Introduction
Subjects and methods
Study group
Anthropometric measurements
Tissue microarray (TMA) construction and immunohistochemistry
Statistical methods
Characteristics | Rest of cohort n = 27514 | CRC cases n = 584 |
p
| beta-catenin + n = 304 (61.0%) | beta- catenin – n = 194 (39.0%) |
p
| Cyclin D1+ n = 400 (80.3%) | Cyclin D1 –n = 98 (19.7%) |
p
| p53 + n = 241 (48.3%) | p53 – n = 258 (51.7%) |
p
| MSI n = 71 (14.6%) | MSS n = 416 (85.4%) |
p
|
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sex
|
<0.001
|
0.863
|
0.226
|
0.722
|
0.057
| ||||||||||
Male (%) | 10783 (39.2) | 280 (47.9) | 145 (47.7) | 91 (46.9) | 185 (46.2) | 52 (53.1) | 112 (46.5) | 124 (48.1) | 26 (36.6) | 203 (48.8) | |||||
Female (%) | 16731 (60.8) | 304 (52.1) | 159 (52.3) | 103 (53.1) | 215 (53.8) | 46 (46.9) | 129 (53.5) | 134 (51.9) | 45 (63.4) | 213 | |||||
Age at baseline (years)
| 58.0 | 61.8 | 61.9 | 62.0 | 62.3 | 60.2 | 61.5 | 62.3 | 64.4 | 61.5 | |||||
Male | 59.2 | 61.7 |
<0.001
| 61.5 | 62.1 |
0.430
| 61.9 | 60.5 |
0.204
| 61.2 | 62.0 |
0.452
| 64.6 | 61.2 |
0.029
|
Female | 57.3 | 62.1 |
<0.001
| 62.5 | 61.7 |
0.638
| 62.7 | 59.7 |
0.001
| 61.7 | 62.6 |
0.252
| 64.3 | 61.7 |
0.024
|
Smoking male (% )
|
0.104
|
0.749
|
0.371
|
0.199
|
0.793
| ||||||||||
Regularly | 2572 (25.5) | 53 (18.9) | 25 (17.2) | 17 (18.7) | 35 (18.9) | 8 (15.4) | 17 (15.2) | 24 (19.2) | 5 (19.2) | 38 (18.5) | |||||
Occasionally | 520 (4.8) | 12 (4.3) | 5 (3.4) | 3 (3.3) | 8 (4.3) | 0 | 5 (4.4) | 3 (2.4) | 1 (3.89 | 7 (3.4) | |||||
Former smoker | 4635 (43.0) | 145 (51.7) | 80 (55.2) | 44 (48.4) | 94 (51.4) | 31 (59.6) | 66 (58.9) | 60 (48.0) | 11 (42.3) | 107 (52.2) | |||||
Never smoker | 3046 (28.3) | 70 (25.0) | 35 (24.1) | 27 (29.7) | 48 (25.9) | 13 (25.0) | 24 (21.4) | 38 (30.4) | 9 (34.6) | 53 (25.9) | |||||
Smoking female (%)
|
0.652
|
0.592
|
0.972
|
0.009
|
0.694
| ||||||||||
Regularly | 4976 (29.8) | 71 (23.4) | 36 (22.6) | 25 (24.3) | 49 (22.8) | 11 (23.9) | 26 (20.2) | 35 (26.1) | 12 (26.7) | 47 (22.1) | |||||
Occasionally | 722 (4.3) | 8 (2.6) | 3 (1.9) | 4 (3.9) | 7 (3.2) | 1 (2.2) | 2 (1.6) | 6 (4.5) | 1 (2.2) | 7 (3.3) | |||||
Former smoke | 4637 (27.7) | 87 (28.6) | 41 (25.7) | 30 (29.1) | 57 (26.5) | 13 (28.3) | 27 (20.9) | 43 (32.1) | 9 (20.0) | 59 (27.7) | |||||
Never smoker | 7386 (44.2) | 138 (45.4) | 79 (49.7) | 44 (42.7) | 102 (47.4) | 21 (45.7) | 74 (57.4) | 50 (37.3) | 23 (51.1) | 100 (46.9) | |||||
Level of education male (%)
|
0.912
|
0.727
|
0.760
|
0.250
|
0.451
| ||||||||||
Not completed | 85 (0.8) | 2 (0.7) | 1 (0.7) | 0 | 1 (0.5) | 0 | 1 (0.9) | 0 | 0 | 1 (0.5) | |||||
6-8 years | 4852 (45.1) | 137 (48.9) | 76 (52.4) | 41 (45.1) | 93 (50.3) | 25 (48.1) | 57 (50.9) | 61 (48.8) | 13 (50.0) | 102 (49.8) | |||||
9-10 years | 2113 (19.6) | 55 (19.6) | 28 (19.3) | 21 (23.1) | 35 (18.9) | 14 (26.9) | 24 (21.4) | 25 (20.0) | 4 (15.4) | 44 (21.5) | |||||
10-12 years | 1279 (11.9) | 29 (10.4) | 16 (11.0) | 10 (11.0) | 21 (11.3) | 4 (7.7) | 7 (6.3) | 18 (14.4) | 6 (23.1) | 20 (9.8) | |||||
1 year university | 998 (9.3) | 19 (6.7) | 9 (6.2) | 5 (5.5) | 12 (6.5) | 2 (3.8) | 9 (8.0) | 5 (4.0) | 1 (3.8) | 13 (6.3) | |||||
University degree | 1424 (13.2) | 38 (13.6) | 15 (10.3) | 14 (15.4) | 23 (12.4) | 7 (13.5) | 14 (12.5) | 16 (12.8) | 2 (7.7) | 25 (12.2) | |||||
Level of education female (%)
|
0.009
|
0.019
|
0.796
|
0.496
|
0.316
| ||||||||||
Not completed | 126 (0.8) | 3 (1.0) | 1 (0.6) | 2 (1.9) | 3 (1.4) | 0 | 2 (1.6) | 1 (0.7) | 0 | 3 (1.4) | |||||
6-8 years | 6419 (38.5) | 150 (49.8) | 88 (56.4) | 48 (46.6) | 111 (52.4) | 22 (47.8) | 73 (56.6) | 61 (46.2) | 25 (55.6) | 105 (50.0) | |||||
9-10 years | 5086 (30.5) | 75 (24.9) | 27 (17.3) | 35 (34.0) | 52 (24.5) | 12 (26.1) | 26 (20.2) | 38 (28.8) | 13 (28.9) | 50 (23.8) | |||||
10-12 years | 1161 (7.0) | 22 (7.3) | 15 (9.6) | 3 (2.9) | 13 (6.1) | 5 (10.9) | 9 (7.0) | 9 (6.8) | 0 | 18 (8.6) | |||||
1 year university | 1399 (8.4) | 26 (8.6) | 13 (8.3) | 9 (8.7) | 18 (8.5) | 3 (6.5) | 9 (7.8) | 13 (9.8) | 5 (11.1) | 18 (8.6) | |||||
University degree | 2496 (15.0) | 25 (8.3) | 12 (7.7) | 6 (5.8) | 15 (7.0) | 4 (8.7) | 9 (7.0) | 10 (7.5) | 2 (4.4) | 16 (7.5) | |||||
Alcohol (g/day)
| |||||||||||||||
Male | 15.5 | 15.7 |
0.868
| 17.4 | 14.3 |
0.070
| 16.2 | 15.0 |
0.648
| 16.9 |
0.731
| 12.6 | 16.6 |
0.331
| |
Female | 7.7 | 6.2 |
0.002
| 6.3 | 5.8 |
0.583
| 6.0 | 6.7 |
0.968
| 6.2 | 5.9 |
0.626
| 4.6 | 6.2 |
0.310
|
Height (cm)
| |||||||||||||||
Male | 176.4 | 176.3 |
0.400
| 176.1 | 176.9 |
0.392
| 176.3 | 176.9 |
0.773
| 176.8 | 176.0 |
0.329
| 176.4 | 176.3 |
0.817
|
Female | 163.6 | 163.3 |
0.220
| 162.8 | 163.6 |
0.179
| 163.4 | 162.6 |
0.394
| 162.2 | 164.2 |
0.006
| 163.1 | 163.3 |
0.620
|
Weight (kg)
| |||||||||||||||
Male | 81.7 | 83.8 |
0.014
| 83.9 | 82.9 |
0.953
| 83.1 | 84.5 |
0.457
| 84.6 | 82.8 |
0.250
| 86.2 | 82.8 |
0.433
|
Female | 68.0 | 70.0 |
0.008
| 70.9 | 68.3 |
0.112
| 70.4 | 71.0 |
0.881
| 69.0 | 71.5 |
0.154
| 68.9 | 70.7 |
0.484
|
BMI (kg/m2)
| |||||||||||||||
Male | 26.2 | 26.9 |
<0.001
| 27.0 | 26.5 |
0.481
| 26.7 | 27.1 |
0.562
| 27.0 | 26.7 |
0.591
| 27.5 | 26.6 |
0.258
|
Female | 25.4 | 26.3 |
0.001
| 26.7 | 25.5 |
0.013
| 26.7 | 27.0 |
0.525
| 26.2 | 26.5 |
0.929
| 25.9 | 26.5 |
0.402
|
WHR (cm/cm)
| |||||||||||||||
Male | 0.94 | 0.95 |
0.021
| 0.95 | 0.94 |
0.027
| 0.95 | 0.95 |
0.676
| 0.95 | 0.95 |
0.482
| 0.94 | 0.95 |
0.889
|
Female | 0.80 | 0.80 |
0.490
| 0.80 | 0.80 |
0.779
| 0.79 | 0.81 |
0.098
| 0.80 | 0.79 |
0.338
| 0.79 | 0.80 |
0.779
|
Waist (cm)
| |||||||||||||||
Male | 94.0 | 96.3 |
<0.001
| 96.6 | 94.9 |
0.424
| 95.6 | 96.8 |
0.575
| 96.9 | 95.4 |
0.427
| 96.6 | 95.5 |
0.586
|
Female | 77.9 | 80.1 |
0.001
| 80.9 | 78.8 |
0.215
| 79.9 | 81.9 |
0.299
| 79.9 | 80.7 |
0.839
| 79.0 | 80.6 |
0.494
|
Hip (cm)
| |||||||||||||||
Male | 99.4 | 101.2 |
<0.001
| 101.0 | 101.0 |
0.602
| 100.8 | 101.6 |
0.687
| 101.7 | 100.7 |
0.391
| 102.2 | 100.8 |
0.554
|
Female | 97.8 | 100.2 |
<0.001
| 101.2 | 98.8 |
0.091
| 100.4 | 101.0 |
0.872
| 99.5 | 101.4 |
0.287
| 99.6 | 100.9 |
0.380
|
Results
Distribution of risk factors in cases and rest of cohort
Hazard ratios of CRC risk defined by different tumour characteristics in women
Tumour characteristics | Quartiles | Height | Weight | Hip | |||
---|---|---|---|---|---|---|---|
Number of cases | Cases | RR | Cases | RR | Cases | RR | |
Positive nuclear beta-catenin | 1 | 31 | 1.00 | 22 | 1.00 | 19 | 1.00 |
2 | 56 | 1.34(0.86-2.08) | 39 | 1.50(0.89-2.52) | 38 | 1.41(0.81-2.46) | |
3 | 39 | 1.32(0.82-2.13) | 46 | 2.04(1.22-3.41) | 37 | 1.28(0.73-2.26) | |
4 | 32 | 1.17(0.70-1.96) | 51 | 1.87(1.12-3.10) | 64 | 1.93(1.14-3.26) | |
p trend | 0.593 | 0.010 | 0.014 | ||||
Negative nuclear beta-catenin | 1 | 20 | 1.00 | 19 | 1.00 | 21 | 1.00 |
2 | 30 | 1.13(0.64-2.00) | 32 | 1.46(0.82-2.57) | 21 | 0.72(0.39-1.32) | |
3 | 26 | 1.33(0.74-2.40) | 22 | 1.17(0.63-2.17) | 30 | 1.03(0.58-1.81) | |
4 | 27 | 1.56(0.86-2.84) | 30 | 1.31(0.73-2.33) | 31 | 0.88(0.50-1.55) | |
p trend | 0.113 | 0.599 | 0.985 | ||||
CyclinD1 positive | 1 | 39 | 1.00 | 35 | 1.00 | 34 | 1.00 |
2 | 70 | 1.36(0.92-2.02) | 54 | 1.32(0.86-2.02) | 45 | 0.92(0.59-1.44) | |
3 | 53 | 1.47(0.97-2.23) | 56 | 1.57(1.03-2.41) | 57 | 1.11(0.72-1.70) | |
4 | 52 | 1.62(1.05-2.49) | 69 | 1.60(1.06-2.42) | 78 | 1.28(0.85-1.93) | |
p trend | 0.031 | 0.019 | 0.110 | ||||
CyclinD1 negative | 1 | 12 | 1.00 | 6 | 1.00 | 6 | 1.00 |
2 | 14 | 0.80(0.37-1.73) | 12 | 1.70(0.63-4.54) | 11 | 1.42(0.52-3.85) | |
3 | 12 | 0.89(0.39-1.99) | 14 | 2.38(0.91-6.22) | 11 | 1.49(0.55-4.07) | |
4 | 8 | 0.61(0.24-1.53) | 14 | 1.96(0.75-5.12) | 18 | 2.13(0.83-5.48) | |
p trend | 0.365 | 0.155 | 0.103 | ||||
p53 positive (>50%) | 1 | 30 | 1.00 | 25 | 1.00 | 19 | 1.00 |
2 | 46 | 1.16(0.73-1.84) | 32 | 1.07(0.63-1.80) | 32 | 1.19(0.67-2.10) | |
3 | 32 | 1.10(0.67-1.83) | 34 | 1.31(0.77-2.20) | 34 | 1.19(0.67-2.10) | |
4 | 21 | 0.78(0.43-1.39) | 38 | 1.21(0.72-2.00) | 44 | 1.31(0.76-2.28) | |
p trend | 0.431 | 0.370 | 0.364 | ||||
P53 negative (<50%) | 1 | 25 | 1.00 | 16 | 1.00 | 21 | 1.00 |
2 | 40 | 1.39(0.82-2.37) | 35 | 1.92(1.06-3.47) | 25 | 0.85(0.48-1.53) | |
3 | 33 | 1.64(0.94-2.84) | 37 | 2.36(1.31-4.26) | 35 | 1.18(0.68-2.04) | |
4 | 39 | 2.17(1.25-3.76)* | 45 | 2.36(1.33-4.21) | 52 | 1.47(0.87-2.47) | |
p trend | 0.004 | 0.004 | 0.042 | ||||
MSI | 1 | 11 | 1.00 | 8 | 1.00 | 9 | 1.00 |
2 | 14 | 1.01(0.46-2.23) | 12 | 1.35(0.55-3.13) | 9 | 0.68(2.271.71) | |
3 | 9 | 0.96(0.39-2.33) | 11 | 1.49(0.60-3.71) | 13 | 0.9(0.40-2.21) | |
4 | 11 | 1.43(0.61-3.38) | 14 | 1.49(0.62-3.59) | 14 | 0.81(0.34-1.90) | |
p trend | 0.477 | 0.387 | 0.864 | ||||
MSS | 1 | 41 | 1.00 | 30 | 1.00 | 27 | 1.00 |
2 | 67 | 1.20(0.81-1.78) | 58 | 1.64(0.05-2.55) | 50 | 1.33(0.83-2.13) | |
3 | 56 | 1.39(0.92-2.09) | 55 | 1.79(1.14-2.80) | 52 | 1.34(0.84-2.13) | |
4 | 48 | 1.28(0.83-1.97) | 69 | 1.87(1.21-2.88) | 83 | 1.85(1.18-2.88) | |
p trend | 0.203 | 0.008 | 0.005 |
Tumour characteristics | Quartiles | BMI | WHR | Waist | |||
---|---|---|---|---|---|---|---|
Number of cases | Cases | RR | Cases | RR | Cases | RR | |
Positive nuclear beta-catenin | 1 | 20 | 1.00 | 43 | 1.00 | 23 | 1.00 |
2 | 40 | 1.73(1.00-2.97) | 29 | 0.83(0.52-1.34) | 33 | 0.97(0.57-1.67) | |
3 | 43 | 1.79(1.05-3.05) | 40 | 0.92(0.59-1.43) | 51 | 1.40(0.85-2.30) | |
4 | 55 | 2.25(1.33-3.80)* | 46 | 1.20(0.79-1.84) | 51 | 1.36(0.82-2.25) | |
p trend | 0.004 | 0.366 | 0.097 | ||||
Negative nuclear beta-catenin | 1 | 22 | 1.00 | 24 | 1.00 | 16 | 1.00 |
2 | 29 | 1.20(0.69-2.09) | 25 | 1.21(0.69-2.12) | 25 | 1.16(0.62-2.18) | |
3 | 28 | 1.06(0.60-1.87) | 32 | 1.31(0.77-2.22) | 37 | 1.51(0.84-2.73) | |
4 | 24 | 0.89(0.49-1.61) | 22 | 0.97(0.54-1.74) | 25 | 1.00(0.53-1.90) | |
p trend | 0.588 | 0.952 | 0.860 | ||||
CyclinD1 positive | 1 | 35 | 1.00 | 55 | 1.00 | 31 | 1.00 |
2 | 53 | 1.31(0.85-2.02) | 48 | 1.07(0.72-1.58) | 49 | 1.09(0.69-1.72) | |
3 | 61 | 1.42(0.94-2.17) | 62 | 1.12(0.77-1.62) | 75 | 1.51(0.99-2.31) | |
4 | 65 | 1.48(0.97-2.25) | 49 | 0.98(0.66-1.45) | 59 | 1.14(0.73-1.78) | |
p trend | 0.076 | 0.997 | 0.357 | ||||
CyclinD1 negative | 1 | 7 | 1.00 | 10 | 1.00 | 8 | 1.00 |
2 | 12 | 1.64(0.64-4.20) | 7 | 0.80(0.31-2.11) | 7 | 0.69(0.25-1.90) | |
3 | 9 | 1.19(0.44-3.23) | 12 | 1.18(0.51-2.74) | 12 | 1.08(0.44-2.66) | |
4 | 18 | 2.46(1.00-6.02) | 17 | 1.92(0.87-4.22) | 19 | 1.81(0.78-4.21) | |
p trend | 0.071 | 0.066 | 0.063 | ||||
p53 positive (>50%) | 1 | 19 | 1.00 | 30 | 1.00 | 21 | 1.00 |
2 | 33 | 1.51(0.85-2.67) | 27 | 1.10(0.65-1.86) | 27 | 0.89(0.50-1.59) | |
3 | 38 | 1.63(0.93-2.84) | 35 | 1.20(0.73-1.96) | 40 | 1.20(0.70-2.05) | |
4 | 39 | 1.65(0.94-2.89) | 37 | 1.41(0.87-2.31) | 41 | 1.23(0.72-2.10) | |
p trend | 0.103 | 0.158 | 0.248 | ||||
P53 negative(<50%) | 1 | 23 | 1.00 | 35 | 1.00 | 18 | 1.00 |
2 | 33 | 1.29(0.75-2.21) | 28 | 0.96(0.58-1.58) | 29 | 1.16(0.64-2.09) | |
3 | 33 | 1.23(0.72-2.11) | 39 | 1.08(0.68-1.71) | 49 | 1.77(1.03-3.06) | |
4 | 44 | 1.61(0.96-2.71) | 31 | 0.95(0.58-1.54) | 37 | 1.28(0.72-2.27) | |
p trend | 0.091 | 0.953 | 0.236 | ||||
MSI | 1 | 10 | 1.00 | 11 | 1.00 | 6 | 1.00 |
2 | 9 | 0.79(0.32-1.95) | 10 | 1.08(0.46-2.55) | 13 | 1.53(0.58-4.05) | |
3 | 14 | 1.09(0.48-2.48) | 14 | 1.22(0.56-2.70) | 16 | 1.59(0.62-4.10) | |
4 | 12 | 0.91(0.39-2.25) | 10 | 0.96(0.41-2.27) | 10 | 0.95(0.34-2.65) | |
p trend | 0.972 | 0.971 | 0.765 | ||||
MSS | 1 | 31 | 1.00 | 57 | 1.00 | 33 | 1.00 |
2 | 56 | 1.60(1.03-2.50) | 44 | 0.94(0.63-1.40) | 43 | 0.92(0.58-1.46) | |
3 | 55 | 1.51(0.97-2.36) | 55 | 0.96(0.66-1.40) | 69 | 1.37(0.90-2.08) | |
4 | 70 | 1.90(1.23-2.93) | 56 | 1.10(0.76-1.60) | 67 | 1.31(0.85-2.00) | |
p trend | 0.009 | 0.625 | 0.065 |
Hazard ratios of CRC risk defined by different tumour characteristics in men
Tumour characteristics | Quartiles | Height | Weight | Hip | |||
---|---|---|---|---|---|---|---|
Number of cases | Cases | RR | Cases | RR | Cases | RR | |
Positive nuclear beta-catenin | 1 | 40 | 1.00 | 29 | 1.00 | 26 | 1.00 |
2 | 36 | 0.97(0.61-1.55) | 42 | 1.41(0.86-2.29) | 33 | 1.28(0.76-2.18) | |
3 | 33 | 0.71(0.44-1.14) | 35 | 1.15(0.69-1.93) | 45 | 1.55(0.93-2.57) | |
4 | 42 | 1.15(0.73-1.81) | 45 | 1.53(0.94-2.49) | 47 | 1.39(0.84-2.30) | |
p trend | 0.877 | 0.180 | 0.182 | ||||
Negative nuclear beta-catenin | 1 | 14 | 1.00 | 19 | 1.00 | 17 | 1.00 |
2 | 26 | 2.13(1.09-4.16) | 19 | 1.02(0.53-1.94) | 11 | 0.65(0.30-1.40) | |
3 | 32 | 1.94(1.00-3.75) | 26 | 1.31(0.71-2.43) | 33 | 1.87(1.02-3.42) | |
4 | 27 | 1.90(0.96-3.79) | 35 | 1.70(0.94-3.07) | 38 | 1.46(0.79-2.70) | |
p trend | 0.122 | 0.048 | 0.036 | ||||
CyclinD1 positive | 1 | 45 | 1.00 | 40 | 1.00 | 36 | 1.00 |
2 | 46 | 1.16(0.76-1.77) | 49 | 1.23(0.80-1.89) | 32 | 0.91(0.56-1.48) | |
3 | 53 | 1.02(0.67-1.54) | 44 | 1.08(0.69-1.68) | 61 | 1.57(1.02-2.41) | |
4 | 52 | 1.25(0.82-1.90) | 63 | 1.57(1.04-2.39) | 67 | 1.38(0.90-2.12) | |
p trend | 0.442 | 0.058 | 0.034 | ||||
CyclinD1 negative | 1 | 10 | 1.00 | 8 | 1.00 | 7 | 1.00 |
2 | 15 | 1.48(0.66-3.34) | 12 | 1.39(0.57-3.42) | 12 | 1.65(0.65-4.21) | |
3 | 13 | 1.00(0.43-2.32) | 17 | 1.85(0.79-4.34) | 16 | 2.12(0.87-5.18) | |
4 | 17 | 1.52(0.68-3.43) | 18 | 1.78(0.76-4.22) | 20 | 1.90(0.78-4.62) | |
p trend | 0.513 | 0.151 | 0.159 | ||||
p53 positive (>50%) | 1 | 22 | 1.00 | 20 | 1.00 | 15 | 1.00 |
2 | 32 | 1.64(0.93-2.90) | 26 | 1.27(0.70-2.30) | 22 | 1.48(0.76-2.90) | |
3 | 32 | 1.31(0.74-2.31) | 33 | 1.42(0.79-2.54) | 38 | 2.29(1.23-4.26) | |
4 | 33 | 1.65(0.93-2.92) | 40 | 1.85(1.06-3.23) | 44 | 2.12(1.14-3.92) | |
p trend | 0.191 | 0.026 | 0.009 | ||||
P53 negative (<50%) | 1 | 32 | 1.00 | 27 | 1.00 | 27 | 1.00 |
2 | 30 | 1.02(0.62-1.70) | 36 | 1.33(0.79-2.22) | 22 | 0.82(0.46-1.46) | |
3 | 33 | 0.84(0.51-1.39) | 27 | 1.06(0.61-1.83) | 39 | 1.36(0.82-2.27) | |
4 | 36 | 1.13(0.68-1.87) | 41 | 1.48(0.88-2.48) | 43 | 1.15(0.69-1.91) | |
p trend | 0.845 | 0.251 | 0.288 | ||||
MSI | 1 | 5 | 1.00 | 4 | 1.00 | 5 | 1.00 |
2 | 9 | 2.07(0.69-6.20) | 7 | 1.76(0.51-6.05) | 5 | 0.94(0.27-3.26) | |
3 | 5 | 0.98(0.28-3.42) | 7 | 1.91(0.55-6.60) | 6 | 1.06(0.32-3.51) | |
4 | 8 | 1.79(0.55-5.77) | 9 | 2.36(0.70-7.96) | 11 | 1.45(0.49-4.32) | |
p trend | 0.630 | 0.176 | 0.431 | ||||
MSS | 1 | 48 | 1.00 | 46 | 1.00 | 39 | 1.00 |
2 | 51 | 1.16(0.77-1.74) | 51 | 1.09(0.73-1.65) | 39 | 1.03(0.65-1.61) | |
3 | 59 | 1.02(0.69-1.53) | 52 | 1.07(0.71-1.62) | 64 | 1.54(1.02-2.33) | |
4 | 58 | 1.25(0.83-1.87) | 67 | 1.38(0.93-2.05) | 74 | 1.40(0.93-2.11) | |
p trend | 0.411 | 0.126 | 0.038 |
Tumour characteristics | Quartiles | BMI | WHR | Waist | |||
---|---|---|---|---|---|---|---|
Number of cases | Cases | HR | Cases | HR | Cases | HR | |
Positive nuclear beta-catenin | 1 | 33 | 1.00 | 29 | 1.00 | 26 | 1.00 |
2 | 31 | 0.90(0.54-1.48) | 28 | 1.21(0.71-2.08) | 27 | 0.90(0.52-1.56) | |
3 | 37 | 0.97(0.60-1.59) | 43 | 1.60(0.99-2.59) | 47 | 1.36(0.84-2.23) | |
4 | 50 | 1.52(0.96-2.41) | 51 | 2.14(1.34-3.42)* | 51 | 1.66(1.02-2.69) | |
p trend | 0.050 | 0.001 | 0.009 | ||||
Negative nuclear beta-catenin | 1 | 25 | 1.00 | 30 | 1.00 | 21 | 1.00 |
2 | 15 | 0.57(0.29-1.10) | 18 | 0.78(0.43-1.45) | 11 | 0.43(0.20-0.91) | |
3 | 21 | 0.72(0.39-1.33) | 26 | 0.98(0.57-1.68) | 33 | 1.21(0.69-2.12) | |
4 | 38 | 1.51(0.86-2.57) | 25 | 0.96(0.54-1.69) | 34 | 1.27(0.72-2.23) | |
p trend | 0.074 | 0.993 | 0.076 | ||||
CyclinD1 positive | 1 | 47 | 1.00 | 45 | 1.00 | 39 | 1.00 |
2 | 33 | 0.69(0.44-1.09) | 39 | 1.13(0.72-1.77) | 29 | 0.62(0.38-1.02) | |
3 | 50 | 0.93(0.61-1.42) | 54 | 1.33(0.89-2.00) | 63 | 1.22(0.80-1.84) | |
4 | 66 | 1.46(0.99-2.16) | 58 | 1.61(1.08-1.42) | 65 | 1.40(0.93-2.10) | |
p trend | 0.019 | 0.015 | 0.009 | ||||
CyclinD1 negative | 1 | 11 | 1.00 | 14 | 1.00 | 8 | 1.00 |
2 | 12 | 0.95(0.41-2.19) | 6 | 0.48(0.17-1.32) | 9 | 1.02(0.39-2.64) | |
3 | 10 | 0.78(0.33-1.86) | 17 | 1.28(0.63-2.61) | 17 | 1.64(0.70-3.84) | |
4 | 22 | 1.75(0.83-3.71) | 18 | 1.32(0.63-2.72) | 21 | 2.01(0.87-4.64) | |
p trend | 0.146 | 0.211 | 0.046 | ||||
p53 positive (>50%) | 1 | 23 | 1.00 | 25 | 1.00 | 16 | 1.00 |
2 | 22 | 0.89(0.49-1.62) | 24 | 1.18(0.66-2.12) | 21 | 1.05(0.54-2.04) | |
3 | 32 | 1.17(0.67-2.04) | 33 | 1.43(0.84-2.44) | 41 | 1.85(1.02-3.33) | |
4 | 42 | 1.69(0.99-2.88) | 37 | 1.72(1.02-2.91) | 41 | 2.05(1.14-3.68) | |
p trend | 0.023 | 0.033 | 0.003 | ||||
P53 negative (<50%) | 1 | 34 | 1.00 | 32 | 1.00 | 30 | 1.00 |
2 | 23 | 0.65(0.38-1.13) | 22 | 0.91(0.52-1.59) | 16 | 0.48(0.26-0.89) | |
3 | 28 | 0.73(0.43-1.24) | 38 | 1.33(0.82-2.15) | 40 | 1.05(0.64-1.71) | |
4 | 46 | 1.44(0.90-2.30) | 39 | 1.52(0.93-2.47) | 45 | 1.25(0.76-2.03) | |
p trend | 0.084 | 0.048 | 0.070 | ||||
MSI | 1 | 5 | 1.00 | 6 | 1.00 | 5 | 1.00 |
2 | 5 | 0.98(0.28-3.42) | 5 | 1.27(0.39-4.18) | 4 | 0.73(0.20-2.72) | |
3 | 6 | 0.95(0.27-3.34) | 9 | 1.82(0.64-5.15) | 9 | 1.58(0.53-4.75) | |
4 | 11 | 2.47(0.84-7.26) | 7 | 1.52(0.48-4.80) | 9 | 1.50(0.49-4.65) | |
p trend | 0.082 | 0.344 | 0.272 | ||||
MSS | 1 | 53 | 1.00 | 55 | 1.00 | 43 | 1.00 |
2 | 40 | 0.72(0.47-1.10) | 40 | 0.90(0.59-1.39) | 34 | 0.67(0.42-1.06) | |
3 | 50 | 0.84(0.56-1.25) | 58 | 1.14(0.78-1.67) | 67 | 1.16(0.78-1.73) | |
4 | 73 | 1.37(0.95-1.99) | 63 | 1.36(0.93-1.98) | 72 | 1.39(0.94-2.05) | |
p trend | 0.053 | 0.071 | 0.012 |