Background
Study
|
Patients (n)
|
Recurrence (%)
|
Disturbance in anal continence (%)
|
---|---|---|---|
Aguilar [1] | 189 | 0.01 | 0 |
Bennett [2] | 108 | 2 | 36 |
Hill [3] | 626 | 1 | 4 |
Koscinski [4] | 55 | 6 | 0 |
Khubchandani [5] | 137 | 5.8 | - |
Lilius [6] | 150 | 5.5 | 13.5 |
Marks and Ritchie [7] | 793 | - | 17-31 |
Mazier[8] | 1000 | 3.9 | 0.01 |
McElwain [9] | 1000 | 3.6 | 7-3.2 |
Parks and Stitz [10] | 400 | 9 | - |
Pearl [11] | 1732 | 1.8 | - |
Methods of meta-analysis
Search methods for identification of studies
Data Extraction
Inclusion Criteria
Exclusion Criteria
Outcomes of Interest
Methodological quality
Assessment of the methodological quality of the studies
Measures of treatment effect
Assessment of heterogeneity
Statistical Analysis
Results
Eligible Studies
Study
|
Patients
|
Treatment
|
Outcomes
|
---|---|---|---|
Greco [18] | 77 trans sphincteric anal fistulas | 32 surgical treatments (cutting seton) vs. 45 fibrin glue | Clinical healing |
Lindsey [19] | 13 simple fistulas (low fistulas) and 29 complex fistulas | 23 surgical treatments (fistulotomy) vs. 19 fibrin glue | Clinical healing |
Results from analysis
Subgroup analysis
-
Fibrin glue in combination with intra-adhesive antibiotics vs. fibrin glue alone.
-
Anal fistula plug vs. fibrin glue.
Fibrin glue in combination with intra-adhesive antibiotics vs. fibrin glue alone
Inclusion Criteria of subgroup analysis
Eligible Studies for subgroup analysis
Anal fistula plug vs. fibrin glue
Inclusion Criteria of subgroup analysis
Eligible Studies for subgroup analysis
Discussion
Cryptoglandular | Crohn's disease | HIV | Rectovaginal | Ileal-pouch anal anastomosis | |
---|---|---|---|---|---|
Abel [12] | 2/3 (66%) | 1/3 (33%) | |||
Sentovich [15] | 25/36 (70%) | 4/5 (80%) | |||
Loungnarath [16] | 5/22 (23%) | 4/13 (31%) | 1/3 (33%) | 3/4 (75%) | |
Lindsey [19] | 10/17 (59%) | 2/2 (100%) | |||
Cintron [20] | 44/68 (65%) | 2/6 (33%) | 1/2 (50%) | 1/3 (33%) | |
Venkatesh [26] | 12/15 (80%) | 0/6 (0%) | |||
Patrij [27] | 51/69 (74%) | ||||
Zmora [28] | 2/10 (20%) | 2/5 | 2/4 (50%) | ||
Total | 154/240 (64%) | 13/37 (35%) | 1/2 (50%) | 2/6 (33%) | 5/8 (63%) |
Complex only | Simple and complex | |||
---|---|---|---|---|
Healed
|
Not healed
|
Healed
|
Not healed
| |
Abel [12] | 6 | 4 | ||
Sentovich [15] | 33 | 15 | ||
Loungnarath [16] | 12 | 27 | ||
Lindsey [19] | 9 | 13 | ||
Cintron [20] | 48 | 31 | ||
Zmora [23] | 32 | 28 | ||
Tinay [24] | 19 | 25 | ||
Buchanan [25] | 3 | 19 | ||
Venkatesh [26] | 18 | 12 | ||
Patrij [27] | 51 | 18 | ||
Zmora [28] | 8 | 16 | ||
Total | 88 (42.5%) | 119 (57.5%) | 151 (63%) | 89 (37%) |