Background
Methods
Study population and acquisition protocols
Controls (35) | Patients (18) | p value | |
---|---|---|---|
Age (years) | 38 ± 16 | 75 ± 13 | <0.0001 |
Gender | 14 ♂/21 ♀ | 8 ♂/10 ♀ | |
Echocardiographic measurements
| |||
Ejection fraction (%) | 65 ± 6 | 66 ± 7 | 0.52 |
End-diastolic diameter (mm) | 47 ± 4 | 45 ± 6 | 0.15 |
End-systolic diameter (mm) | 31 ± 5 | 27 ± 6 | 0.01 |
Diastolic septal thickness (mm) | 8.2 ± 1.3 | 12.2 ± 2.7 | <0.0001 |
Diastolic posterior wall thickness (mm) | 8.3 ± 1.1 | 11.2 ± 2.3 | <0.0001 |
Lateral mitral annulus systolic (S') velocity (cm/s) | 11.3 ± 2.2 | 8.0 ± 2.1 | <0.0001 |
Aortic valve area/Body surface area (cm2/m2) | 0.51 ± 0.15 | ||
Mean aortic gradient (mmHg) | 51 ± 20 | ||
CMR measurements
| |||
Ejection fraction (%) | 64 ± 5 | 67 ± 14 | 0.06 |
End-diastolic Volume (ml) | 128 ± 33 | 101 ± 28 | 0.0009 |
End-systolic Volume (ml) | 46 ± 13 | 35 ± 19 | 0.004 |
LV mass/End-diastolic Volume (g/ml) | 0.96 ± 0.25 | 1.61 ± 0.55 | <0.0001 |
LV mass/Body surface area (g/m2) | 65 ± 10 | 89 ± 30 | 0.0002 |
Semi-automated segmentation of blood flow velocity images
Blood flow functional parameters
Semi-automated detection of the myocardial velocity profiles
Myocardial longitudinal velocities
Evaluation of inter-operator variability
Statistical analysis
Results
Inter-operator variability | |
---|---|
EMR | 0.14 ± 0.75% |
AMR | 0.11 ± 0.60% |
E'MR | 4.25 ± 5.89% |
DTMR | 1.96 ± 2.95% |
EfMR | 0.14 ± 0.49% |
AfMR | 0.41 ± 1.44% |
FVMR | 0.34 ± 0.81% |
Echocardiographic and CMR diastolic parameters
Controls | Patients | p value | |
---|---|---|---|
Echocardiographic measurements | |||
EUS/AUS | 1.39 ± 0.60 | 0.76 ± 0.27 | <0.0001 |
DTUS (ms) | 180 ± 56 | 261 ± 59 | 0.0001 |
E'US (cm/s) | 15.7 ± 4.2 | 8.0 ± 2.5 | <0.0001 |
EUS/E'US | 5.3 ± 1.8 | 11.8 ± 7.6 | <0.0001 |
CMR measurements
| |||
EMR/AMR | 1.33 ± 0.40 | 0.74 ± 0.27 | <0.0001 |
EfMR/AfMR | 1.44 ± 0.58 | 0.54 ± 0.23 | <0.0001 |
EfMR/FVMR (s-1) | 4.26 ± 0.93 | 2.55 ± 0.61 | <0.0001 |
DTMR (ms) | 185 ± 35 | 260 ± 40 | <0.0001 |
E'MR (cm/s) | 11.3 ± 3.5 | 7.3 ± 1.6 | <0.0002 |
EMR/E'MR | 5.3 ± 1.3 | 8.2 ± 2.5 | <0.0002 |
IVRTMR (ms) | 78 ± 29 | 94 ± 35 | 0.1 |
Abnormality detection
Sensitivity | Specificity | NPV | PPV | Accuracy | ROC threshold | AUC | |
---|---|---|---|---|---|---|---|
Echocardiographic measurements | |||||||
EUS/AUS | 0.78 | 0.94 | 0.88 | 0.89 | 0.89 | 0.77 | 0.89 |
DTUS (ms) | 0.83 | 0.76 | 0.65 | 0.90 | 0.79 | 212 | 0.84 |
EUS/E'US | 0.89 | 0.83 | 0.73 | 0.94 | 0.85 | 6.23 | 0.88 |
CMR measurements
| |||||||
EMR/AMR | 0.83 | 0.89 | 0.79 | 0.91 | 0.87 | 0.86 | 0.91 |
EfMR/AfMR | 0.83 | 0.91 | 0.83 | 0.91 | 0.89 | 0.71 | 0.95 |
EfMR/FVMR (s-1) | 0.89 | 0.91 | 0.84 | 0.94 | 0.91 | 3.17 | 0.95 |
DTMR (ms) | 0.94 | 0.80 | 0.71 | 0.97 | 0.85 | 200 | 0.92 |
EMR/E'MR | 0.80 | 0.87 | 0.75 | 0.90 | 0.85 | 6.5 | 0.84 |