This protocol was drafted by SD and the search strategy was developed by UN. It was revised following critical review initially by AS, SL and IA and then by all the co-authors. All authors read and approved the final manuscript.
Competing interests
S Dhami: support to co-ordinate the undertaking of the systematic review; U Nurmatov: support to undertake the review; I Agache: none; S Lau: grant from Allergopharma; drug monitoring committee immunotherapy Merck; grants and research support from Merck, Allergopharma; A Muraro: consulting fee Meda, Nestle, Nutricia, Novartis, ALK; co-investigator for research protocol for Nestle and Nutricia; M Jutel: consulting fee Anergis, Allergopharma; scientific/governmental grant from NCN Poland; fee for review activities Biomag; G Roberts: Materials for research programme (ALK-Abello), research grant (ALK-Abello), advisory board (ALK-Abello), speaker (Allergy Therapeutics, ALK-Abelo); C Akdis: consulting fee Novartis, Boehringer-Ingelheim; stocks Davos Diagnostics, Allimentary Health Pharma Davos; research grant Novartis, Allergopharma; M Bonini: none; M Calderon: lectures honorarium (ALK, Stallergens, Merck and Allergopharma), consultancy honorarium (ALK, Stallergenes and Hal); T Casale: grants from Merck, Stallergenes, Circassia for conduct of clinical trials to institution Circassia advisory board; O Cavkaytar: none; L Cox: fees for participanting in review activities from Circassia, Biomay, Medimmune; consulting fee for chronic urticaria Genentech; P Demoly: Advisory board (ALK-Abello, Allergopharma, Cirassia, Chiesi, DBV, Stallergens, Thermo Fisher Scientific); B Flood: none; E Hamelmann: Research grant (Allergopharma); K Izuhara: none; Ö Kalayci: none; J Kleine Tebbe: Consulting fees fromALK‐Abelló, Allergy Therapeutics, Circassia, LETI, Merck USA; lecture fees ALK‐Abelló, Allergopharma, Bencard, Circassia, HAL, LETI, Lofarma, Novartis, Stallergenes; fees for review activities from Merck-USA, Lofarma, LETI, Biotech Tools; consulting fee ALK; A Nieto: consulting fee from ALK, Leti, Merck, Stallergenes, Diater, Immunothek, ATL; fee for review activities Leti; provision of assistance Leti, Immunotek; N Papadopoulos: grant GSK, Merck, Nestle; consulting fee GSK, ABBVIE, Novartis, Menarini, MEDA, AlK‐ABELLO, Allergopharma, Uriach, Stallergenes; payment for development of educational presentations from Abbvie, Sanofi, Menarini, Meda; O Pfaar: Research grants, advisor and/or speaker (ALK-Abelló, Allergopharma, Stallergenes, HAL Allergy, Artu Biologicals, Allergy Therapeutics/Bencard, Hartington, Lofarma, Novartis/Leti, GlaxoSmithKline, Essex Pharma, Cytos, Curalogic, Roxall, Biomay, Thermo Fisher, Circassia, European Union (FP-7 Health-2013 Innovation 1), Biotech Tools s.a., and Meda Pharma GmbH. Travel grants (HAL Allergy and Allergopharma). Advisor (Bencard, HAL Allergy, Novartis/Leti, Meda, ALK-Abelló, Allergopharma, Biotech Tools s.a., GfK Bridgehead, Navigant Consulting, Sanofi, Guidepoint Global Advisors, Thermo Fisher and Stallergenes). Scientific Board Member of Mobile Chamber Experts (MCX), a GA2LEN Partner; L Rosenwasser: fees for participanting in review activities from Sanofi, Circassia, Regeneron; NIH/NHLBI Asthma PRC; D Ryan: consultant fee Stallergennes; C Schmidt-Weber: grant Allergopharma, Leti, Regeneron; Member of the scientific advisory board of Leti; consultant for PLS-Design, Allergopharma, Leti; shares of PLS-Design; S Szefler: research grant from GSK; member of the IMIH/NAEPP Expert Panel 3 for the Diagnosis and management of Asthma, as well as the Global Strategy for Asthma (GINA Science Committee and Board of Directors. Consultant to Aerocrine, Astra Zeneca, Boehringer-lngelheim, Genentech, Glaxo Smith Kline, Merck, Novartis and Roche; U Wahn: consulting for Stalergenes for FDA hearings (2013); speaker or consultant honoraria from Stallergens, ALK-Abello, Allergopharma, Novartis, Merck; R.Gerth van Wijk: Research grant (ALK-Abello, DBV); J Wilkinson: none; A Sheikh: support to co-ordinate the undertaking of the systematic review and development of the guidelines.