Introduction
Materials and methods
Immunohistochemistry
Statistical analysis
Results
Characteristics | n (%) |
---|---|
Age (mean ± SD, range) (years)
| 60.3 ± 9.7, 42-74 |
Gender
| |
Female | 8 (24) |
Male | 26 (76) |
Operation
| |
Total Gastrectomy | 13 (47) |
Subtotal Gastrectomy | 21 (53) |
Localization
| |
Cardia | 10 (29) |
Fundus/body | 6 (18) |
Antrum | 13 (38) |
Major curvatura | 5 (15) |
Lauren classification
| |
Intestinal | 24 (71) |
Diffuse | 10 (29) |
Depth of invasion
| |
T1 | 1 (3) |
T2 | 2 (6) |
T3 | 28 (82) |
T4 | 3 (9) |
Lymph node metastasis
| |
N0 | 2 (6) |
N1 | 18 (53) |
N2 | 8 (24) |
N3 | 6 (18) |
Venous invasion
| 12 (35) |
Lymphatic invasion
| 26 (76) |
Perineural invasion
| 24 (71) |
Stage
| |
I | 1 (3) |
II | 1 (3) |
III | 24 (71) |
IV | 8 (23) |
DFS (mean ± sd, months) | 38 ± 3 (32-44) |
OS (mean ± sd, months) | 42 ± 4 (38-50) |
Clinical status
| |
NED | 25 (74) |
Death | 8 (24) |
With disease | 1 (2) |
Plakophilin expression (mean ± sd) (range)* | Gastric cancer n = 34 | Controls n = 20 | p-value** |
---|---|---|---|
PKP1 | 3.42 ± 2.55 (0-6) | 3.60 ± 2.55 (0-6) | 0.628 |
PKP2 | 2.06 ± 2.02 (0-6) | 5.60 ± 0.50 (5-6) | 0.0000001 |
PKP3 | 2.44 ± 2.50 (0-6) | 5.00 ± 1.86 (0-6) | 0.0001 |
Immunohistochemistry | Lymph node status (n = 32 cases) | |||
---|---|---|---|---|
N0 | N1 | N2 | N3 | |
0-4 | 7 | 6 | 6 | |
5-6 | 1 | 10 | 2 |
Immunohistochemistry Staining (n = 32 cases) | Stage III | Stage IV |
---|---|---|
0-4 | 11 | 8 |
5-6 | 13 | 0 |