Octogenarians form a distinctive group of elderly patients, due to the decrease of functional capacity and increase of multimorbidity, impaired cognitive functioning, and disabilities after age 80 years.
3 How to best treat these increasingly vulnerable octogenarians with CRC remains a challenging issue. For example, elderly patients with rectal cancer less often receive (neo)adjuvant treatment and extended surgical resections and more often undergo surgery with a palliative intent.
4,
5 To decide whether to offer older patients the same invasive treatment as younger patients, knowledge about the differences in postoperative outcomes between older and younger patients is important. In literature, a discrepancy between the reported postoperative outcomes in the elderly exists. Some studies show that postoperative complications occur more frequently in the elderly population compared with younger patients.
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9 Other studies report smaller differences or no differences at all.
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12 A similar controversy exists regarding the long-term postoperative survival of elderly after surgical treatment for CRC. Some studies show a decreased survival in elderly patients with CRC compared with younger patients.
1,
9,
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15 In contrast, some studies report fairly good long-term survival in the elderly.
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The purpose of this study was to analyse postoperative complications and long-term survival in a consecutive cohort of octogenarians who were surgically treated for CRC. After comparison of our results with the existing literature, an assessment postoperative complications and impaired long-term survival octogenarians is made.
Discussion
With a study population of 108 patients, our study is the largest study focussing on both postoperative complications and long-term survival in octogenarians. Twenty-five percent of the patients developed major postoperative complications. No significant risk factors for the development of postoperative complications were present in our study. Approximately 40% of octogenarians with CRC survived for a period of at least 5 years after surgery. Factors most strongly associated with an impaired survival were the development of postoperative complications, higher burden of comorbidity, emergency procedures, and the presence of tumour-positive lymph nodes. The influence of increased age on the postoperative survival was less striking.
In our study, 25% of the patients developed major postoperative complications. Although high, this is a relatively low percentage compared with the 21–61% complication rate in octogenarians reported in literature.
6,
7,
23 However, it is comparable to studies, including younger patients, reporting a complication rate of 21–35%.
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12,
24 This might indicate that the population included in this study was relatively fit before surgery. We found no significant risk factors for the development of postoperative complications. In comparable studies in younger populations, several risk factors, such as age, higher ASA score, and preoperative comorbidity and functioning, has been reported.
6,
7,
23 Research focused on the elderly population showed that risk factors in the elderly differ from risk factors in a younger population and include risk factors, such as increased frailty.
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26 Even though comorbidity is an aspect of frailty, in our population a higher burden of comorbidity alone did not predict the development of postoperative complications. This might indicate that the integrated concept of frailty is more predictive for the development of complications in this patient group than each aspect of frailty separately. The absence of finding risk factors for the development of postoperative complications in our study can be explained by the fact that the information on other aspects of frailty and factors, such as cognitive functioning and functioning in daily life is very limited.
The 30-day and 1-year survival rates in our study are in accordance with literature, even though these survival rates are diminished compared with the younger population.
27,
28 This excess mortality in the elderly has been described before, but its aetiology remains complex with several possible risk factors influencing the short-term survival.
1,
27,
28 The 5-year survival rate in our study was approximately 40% in a population with a median age of 83 years, which is at the high end of the spectrum of the 5-year survival in elderly after surgical treatment for CRC reported in the current literature, which ranges from 23 to 40%.
9,
12,
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18 When comparing our survival rate to the remaining life expectancy of healthy 80-year-old persons in the Netherlands, which is 8.4 years for men and 10.1 years for women, our data indicate that octogenarians can approach a normal life expectancy after surgical treatment for CRC.
29 Our results showed that postoperative complications, higher burden of comorbidity, emergency procedures, and tumour-positive lymph nodes were the main predictors for reduced survival, which is in line with other studies.
7,
13,
17,
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34 The effect of age on survival is not clear. Some studies describe an important effect of age on survival, whereas in other studies age was less important.
13,
18,
30,
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35 In our study, we found no strong effect of age on survival. This might be explained by the way the octogenarians were selected in this study; we selected patients who were deemed fit enough to undergo major surgery by both the surgeon and anaesthesiologist and could be operated on with curative intent. This might have led to the selection of a homogenous group of fit octogenarians.
In our study, the occurrence of complications was the strongest risk factor for reduced survival. Although well-selected octogenarians are not necessarily at a higher risk of postoperative complications compared with younger patients, in case of complications, the median postoperative survival is decreased with 53 months. Furthermore, 8% of the deceased patients died of conditions directly related to the surgical procedure, which is relatively high in this relatively fit group of elderly patients.
This underlines the importance of the prevention of postoperative complications in this age category specifically. Therefore, extra considerations are necessary for preventing postoperative complications, which occur predominantly in the elderly population or have more serious course in this population. A condition that occurs predominantly in the elderly is the development of postoperative delirium.
36,
37 During the postoperative period, awareness and measures to prevent postoperative delirium are important, because the occurrence of postoperative delirium can possibly be prevented in a substantial number of the cases.
37 Strategies for screening and correction of polypharmacy, which are associated with an increased risk of delirium, and preventive measures for postoperative delirium should be an integrated part of the surgical treatment of elderly with CRC.
37
In our population, patients who underwent open procedures did not have a higher complication risk compared with laparoscopic procedures. A possible explanation could be the patient selection in this study. The literature shows that laparoscopy is safe in the elderly with increased comorbidity and leads to better short-term outcomes with equivalent long-term oncologic outcomes compared with open procedures.
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40 Therefore, further increase of laparoscopic procedures in the elderly might lead to a decrease in postoperative complications.
An important surgical complication in all patients undergoing surgical resection of CRC is anastomotic leakage, because it influences short-term outcomes but also is related to higher long-term mortality.
24,
41 The rate of anastomotic leakage in our population is slightly increased compared with the literature.
42 The aetiology of anastomotic leakages is complex, and a number of possible risk factors, such as emergency procedures, malnutrition, and increased comorbidity have been described.
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44 In our population, there were no differences in patients with or without an anastomotic leakage with regard to the presence of malnutrition, percentage of emergency procedures, or burden of comorbidity. Furthermore, surgical techniques to create a tension-free anastomosis are important to prevent anastomotic leakage. To our knowledge, no compromises were made in the resection of the colorectal tumours and tension-free anastomosis were created in our population. An explanation for the relatively high rate of anastomotic leakage might be the increased age of our patient group, because research has shown that age per se is an important risk factor for developing anastomotic leakage, probably due to a combination of risk factors more present in the elderly.
45 Furthermore, increased age is associated with a higher risk of death after anastomotic leakage.
43 Prevention of anastomotic leakage could be achieved, partly, by change of surgical treatment strategies in the elderly, e.g., bowel diversion with a colostomy instead of a primary anastomosis. The downside of a colostomy is the relatively high number of early complications.
46 Even though most complications are relatively minor from a medical point of view, including retraction, leakage, or skin irritation, these complications could greatly diminish quality of life.
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48 Therefore, patient consultation about the risk of anastomotic leakage and subsequently higher mortality risk versus the possible loss of quality of life after colostomy is important in the decision of whether to perform an anastomosis or colostomy.
The impact of survival in the first postoperative year on the total survival in elderly with CRC has been described in literature; if patients survive the first year after surgery, there is a reasonably good long-term survival.
27,
49 Our results show that postoperative complications are a great risk of mortality in the early postoperative period. Therefore, prevention of postoperative complications can contribute to better 1-year and long-term survival. For prevention of postoperative complications in the elderly, the involvement of a geriatrician in perioperative decision-making and care, in addition to tailor-made surgical strategies, can be helpful. A geriatrician, possibly with use of a comprehensive geriatric assessment (CGA), can help to select those patients who might benefit from additional measures in the preoperative period. The CGA, which focuses not only on physical domains but also on domains, such as cognition and functioning, has proven to be useful in the detection of frail patients who are at an increased risk for developing postoperative complications.
25,
26 In these frail patients, management of patient and family expectations on outcome before surgery is important and should become more integrated in preoperative decision-making. In the future, the use of CGAs might help to select patients who can benefit from rehabilitation programs, although the exact content and duration of these programs is not clear at present. The geriatric consultation should extend to the postoperative period, because it can improve early detection, treatment, and possibly prevention of postoperative complications.
The strengths of this study are the duration of the follow-up period and the relatively large group of patients included. Furthermore, the survival status of the patients has been checked with the Dutch basic registration of persons and addresses, providing reliable information about the actual survival. With a follow-up period extending to almost 9 years, this study gives insights in the factors that influence the long-term survival.
The main limitation of this study is that only octogenarians who underwent surgical treatment were included, and selection bias seems plausible. The healthier patients were selected for surgical treatment. However, what we can learn from this data is that surgical treatment in octogenarians diagnosed with cancer can have good results.
Furthermore, only ASA score and CCI were used to evaluate the condition of the patients, leading to limited information about the functional status of the patients. Information about functioning in daily life, frailty, muscle strength, cognitive functioning, general performance, and presence of sarcopenia was not recorded. These factors could provide better insight to the condition of the patients and could reveal additional risk factors for development of postoperative complications and impaired survival in octogenarians surgically treated for CRC. In future research, these factors should be considered.