Skip to main content

01.11.2011 | Cornea | Ausgabe 11/2011

Graefe's Archive for Clinical and Experimental Ophthalmology 11/2011

Long-term outcome and prognostic factor analysis for keratolimbal allografts

Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 11/2011
Eui Seok Han, Won Ryang Wee, Jin Hak Lee, Mee Kum Kim
Wichtige Hinweise
Commercial interest or financial relationship: none
We have full control of all primary data, and we agree to allow Graefe's Archive for Clinical and Experimental Ophthalmology to review our data upon request.
Institutional review board (H-1006-143-322).



To evaluate the long-term results of keratolimbal allograft (KLAL) and elucidate the prognostic factors of KLAL survival.


Twenty-four eyes of 22 patients underwent KLAL one or more times, and were followed up more than 1 year postoperatively. Their medical records were reviewed. The success of KLAL and penetrating keratoplasty (PKP) was evaluated. KLAL success was defined as absence of persistent corneal epithelial defect, corneal conjunctivalization, or neovascularization on the corneal edge of the graft. Prognostic factors for survival of KLAL were analyzed, including preoperative diagnosis, history of graft rejection, symblepharon, concurrent surgery, immunosuppressant dose, and interval for full epithelialization time. The prognostic factors were evaluated by univariate survival analysis or multivariate Cox proportional hazards survival regression.


KLAL had been successful in 33.3% of the eyes over an average of 47.9 months. Fifteen episodes of KLAL rejection developed in ten eyes (41.7%), but 13 cases (86.7%) were reversible. Of 45 KLAL procedures, eyelid deformity, symblepharon, and the interval of full epithelialization were significantly associated with KLAL success by univariate analysis, and the presence of symblepharon was identified by multivariate Cox regression analysis as the most important prognostic factor to affect KLAL outcome (p = 0.010).


KLAL has been partly successful for reconstruction of limbal stem cell deficiency, and symblepharon has been identified as a significant prognostic factor for KLAL survival. Surgical correction of symblepharon is important before KLAL and PKP.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

e.Med Interdisziplinär

Für Ihren Erfolg in Klinik und Praxis - Die beste Hilfe in Ihrem Arbeitsalltag als Mediziner

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf

Jetzt e.Med zum Sonderpreis bestellen!

Über diesen Artikel

Weitere Artikel der Ausgabe 11/2011

Graefe's Archive for Clinical and Experimental Ophthalmology 11/2011 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

28.08.2020 | Leitthema | Ausgabe 10/2020

Künstliche Intelligenz in der Augenheilkunde

Leitfaden für Ärzte zur kritischen Bewertung von Studien