nach oben

Neurological Sciences

Erschienen in:

17.07.2021 | Original Article

LncRNA SERPINB9P1 expression and polymorphisms are associated with ischemic stroke in a Chinese Han population

verfasst von: Jiao Huang, Lulu Zhu, Xinyi Zhao, Xulong Wu, Jialei Yang, Bingyi Xu, Zhi Zhao, Lian Gu, Li Su

Erschienen in: Neurological Sciences | Ausgabe 2/2022

Einloggen, um Zugang zu erhalten

Abstract

Long noncoding RNAs (lncRNAs) were reported to play important roles in the pathogenesis of ischemic stroke (IS). Our study aimed to investigate the role of lncRNA SERPINB9P1 expression in ischemic stroke and the association between SERPINB9P1 polymorphisms and IS risk, as well as examine the correlation of SERPINB9P1 expression and variants with clinical parameters of IS. The SERPINB9P1 levels in human participants and oxygen–glucose deprivation (OGD)–treated human A172 cells were measured by qRT-PCR. The SERPINB9P1 polymorphisms (rs375556 and rs318429) were genotyped by the MassARRAY platform. We found that the SERPINB9P1 expression was significantly downregulated in patients with IS compared with that in healthy controls. On the 14th day in the hospital, the SERPINB9P1 level in patients with moderate and severe stroke was significantly downregulated compared with the normal group. After stratification by gender, the rs375556 polymorphism was significantly associated with susceptibility to female IS in the recessive model, and the significant association remained after adjusting for age. After adjusting for gender and age, rs318429 was significantly associated with FPG and D-D levels, and rs375556 was significantly associated with INR and PTA levels in IS cases. Besides, the lncRNA SERPINB9P1 expressed downregulated in OGD/reoxygenation-treated human A172 cells. In conclusion, the lncRNA SERPINB9P1 may protect against cerebral ischemia–reperfusion injury and neurological impairment after IS. The SERPINB9P1 rs375556 polymorphism was associated with susceptibility to female IS, and SERPINB9P1 polymorphisms may influence the metabolism of blood glucose and regulation of coagulation function in patients with IS.

Akhter MS, Biswas A, Abdullah SM, Behari M, Saxena R (2017) The role of PAI-1 4G/5G promoter polymorphism and its levels in the development of ischemic stroke in young Indian population. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 23:1071–1076CrossRef

Baek JY, Yeo HY, Chang HJ, Kim KH, Kim SY, Park JW, Park SC, Choi HS, Kim DY, Oh JH (2014) Serpin B5 is a CEA-interacting biomarker for colorectal cancer. Int J Cancer 134:1595–1604PubMedCrossRef

Buchthal B, Weiss U, Bading H (2018) Post-injury nose-to-brain delivery of activin A and serpinB2 reduces brain damage in a mouse stroke model. Molecular therapy: the journal of the American Society of Gene Therapy 26:2357–2365CrossRef

Cabezas-Llobet N, Camprubi S, Garcia B, Alberch J, Xifro X (2018) Human alpha 1-antitrypsin protects neurons and glial cells against oxygen and glucose deprivation through inhibition of interleukins expression. Biochim Biophys Acta 1862:1852–1861CrossRef

Campos MA, Lascano J (2014) alpha1 Antitrypsin deficiency: current best practice in testing and augmentation therapy. Ther Adv Respir Dis 8:150–161PubMedCrossRef

Cheng H, Sun M, Wang ZL, Wu Q, Yao J, Ren G, Sun XL (2020) LncRNA RMST-mediated miR-107 transcription promotes OGD-induced neuronal apoptosis via interacting with hnRNPK. Neurochemistry international 133:104644.

Cheng X, Xu J, Gu M, Wang M, Sun B, Li Z, Ni G, Wang G, Weng Z, Shi Y, Zhang Z, Liu X (2018) Genetic variants in ALDH2 predict risk of ischemic stroke in a Chinese population. Gene 678:49–54PubMedCrossRef

Choi SW, Kim BB, Choi DH, Park G, Shin BC, Song H, Kim D, Kim DM (2017) Stroke or left atrial thrombus prediction using antithrombin III and mean platelet volume in patients with nonvalvular atrial fibrillation. Clin Cardiol 40:1013–1019PubMedPubMedCentralCrossRef

Cucchiara B, George DK, Kasner SE, Knutsson M, Denison H, Ladenvall P, Amarenco P, Johnston SC (2019) Disability after minor stroke and TIA: a secondary analysis of the SOCRATES trial. Neurology 93:e708–e716PubMedCrossRef

10.

Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ, Alzheimer’s Disease Neuroimaging I, Alzheimer Disease Genetics C, Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ, (2018) Sex-specific genetic predictors of Alzheimer’s disease biomarkers. Acta Neuropathol 136:857–872PubMedPubMedCentralCrossRef

11.

Ferreira LE, Secolin R, Lopes-Cendes I, Cabral NL, Franca PHC (2019) Association and interaction of genetic variants with occurrence of ischemic stroke among Brazilian patients. Gene 695:84–91PubMedCrossRef

12.

Flores AE, Pascotini ET, Kegler A, Gabbi P, Bochi GV, Barbisan F, Duarte T, Prado ALC, Duarte M, da Cruz IBM, Moresco RN, Santos ARS, Bresciani G, Royes LFF, Fighera MR (2017) ALA16VAL-MnSOD gene polymorphism and stroke: association with dyslipidemia and glucose levels. Gene 627:57–62PubMedCrossRef

13.

Flossmann E, Schulz UG, Rothwell PM (2004) Systematic review of methods and results of studies of the genetic epidemiology of ischemic stroke. Stroke 35:212–227PubMedCrossRef

14.

Gao N, Tang H, Gao L, Tu G, Luo H, Xia Y (2020) CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study. BMC Neurol 20:77PubMedPubMedCentralCrossRef

15.

Ge Y (2020) The clinical value of serum cystatin C and coagulation function test in patients with acute cerebral infarction. Electronic Journal of General Stomatology 7:174–175

16.

Ghaedi H, Zare A, Omrani MD, Doustimotlagh AH, Meshkani R, Alipoor S, Alipoor B (2018) Genetic variants in long noncoding RNA H19 and MEG3 confer risk of type 2 diabetes in an Iranian population. Gene 675:265–271PubMedCrossRef

17.

Gu L, Huang J, Li J, Huang S, Li M, Gong L, Li T, Su L (2018) Association of CALM1 rs3179089 Polymorphism with ischemic stroke in Chinese Han population. NeuroMol Med 20:271–279CrossRef

18.

Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V (2013) Update of the human and mouse SERPIN gene superfamily. Hum Genomics 7:22PubMedPubMedCentralCrossRef

19.

Hu X, Zan X, Xie Z, Li Y, Lin S, Li H, You C (2017) Association between plasminogen activator inhibitor-1 genetic polymorphisms and stroke susceptibility. Mol Neurobiol 54:328–341PubMedCrossRef

20.

Huang J, Yang J, Li J, Chen Z, Guo X, Huang S, Gu L, Su L (2019) Association of long noncoding RNA H19 polymorphisms with the susceptibility and clinical features of ischemic stroke in southern Chinese Han population. Metab Brain Dis 34:1011–1021PubMedCrossRef

21.

Hurley MJ, Durrenberger PF, Gentleman SM, Walls AF, Dexter DT (2015) Altered expression of brain proteinase-activated receptor-2, trypsin-2 and serpin proteinase inhibitors in Parkinson’s disease. Journal of molecular neuroscience: MN 57:48–62PubMedCrossRef

22.

Hurth H, Birkenhauer U, Steiner J, Schlak D, Hennersdorf F, Ebner FH (2020) Delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage - serum D-dimer and C-reactive protein as early markers. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 29:104558.

23.

Ishii N, Ozaki K, Sato H, Mizuno H, Susumu S, Takahashi A, Miyamoto Y, Ikegawa S, Kamatani N, Hori M, Satoshi S, Nakamura Y, Tanaka T (2006) Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction. J Hum Genet 51:1087–1099PubMedCrossRef

24.

Kim JW, Lee SH, Ko HM, Kwon KJ, Cho KS, Choi CS, Park JH, Kim HY, Lee J, Han SH, Ignarro LJ, Cheong JH, Kim WK, Shin CY (2011) Biphasic regulation of tissue plasminogen activator activity in ischemic rat brain and in cultured neural cells: essential role of astrocyte-derived plasminogen activator inhibitor-1. Neurochem Int 58:423–433PubMedCrossRef

25.

Krishnamurthi RV, Ikeda T, Feigin VL (2020) Global, regional and country-specific burden of ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage: a systematic analysis of the global burden of disease study 2017. Neuroepidemiology 54:171–179PubMedCrossRef

26.

Liang Y, Zhang R, Zhang S, Ji G, Shi P, Yang T, Liu F, Feng J, Li C, Guo D, Chen M (2017) Association of ACYP2 and TSPYL6 genetic polymorphisms with risk of ischemic stroke in Han Chinese population. Mol Neurobiol 54:5988–5995PubMedCrossRef

27.

Liu C, Yang J, Zhang C, Liu M, Geng X, Ji X, Du H, Zhao H (2018) Analysis of long non-coding RNA expression profiles following focal cerebral ischemia in mice. Neurosci Lett 665:123–129PubMedCrossRef

28.

Lucas A, Yaron JR, Zhang L, Ambadapadi S (2018) Overview of Serpins and Their Roles in Biological Systems. Methods Mol Biol 1826:1–7PubMedCrossRef

29.

Zurück zum Zitat Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD, Jr., Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jimenez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O’Donnell MJ, Psaty BM, Pulit SL, Rannikmae K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Consortium AF, Cohorts for H, Aging Research in Genomic Epidemiology C, International Genomics of Blood Pressure C, Consortium I, Starnet, Bis JC, Pastinen T, Ruusalepp A, Schadt EE, Koplev S, Bjorkegren JLM, Codoni V, Civelek M, Smith NL, Tregouet DA, Christophersen IE, Roselli C, Lubitz SA, Ellinor PT, Tai ES, Kooner JS, Kato N, He J, van der Harst P, Elliott P, Chambers JC, Takeuchi F, Johnson AD, BioBank Japan Cooperative Hospital G, Consortium C, Consortium E-C, Consortium EP-I, International Stroke Genetics C, Consortium M, Neurology Working Group of the CC, Network NSG, Study UKYLD, Consortium M, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT, Jr., Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M (2018) Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet 50:524–537PubMedCrossRef Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD, Jr., Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jimenez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O’Donnell MJ, Psaty BM, Pulit SL, Rannikmae K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Consortium AF, Cohorts for H, Aging Research in Genomic Epidemiology C, International Genomics of Blood Pressure C, Consortium I, Starnet, Bis JC, Pastinen T, Ruusalepp A, Schadt EE, Koplev S, Bjorkegren JLM, Codoni V, Civelek M, Smith NL, Tregouet DA, Christophersen IE, Roselli C, Lubitz SA, Ellinor PT, Tai ES, Kooner JS, Kato N, He J, van der Harst P, Elliott P, Chambers JC, Takeuchi F, Johnson AD, BioBank Japan Cooperative Hospital G, Consortium C, Consortium E-C, Consortium EP-I, International Stroke Genetics C, Consortium M, Neurology Working Group of the CC, Network NSG, Study UKYLD, Consortium M, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT, Jr., Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M (2018) Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet 50:524–537PubMedCrossRef

30.

Mangan MS, Melo-Silva CR, Luu J, Bird CH, Koskinen A, Rizzitelli A, Prakash M, Scarff KL, Mullbacher A, Regner M, Bird PI (2017) A pro-survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection. Immunol Cell Biol 95:884–894PubMedCrossRef

31.

Meadows KL (2018) Ischemic stroke and select adipose-derived and sex hormones: a review. Hormones 17:167–182PubMedCrossRef

32.

Mehta SL, Kim T, Vemuganti R (2015) Long noncoding RNA FosDT promotes ischemic brain injury by interacting with REST-associated chromatin-modifying proteins. The Journal of neuroscience: the official journal of the Society for Neuroscience 35:16443–16449CrossRef

33.

Meschia JF, Nalls M, Matarin M, Brott TG, Brown RD, Jr., Hardy J, Kissela B, Rich SS, Singleton A, Hernandez D, Ferrucci L, Pearce K, Keller M, Worrall BB, Siblings With Ischemic Stroke Study I (2011) Siblings with ischemic stroke study: results of a genome-wide scan for stroke loci. Stroke 42:2726–2732CrossRef

34.

Mukhopadhyay S, Johnson TA, Sarkar R, Antalis TM (2018) Serpins in venous thrombosis and venous thrombus resolution. Methods Mol Biol 1826:197–211PubMedPubMedCentralCrossRef

35.

Neurology Working Group of the Cohorts for H, Aging Research in Genomic Epidemiology Consortium tSGN, the International Stroke Genetics C (2016) Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. The Lancet Neurology 15:695–707CrossRef

36.

Pan JX (2017) LncRNA H19 promotes atherosclerosis by regulating MAPK and NF-kB signaling pathway. Eur Rev Med Pharmacol Sci 21:322–328PubMed

37.

Petrone AB, O’Connell GC, Regier MD, Chantler PD, Simpkins JW, Barr TL (2016) The role of arginase 1 in post-stroke immunosuppression and ischemic stroke severity. Transl Stroke Res 7:103–110PubMedCrossRef

38.

Poorthuis MH, Algra AM, Algra A, Kappelle LJ, Klijn CJ (2017) Female- and male-specific risk factors for stroke: a systematic review and meta-analysis. JAMA Neurol 74:75–81PubMedCrossRef

39.

Praetner M, Zuchtriegel G, Holzer M, Uhl B, Schaubacher J, Mittmann L, Fabritius M, Furst R, Zahler S, Funken D, Lerchenberger M, Khandoga A, Kanse S, Lauber K, Krombach F, Reichel CA (2018) Plasminogen activator inhibitor-1 promotes neutrophil infiltration and tissue injury on ischemia-reperfusion. Arterioscler Thromb Vasc Biol 38:829–842PubMedCrossRef

40.

Reyahi A, Nik AM, Ghiami M, Gritli-Linde A, Ponten F, Johansson BR, Carlsson P (2015) Foxf2 is required for brain pericyte differentiation and development and maintenance of the blood-brain barrier. Dev Cell 34:19–32PubMedCrossRef

41.

Sanad EF, Hamdy NM, El-Etriby AK, Sebak SA, El-Mesallamy HO (2017) Peripheral leucocytes and tissue gene expression of granzyme B/perforin system and serpinB9: impact on inflammation and insulin resistance in coronary atherosclerosis. Diabetes Res Clin Pract 131:132–141PubMedCrossRef

42.

Tan RY, Markus HS (2015) Monogenic causes of stroke: now and the future. J Neurol 262:2601–2616PubMedCrossRef

43.

van der Burgh R, Meeldijk J, Jongeneel L, Frenkel J, Bovenschen N, van Gijn M, Boes M (2016) Reduced serpinB9-mediated caspase-1 inhibition can contribute to autoinflammatory disease. Oncotarget 7:19265–19271PubMedPubMedCentralCrossRef

44.

Wang J, Zhao H, Fan Z, Li G, Ma Q, Tao Z, Wang R, Feng J, Luo Y (2017) Long noncoding RNA H19 Promotes neuroinflammation in ischemic stroke by driving histone deacetylase 1-dependent M1 microglial polarization. Stroke 48:2211–2221PubMedCrossRef

45.

Wang L, Liu J, Yang Y, Peng B, Wang Y (2018) Report on stroke prevention and treatment in China 2017. Chinese Journal of Cerebrovascular Disease 15:611–617

46.

Wang Y, Liu J, Wu H, Cai Y (2018) Combined biomarkers composed of environment and genetic factors in stroke. Biosci Trends 12:360–368PubMedCrossRef

47.

Wei YS, Xiang Y, Liao PH, Wang JL, Peng YF (2016) An rs4705342 T>C polymorphism in the promoter of miR-143/145 is associated with a decreased risk of ischemic stroke. Sci Rep 6:34620PubMedPubMedCentralCrossRef

48.

Williams FM, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, Traylor M, Bevan S, Dichgans M, Rothwell PM, Sudlow C, Farrall M, Silander K, Kaunisto M, Wagner P, Saarela O, Kuulasmaa K, Virtamo J, Salomaa V, Amouyel P, Arveiler D, Ferrieres J, Wiklund PG, Ikram MA, Hofman A, Boncoraglio GB, Parati EA, Helgadottir A, Gretarsdottir S, Thorsteinsdottir U, Thorleifsson G, Stefansson K, Seshadri S, DeStefano A, Gschwendtner A, Psaty B, Longstreth W, Mitchell BD, Cheng YC, Clarke R, Ferrario M, Bis JC, Levi C, Attia J, Holliday EG, Scott RJ, Fornage M, Sharma P, Furie KL, Rosand J, Nalls M, Meschia J, Mosely TH, Evans A, Palotie A, Markus HS, Grant PJ, Spector TD, Euro CI, Wellcome Trust Case Control C, Monica Risk GA, Monograph, MetaStroke, International Stroke Genetics C (2013) Ischemic stroke is associated with the ABO locus: the EuroCLOT study. Ann Neurol 73:16–31PubMedCrossRef

49.

Wu N, Chen X, Cai T, Wu L, Xiang Y, Zhang M, Li Y, Song Z, Zhong L (2015) Association of inflammatory and hemostatic markers with stroke and thromboembolic events in atrial fibrillation: a systematic review and meta-analysis. Can J Cardiol 31:278–286PubMedCrossRef

50.

Wu W, Asakawa T, Yang Q, Zhao J, Lu L, Luo Y, Gong P, Han S, Li W, Namba H, Wang L (2017) Effects of neuroserpin on clinical outcomes and inflammatory markers in Chinese patients with acute ischemic stroke. Neurol Res 39:862–868PubMedCrossRef

51.

Wzorek J, Karpinski M, Wypasek E, Michalski M, Szczudlik A, Malinowski KP, Undas A (2018) Alpha-2-antiplasmin Arg407Lys polymorphism and cryptogenic ischemic cerebrovascular events: association with neurological deficit. Neurol Neurochir Pol 52:352–358PubMedCrossRef

52.

Xu X, Zhuang C, Chen L (2020) Exosomal long non-coding RNA expression from serum of patients with acute minor stroke. Neuropsychiatr Dis Treat 16:153–160PubMedPubMedCentralCrossRef

53.

Yang J, Gu L, Guo X, Huang J, Chen Z, Huang G, Kang Y, Zhang X, Long J, Su L (2018) LncRNA ANRIL expression and ANRIL gene polymorphisms contribute to the risk of ischemic stroke in the Chinese Han population. Cell Mol Neurobiol 38:1253–1269PubMedCrossRef

54.

Yi X, Lin J, Wang C, Zhou Q (2017) CYP genetic variants, CYP metabolite levels, and neurologic deterioration in acute ischemic stroke in Chinese population. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 26:969–978CrossRef

55.

Young JL, Sukhova GK, Foster D, Kisiel W, Libby P, Schonbeck U (2000) The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells. J Exp Med 191:1535–1544PubMedPubMedCentralCrossRef

56.

Zhang H, Yin Y, Zhang C, Zhang D (2019) Costs of hospitalization for stroke from two urban health insurance claims data in Guangzhou City, southern China. BMC Health Serv Res 19:671PubMedPubMedCentralCrossRef

57.

Zhang J, Yuan L, Zhang X, Hamblin MH, Zhu T, Meng F, Li Y, Chen YE, Yin KJ (2016) Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia. Exp Neurol 277:162–170PubMedCrossRef

58.

Zhang Y, Cheng X, Liang H, Jin Z (2018) Long non-coding RNA HOTAIR and STAT3 synergistically regulate the cervical cancer cell migration and invasion. Chem Biol Interact 286:106–110PubMedCrossRef

59.

Zhang Y, Zhang Y (2020) lncRNA ZFAS1 improves neuronal injury and inhibits inflammation, oxidative stress, and apoptosis by sponging miR-582 and upregulating NOS3 expression in cerebral ischemia/reperfusion injury. Inflammation 43:1337–1350PubMedCrossRef

60.

Zheng Z, Liu S, Wang C, Han X (2018) A functional polymorphism rs145204276 in the promoter of long noncoding RNA GAS5 is associated with an increased risk of ischemic stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 27:3535–3541CrossRef

61.

Zhou M, Wang H, Zeng X, Yin P, Zhu J, Chen W, Li X, Wang L, Wang L, Liu Y, Liu J, Zhang M, Qi J, Yu S, Afshin A, Gakidou E, Glenn S, Krish VS, Miller-Petrie MK, Mountjoy-Venning WC, Mullany EC, Redford SB, Liu H, Naghavi M, Hay SI, Wang L, Murray CJL, Liang X (2019) Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 394:1145–1158PubMedPubMedCentralCrossRef

62.

Zhu M, Li N, Luo P, Jing W, Wen X, Liang C, Tu J (2018) Peripheral blood leukocyte expression of lncRNA MIAT and its diagnostic and prognostic value in ischemic stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 27:326–337CrossRef

63.

Zhu R, Liu X, He Z (2018) Long non-coding RNA H19 and MALAT1 gene variants in patients with ischemic stroke in a northern Chinese Han population. Mol Brain 11:58PubMedPubMedCentralCrossRef

Titel: LncRNA SERPINB9P1 expression and polymorphisms are associated with ischemic stroke in a Chinese Han population
verfasst von: Jiao Huang
Lulu Zhu
Xinyi Zhao
Xulong Wu
Jialei Yang
Bingyi Xu
Zhi Zhao
Lian Gu
Li Su
Publikationsdatum: 17.07.2021
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 2/2022
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-021-05418-5

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2022

Motor and non-motor symptom improvement after mRNA-1273 vaccine in a Parkinson’s disease patient

The sustained improvement after lumbar puncture in an idiopathic normal pressure hydrocephalus subject with synucleinopathy

Predicting value of fibrinogen in identifying cerebrovascular ischemic events in patients with dizziness/vertigo

Transcranial magnetic stimulation implementation on stroke prognosis

Patient’s point of view on the use of telemedicine in multiple sclerosis: a web-based survey

Psychological factors associated with headache frequency, intensity, and headache-related disability in migraine patients

Leitlinien kompakt für die Neurologie

Update Neurologie