | 0.27 | 0.0011 | cytoskeleton/motility |
AK024835 | CNN2 | 0.47 | 0.003 | cytoskeleton/motility |
NM_006350 | FST | 0.11 | 0.00001 | extracellular matrix |
AF177941 | COLSA3 | 0.14 | 0.00001 | extracellular matrix |
L22548 | COL18A1 | 0.49 | 0.0011 | extracellular matrix |
M58051 | FGFR3 | 0.007 | 0.0039 | growth factor receptor |
NM_004887 | CXCL14 | 0.009 | 0.0014 | chemokine |
AF289090 | BMP7 | 0.13 | 0.002 | cytokine |
K03222 | TGFA | 0.2 | 0.0048 | growth factor |
M31682 | INHBB | 0.20 | 0.00001 | cytokine |
NM_004750 | CRLF1 | 0.26 | 0.0003 | cytokine binding |
NM_002514 | NOV (CCN3) | 0.28 | 0.0009 | growth factor |
NM_000685 | AGTR1 | 0.30 | 0.005 | growth factor receptor |
D16431 | HDGF | 0.42 | 0.0046 | creatine kinase |
L36719 | MAP2K3 | 0.22 | 0.0048 | protein kinase activity |
AJ290975 | ITPKC | 0.28 | 0.0036 | protein kinase activity |
NM_001569 | IRAK1 | 0.33 | 0.0001 | protein kinase activity |
AB025285 | ERBB2 | 0.45 | 0.0003 | protein kinase |
AF029082 | SFN | 0.001 | 0.0028 | signal transduction |
AB065865 | HM74 | 0.04 | 0.0047 | signal transduction |
AA021034 | LTB4R | 0.06 | 0.0006 | signal transduction |
NM_004445 | EPHB6 | 0.12 | 0.0038 | signal transduction |
AF025304 | EPHB2 | 0.17 | 0.0021 | signal transduction |
AB026663 | MC1R | 0.17 | 0.0046 | signal transduction |
AF035442 | VAV3 | 0.17 | 0.004 | signal transduction |
NM_014030 | GIT1 | 0.21 | 0.0025 | signal transduction |
AB011152 | CENTD1 | 0.21 | 0.0003 | signal transduction |
AK095244 | CYB561 | 0.23 | 0.0001 | signal transduction |
AF106858 | GPR56 | 0.23 | 0.0002 | signal transduction |
AF231024 | CELSR1 | 0.23 | 0.0006 | signal transduction |
AF234887 | CELSR2 | 0.24 | 0.0003 | signal transduction |
NM_007197 | FZD10 | 0.25 | 0.0009 | signal transduction |
NM_014349 | APOL3 | 0.25 | 0.002 | signal transduction |
NM_004039 | ANXA2 | 0.27 | 0.0044 | signal transduction |
AI285986 | THBD | 0.29 | 0.0004 | signal transduction |
M57730 | EFNA1 | 0.31 | 0.0032 | signal transduction |
NM_002118 | HLA-DMB | 0.33 | 0.0008 | signal transduction |
AF427491 | TUBB4 | 0.36 | 0.001 | signal transduction |
NM_005279 | GPR1 | 0.40 | 0.0033 | signal transduction |
X60592 | TNFRSF5 | 0.40 | 0.0032 | signal transduction |
BC052968 | EPHB3 | 0.42 | 0.0001 | signal transduction |
M64749 | CMKOR1 | 0.46 | 0.0014 | signal transduction |
M21188 | IDE | 0.46 | 0.0031 | signal transduction |
AB018325 | CENTD2 | 0.47 | 0.0004 | signal transduction |
AK054968 | ITGB5 | 0.49 | 0.0005 | signal transduction |
NM_001730 | KLF5 | 0.04 | 0.0021 | transcription factor |
NM_004350 | RUNX3 | 0.08 | 0.0001 | transcription factor |
U34070 | CEBPA | 0.11 | 0.0005 | transcription factor |
AF062649 | PTTG1 | 0.15 | 0.0039 | transcription factor |
NM_004235 | KLF4 | 0.20 | 0.0005 | transcription factor |
X52773 | RXRA | 0.20 | 0.0011 | transcription factor |
AF202118 | HOXD1 | 0.21 | 0.0006 | transcription factor |
NM_000376 | VDR | 0.21 | 0.0001 | transcription factor |
NM_006548 | IMP-2 | 0.26 | 0.0031 | transcription factor |
NM_007315 | STAT1 | 0.32 | 0.00001 | transcription factor |
NM_004430 | EGR3 | 0.34 | 0.002 | transcription factor |
NM_003644 | GAS7 | 0.36 | 0.0033 | transcription factor |
NM_005900 | MADH1 | 0.48 | 0.0028 | transcription factor |
X14454 | IRF1 | 0.49 | 0.0013 | transcription factor |
AF067572 | STAT6 | 0.49 | 0.0001 | transcription factor |
NM_005596 | NFIB | 0.49 | 0.0041 | transcription factor |
AB002282 | EDF1 | 0.40 | 0.0002 | transcription coactivator |
AK075393 | CTSB | 0.50 | 0.0016 | protease activity |
AB021227 | MMP24 | 0.29 | 0.0001 | protease activity |
AB007774 | CSTA | 0.02 | 0.0018 | cysteine protease inhibitor |
AF143883 | ALOX12 | 0.06 | 0.0016 | catalytic activity |
AF440204 | PTGS1 | 0.08 | 0.00001 | catalytic activity |
NM_000777 | CYP3A5 | 0.14 | 0.0041 | catalytic activity |
NM_016593 | CYP39A1 | 0.21 | 0.0027 | catalytic activity |
BC001491 | HMOX1 | 0.23 | 0.0028 | catalytic activity |
BC020734 | PGDS | 0.26 | 0.00001 | catalytic activity |
AL133324 | GSS | 0.39 | 0.002 | catalytic activity |
AF055027 | CARM1 | 0.41 | 0.00001 | catalytic activity |
NM_001630 | ANXA8 | 0.01 | 0.0006 | calcium ion binding |
AB011542 | EGFL5 | 0.43 | 0.0001 | calcium ion binding |
NM_005979 | S100A13 | 0.31 | 0.001 | calcium ion binding |
NM_020672 | S100A14 | 0.02 | 0.0005 | calcium ion binding |
NM_005978 | S100A2 | 0.003 | 0.005 | calcium ion binding |
BC012610 | HF1 | 0.22 | 0.00001 | complement activation |
AF052692 | GJB3 | 0.03 | 0.0001 | connexon channel activity |
M12529 | APOE | 0.21 | 0.0001 | metabolism |
NM_004925 | AQP3 | 0.01 | 0.0003 | transporter activity |
Gene Bank | Symbol | F. Change LAA:Scar | F. Change LC:Scar | P value | Function |
---|---|---|---|---|---|
NM_006198 | PCP4 | 68.14 | 6.66 | 0.0017 | system development |
S67238 | MYOSIN | 62.78 | 36.69 | 0.0034 | cytoskeleton/motility |
NM_004342 | Cald1 | 21.43 | 9.32 | 0.0047 | cytoskeleton/motility |
NM_013437 | LRP12 | 20.6 | 6.82 | 0.0053 | cellular process |
AC004010 | AMIGO2 | 19.07 | 10.61 | 0.0021 | cell adhesion |
AF040254 | OCX | 18.71 | 5.39 | 0.0099 | signal transduction |
NM_015385 | SORBS1 | 17.44 | 9.26 | 0.0003 | cytoskeleton/motility |
NM_012278 | ITGB1BP2 | 17.42 | 9.9 | 0.0018 | signal transduction |
NM_006101 | KNTC2 | 17.33 | 5.23 | 0.0022 | transcription factor |
NM_001845 | COL4A1 | 16.08 | 5.94 | 0.0029 | cytoskeleton/motility |
AF104857 | CDC42EP3 | 16.08 | 3.78 | 0.0002 | cytoskeleton/motility |
AW188131 | DDX17 | 15.65 | 9.11 | 0.0005 | translation factor |
NM_001057 | TACR2 | 15.6 | 4.51 | 0.0062 | signal transduction |
AI375002 | ZNF447 | 14.55 | 8.04 | 0.0061 | transcription factor |
NM_014890 | DOC1 | 14.35 | 5.19 | 0.0002 | proteolysis |
NM_001784 | CD97 | 13.16 | 6.35 | 0.00004 | signal transduction |
BF111821 | WSB1 | 12.34 | 7.36 | 0.0024 | signal transduction |
AW152664 | PNN | 12.19 | 8.26 | 0.003 | transcription factor |
NM_002380 | MATN2 | 11.86 | 5.62 | 0.0011 | extracellular matrix |
NM_007362 | NCBP2 | 11.38 | 8.04 | 0.0034 | RNA processing |
AK023406 | Macf1 | 8.8 | 4.77 | 0.0041 | ECM signaling |
AF095192 | BAG2 | 8.01 | 4.34 | 0.0018 | apoptosis |
NM_004196 | CDKL1 | 7.91 | 2.83 | 0.0017 | cell cycle |
BF512200 | MBNL2 | 7.58 | 3.01 | 0.0014 | muscle differentiaon |
AW043713 | Sulfl | 6.9 | 0.78 | 0.0039 | hydrolase activity |
NM_004781 | VAMP3 | 6.76 | 3.02 | 0.0016 | trafficking |
AI149535 | STAT5B | 5.62 | 3.94 | 0.0043 | transcription factor |
NM_016277 | RAB23 | 5.61 | 2.68 | 0.0055 | signal transduction |
AI582238 | TRA1 | 5.13 | 3.46 | 0.0042 | calcium ion binding |
NM_005722 | ACTR2 | 4.04 | 2.49 | 0.0001 | cytoskeleton/motility |
AF016005 | RERE | 4.02 | 2.87 | 0.008 | transcription factor |
AL046979 | TNS1 | 3.65 | 2.14 | 0.0047 | signal transduction |
NM_005757 | MBNL2 | 3.57 | 0.84 | 0.0049 | muscle development |
AJ133768 | LDB3 | 3.3 | 1.53 | 0.0056 | cytoskeleton/motility |
AI650819 | CUL4B | 3.04 | 1.59 | 0.0045 | metabolism |
AL031602 | MT1K | 0.61 | 0.33 | 0.0086 | cadmium ion binding |
U85658 | TFAP2C | 0.27 | 0.14 | 0.0083 | transcription factor |
NM_003790 | TNFRSF25 | 0.19 | 0.11 | 0.007 | apoptosis |
BC002495 | BAIAP2 | 0.18 | 0.11 | 0.0003 | signal transduction |
AV691491 | TMEM30B | 0.13 | 0.09 | 0.0093 | cell cycle control |
AI889941 | COL4A6 | 10.4 | 30.21 | 0.007 | extracellular matrix |
AW451711 | PBX1 | 14.44 | 18.14 | 0.0001 | transcription factor |
NM_014668 | GREB1 | 7.18 | 15.94 | 0.0089 | |
NM_004619 | TRAF5 | 6.47 | 11.46 | 0.0091 | signal transduction |
NM_005418 | ST5 | 5.83 | 8.1 | 0.0044 | signal transduction |
BC002811 | SUMO2 | 0.47 | 0.83 | 0.0035 | protein binding |
AV700891 | ETS2 | 0.28 | 0.54 | 0.0082 | transcription factor |
AB042557 | PDE4DIP | 0.2 | 0.39 | 0.0019 | signaling |
NM_014485 | PGDS | 0.17 | 0.31 | 0.0027 | catalytic activity |
AI984221 | COL5A3 | 0.08 | 0.17 | 0.0011 | extracellular matrix |
NM_006823 | PKIA | 0.08 | 0.17 | 0.0034 | Kinase regulator |
AU144284 | IRF6 | 0.04 | 0.15 | 0.0026 | transcription factor |
NM_000962 | PTGS1 | 0.06 | 0.11 | 0.0046 | catalytic activity |
NM_022898 | BCL11B | 0.05 | 0.09 | 0.0099 | transcription factor |
NM_001982 | ERBB3 | 0.02 | 0.06 | 0.0066 | signal transduction |
NM_002705 | PPL | 0.005 | 0.031 | 0.0073 | hydrolase activity |
NM_001630 | ANXA8 | 0.006 | 0.02 | 0.0079 | calcium ion binding |
N74607 | AQP3 | 0.006 | 0.02 | 0.0098 | transporter activity |
NM_000142 | FGFR3 | 0.007 | 0.009 | 0.01 | Growth factor |
Receptor |