Background
Methods
Processing gene expression data
Drug-repurposing analysis
Drug-target enrichment analysis
Results
Analysis of gene expression signatures
Connections between SLE and drug gene expression signatures
Scorea
| Biological target | Action | Drugs |
p value |
---|---|---|---|---|
+ | Topoisomerase II | Inhibitor | Amsacrine, amonafide, teniposide, etoposide, idarubicin | 2.829 × 10–4
|
+ | HDAC | Inhibitor | Panobinostat, scriptaid, dacinostat, vorinostat, trichostatin A | 1.451 × 10–4
|
+ | Protein kinase C delta | Activator | Phorbol-12-myristate-13-acetate, ingenol | 3.172 × 10–3
|
+ | Histone lysine methyltransferase | Inhibitor | Chaetocin | |
+ | ARFGAP1 | Inhibitor | QS11 | |
+ | PDK1 | Inhibitor | BX795 | |
+ | Retinoic acid receptor beta | Inhibitor | Le135 | |
+ | Arginase | Inhibitor | Inhibitor Bec | |
+ | JAK2/STAT3 | Inhibitor | Cucurbitacin I | |
+ | Fatty acid synthetase | Inhibitor | Cerulenin | |
+ | Src, Bcr-Abl tyrosine kinase | Inhibitor | AG957 | |
+ | PLD2 | Inhibitor | CAY10594 | |
+ | IKKβ | Inhibitor | Parthenolide | |
+ | IMPDH1 | Inhibitor | Mycophenolic acid | |
+ | FTL3 | Inhibitor | Midostaurin | |
+ | DNA | Crosslinker | Mitomycin C | |
+ | Tubulin | Inhibitor | Vinblastine | |
+ | Hsp90 | Inhibitor | Radicol | |
+ | Multiple targets | Inhibitor | Resveratrol | |
– | PI3K | Inhibitor | PI828, GDC0941, NVP-BEZ235,PP110, TGX115 | 4.915 × 10–6
|
– | mTOR | Inhibitor | NVP-BEZ235, AZD8055, TGX115, Ku0063794 | 1.792 × 10–5
|
– | CDK | Inhibitor | BML259, indirubin | 1.463 × 10–2
|
– | IKBalfa | Inhibitor | Evodiamine | |
– | Farnesyltransferase | Inhibitor | Tipifarnib | |
– | IGF1R | Inhibitor | Linsitinib | |
– | MAP2K1 | Inhibitor | Selumetinib | |
– | CHK1 | Inhibitor | SB218078 | |
– | Piruvate kinase | Inhibitor | M2PK activator | |
– | Rho kinase | Inhibitor | Rho kinase inhibitor III | |
– | Voltage-dependent calcium channel | Inhibitor | Nifedipine | |
– | Braf | Inhibitor | Vemurafenib |
Study of gene effect-caused profiles
Score | Type of experiment | Genes |
---|---|---|
+ | Knock-in |
IFNB1, IFNG, CD40, BCL10, KLF6, LYN, TIRAP
|
+ | Knock-down |
CLCN3, PPP1R14B, LMNB2, TBX2, PMM2, MYC, ATP6V1F, MAX, PEPD, PUF60, PHB2, AKR1A1, BTG1, ABHD2, TFDP1, PAX8, FOSL2, NT5E, RRM1, NR2F6, RAMP1, RYK, CISH, PPP2R1A, CD14, UFD1L, HTRA1, SLC35A1, TWF2, NNT, HOMER2, HS2ST1, ZNF768, GGT1, DFFB, HSPA2, PRKDC, ARPC5, NFKBIA, SLC39A8, THAP11, GSTP1, ETV1, GCAT, KIAA0907, DLX3, ELK1, PIAS4, MEOX2, GPER, NRAS, TCEB3C, KIF2C, POLR2F, CTBP2, CHAF1B, CEP55, HOOK2, ZNF8, NDUFB7, NISCH, HOXC10, AQP12A, YES1, PSMD5, JAG1, MDH2, POLR2I, DDF1, HRAS, HDAC10, SLC25A14, MED7, HMGCR, PDXP, FDX1, NIPBL, PRKAG3, PPIA, EIF2AK3, B4GALT1, UCK2, JUN, MED4, YBX1, BUB1B, CRCP, MED1, HDAC11, SBNO1
|
– | Knock-down |
MITF, ETFA, PIP4K2B, VRK2, SPEN, NSDHL, ZNF586, GNPDA1, SIX4, PARN, DUSP14, IQGAP1, LRRK2, GPR123, SF1, FEZ2, IPMK, SAT1, ELF4, RPTOR, EIF4E, ARL3, KARS, CSNK1A1, SPTLC2, MEN1, SNX17, VEGFC, PPP3CA, BNIP3, ERBB3, ERO1L, COPB2, SERPINC1, AK4, HLA_A, PIK3CA, PIK3C2A, IGF2R, LYPLA1, STX4, ATM, ESPL1, IGF1R, ST3GAL5, MTOR, GRN, HSP90AA1, PRPF4B, TM9SF3
|