Erschienen in:
01.11.2009 | Case Report
Pancytopenia Associated with Levetiracetam Treatment
verfasst von:
Dr Massimo Gallerani, Elisa Mari, Benedetta Boari, Rossella Carletti, Anna Marra, Michele Cavallo
Erschienen in:
Clinical Drug Investigation
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Ausgabe 11/2009
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Abstract
Levetiracetam is a pyrrolidine derivate that is approved for the treatment of seizures. It has a favourable pharmacokinetic profile, no clearly established pharmacological interactions, good tolerability and offers the possibility of rapid treatment.
We describe a case of pancytopenia and multiple infections observed in the context of levetiracetam treatment. A 65-year-old woman who underwent surgical removal of a meningioma developed progressive pancytopenia complicated by pneumonia and multiple liver abscesses after starting levetiracetam therapy. Bone marrow aspiration and biopsy confirmed the diagnosis. A gradual spontaneous recovery of normal haematopoiesis followed discontinuation of levetiracetam.