Introduction
Methods
Search method for identification of studies
Inclusion criteria for considering studies for this review
Types of studies
Study subjects
Index test
Target condition
Reference standard
Results presentation
Data collection and analysis
Selection of studies
Data extraction and management
Assessment of methodologic quality
Bollow et al.(1995)
[10]
| Klauser et al.(2004)
[11]
| Brandt et al.(2007)
[12]
| Weber et al.(2010)
[13]
| Wick et al.(2010)
[14]
| Kim et al.(2008)
[15]
| Weber et al.(2009)
[16]
| Bennett et al.(2009)
[17]
| Bennett et al.(2009)
[18]
| |
---|---|---|---|---|---|---|---|---|---|
Study sampling (0-1)
| 1 | 0 | 1 | 2 | 1 | 1 | 2 | 1 | 1 |
Diagnosis (0-1)
| 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 |
MRI evaluation (0-1)
| 0 | 0 | 0 | 2 | 2 | 1 | 2 | 2 | 1 |
Data analysis and presentation of results (0-1)
| 0 | 1 | 1 | 2 | 0 | 1 | 2 | 1 | 1 |
Total (0-8)
|
2
|
1
|
2
|
7
|
3
|
4
|
7
|
4
|
3
|
Statistical analysis and data synthesis
Results
Description of studies
Study | Reasons for exclusion |
---|---|
Ahlstrom H, et al. (1990) [6] | < 20 controls |
Algin O, et al. (2009) [25] | < 20 controls |
Algin O, et al. (2010) [26] | < 20 controls |
Baraliakos X, et al. (2005) [27] | No controls |
Bejia I, et al. (2004) [28] | < 20 cases |
Blum U, et al. (1996) [29] | Field strength, < 1.5 Tesla |
Bochkova AG, et al. (2010) [30] | No controls |
Bollow M, et al. (1993) [31] | Double publication on Bollow et al. [10] |
Bollow M, et al. (1994) [32] | Double publication on Bollow et al. [10] |
Bozgeyik Z, et al. (2008) [33] | No controls |
Braun J, et al. (1994) [34] | < 20 controls |
Braun J, et al. (1998) [35] | Reference standard (HLA-B27 status) not a clinical diagnosis |
Bredella MA, et al. (2006) [36] | No controls |
Chung H Y, et al. (2011) [37] | No controls |
Docherty P, et al. (1992) [38] | < 20 controls |
Friedburg H, et al. (1987) [39] | No controls |
Gleeson TG, et al. (2005) [40] | < 20 cases |
Gupta AD, et al. (2009) [41] | < 20 controls |
Hanly JGJ, et al. (1994) [42] | < 20 controls |
Heuft-Dorenbosch L, et al. (2006) [43] | Reference standard (plain radiographic) not a clinical diagnosis |
Heuft-Dorenbosch L, et al. (2006) [44] | No controls |
Heuft-Dorenbosch L, et al. (2007) [45] | No controls |
Inanc N, et al. (2005) [46] | Reference standard (plain radiographic) not a clinical diagnosis |
Jevtic V, et al. (1996) [47] | No controls |
Liao Z, et al. (2009) [48] | No MRI of the control group |
Liao Z, et al. (2011) [49] | No controls |
Luukkainen RK, et al. (2007) [50] | No controls |
Marc V, et al. (1997) [51] | < 20 controls |
McNally EG, et al. (2001) [52] | < 20 cases |
Muche B, et al. (2003) [53] | No controls |
Murphey MD, et al. (1991) [54] | < 20 controls |
Orchard TR, et al. (2009) [55] | < 20 cases |
Peterova V et al. (2006) [56] | No controls |
Puhakka KB, et al. (2003) [57] | No controls |
Remy, et al. (1996) [58] | No controls |
Rennie WJ, et al. (2009) [59] | < 20 controls |
Rudwaleit M, et al. (2009) [60] | < 20 controls |
Rudwaleit M, et al. (2009) [8] | Insufficient result presentation |
Rudwaleit M, et al. (2009) [61] | Insufficient result presentation |
Sreedhar C, et al. (2006) [62] | < 20 cases |
Weber U, et al. (2007) [63] | < 20 controls |
Weber U, et al. (2010) [64] | Double publication on Weber et al. [13] |
Wecbach et al. (2009) [65] | No controls |
Wienands K, et al. (1990) [66] | No controls |
Williamson L, et al. (2004) [67] | Reference standard (orthopedic test) not a clinical diagnosis |
Wittram C, et al. (1996) [68] | < 20 controls |
Wittram C, et al. (1996) [69] | < 20 controls |
Yu W, et al. (1998) [70] | < 20 controls |
Study | Reasons for exclusion |
---|---|
Althoff CE, et al. (2009) [71] | Insufficient result presentation |
Aydin SZ, et al (2011) [72] | < 20 controls |
Baraliakos X, et al. (2008) [73] | No controls |
Battafarano DF, et al. (1993) [74] | < 20 controls |
Bennett AN, et al. (2008) [7] | No controls |
Bigot J, et al. (1999) [75] | < 20 control |
Brandt J, et al. (1999) [76] | No controls |
Chiowchanwisawakit P, et al. (2011) [77] | No controls |
Dougados M, et al. (2001) [78] | Insufficient result presentation |
Hermann J, et al. (2009) [79] | Insufficient result presentation |
Madsen K, et al. (2010) [80] | No controls |
Macsymowych WP, et al. (2010) [81] | No controls |
Marzo-Ortega H, et al. (2008) [82] | < 20 in each control group |
Oostveen J, et al. (1999) [83] | No controls |
Pedersen SJ, et al. (2011) [84] | No controls |
Puhakka KB, et al. (2004) [85] | No controls |
Remplik P, et al. (2005) [86] | < 20 cases |
Shankar S, et al. (2009) [87] | Insufficient result presentation |
Song IH, et al. (2011) [88] | No controls |
Description of included articles
Study type | Total number | Number of AS patients (DD) | Number of SpA patients (DD) | Number of IBP patients (DD) | Number of NILBP patients (DD) | Number of no LBP patients | |
---|---|---|---|---|---|---|---|
Sacroiliac joint | |||||||
Bollow et al. (1995) [10] | Prospective case-control | 125 | 36 (3.1 years) | 36 (5.9 years) | 53 (5.7 years) | ||
Klauser et al. (2004) [11] | Prospective case-control | 133 | 103 (NR) | 30 | |||
Brandt et al. (2007) [12] | Prospective cohort | 158 | 32 (NR) | 58 (NR) | 68 (NR) | ||
Weber et al. (2010) [13] | Prospective case-control | 187 | 75 (6.1 years) | 27 (29 mo) | 26 (NR) | 59 | |
Wick et al. (2010) [14] | Retrospective cohort | 156 | 27 (NR) | 101 (NR) | 28 (NR) | ||
Spine
| |||||||
Kim et al. (2008) [15] | Retrospective case control | 104 | 52 (NR) | 52 (NR) | |||
Weber et al. (2009) [16] | Prospective case-control | 85 | 35 (8 years) | 25 (10 mo) | 35 | ||
Bennett et al. (2009) [17] | Retrospective cohort | 185 | 64 (8.5 years) | 110 (NR) | 11 | ||
Bennett et al. (2009) [18] | Retrospective cohort | 185 | 64 (8.5 years) | 110 (NR) | 11 |
Field strength | Sequence 1 | Sequence 2 | Sequence 3 | Sequence 4 | Sequence 5 | Sequence 6 | |
---|---|---|---|---|---|---|---|
Sacroiliac joint | |||||||
Bollow et al. (1995) [10] | 1.5 T | Semi axial T1w SE | Dynamic T2*w GRE, FLASH, | Dynamic T2*w GRE, FLASH, Gd | |||
Klauser et al. (2004) [11] | 1.5 T | Semi axial T1w, SE | Semi axial T2 w TSE | Semi axial T1w, SE FS | Semi cor. T1w, SE | Semi cor. TIRM | Semi axial + Semi cor. T1w, SE, FS, Gd |
Brandt et al. (2007) [12] | a1.5 T | NR | |||||
Weber et al. (2010) [13] | a1.5 T | Semi cor. T1 w, SE | Semi cor. STIR | ||||
Wick et al. (2010) [14] | 1.5 T | Semi cor. T1 w, SE | Semi cor. TIRM | Semi cor. T2w, MEDIC FS | Semi cor. + semi axial T1w, SE, FS | Semi axial T1w, SE, FS, Gd | Semi axial T1w, SE, Gd |
Spine
| |||||||
Kim et al. (2008) [15] | 1.5 T | Sagittal T1w SE | Sagittal T2w FSE | ||||
Weber et al. (2009) [16] | 1.5 T | Sagittal turbo STIR | |||||
Bennett et al. (2009) [17] | a1.5 T | Sagittal T1, SE | Sagittal STIR | ||||
Bennett et al. (2009) [18] | a1.5T | Sagittal T1w, SE | Sagittal STIR |
Assessment of methodologic quality
Association between MRI findings and the clinical diagnosis of SpA
MRI findings | Sensitivity of MRI findings (95% CI) | Specificity of MRI findings (95% CI) | Cases, number | Controls, number | ||
---|---|---|---|---|---|---|
AS | IBP | NLSBP | No LBP | |||
BMO | 0.85 (0.76-0.92) | 0.93 (0.84-0.97) | 75 | 59 | ||
Erosions | 0.91 (0.82-0.95) | 0.98 (0.91-1.00) | 75 | 59 | ||
Fat infiltration | 0.91 (0.82-0.95) | 0.86 (0.76-0.93) | 75 | 59 | ||
Ankylosis | 0.27 (0.18-0.38) | 1.00 (0.94-1.00) | 75 | 59 | ||
Global assessment | 0.99 | 0.96 | 75 | 59 | ||
BMO | 0.85 (0.76-0.92) | 0.77 (0.58-0.89) | 75 | 26 | ||
Erosions | 0.91 (0.82-0.95) | 0.96 (0.81-0.99) | 75 | 26 | ||
Fat infiltration | 0.91 (0.82-0.95) | 0.85 (0.67-0.94) | 75 | 26 | ||
Ankylosis | 0.26 (0.18-0.38) | 1.00 (0.87-1.00) | 75 | 26 | ||
Global assessment | 0.99 | 0.92 | 75 | 26 | ||
BMO | 0.67 (0.48-0.81) | 0.93 (0.84-0.97) | 27 | 59 | ||
Erosions | 0.48 (0.31-0.66) | 0.98 (0.91-1.00) | 27 | 59 | ||
Fat infiltration | 0.37 (0.22-0.56) | 0.86 (0.76-0.93) | 27 | 59 | ||
Global assessment | 0.52 | 0.96 | 27 | 59 | ||
BMO | 0.67 (0.48-0.81) | 0.77 (0.58-0.89) | 27 | 26 | ||
Erosions | 0.48 (0.31-0.66) | 0.96 (0.81-0.99) | 27 | 26 | ||
Fat infiltration | 0.37 (0.22-0.56) | 0.85 (0.67-0.94) | 27 | 26 | ||
Global assessment | 0.52 | 0.92 | 27 | 26 |
MRI findings | Sensitivity of MRI findings (95% CI) | Specificity of MRI findings (95% CI) | Cases, number | Controls, number | |
---|---|---|---|---|---|
AS | IBP | No LBP | |||
≥ 1 CIL | 0.77 (0.61-0.88) | 0.77 (0.61-0.88) | 35 | 35 | |
≥ 2 CIL | 0.69 (0.52-0.81) | 0.94 (0.81-0.98) | 35 | 35 | |
≥ 3 CIL | 0.66 (0.49-0.79) | 0.94 (0.81-0.98) | 35 | 35 | |
≥ 1 tCIL | 0.69 (0.52-0.81) | 0.83 (0.67-0.92) | 35 | 35 | |
≥ 2 tCIL | 0.57 (0.41-0.72) | 0.94 (0.81-0.98) | 35 | 35 | |
≥ 3 tCIL | 0.46 (0.30-0.62) | 0.97 (0.85-0.99) | 35 | 35 | |
≥ 1 lCIL | 0.51 (0.36-0.67) | 0.94 (0.81-0.98) | 35 | 35 | |
≥ 1 NIL | 0.06 (0.02-0.19) | 0.97 (0.85-0.99) | 35 | 35 | |
≥ 1 LIL | 0.31 (0.19-0.48) | 0.97 (0.85-0.99) | 35 | 35 | |
≥ 1 FIL/PIL | 0.09 (0.03-0.22) | 1.00 (0.90-1.00) | 35 | 35 | |
≥ 1 CIL | 0.40 (0.23-0.59) | 0.88 (0.70-0.96) | 25 | 25 | |
≥ 2 CIL | 0.32 (0.17-0.52) | 0.96 (0.80-0.99) | 25 | 25 | |
≥ 3 CIL | 0.12 (0.04-0.30) | 0.96 (0.80-0.99) | 25 | 25 | |
≥ 1 tCIL | 0.32 (0.17-0.52) | 0.88 (0.70-0.96) | 25 | 25 | |
≥ 2 tCIL | 0.24 (0.11-0.43) | 0.96 (0.80-0.99) | 25 | 25 | |
≥ 3 tCIL | 0.12 (0.04-0.30) | 0.96 (0.80-0.99) | 25 | 25 | |
≥ 1 lCIL | 0.24 (0.11-0.43) | 1.00 (0.87-1.00) | 25 | 25 | |
≥ 1 NIL | 0.04 (0.01-0.20) | 0.96 (0.80-0.99) | 25 | 25 | |
≥ 1 lCIL | 0.12 (0.04-0.30) | 0.96 (0.80-0.99) | 25 | 25 | |
≥ 1 FIL/PIL | 0.00 (0.00-0.13) | 1.00 (0.87-1.00) | 25 | 25 |