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01.12.2016 | Case report | Ausgabe 1/2016 Open Access

BMC Clinical Pathology 1/2016

Liver cancer with concomitant TP53 and CTNNB1 mutations: a case report

Zeitschrift:
BMC Clinical Pathology > Ausgabe 1/2016
Autoren:
Juliane Friemel, Markus Rechsteiner, Marion Bawohl, Lukas Frick, Beat Müllhaupt, Mickaël Lesurtel, Achim Weber

Abstract

Background

In the spectrum of molecular alterations found in hepatocellular carcinoma (HCC), somatic mutations in the WNT/β-catenin pathway and the p53/cell cycle control pathway are among the most frequent ones. It has been suggested that both mutations occur in a mutually exclusive manner and they are used as molecular classifiers in HCC classification proposals.

Case presentation

Here, we report the case of a treatment-naïve mixed hepatocellular/cholangiocellular carcinoma (HCC/CCC) with morphological and genetic intratumor heterogeneity. Within the predominant part of the tumor with hepatocellular differentiation, a p.D32V mutation in exon 3 of the CTNNB1 gene occurred concomitantly with a TP53 intron 7/exon 8 splice site mutation.

Conclusion

Intratumor heterogeneity challenges the concept of CTNNB1 and TP53 gene mutations being mutually exclusive molecular classifiers in HCC, which has implications for HCC classification approaches.
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