nach oben

Alzheimer's Research & Therapy

Erschienen in:

01.08.2010 | Review

Role of structural MRI in Alzheimer's disease

verfasst von: Prashanthi Vemuri, Clifford R Jack Jr

Erschienen in: Alzheimer's Research & Therapy | Ausgabe 4/2010

Einloggen, um Zugang zu erhalten

Abstract

Atrophy measured on structural magnetic resonance imaging (sMRI) is a powerful biomarker of the stage and intensity of the neurodegenerative aspect of Alzheimer's disease (AD) pathology. In this review, we will discuss the role of sMRI as an AD biomarker by summarizing (a) the most commonly used methods to extract information from sMRI images, (b) the different roles in which sMRI can be used as an AD biomarker, and (c) comparisons of sMRI with other major AD biomarkers.

Nur mit Berechtigung zugänglich

Jack CR, Lowe VJ, Weigand SD, Wiste HJ, Senjem ML, Knopman DS, Shiung MM, Gunter JL, Boeve BF, Kemp BJ, Weiner M, Petersen RC, Alzheimer's Disease Neuroimaging Initiative: Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain. 2009, 132: 1355-1365. 10.1093/brain/awp062.PubMedCentralCrossRefPubMed

Mormino EC, Kluth JT, Madison CM, Rabinovici GD, Baker SL, Miller BL, Koeppe RA, Mathis CA, Weiner MW, Jagust WJ, Alzheimer's Disease Neuroimaging Initiative: Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain. 2009, 132: 1310-1323. 10.1093/brain/awn320.PubMedCentralCrossRefPubMed

DeKosky ST, Scheff SW: Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol. 1990, 27: 457-464. 10.1002/ana.410270502.CrossRefPubMed

Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R: Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol. 1991, 30: 572-580. 10.1002/ana.410300410.CrossRefPubMed

Ingelsson M, Fukumoto H, Newell KL, Growdon JH, Hedley-Whyte ET, Frosch MP, Albert MS, Hyman BT, Irizarry MC: Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology. 2004, 62: 925-931.CrossRefPubMed

Jack CR, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ: Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol. 2010, 9: 119-128. 10.1016/S1474-4422(09)70299-6.PubMedCentralCrossRefPubMed

Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C, Medical Research Council Cognitive Function and Ageing Study: Age, neuropathology, and dementia. N Engl J Med. 2009, 360: 2302-2309. 10.1056/NEJMoa0806142.CrossRefPubMed

Fox NC, Scahill RI, Crum WR, Rossor MN: Correlation between rates of brain atrophy and cognitive decline in AD. Neurology. 1999, 52: 1687-1689.CrossRefPubMed

Frisoni GB, Fox NC, Jack CR, Scheltens P, Thompson PM: The clinical use of structural MRI in Alzheimer disease. Nat Rev Neurol. 2010, 6: 67-77. 10.1038/nrneurol.2009.215.PubMedCentralCrossRefPubMed

10.

Gómez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, Parisi JE, Hyman BT: Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol. 1997, 41: 17-24. 10.1002/ana.410410106.CrossRefPubMed

11.

Gosche KM, Mortimer JA, Smith CD, Markesbery WR, Snowdon DA: Hippocampal volume as an index of Alzheimer neuropathology: findings from the Nun Study. Neurology. 2002, 58: 1476-1482.CrossRefPubMed

12.

Jack CR, Dickson DW, Parisi JE, Xu YC, Cha RH, O'Brien PC, Edland SD, Smith GE, Boeve BF, Tangalos EG, Kokmen E, Petersen RC: Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. Neurology. 2002, 58: 750-757.PubMedCentralCrossRefPubMed

13.

Silbert LC, Quinn JF, Moore MM, Corbridge E, Ball MJ, Murdoch G, Sexton G, Kaye JA: Changes in premorbid brain volume predict Alzheimer's disease pathology. Neurology. 2003, 61: 487-492.CrossRefPubMed

14.

Braak H, Braak E: Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991, 82: 239-259. 10.1007/BF00308809.CrossRefPubMed

15.

Scheltens P, Leys D, Barkhof F, Huglo D, Weinstein HC, Vermersch P, Kuiper M, Steinling M, Wolters EC, Valk J: Atrophy of medial temporal lobes on MRI in 'probable' Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry. 1992, 55: 967-972. 10.1136/jnnp.55.10.967.PubMedCentralCrossRefPubMed

16.

Duara R, Loewenstein DA, Potter E, Appel J, Greig MT, Urs R, Shen Q, Raj A, Small B, Barker W, Schofield E, Wu Y, Potter H: Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease. Neurology. 2008, 71: 1986-1992. 10.1212/01.wnl.0000336925.79704.9f.PubMedCentralCrossRefPubMed

17.

Jack CR, Petersen RC, O'Brien PC, Tangalos EG: MR-based hippocampal volumetry in the diagnosis of Alzheimer's disease. Neurology. 1992, 42: 183-188.CrossRefPubMed

18.

Ashburner J, Friston KJ: Voxel-based morphometry--the methods. Neuroimage. 2000, 11: 805-821. 10.1006/nimg.2000.0582.CrossRefPubMed

19.

Fan Y, Shen D, Davatzikos C: Classification of structural images via high-dimensional image warping, robust feature extraction, and SVM. Med Image Comput Comput Assist Interv. 2005, 8: 1-8. full_text.PubMed

20.

Alexander GE, Moeller JR: Application of the scaled subprofile model to functional imaging in neuropsychiatric disorders: a principal component approach to modeling regional patterns of brain function in disease. Human Brain Mapping. 1994, 2: 79-94. 10.1002/hbm.460020108.CrossRef

21.

Vemuri P, Gunter JL, Senjem ML, Whitwell JL, Kantarci K, Knopman DS, Boeve BF, Petersen RC, Jack CR: Alzheimer's disease diagnosis in individual subjects using structural MR images: validation studies. Neuroimage. 2008, 39: 1186-1197. 10.1016/j.neuroimage.2007.09.073.PubMedCentralCrossRefPubMed

22.

Klöppel S, Stonnington CM, Chu C, Draganski B, Scahill RI, Rohrer JD, Fox NC, Jack CR, Ashburner J, Frackowiak RS: Automatic classification of MR scans in Alzheimer's disease. Brain. 2008, 131: 681-689. 10.1093/brain/awm319.PubMedCentralCrossRefPubMed

23.

Freeborough PA, Fox NC: The boundary shift integral: an accurate and robust measure of cerebral volume changes from registered repeat MRI. IEEE Trans Med Imaging. 1997, 16: 623-629. 10.1109/42.640753.CrossRefPubMed

24.

Jack CR, Shiung MM, Gunter JL, O'Brien PC, Weigand SD, Knopman DS, Boeve BF, Ivnik RJ, Smith GE, Cha RH, Tangalos EG, Petersen RC: Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD. Neurology. 2004, 62: 591-600.PubMedCentralCrossRefPubMed

25.

Thompson PM, Apostolova LG: Computational anatomical methods as applied to ageing and dementia. Br J Radiol. 2007, 80 (Spec No 2): S78-91. 10.1259/BJR/20005470.CrossRefPubMed

26.

Scahill RI, Schott JM, Stevens JM, Rossor MN, Fox NC: Mapping the evolution of regional atrophy in Alzheimer's disease: unbiased analysis of fluid-registered serial MRI. Proc Natl Acad Sci USA. 2002, 99: 4703-4707. 10.1073/pnas.052587399.PubMedCentralCrossRefPubMed

27.

Shi F, Liu B, Zhou Y, Yu C, Jiang T: Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: meta-analyses of MRI studies. Hippocampus. 2009, 19: 1055-1064. 10.1002/hipo.20573.CrossRefPubMed

28.

Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, Meguro K, O'Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P: Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 2007, 6: 734-746. 10.1016/S1474-4422(07)70178-3.CrossRefPubMed

29.

Petersen RC: Mild cognitive impairment. Continuum Lifelong Learning Neurol. 2007, 13: 15-38.CrossRef

30.

Yuan Y, Gu ZX, Wei WS: Fluorodeoxyglucose-positron-emission tomography, single-photon emission tomography, and structural MR imaging for prediction of rapid conversion to Alzheimer disease in patients with mild cognitive impairment: a meta-analysis. AJNR Am J Neuroradiol. 2009, 30: 404-410. 10.3174/ajnr.A1357.CrossRefPubMed

31.

Fox NC, Freeborough PA: Brain atrophy progression measured from registered serial MRI: validation and application to Alzheimer's disease. J Magn Reson Imaging. 1997, 7: 1069-1075. 10.1002/jmri.1880070620.CrossRefPubMed

32.

Jack CR, Slomkowski M, Gracon S, Hoover TM, Felmlee JP, Stewart K, Xu Y, Shiung M, O'Brien PC, Cha R, Knopman D, Petersen RC: MRI as a biomarker of disease progression in a therapeutic trial of milameline for AD. Neurology. 2003, 60: 253-260. 10.1001/archneur.60.2.253.PubMedCentralCrossRefPubMed

33.

Fox NC, Cousens S, Scahill R, Harvey RJ, Rossor MN: Using serial registered brain magnetic resonance imaging to measure disease progression in Alzheimer disease: power calculations and estimates of sample size to detect treatment effects. Arch Neurol. 2000, 57: 339-344. 10.1001/archneur.57.3.339.CrossRefPubMed

34.

Vemuri P, Wiste HJ, Weigand SD, Knopman DS, Trojanowski JQ, Shaw LM, Bernstein MA, Aisen PS, Weiner M, Petersen RC, Jack CR, Alzheimer's Disease Neuroimaging Initiative: Serial MRI and CSF Biomarkers in Normal Aging, MCI and AD. Neurology. 2010, 75: 143-151. 10.1212/WNL.0b013e3181e7ca82.PubMedCentralCrossRefPubMed

35.

Hashimoto M, Kazui H, Matsumoto K, Nakano Y, Yasuda M, Mori E: Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer's disease?. Am J Psychiatry. 2005, 162: 676-682. 10.1176/appi.ajp.162.4.676.CrossRefPubMed

36.

Krishnan KR, Charles HC, Doraiswamy PM, Mintzer J, Weisler R, Yu X, Perdomo C, Ieni JR, Rogers S: Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease. Am J Psychiatry. 2003, 160: 2003-2011. 10.1176/appi.ajp.160.11.2003.CrossRefPubMed

37.

Fox NC, Black RS, Gilman S, Rossor MN, Griffith SG, Jenkins L, Koller M, AN1792(QS-21)-201 Study: Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease. Neurology. 2005, 64: 1563-1572. 10.1212/01.WNL.0000159743.08996.99.CrossRefPubMed

38.

McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A: Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005, 65: 1863-1872. 10.1212/01.wnl.0000187889.17253.b1.CrossRefPubMed

39.

Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, O'Brien JT: Medial temporal lobe atrophy on MRI in dementia with Lewy bodies. Neurology. 1999, 52: 1153-1158.CrossRefPubMed

40.

Duara R, Barker W, Luis CA: Frontotemporal dementia and Alzheimer's disease: differential diagnosis. Dement Geriatr Cogn Disord. 1999, 10 (Suppl 1): 37-42. 10.1159/000051210.CrossRefPubMed

41.

Galton CJ, Patterson K, Graham K, Lambon-Ralph MA, Williams G, Antoun N, Sahakian BJ, Hodges JR: Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia. Neurology. 2001, 57: 216-225.CrossRefPubMed

42.

de Leon MJ, DeSanti S, Zinkowski R, Mehta PD, Pratico D, Segal S, Rusinek H, Li J, Tsui W, Saint Louis LA, Clark CM, Tarshish C, Li Y, Lair L, Javier E, Rich K, Lesbre P, Mosconi L, Reisberg B, Sadowski M, DeBernadis JF, Kerkman DJ, Hampel H, Wahlund LO, Davies P: Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging. 2006, 27: 394-401. 10.1016/j.neurobiolaging.2005.07.003.CrossRefPubMed

43.

Vemuri P, Wiste HJ, Weigand SD, Shaw LM, Trojanowski JQ, Weiner MW, Knopman DS, Petersen RC, Jack CR, Alzheimer's Disease Neuroimaging Initiative: MRI and CSF biomarkers in normal, MCI, and AD subjects: diagnostic discrimination and cognitive correlations. Neurology. 2009, 73: 287-293. 10.1212/WNL.0b013e3181af79e5.PubMedCentralCrossRefPubMed

44.

Walhovd KB, Fjell AM, Brewer J, McEvoy LK, Fennema-Notestine C, Hagler DJ, Jennings RG, Karow D, Dale AM, Alzheimer's Disease Neuroimaging Initiative: Combining MR imaging, positron-emission tomography, and CSF biomarkers in the diagnosis and prognosis of Alzheimer disease. AJNR Am J Neuroradiol. 2010, 31: 347-354. 10.3174/ajnr.A1809.PubMedCentralCrossRefPubMed

45.

Brys M, Glodzik L, Mosconi L, Switalski R, De Santi S, Pirraglia E, Rich K, Kim BC, Mehta P, Zinkowski R, Pratico D, Wallin A, Zetterberg H, Tsui WH, Rusinek H, Blennow K, de Leon MJ: Magnetic resonance imaging improves cerebrospinal fluid biomarkers in the early detection of Alzheimer's disease. J Alzheimers Dis. 2009, 16: 351-362.PubMedCentralPubMed

46.

de Leon MJ, DeSanti S, Zinkowski R, Mehta PD, Pratico D, Segal S, Clark C, Kerkman D, DeBernardis J, Li J, Lair L, Reisberg B, Tsui W, Rusinek H: MRI and CSF studies in the early diagnosis of Alzheimer's disease. J Intern Med. 2004, 256: 205-223. 10.1111/j.1365-2796.2004.01381.x.CrossRefPubMed

47.

Vemuri P, Wiste HJ, Weigand SD, Shaw LM, Trojanowski JQ, Weiner MW, Knopman DS, Petersen RC, Jack CR, Alzheimer's Disease Neuroimaging Initiative: MRI and CSF biomarkers in normal, MCI, and AD subjects: predicting future clinical change. Neurology. 2009, 73: 294-301. 10.1212/WNL.0b013e3181af79fb.PubMedCentralCrossRefPubMed

48.

Wahlund LO, Blennow K: Cerebrospinal fluid biomarkers for disease stage and intensity in cognitively impaired patients. Neurosci Lett. 2003, 339: 99-102. 10.1016/S0304-3940(02)01483-0.CrossRefPubMed

49.

Henneman WJ, Vrenken H, Barnes J, Sluimer IC, Verwey NA, Blankenstein MA, Klein M, Fox NC, Scheltens P, Barkhof F, van der Flier WM: Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease. Neurology. 2009, 73: 935-940. 10.1212/WNL.0b013e3181b879ac.PubMedCentralCrossRefPubMed

50.

Thomann PA, Kaiser E, Schönknecht P, Pantel J, Essig M, Schröder J: Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease. J Psychiatry Neurosci. 2009, 34: 136-142.PubMedCentralPubMed

51.

Herukka SK, Pennanen C, Soininen H, Pirttilä T: CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy. J Alzheimers Dis. 2008, 14: 51-57.PubMed

52.

Sluimer JD, Bouwman FH, Vrenken H, Blankenstein MA, Barkhof F, van der Flier WM, Scheltens P: Whole-brain atrophy rate and CSF biomarker levels in MCI and AD: a longitudinal study. Neurobiol Aging. 2008, 31: 758-764. 10.1016/j.neurobiolaging.2008.06.016.CrossRefPubMed

53.

Chou YY, Leporé N, Avedissian C, Madsen SK, Parikshak N, Hua X, Shaw LM, Trojanowski JQ, Weiner MW, Toga AW, Thompson PM, Alzheimer's Disease Neuroimaging Initiative: Mapping correlations between ventricular expansion and CSF amyloid and tau biomarkers in 240 subjects with Alzheimer's disease, mild cognitive impairment and elderly controls. Neuroimage. 2009, 46: 394-410. 10.1016/j.neuroimage.2009.02.015.PubMedCentralCrossRefPubMed

54.

Fagan AM, Head D, Shah AR, Marcus D, Mintun M, Morris JC, Holtzman DM: Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly. Ann Neurol. 2009, 65: 176-183. 10.1002/ana.21559.PubMedCentralCrossRefPubMed

55.

Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Brewer JB, Dale AM, Alzheimer's Disease Neuroimaging Initiative: CSF biomarkers in prediction of cerebral and clinical change in mild cognitive impairment and Alzheimer's disease. J Neurosci. 2010, 30: 2088-2101. 10.1523/JNEUROSCI.3785-09.2010.PubMedCentralCrossRefPubMed

56.

Schoonenboom NS, van der Flier WM, Blankenstein MA, Bouwman FH, Van Kamp GJ, Barkhof F, Scheltens P: CSF and MRI markers independently contribute to the diagnosis of Alzheimer's disease. Neurobiol Aging. 2008, 29: 669-675. 10.1016/j.neurobiolaging.2006.11.018.CrossRefPubMed

57.

Schönknecht P, Pantel J, Hartmann T, Werle E, Volkmann M, Essig M, Amann M, Zanabili N, Bardenheuer H, Hunt A, Schröder J: Cerebrospinal fluid tau levels in Alzheimer's disease are elevated when compared with vascular dementia but do not correlate with measures of cerebral atrophy. Psychiatry Res. 2003, 120: 231-238. 10.1016/S0165-1781(03)00197-5.CrossRefPubMed

58.

Mosconi L, Sorbi S, de Leon MJ, Li Y, Nacmias B, Myoung PS, Tsui W, Ginestroni A, Bessi V, Fayyazz M, Caffarra P, Pupi A: Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease. J Nucl Med. 2006, 47: 1778-1786.PubMed

59.

De Santi S, de Leon MJ, Rusinek H, Convit A, Tarshish CY, Roche A, Tsui WH, Kandil E, Boppana M, Daisley K, Wang GJ, Schlyer D, Fowler J: Hippocampal formation glucose metabolism and volume losses in MCI and AD. Neurobiol Aging. 2001, 22: 529-539. 10.1016/S0197-4580(01)00230-5.CrossRefPubMed

60.

Kawachi T, Ishii K, Sakamoto S, Sasaki M, Mori T, Yamashita F, Matsuda H, Mori E: Comparison of the diagnostic performance of FDG-PET and VBM-MRI in very mild Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2006, 33: 801-809. 10.1007/s00259-005-0050-x.CrossRefPubMed

61.

Matsunari I, Samuraki M, Chen WP, Yanase D, Takeda N, Ono K, Yoshita M, Matsuda H, Yamada M, Kinuya S: Comparison of 18F-FDG PET and optimized voxel-based morphometry for detection of Alzheimer's disease: aging effect on diagnostic performance. J Nucl Med. 2007, 48: 1961-1970. 10.2967/jnumed.107.042820.CrossRefPubMed

62.

Ishii K, Soma T, Kono AK, Sofue K, Miyamoto N, Yoshikawa T, Mori E, Murase K: Comparison of regional brain volume and glucose metabolism between patients with mild dementia with lewy bodies and those with mild Alzheimer's disease. J Nucl Med. 2007, 48: 704-711. 10.2967/jnumed.106.035691.CrossRefPubMed

63.

Hinrichs C, Singh V, Mukherjee L, Xu G, Chung MK, Johnson SC, Alzheimer's Disease Neuroimaging Initiative: Spatially augmented LPboosting for AD classification with evaluations on the ADNI dataset. Neuroimage. 2009, 48: 138-149. 10.1016/j.neuroimage.2009.05.056.PubMedCentralCrossRefPubMed

64.

Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergström M, Savitcheva I, Huang GF, Estrada S, Ausén B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Långström B: Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol. 2004, 55: 306-319. 10.1002/ana.20009.CrossRefPubMed

65.

Driscoll I, Zhou Y, An Y, Sojkova J, Davatzikos C, Kraut MA, Ye W, Ferrucci L, Mathis CA, Klunk WE, Wong DF, Resnick SM: Lack of association between (11)C-PiB and longitudinal brain atrophy in non-demented older individuals. Neurobiol Aging. 2010,

66.

Storandt M, Mintun MA, Head D, Morris JC: Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition. Arch Neurol. 2009, 66: 1476-1481. 10.1001/archneurol.2009.272.PubMedCentralCrossRefPubMed

67.

Chételat G, Villemagne VL, Bourgeat P, Pike KE, Jones G, Ames D, Ellis KA, Szoeke C, Martins RN, O'Keefe GJ, Salvado O, Masters CL, Rowe CC, Australian Imaging Biomarkers and Lifestyle Research Group: Relationship between atrophy and beta-amyloid deposition in Alzheimer disease. Ann Neurol. 2010, 67: 317-324.PubMed

68.

Bourgeat P, Chételat G, Villemagne VL, Fripp J, Raniga P, Pike K, Acosta O, Szoeke C, Ourselin S, Ames D, Ellis KA, Martins RN, Masters CL, Rowe CC, Salvado O, AIBL Research Group: Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia. Neurology. 2010, 74: 121-127. 10.1212/WNL.0b013e3181c918b5.CrossRefPubMed

69.

Jack CR, Lowe VJ, Senjem ML, Weigand SD, Kemp BJ, Shiung MM, Knopman DS, Boeve BF, Klunk WE, Mathis CA, Petersen RC: 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Brain. 2008, 131: 665-680. 10.1093/brain/awm336.PubMedCentralCrossRefPubMed

70.

Archer HA, Edison P, Brooks DJ, Barnes J, Frost C, Yeatman T, Fox NC, Rossor MN: Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study. Ann Neurol. 2006, 60: 145-147. 10.1002/ana.20889.CrossRefPubMed

71.

Scheinin NM, Aalto S, Koikkalainen J, Lötjönen J, Karrasch M, Kemppainen N, Viitanen M, Någren K, Helin S, Scheinin M, Rinne JO: Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls. Neurology. 2009, 73: 1186-1192. 10.1212/WNL.0b013e3181bacf1b.CrossRefPubMed

72.

Teipel SJ, Ewers M, Wolf S, Jessen F, Kölsch H, Arlt S, Luckhaus C, Schönknecht P, Schmidtke K, Heuser I, Frölich L, Ende G, Pantel J, Wiltfang J, Rakebrandt F, Peters O, Born C, Kornhuber J, Hampel H: Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease. Psychiatry Res. 2010, 182: 244-250. 10.1016/j.pscychresns.2010.03.003.CrossRefPubMed

73.

Hampel H, Bürger K, Pruessner JC, Zinkowski R, DeBernardis J, Kerkman D, Leinsinger G, Evans AC, Davies P, Möller HJ, Teipel SJ: Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease. Arch Neurol. 2005, 62: 770-773. 10.1001/archneur.62.5.770.CrossRefPubMed

74.

Schoonenboom SN, Visser PJ, Mulder C, Lindeboom J, Van Elk EJ, Van Kamp GJ, Scheltens PH: Biomarker profiles and their relation to clinical variables in mild cognitive impairment. Neurocase. 2005, 11: 8-13. 10.1080/13554790490896785.CrossRefPubMed

75.

Leow AD, Yanovsky I, Parikshak N, Hua X, Lee S, Toga AW, Jack CR, Bernstein MA, Britson PJ, Gunter JL, Ward CP, Borowski B, Shaw LM, Trojanowski JQ, Fleisher AS, Harvey D, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM, Alzheimer's Disease Neuroimaging Initiative: Alzheimer's disease neuroimaging initiative: a one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition. Neuroimage. 2009, 45: 645-655. 10.1016/j.neuroimage.2009.01.004.PubMedCentralCrossRefPubMed

76.

Schuff N, Woerner N, Boreta L, Kornfi eld T, Shaw LM, Trojanowski JQ, Thompson PM, Jack CR, Weiner MW, Alzheimer's Disease Neuroimaging Initiative: MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain. 2009, 132: 1067-1077. 10.1093/brain/awp007.PubMedCentralCrossRefPubMed

77.

Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Blennow K, Brewer JB, Dale AM, the Alzheimer's Disease Neuroimaging Initiative: Brain atrophy in healthy aging is related to CSF levels of A{beta}1-42. Cereb Cortex. 2010, 20: 2069-2079. 10.1093/cercor/bhp279.PubMedCentralCrossRefPubMed

78.

Yamaguchi S, Meguro K, Itoh M, Hayasaka C, Shimada M, Yamazaki H, Yamadori A: Decreased cortical glucose metabolism correlates with hippocampal atrophy in Alzheimer's disease as shown by MRI and PET. J Neurol Neurosurg Psychiatry. 1997, 62: 596-600. 10.1136/jnnp.62.6.596.PubMedCentralCrossRefPubMed

79.

Ishii K, Sasaki H, Kono AK, Miyamoto N, Fukuda T, Mori E: Comparison of gray matter and metabolic reduction in mild Alzheimer's disease using FDG-PET and voxel-based morphometric MR studies. Eur J Nucl Med Mol Imaging. 2005, 32: 959-963. 10.1007/s00259-004-1740-5.CrossRefPubMed

80.

Samuraki M, Matsunari I, Chen WP, Yajima K, Yanase D, Fujikawa A, Takeda N, Nishimura S, Matsuda H, Yamada M: Partial volume effect-corrected FDG PET and grey matter volume loss in patients with mild Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2007, 34: 1658-1669. 10.1007/s00259-007-0454-x.CrossRefPubMed

81.

Chételat G, Desgranges B, Landeau B, Mézenge F, Poline JB, de la Sayette V, Viader F, Eustache F, Baron JC: Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease. Brain. 2008, 131: 60-71. 10.1093/brain/awm288.CrossRefPubMed

82.

Walhovd KB, Fjell AM, Amlien I, Grambaite R, Stenset V, Bjørnerud A, Reinvang I, Gjerstad L, Cappelen T, Due-Tønnessen P, Fladby T: Multimodal imaging in mild cognitive impairment: metabolism, morphometry and diffusion of the temporal-parietal memory network. Neuroimage. 2009, 45: 215-223. 10.1016/j.neuroimage.2008.10.053.CrossRefPubMed

83.

Morbelli S, Piccardo A, Villavecchia G, Dessi B, Brugnolo A, Piccini A, Caroli A, Frisoni G, Rodriguez G, Nobili F: Mapping brain morphological and functional conversion patterns in amnestic MCI: a voxel-based MRI and FDG-PET study. Eur J Nucl Med Mol Imaging. 2010, 37: 36-45. 10.1007/s00259-009-1218-6.CrossRefPubMed

Titel: Role of structural MRI in Alzheimer's disease
verfasst von: Prashanthi Vemuri
Clifford R Jack Jr
Publikationsdatum: 01.08.2010
Verlag: BioMed Central
Erschienen in: Alzheimer's Research & Therapy / Ausgabe 4/2010
Elektronische ISSN: 1758-9193
DOI: https://doi.org/10.1186/alzrt47

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Thrombektomie auch bei großen Infarkten von Vorteil

16.05.2024 Ischämischer Schlaganfall Nachrichten

Auch ein sehr ausgedehnter ischämischer Schlaganfall scheint an sich kein Grund zu sein, von einer mechanischen Thrombektomie abzusehen. Dafür spricht die LASTE-Studie, an der Patienten und Patientinnen mit einem ASPECTS von maximal 5 beteiligt waren.

Schwindelursache: Massagepistole lässt Otholiten tanzen

14.05.2024 Benigner Lagerungsschwindel Nachrichten

Wenn jüngere Menschen über ständig rezidivierenden Lagerungsschwindel klagen, könnte eine Massagepistole der Auslöser sein. In JAMA Otolaryngology warnt ein Team vor der Anwendung hochpotenter Geräte im Bereich des Nackens.

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Viertel reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2010

The role of animal models in advancing amyloid-beta immunotherapy to the clinic

Review of Alzheimer's disease scales: is there a need for a new multi-domain scale for therapy evaluation in medical practice?

The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?