Background
Methods
Enrolment criteria
CMR protocol
CMR interpretation
Statistical analysis
Results
N | 50 | FH of HCM, n (%) | 19 (38) |
---|---|---|---|
Male gender, n (%) | 37 (74) |
CMR findings
| |
Age, years | 46.9 ± 11.7 | LV EDV, ml/m2
| 78.7 ± 13.1 |
Height, cm | 171.2 ± 9.0 | LV EF, % | 62.3 ± 5.9 |
Weight, kg | 81.7 ± 14.6 | LV Mass, g/m2 | 72.8 ± 26.3 |
Body mass index, kg/m2
| 27.7 ± 3.7 | LAV, ml/m2
| 59.3 ± 13.5 |
Systolic blood pressure, mmHg | 125.5 ± 17.6 | LGE, n (%) | 35 (70) |
Diastolic blood pressure, mmHg | 74.5 ± 12.5 |
Medications
| |
Heart rate | 60.6 ± 10.2 | Beta blocker, n (%) | 24 (48) |
Echocardiography
| CC blocker, n (%) | 8 (16) | |
Maximum wall thicknessa (mm) | 19.3 ± 4.9 | Disopyramide, n (%) | 4 (8) |
LVOT obstruction, n (%) | 11 (22) | Diuretic, n (%) | 2 (4) |
Resting LVOT gradient, mmHg | 68.5 ± 40.0 |
Segment thickness | LGE | Native T1 | ECV | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
<15 mm | >15 mm |
P value | -ve | +ve |
P value | <1239.4 ms | >1239.4 ms |
P value | <29.5% | >29.5% |
P value | |
Ecc-FT (%) | −20.3 ± 8.3 | −8.5 ± 8.6 | <0.001 | −20.1 ± 8.7 | −10.6 ± 8.5 | <0.001 | −21.2 ± 8.1 | −15.8 ± 9.7 | <0.001 | −20.0 ± 8.2 | −17.0 ± 10.4 | <0.001 |
Segments analysed | 684 | 99 | 676 | 107 | 437 | 346 | 467 | 316 | ||||
Err-FT (%) | 45.0 ± 27.2 | 15.2 ± 12.8 | <0.001 | 44.8 ± 27.5 | 18.7 ± 15.5 | <0.001 | 47.9 ± 27.4 | 32.7 ± 25.6 | <0.001 | 43.3 ± 26.0 | 38.2 ± 29.7 | <0.001 |
Segments analysed | 689 | 99 | 681 | 107 | 441 | 347 | 468 | 320 | ||||
Ecc-SPAMM (%) | −20.5 ± 8.1 | −11.1 ± 4.8 | <0.001 | −20.6 ± 8.0 | −11.2 ± 4.7 | <0.001 | −21.6 ± 7.5 | −16.9 ± 8.5 | <0.001 | −20.8 ± 7.8 | −17.5 ± 8.7 | <0.001 |
Segments analysed | 494 | 48 | 488 | 54 | 320 | 222 | 349 | 193 |
Mixed effects model with random intercept
Segment thickness | BIC | LGE | BIC | Native T1 | BIC | Extracellular volume | BIC | |||
---|---|---|---|---|---|---|---|---|---|---|
Ecc-FT | Univariable | Beta |
1.325 (1.200;1.450)
| 5345.6 |
9.234
(7.444;11.024)
| 5592.9 |
0.039 (0.031;0.047)
| 5476.3 |
0.268 (0.168;0.368)
| 5368.1 |
P value |
<0.001
|
<0.001
|
<0.001
|
<0.001
| ||||||
Multivariable 1 | Beta |
1.317 (1.165;1.470)
| 5074.1 | 1.294 (-0.601;3.191) | −0.046 (-0.136;0.045) | |||||
P value |
<0.001
| 0.195 | 0.394 | |||||||
Multivariable 2 | Beta |
1.219 (1.070;1.368)
| 5214.3 | 0.331 (-1.470;2.131) |
0.015 (0.008;0.022)
| |||||
P value |
<0.001
| 0.718 |
<0.001
| |||||||
Err-FT | Univariable | Beta |
−3.573 (−3.963;−3.183)
| 7167.8 |
−25.595 (-30.940;-20.251)
| 7354.3 |
−0.118 (−0.142;−0.093)
| 7177.7 |
−0.693 (−0.991;−0.394)
| 6997.0 |
P value |
<0.001
|
<0.001
|
<0.001
|
<0.001
| ||||||
Multivariable 1 | Beta |
−3.532 (-4.011;-3.073)
| 6758.4 | −4.861 (-10.661;0.941) | 0.201 (-0.080;0.481) | |||||
P value |
<0.001
| 0.101 | 0.161 | |||||||
Multivariable 2 | Beta |
−3.193 (-3.659;-2.726)
| 6986.5 | −1.266 (-6.868;4.336) |
−0.053 (-0.075;-0.030)
| |||||
P value |
<0.001
| 0.658 |
<0.001
| |||||||
Ecc-SPAMM | Univariable | Beta |
1.039 (0.881;1.198)
| 3651.4 |
8.525 (6.382;10.667)
| 3738.8 |
0.033 (0.024;0.042)
| 3681.3 |
0.292 (0.167;0.417)
| 3601.5 |
P value |
<0.001
|
<0.001
|
<0.001
|
<0.001
| ||||||
Multivariable 1 | Beta |
0.964 (0.782;1.146)
| 3451.0 |
2.603 (0.341;4.866)
| 0.061 (-0.055;0.177) | |||||
P value |
<0.001
|
0.024
| 0.303 | |||||||
Multivariable 2 | Beta |
0.0849 (0.669;1.030)
| 3581.4 | 2.194 (-0.029;4.417) |
0.017 (0.008;0.025)
| |||||
P value |
<0.001
| 0.053 |
<0.001
|