Findings
Background
Methods
Patients
Age | Sex | Eye | Treatment before strating rebamipide eyedrop | Blepharitis | BUT | |
---|---|---|---|---|---|---|
Case 1 | 21 | Male | Right | None | - | 2 sec |
Left | - | 2 sec | ||||
Case 2 | 15 | Male | Right | Olopatadine (0.1%, 4/day) and a topical antibacterial agent (chloramphenicol plus colistin, 4/day) | + | 4 sec |
Left | + | 3 sec | ||||
Case 3 | 31 | Male | Right | None | - | 3 sec |
Case 4 | 49 | Female | Left | A systemic anti-allergic agent (epinastine), topical olopatadine (0.1%, 4/day), and a topical antibacterial agent (gatifloxacin, 4/day) | + | 2 sec |
Collection of tears
Measurement of IL-8, total IgE and ECP in the tears
Statistical analysis of the reduction in IL-8, total IgE, and ECP
Analysis of changes in subjective symptoms
Results
Reduction in IL-8
Reduction in ECP
Reduction in total IgE
Improvement of subjective symptoms (itching, foreign body sensation and eye mucus)
Itching | Foreign body sensation | Eye mucus | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Pre | 2 w | 4 ~ 6 w | Pre | 2 w | 4 ~ 6 w | Pre | 2 w | 4 ~ 6 w | ||
Case 1 | R | 6 | 3 | 2 | 4 | 0 | 1 | 7 | 3 | 3 |
L | 6 | 3 | 2 | 4 | 1 | 1 | 7 | 3 | 2 | |
Case 2 | R | 9 | 5 | 6 | 8 | 3 | 4 | 8 | 3 | 4 |
L | 9 | 5 | 7 | 8 | 3 | 3 | 8 | 3 | 4 | |
Case 3 | R | 7 | 5 | 3 | 4 | 3 | 3 | 6 | 5 | 3 |
Case 4 | L | 10 | 7 | 3 | 8 | 5 | 2 | 10 | 8 | 4 |
Average | 7.8 | 4.7 | 3.8 | 6 | 2.5 | 2.3 | 7.7 | 4.2 | 3.3 | |
p value compared with pre* | 0.0280 | 0.0428 | 0.0332 | 0.0160 | 0.0489 | 0.0088 | ||||
Case 3 | L** | 7 | 5 | 3 | 4 | 3 | 3 | 6 | 5 | 3 |
Case 4 | R*** | 10 | 6 | 2 | 8 | 5 | 2 | 10 | 8 | 3 |