Background
Methods
Study population
CMR protocol
Image and data analyses
Statistical methods
Results
Patient characteristics and CMR parameters
Mean (Range or % Patients) | |
---|---|
Age (years)
| 45 (25–59) |
Women
| 4 (17) |
BMI
*
(kg/m
2
)
| 26 (14–47) |
Maximum hypertrophy (mm)
| 23 (16–32) |
# Hypertrophied segments ≥ 15 mm
| 4.5 (2–9) |
Presence SAM
‡
| 13 (62) |
Presence MR
§
| 13 (57) |
Presence LGE
||
| 20 (83) |
LV EF
¶
(%)
| 66 (58–81) |
LVEDV
#
(mL)
| 160 (56–285) |
LVEDVI
**
(mL/m
2
)
| 80 (43–134) |
Presence LA
†
dilation
| 14 (70) |
Late gadolinium enhancement
AVJ motion analysis
Median | 25thpercentile | 75thpercentile | Median | 25thpercentile | 75thpercentile | P | |
---|---|---|---|---|---|---|---|
Lateral AVJ
*
|
Control
|
HCM
‡
| |||||
MD
§
| -0.149 | -0.165 | -0.125 | -0.107 | -0.121 | -0.083 | <0.001 |
MVED
||
(s
-1
)
| 1.082 | 0.854 | 1.343 | 0.506 | 0.395 | 0.634 | <0.001 |
VDS
¶
(s
-1
)
| 0.012 | -0.008 | 0.037 | 0.067 | 0.047 | 0.078 | <0.001 |
VDS/MVED
| 0.009 | -0.006 | 0.037 | 0.141 | 0.073 | 0.166 | <0.001 |
Septal AVJ
|
Control
|
HCM
| |||||
MD
| -0.149 | -0.173 | -0.130 | -0.116 | -0.130 | -0.100 | <0.001 |
MVED (s
-1
)
| 0.947 | 0.628 | 1.033 | 0.537 | 0.406 | 0.635 | 0.001 |
VDS (s
-1
)
| 0.027 | 0.004 | 0.060 | 0.074 | 0.040 | 0.109 | 0.006 |
VDS/MVED
| 0.029 | 0.004 | 0.056 | 0.126 | 0.090 | 0.249 | <0.001 |
Lateral | P | P |
---|---|---|
AVJ* | HCM‡LGE§+ | HCM LGE- |
vs | vs | |
Healthy Volunteers | Healthy Volunteers | |
MD
||
| <0.001 | NS |
MVED
¶
(s
-1
)
| <0.001 | 0.001 |
VDS
#
(s
-1
)
| <0.001 | 0.003 |
VDS/MVED
| <0.001 | 0.001 |
Septal
|
P
|
P
|
AVJ
|
HCM LGE+
|
HCM LGE-
|
vs
|
vs
| |
Healthy Volunteers
|
Healthy Volunteers
| |
MD
| <0.001 | NS |
MVED (s
-1
)
| 0.001 | 0.032 |
VDS (s
-1
)
| 0.005 | 0.045 |
VDS/MVED
| <0.001 | 0.023 |