Background
Methods
Searching strategy
Criteria for inclusion and exclusion
Quality assessment and data extraction
Statistical analysis
Trial sequential analysis
Results
Searching results
First author | Year | Country | Age group | Type of case | Type of control | Ethnicity | Case | Control | HWEa in control | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GG | GC | CC | GG | GC | CC | ||||||||
Schluter B | 2002 | USA | Adult | Sepsis, severe sepsis | Healthy | Caucasian | 25 | 46 | 24 | 71 | 94 | 42 | Yes |
Non-survivor | Survivor | 2 | 17 | 6 | 11 | 8 | 6 | Yes | |||||
Harding D | 2003 | UK | Infant | Septicemia | Preterm infant | Mainly Caucasian | 24 | 27b | 30 | 76b | N/A | ||
Balding J | 2003 | Ireland | Adult | Meningococcal sepsis | Healthy | Caucasian | 59 | 97 | 27 | 123 | 209 | 68 | Yes |
Non-survivor | Survivor | 13 | 10 | 2 | 46 | 87 | 25 | Yes | |||||
Treszl A | 2003 | Hungary | Neonate | Sepsis | VLBWc neonate | Caucasian | 18 | 13 | 2 | 34 | 29 | 7 | Yes |
Barber RC | 2004 | USA | Adult | Severe sepsis | ICU patients with no or mild sepsis | Mixed | 17 | 19b | 69 | 54b | N/A | ||
Ahrens P | 2004 | Germany | Infant | Sepsis | VLBWc infants | Caucasian | 24 | 21 | 5 | 97 | 177 | 32 | No |
Michalek J | 2006 | Czech Republic | aged 0–19 years | SIRSd, sepsis, severe sepsis, septic shock and MODSe | Healthy | Caucasian | 103 | 172 | 48 | 160 | 345 | 139 | Yes |
McDaniel DO | 2006 | USA | not clearf | Sepsis | ICU patients | African American | 16g | 0 | 6g | 0 | N/A | ||
Caucasian | 12g | 3 | 13g | 8 | N/A | ||||||||
Sipahi T | 2006 | Turkey | aged 0–15 years | Severe sepsis | Healthy | not clear | 26 | 14 | 4 | 52 | 19 | 6 | No |
Non-survivor | Survivor | 9 | 5 | 1 | 17 | 9 | 3 | Yes | |||||
Baier RJ | 2006 | USA | Infant | Sepsis | VLBWc infant | African American | 94 | 18 | 2 | 110 | 9 | 0 | Yes |
Caucasian | 12 | 16 | 3 | 7 | 16 | 3 | Yes | ||||||
Non-survivor | Survivor | African American | 10 | 1 | 0 | 84 | 17 | 2 | Yes | ||||
Caucasian | 1 | 1 | 1 | 11 | 15 | 2 | Yes | ||||||
Göpel W | 2006 | Germany | Infant | Sepsis | VLBWc infant | Mainly Caucasian | 29 | 50 | 18 | 128 | 143 | 49 | Yes |
Sabeinikovs O | 2008 | Latvia | Infant | Non-survivor | Survivor | Caucasian | 10 | 21 | 13 | 20 | 32 | 7 | Yes |
Abdel-Hady H | 2009 | Egypt | Neonate | Sepsis | Neonates investigated for neonatal hyperbilirubinemia | Caucasian | 17 | 26 | 11 | 28 | 32 | 11 | Yes |
Non-survivor | Survivor | 2 | 5 | 6 | 15 | 21 | 5 | Yes | |||||
Solé-Violán J | 2010 | Spain | Adult | Severe sepsis and septic shock | CAPh | Caucasian | 141 | 144 | 36 | 392 | 341 | 84 | Yes |
Davis SM | 2010 | USA | Female adult | Puerperal group streptococcus sepsis | Healthy | Caucasian | 10 | 11 | 2 | 21 | 22 | 9 | Yes |
Carregaro F | 2011 | Brazil | Adult | Sepsis, severe sepsis and septic shock | Healthy | Mainly Caucasiani | 49 | 39 | 9 | 94 | 96 | 17 | Yes |
Accardo Palumbo A | 2011 | Italy | aged 13–82 years | Sepsis | Burned patient | not clear | 14g | 2 | 22g | 4 | N/A | ||
Watanabe E | 2012 | USA | Adult | Non-survivor | Survivor | Caucasian | 113 | 149 | 46 | 245 | 363 | 125 | Yes |
Martín-Loeches I | 2012 | Spain | Adult | Sepsis, severe sepsis and septic shock | Healthy | Caucasian | 581 | 516 | 130 | 438 | 413 | 102 | Yes |
Feng B | 2015 | China | Adult | Non-survivor | Survivor | Asian | 42 | 20 | 1 | 139 | 72 | 3 | Yes |
Allam G | 2015 | Saudi Arabia | Infant | Early-onset sepsis | Healthy | not clear | 39 | 20 | 10 | 13 | 32 | 23 | Yes |
Lorente L | 2016 | Spain | Adult | Non-survivor | Survivor | not clear | 47 | 36 | 3 | 76 | 74 | 27 | Yes |
Mao ZR | 2016 | China | Adult | Sepsis | Healthy | Asian | 56 | 37 | 95 | 97 | 66 | 37 | No |
Jimenez-Sousa MA | 2017 | Spain | Adult | Septic shock | Healthy | Not clear | 93 | 90 | 19 | 43 | 51 | 13 | Yes |
The association between IL-6-174 G/C polymorphism and the risk of sepsis
Meta-analysis | Heterogeneity test | Egger’s test | ||||
---|---|---|---|---|---|---|
no. of studies | OR (95% CI) | P value |
I
2
| P value | P value | |
The association between IL-6 -174G/C polymorphism and the risk of sepsis | ||||||
Overall | ||||||
GC + CC vs GG | 18 | 0.965 (0.782–1.192) | 0.743 | 72.80% | < 0.001 | 0.694 |
CC vs. GC + GG | 18 | 0.992 (0.726–1.356) | 0.96 | 72.90% | < 0.001 | 0.81 |
GC vs. GG | 16 | 0.950 (0.798–1.133) | 0.57 | 52.00% | 0.008 | 0.696 |
CC vs.GG | 16 | 0.992 (0.686–1.435) | 0.966 | 77.80% | < 0.001 | 0.989 |
C vs. G | 16 | 1.014 (0.831–1.236) | 0.894 | 84.20% | < 0.001 | 0.705 |
Non-adult | ||||||
GC + CC vs GG | 9 | 0.796 (0.522–1.214) | 0.29 | 78.40% | < 0.001 | 0.754 |
CC vs. GC + GG | 8 | 0.785 (0.614–1.003) | 0.053 | 41.50% | 0.101 | 0.337 |
GC vs. GG | 8 | 0.879 (0.578–1.336) | 0.545 | 72.90% | 0.001 | 0.694 |
CC vs.GG | 8 | 0.779 (0.427–1.421) | 0.415 | 69.60% | 0.002 | 0.38 |
C vs. G | 8 | 0.896 (0.643–1.248) | 0.516 | 80.10% | < 0.001 | 0.475 |
Adult | ||||||
GC + CC vs GG | 9 | 1.112 (0.900–1.374) | 0.324 | 59.20% | 0.012 | 0.464 |
CC vs. GC + GG | 10 | 1.080 (0.700–1.666) | 0.73 | 79.50% | < 0.001 | 0.73 |
GC vs. GG | 9 | 0.988 (0.874–1.117) | 0.851 | 0% | 0.711 | 0.816 |
CC vs.GG | 9 | 1.208 (0.766–1.905) | 0.416 | 79.60% | < 0.001 | 0.904 |
C vs. G | 9 | 1.124 (0.868–1.455) | 0.375 | 86.40% | < 0.001 | 0.63 |
Caucasian | ||||||
GC + CC vs GG | 16 | 0.857 (0.699–1.050) | 0.136 | 65.20% | < 0.001 | 0.725 |
CC vs. GC + GG | 17 | 0.892 (0.771–1.033) | 0.127 | 6.70% | 0.376 | 0.712 |
GC vs. GG | 15 | 0.912 (0.756–1.099) | 0.333 | 52.50% | 0.009 | 0.954 |
CC vs.GG | 15 | 0.853 (0.643–1.132) | 0.271 | 55.00% | 0.005 | 0.962 |
C vs. G | 15 | 0.913 (0.787–1.059) | 0.228 | 66.20% | < 0.001 | 0.821 |
Healthy control | ||||||
GC + CC vs GG | 10 | 0.919 (0.686–1.232) | 0.574 | 78.60% | < 0.001 | 0.709 |
CC vs. GC + GG | 10 | 0.985 (0.623–1.557) | 0.949 | 84.30% | < 0.001 | 0.979 |
GC vs. GG | 10 | 0.894 (0.791–1.010) | 0.072 | 47.30% | 0.047 | 0.871 |
CC vs.GG | 10 | 0.896 (0.531–1.511) | 0.681 | 85.50% | < 0.001 | 0.995 |
C vs. G | 10 | 0.964 (0.726–1.282) | 0.803 | 89.30% | < 0.001 | 0.747 |
Mendelian population | ||||||
GC + CC vs GG | 13 | 0,947 (0.768–1.167) | 0.607 | 66.60% | < 0.001 | 0.701 |
CC vs. GC + GG | 13 | 0.903 (0.777–1.049) | 0.101 | 27.7%% | 0.165 | 0.807 |
GC vs. GG | 13 | 0.971 (0.805–1.171) | 0.758 | 53.10% | 0.012 | 0.645 |
CC vs.GG | 13 | 0.880 (0.647–1.197) | 0.416 | 61.50% | 0.002 | 0.698 |
C vs. G | 13 | 0.945 (0.806–1.109) | 0.489 | 71.00% | < 0.001 | 0.81 |
The association between IL-6 -174G/C polymorphism and the mortality of sepsis | ||||||
Overall | ||||||
GC + CC vs GG | 10 | 1.050 (0.705–1.563) | 0.812 | 57.90% | 0.011 | 0.059 |
CC vs. GC + GG | 10 | 1.299 (0.665–2.538) | 0.444 | 62.20% | 0.005 | 0.173 |
GC vs. GG | 10 | 1.045 (0.709–1.540) | 0.825 | 51.10% | 0.031 | 0.143 |
CC vs.GG | 10 | 1.340 (0.611–2.939) | 0.465 | 67.00% | 0.001 | 0.113 |
C vs. G | 10 | 1.103 (0.795–1.531) | 0.558 | 69.50% | 0.001 | 0.134 |
Non-adult | ||||||
GC + CC vs GG | 4 | 1.434 (0.810–2.538) | 0.216 | 0% | 0.449 | 0.883 |
CC vs. GC + GG | 4 | 2.957 (1.442–6.066) | 0.003 | 0% | 0.434 | 0.684 |
GC vs. GG | 4 | 1.098 (0.588–2.050) | 0.77 | 0% | 0.746 | 0.871 |
CC vs.GG | 4 | 3.221 (1.431–7.250) | 0.005 | 3% | 0.38 | 0.872 |
C vs. G | 4 | 1.631 (1.101–2.416) | 0.015 | 31.90% | 0.221 | 0.783 |
Adult | ||||||
GC + CC vs GG | 6 | 1.005 (0.593–1.705) | 0.985 | 73.10% | 0.002 | 0.126 |
CC vs. GC + GG | 6 | 1.204 (0.342–4.236) | 0.772 | 86.50% | < 0.001 | 0.486 |
GC vs. GG | 6 | 1.078 (0.639–1.818) | 0.778 | 70.30% | 0.005 | 0.127 |
CC vs.GG | 6 | 0.868 (0.341–2.208) | 0.766 | 66.60% | 0.01 | 0.302 |
C vs. G | 6 | 0.940 (0.654–1.352) | 0.739 | 70.90% | 0.004 | 0.377 |
Caucasian | ||||||
GC + CC vs GG | 9 | 1.206 (0.723–2.007) | 0.474 | 65.70% | 0.003 | 0.094 |
CC vs. GC + GG | 9 | 1.376 (0.656–2.884) | 0.399 | 67.90% | 0.002 | 0.097 |
GC vs. GG | 9 | 1.143 (0.713–1.834) | 0.579 | 55.50% | 0.021 | 0.174 |
CC vs.GG | 9 | 1.430 (0.598–3.420) | 0.422 | 71.30% | < 0.001 | 0.071 |
C vs. G | 9 | 1.180 (0.802–1.737) | 0.401 | 73.50% | < 0.001 | 0.101 |