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23.09.2022 | Original Article

Long-term use of broad-spectrum antibiotics affects Ly6C^hi monocyte recruitment and IL-17A and IL-22 production through the gut microbiota in tumor-bearing mice treated with chemotherapy

verfasst von: Yanhong Wu, Xiaolei Tang, Feng Hu, Tao Zhu, Hui Liu, Yanjing Xiong, Xiaoxuan Zuo, Aiping Xu, Xiufen Zhuang

Erschienen in: Immunologic Research | Ausgabe 6/2022

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Abstract

The protective effects of antibiotics against infection in cancer patients treated with chemotherapy remains unclear and related studies have been performed in healthy or pathogen-infected animal models. Here, we aimed to study the effects of antibiotic use on intestinal infection in tumor-bearing mice treated with chemotherapy and to determine the underlying mechanisms. Subcutaneous CT26 tumor-bearing mice were assigned to four groups: the control (Ctrl) group without any treatment, the antibiotic (ATB) group treated with a mixture of ampicillin, streptomycin, and colistin, the 5-fluorouracil (FU) group treated with four cycles of intraperitoneal injections of FU, and the ATB + FU group treated with the combination of ATB and FU. Gut microbial composition was determined and mesenteric lymph nodes (mLNs) were isolated for bacterial culturing. Intestinal permeability and integrity were assessed and the expression of cytokines was analyzed by quantitative PCR, ELISA, or flow cytometry (FCM). Monocytes in the colonic lamina propria (LP) were measured by FCM. Compared with the Ctrl and FU groups, the numbers of positive bacterial culturing results for mLNs were higher, and gut bacterial compositions were altered in the ATB and ATB + FU groups, with significantly decreased alpha diversity in the ATB + FU group. Intestinal integrity regarding the expression of tight junction proteins and intestinal permeability were not impaired significantly after treatments, but the colons were shorter in the ATB + FU group. The expression levels of intestinal IL-17A and IL-22, as well as the percentages of IL-17A⁺ cells in the colonic LP of the ATB + FU group, were lower than those in the FU group. The percentages of Ly6C^hi monocytes in the colonic LP were lower, but those in the spleen were higher in the ATB + FU group than in the FU group. The mRNA levels of colonic CCL8 were reduced in the ATB + FU group. Antibiotic use is associated with an increased incidence of intestinal infections in tumor-bearing mice treated with chemotherapy, which might in turn be associated with a dysregulated gut microbiota that inhibits colonic monocyte recruitment and IL-17A and IL-22 production.

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Culakova E, Thota R, Poniewierski MS, Kuderer NM, Wogu AF, Dale DC, Crawford J, Lyman GH. Patterns of chemotherapy-associated toxicity and supportive care in US oncology practice: a nationwide prospective cohort study. Cancer Med. 2014;3(2):434–44. https://doi.org/10.1002/cam4.200.CrossRefPubMedPubMedCentral

Kuderer NM, Dale DC, Crawford J, Lyman GH. Impact of primary prophylaxis with granulocyte colony-stimulating factor on febrile neutropenia and mortality in adult cancer patients receiving chemotherapy: a systematic review. J clin oncol. 2007;25(21):3158–67. https://doi.org/10.1200/JCO.2006.08.8823.CrossRefPubMed

Aapro MS, Bohlius J, Cameron DA, Dal Lago L, Donnelly JP, Kearney N, Lyman GH, Pettengell R, Tjan-Heijnen VC, Walewski J, et al. 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours. Eur J Cancer. 2011;47(1):8–32. https://doi.org/10.1016/j.ejca.2010.10.013.CrossRefPubMed

Weycker D, Chandler D, Barron R, Xu H, Wu H, Edelsberg J, Lyman GH. Risk of infection among patients with non-metastatic solid tumors or non-Hodgkin’s lymphoma receiving myelosuppressive chemotherapy and antimicrobial prophylaxis in US clinical practice. J Oncol Pharm Pract. 2017;23(1):33–42. https://doi.org/10.1177/1078155215614997.CrossRefPubMed

Sulis ML, Blonquist TM, Stevenson KE, Hunt SK, Kay-Green S, Athale UH, Clavell LA, Cole PD, Kelly KM, Laverdiere C, et al. Effectiveness of antibacterial prophylaxis during induction chemotherapy in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2018;65(5):e26952. https://doi.org/10.1002/pbc.26952.CrossRefPubMed

Felsenstein S, Orgel E, Rushing T, Fu C, Hoffman JA. Clinical and microbiologic outcomes of quinolone prophylaxis in children with acute myeloid leukemia. Pediatr Infect Dis J. 2015;34(4):e78-84. https://doi.org/10.1097/INF.0000000000000591.CrossRefPubMed

Beyar-Katz O, Dickstein Y, Borok S, Vidal L, Leibovici L, Paul M. Empirical antibiotics targeting gram-positive bacteria for the treatment of febrile neutropenic patients with cancer. Cochrane Database Syst Rev. 2017;6:CD003914. https://doi.org/10.1002/14651858.CD003914.pub4.CrossRefPubMed

Lewis JD, Chen EZ, Baldassano RN, Otley AR, Griffiths AM, Lee D, Bittinger K, Bailey A, Friedman ES, Hoffmann C, et al. Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn’s disease. Cell Host Microbe. 2015;18(4):489–500. https://doi.org/10.1016/j.chom.2015.09.008.CrossRefPubMedPubMedCentral

Keith JW, Pamer EG. Enlisting commensal microbes to resist antibiotic-resistant pathogens. J Exp Med. 2019;216(1):10–9. https://doi.org/10.1084/jem.20180399.CrossRefPubMedPubMedCentral

10.

Dessein R, Gironella M, Vignal C, Peyrin-Biroulet L, Sokol H, Secher T, Lacas-Gervais S, Gratadoux JJ, Lafont F, Dagorn JC, et al. Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis. Gut. 2009;58(6):771–6. https://doi.org/10.1136/gut.2008.168443.CrossRefPubMed

11.

Brandl K, Plitas G, Mihu CN, Ubeda C, Jia T, Fleisher M, Schnabl B, DeMatteo RP, Pamer EG. Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits. Nature. 2008;455(7214):804–7. https://doi.org/10.1038/nature07250.CrossRefPubMedPubMedCentral

12.

Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch SV, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 2009;139(3):485–98. https://doi.org/10.1016/j.cell.2009.09.033.CrossRefPubMedPubMedCentral

13.

Sorbara MT, Pamer EG. Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them. Mucosal Immunol. 2019;12(1):1–9. https://doi.org/10.1038/s41385-018-0053-0.CrossRefPubMed

14.

Potgens SA, Brossel H, Sboarina M, Catry E, Cani PD, Neyrinck AM, Delzenne NM, Bindels LB. Klebsiella oxytoca expands in cancer cachexia and acts as a gut pathobiont contributing to intestinal dysfunction. Sci Rep. 2018;8(1):12321. https://doi.org/10.1038/s41598-018-30569-5.CrossRefPubMedPubMedCentral

15.

Taur Y, Pamer EG. The intestinal microbiota and susceptibility to infection in immunocompromised patients. Curr Opin Infect Dis. 2013;26(4):332–7. https://doi.org/10.1097/QCO.0b013e3283630dd3.CrossRefPubMedPubMedCentral

16.

Cole GT, Halawa AA, Anaissie EJ. The role of the gastrointestinal tract in hematogenous candidiasis: from the laboratory to the bedside. Clin Infect Dis. 1996;22(Suppl 2):S73-88. https://doi.org/10.1093/clinids/22.supplement_2.s73.CrossRefPubMed

17.

Hecht JR, Pillai M, Gollard R, Heim W, Swan F, Patel R, Dreiling L, Mo M, Malik I. A randomized, placebo-controlled phase ii study evaluating the reduction of neutropenia and febrile neutropenia in patients with colorectal cancer receiving pegfilgrastim with every-2-week chemotherapy. Clin Colorectal Cancer. 2010;9(2):95–101. https://doi.org/10.3816/CCC.2010.n.013.CrossRefPubMed

18.

Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, Fierer N, Pena AG, Goodrich JK, Gordon JI, et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010;7(5):335–6. https://doi.org/10.1038/nmeth.f.303.CrossRefPubMedPubMedCentral

19.

Quast C, Pruesse E, Yilmaz P, Gerken J, Schweer T, Yarza P, Peplies J, Glockner FO. The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Nucleic Acids Res. 2013;41(Database issue):D590-596. https://doi.org/10.1093/nar/gks1219.CrossRefPubMed

20.

Ganta VC, Cromer W, Mills GL, Traylor J, Jennings M, Daley S, Clark B, Mathis JM, Bernas M, Boktor M, et al. Angiopoietin-2 in experimental colitis. Inflamm Bowel Dis. 2010;16(6):1029–39. https://doi.org/10.1002/ibd.21150.CrossRefPubMed

21.

Viaud S, Saccheri F, Mignot G, Yamazaki T, Daillere R, Hannani D, Enot DP, Pfirschke C, Engblom C, Pittet MJ, et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science. 2013;342(6161):971–6. https://doi.org/10.1126/science.1240537.CrossRefPubMedPubMedCentral

22.

Qiu Z, Sheridan BS. Isolating lymphocytes from the mouse small intestinal immune system. Journal of visualized experiments: JoVE. 2018;(132):e57281. https://doi.org/10.3791/57281

23.

Richard P, Amador Del Valle G, Moreau P, Milpied N, Felice MP, Daeschler T, Harousseau JL, Richet H. Viridans streptococcal bacteraemia in patients with neutropenia. Lancet. 1995;345(8965):1607–9. https://doi.org/10.1016/s0140-6736(95)90117-5.CrossRefPubMed

24.

Li HL, Lu L, Wang XS, Qin LY, Wang P, Qiu SP, Wu H, Huang F, Zhang BB, Shi HL, et al. Alteration of gut microbiota and inflammatory cytokine/chemokine profiles in 5-fluorouracil induced intestinal mucositis. Front Cell Infect Microbiol. 2017;7:455. https://doi.org/10.3389/fcimb.2017.00455.CrossRefPubMedPubMedCentral

25.

Pappu R, Ramirez-Carrozzi V, Sambandam A. The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases. Immunology. 2011;134(1):8–16. https://doi.org/10.1111/j.1365-2567.2011.03465.x.CrossRefPubMedPubMedCentral

26.

Kim M, Galan C, Hill AA, Wu WJ, Fehlner-Peach H, Song HW, Schady D, Bettini ML, Simpson KW, Longman RS, et al. Critical role for the microbiota in CX3CR1(+) intestinal mononuclear phagocyte regulation of intestinal T cell responses. Immunity. 2018;49(1):151-163 e155. https://doi.org/10.1016/j.immuni.2018.05.009.CrossRefPubMedPubMedCentral

27.

Bain CC, Bravo-Blas A, Scott CL, Perdiguero EG, Geissmann F, Henri S, Malissen B, Osborne LC, Artis D, Mowat AM. Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice. Nat Immunol. 2014;15(10):929–37. https://doi.org/10.1038/ni.2967.CrossRefPubMedPubMedCentral

28.

Xiong H, Keith JW, Samilo DW, Carter RA, Leiner IM, Pamer EG. Innate lymphocyte/Ly6C(hi) monocyte crosstalk promotes klebsiella pneumoniae clearance. Cell. 2016;165(3):679–89. https://doi.org/10.1016/j.cell.2016.03.017.CrossRefPubMedPubMedCentral

29.

Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, et al. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009;325(5940):612–6. https://doi.org/10.1126/science.1175202.CrossRefPubMedPubMedCentral

30.

Hamouda N, Sano T, Oikawa Y, Ozaki T, Shimakawa M, Matsumoto K, Amagase K, Higuchi K, Kato S. Apoptosis, Dysbiosis and expression of inflammatory cytokines are sequential events in the development of 5-fluorouracil-induced intestinal mucositis in mice. Basic Clin Pharmacol Toxicol. 2017;121(3):159–68. https://doi.org/10.1111/bcpt.12793.CrossRefPubMed

31.

Sougiannis AT, VanderVeen BN, Enos RT, Velazquez KT, Bader JE, Carson M, Chatzistamou I, Walla M, Pena MM, Kubinak JL, et al. Impact of 5 fluorouracil chemotherapy on gut inflammation, functional parameters, and gut microbiota. Brain Behav Immun. 2019;80:44–55. https://doi.org/10.1016/j.bbi.2019.02.020.CrossRefPubMedPubMedCentral

32.

Pickard JM, Zeng MY, Caruso R, Nunez G. Gut microbiota: role in pathogen colonization, immune responses, and inflammatory disease. Immunol Rev. 2017;279(1):70–89. https://doi.org/10.1111/imr.12567.CrossRefPubMedPubMedCentral

33.

Ducarmon QR, Zwittink RD, Hornung BVH, van Schaik W, Young VB, Kuijper EJ. Gut microbiota and colonization resistance against bacterial enteric infection. Microbiology and molecular biology reviews: MMBR. 2019;83(3):e00007–19. https://doi.org/10.1128/MMBR.00007-19

34.

Becattini S, Taur Y, Pamer EG. Antibiotic-induced changes in the intestinal microbiota and disease. Trends Mol Med. 2016;22(6):458–78. https://doi.org/10.1016/j.molmed.2016.04.003.CrossRefPubMedPubMedCentral

35.

Taur Y, Pamer EG. Microbiome mediation of infections in the cancer setting. Genome medicine. 2016;8(1):40. https://doi.org/10.1186/s13073-016-0306-z.CrossRefPubMedPubMedCentral

36.

Yang JY, Lee YS, Kim Y, Lee SH, Ryu S, Fukuda S, Hase K, Yang CS, Lim HS, Kim MS, et al. Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice. Mucosal Immunol. 2017;10(1):104–16. https://doi.org/10.1038/mi.2016.42.CrossRefPubMed

37.

Yanagibashi T, Hosono A, Oyama A, Tsuda M, Suzuki A, Hachimura S, Takahashi Y, Momose Y, Itoh K, Hirayama K, et al. IgA production in the large intestine is modulated by a different mechanism than in the small intestine: bacteroides acidifaciens promotes IgA production in the large intestine by inducing germinal center formation and increasing the number of IgA+ B cells. Immunobiology. 2013;218(4):645–51. https://doi.org/10.1016/j.imbio.2012.07.033.CrossRefPubMed

38.

Jacobson A, Lam L, Rajendram M, Tamburini F, Honeycutt J, Pham T, Van Treuren W, Pruss K, Stabler SR, Lugo K, et al. A gut commensal-produced metabolite mediates colonization resistance to salmonella infection. Cell host & microbe. 2018;24(2):296-307 e297. https://doi.org/10.1016/j.chom.2018.07.002.CrossRef

39.

Ray N, Jeong H, Kwon D, Kim J, Moon Y. Antibiotic exposure aggravates bacteroides-linked uremic toxicity in the gut-kidney axis. Front Immunol. 2022;13:737536. https://doi.org/10.3389/fimmu.2022.737536.CrossRefPubMedPubMedCentral

40.

Lo BC, Shin SB, Canals Hernaez D, Refaeli I, Yu HB, Goebeler V, Cait A, Mohn WW, Vallance BA, McNagny KM. IL-22 preserves gut epithelial integrity and promotes disease remission during chronic salmonella infection. J Immunol. 2019;202(3):956–65. https://doi.org/10.4049/jimmunol.1801308.CrossRefPubMed

41.

Kim S, Covington A, Pamer EG. The intestinal microbiota: antibiotics, colonization resistance, and enteric pathogens. Immunol Rev. 2017;279(1):90–105. https://doi.org/10.1111/imr.12563.CrossRefPubMedPubMedCentral

42.

Kayama H, Okumura R, Takeda K. Interaction between the microbiota, epithelia, and immune cells in the intestine. Annu Rev Immunol. 2020;38:23–48. https://doi.org/10.1146/annurev-immunol-070119-115104.CrossRefPubMed

43.

Mendes V, Galvao I, Vieira AT. Mechanisms by which the gut microbiota influences cytokine production and modulates host inflammatory responses. J Interferon Cytokine Res. 2019;39(7):393–409. https://doi.org/10.1089/jir.2019.0011.CrossRefPubMed

44.

Joeris T, Muller-Luda K, Agace WW, Mowat AM. Diversity and functions of intestinal mononuclear phagocytes. Mucosal Immunol. 2017;10(4):845–64. https://doi.org/10.1038/mi.2017.22.CrossRefPubMed

45.

Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol. 2010;10(7):490–500. https://doi.org/10.1038/nri2785.CrossRefPubMed

46.

Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003;19(1):71–82. https://doi.org/10.1016/s1074-7613(03)00174-2.CrossRefPubMed

47.

Guilliams M, Mildner A, Yona S. Developmental and functional heterogeneity of monocytes. Immunity. 2018;49(4):595–613. https://doi.org/10.1016/j.immuni.2018.10.005.CrossRefPubMed

48.

Bain CC, Scott CL, Uronen-Hansson H, Gudjonsson S, Jansson O, Grip O, Guilliams M, Malissen B, Agace WW, Mowat AM. Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors. Mucosal Immunol. 2013;6(3):498–510. https://doi.org/10.1038/mi.2012.89.CrossRefPubMed

49.

Sanchez-Tarjuelo R, Cortegano I, Manosalva J, Rodriguez M, Ruiz C, Alia M, Prado MC, Cano EM, Ferrandiz MJ, de la Campa AG, et al. The TLR4-MyD88 signaling axis regulates lung monocyte differentiation pathways in response to Streptococcus pneumoniae. Front Immunol. 2020;11:2120. https://doi.org/10.3389/fimmu.2020.02120.CrossRefPubMedPubMedCentral

50.

Jin L, Getahun A, Knowles HM, Mogan J, Akerlund LJ, Packard TA, Perraud AL, Cambier JC. STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration. J Immunol. 2013;190(6):2835–43. https://doi.org/10.4049/jimmunol.1201788.CrossRefPubMed

51.

Kim YG, Kamada N, Shaw MH, Warner N, Chen GY, Franchi L, Nunez G. The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes. Immunity. 2011;34(5):769–80. https://doi.org/10.1016/j.immuni.2011.04.013.CrossRefPubMedPubMedCentral

52.

Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, et al. Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med. 2012;209(1):123–37. https://doi.org/10.1084/jem.20111009.CrossRefPubMedPubMedCentral

53.

Jones GR, Bain CC, Fenton TM, Kelly A, Brown SL, Ivens AC, Travis MA, Cook PC, MacDonald AS. Dynamics of colon monocyte and macrophage activation during colitis. Front Immunol. 2018;9:2764. https://doi.org/10.3389/fimmu.2018.02764.CrossRefPubMedPubMedCentral

54.

Zhang Z, Clarke TB, Weiser JN. Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice. J Clin Investig. 2009;119(7):1899–909. https://doi.org/10.1172/JCI36731.CrossRefPubMedPubMedCentral

55.

De Trez C, Magez S, Akira S, Ryffel B, Carlier Y, Muraille E. iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant mice. PLoS Pathog. 2009;5(6):e1000494. https://doi.org/10.1371/journal.ppat.1000494.CrossRefPubMedPubMedCentral

56.

Schulthess J, Pandey S, Capitani M, Rue-Albrecht KC, Arnold I, Franchini F, Chomka A, Ilott NE, Johnston DGW, Pires E, et al. The short chain fatty acid butyrate imprints an antimicrobial program in macrophages. Immunity. 2019;50(2):432 e437-445. https://doi.org/10.1016/j.immuni.2018.12.018.CrossRef

57.

Rubino SJ, Geddes K, Girardin SE. Innate IL-17 and IL-22 responses to enteric bacterial pathogens. Trends Immunol. 2012;33(3):112–8. https://doi.org/10.1016/j.it.2012.01.003.CrossRefPubMed

58.

Wilharm A, Tabib Y, Nassar M, Reinhardt A, Mizraji G, Sandrock I, Heyman O, Barros-Martins J, Aizenbud Y, Khalaileh A, et al. Mutual interplay between IL-17-producing gammadeltaT cells and microbiota orchestrates oral mucosal homeostasis. Proc Natl Acad Sci USA. 2019;116(7):2652–61. https://doi.org/10.1073/pnas.1818812116.CrossRefPubMedPubMedCentral

59.

Cypowyj S, Picard C, Marodi L, Casanova JL, Puel A. Immunity to infection in IL-17-deficient mice and humans. Eur J Immunol. 2012;42(9):2246–54. https://doi.org/10.1002/eji.201242605.CrossRefPubMedPubMedCentral

60.

Chen YS, Chen IB, Pham G, Shao TY, Bangar H, Way SS, Haslam DB. IL-17-producing gammadelta T cells protect against Clostridium difficile infection. J Clin Investig. 2020;130(5):2377–90. https://doi.org/10.1172/JCI127242.CrossRefPubMedPubMedCentral

61.

Hueber W, Sands BE, Lewitzky S, Vandemeulebroecke M, Reinisch W, Higgins PD, Wehkamp J, Feagan BG, Yao MD, Karczewski M, et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn’s disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut. 2012;61(12):1693–700. https://doi.org/10.1136/gutjnl-2011-301668.CrossRefPubMed

62.

Zhang HJ, Xu B, Wang H, Xu B, Wang GD, Jiang MZ, Lei C, Ding ML, Yu PF, Nie YZ, et al. IL-17 is a protection effector against the adherent-invasive Escherichia coli in murine colitis. Mol Immunol. 2018;93:166–72. https://doi.org/10.1016/j.molimm.2017.11.020.CrossRefPubMed

63.

Basu R, O’Quinn DB, Silberger DJ, Schoeb TR, Fouser L, Ouyang W, Hatton RD, Weaver CT. Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity. 2012;37(6):1061–75. https://doi.org/10.1016/j.immuni.2012.08.024.CrossRefPubMedPubMedCentral

64.

Zheng Y, Valdez PA, Danilenko DM, Hu Y, Sa SM, Gong Q, Abbas AR, Modrusan Z, Ghilardi N, de Sauvage FJ, et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med. 2008;14(3):282–9. https://doi.org/10.1038/nm1720.CrossRefPubMed

65.

Matsunaga Y, Clark T, Wanek AG, Bitoun JP, Gong Q, Good M, Kolls JK. Intestinal IL-17R signaling controls secretory IgA and oxidase balance in Citrobacter rodentium infection. J Immunol. 2021;206(4):766–75. https://doi.org/10.4049/jimmunol.2000591.CrossRefPubMed

66.

Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA, Molina DA, Salcedo R, Back T, Cramer S, et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science. 2013;342(6161):967–70. https://doi.org/10.1126/science.1240527.CrossRefPubMedPubMedCentral

67.

Soler AP, Miller RD, Laughlin KV, Carp NZ, Klurfeld DM, Mullin JM. Increased tight junctional permeability is associated with the development of colon cancer. Carcinogenesis. 1999;20(8):1425–31. https://doi.org/10.1093/carcin/20.8.1425.CrossRefPubMed

68.

Zhu HC, Jia XK, Fan Y, Xu SH, Li XY, Huang MQ, Lan ML, Xu W, Wu SS. Alisol B 23-Acetate ameliorates azoxymethane/dextran sodium sulfate-induced male murine colitis-associated colorectal cancer via modulating the composition of gut microbiota and improving intestinal barrier. Front Cell Infect Microbiol. 2021;11:640225. https://doi.org/10.3389/fcimb.2021.640225.CrossRefPubMedPubMedCentral

69.

Fong W, Li Q, Yu J. Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer. Oncogene. 2020;39(26):4925–43. https://doi.org/10.1038/s41388-020-1341-1.CrossRefPubMedPubMedCentral

70.

Chin KF, Kallam R, O’Boyle C, MacFie J. Bacterial translocation may influence the long-term survival in colorectal cancer patients. Dis Colon Rectum. 2007;50(3):323–30. https://doi.org/10.1007/s10350-006-0827-4.CrossRefPubMed

Titel: Long-term use of broad-spectrum antibiotics affects Ly6Chi monocyte recruitment and IL-17A and IL-22 production through the gut microbiota in tumor-bearing mice treated with chemotherapy
verfasst von: Yanhong Wu
Xiaolei Tang
Feng Hu
Tao Zhu
Hui Liu
Yanjing Xiong
Xiaoxuan Zuo
Aiping Xu
Xiufen Zhuang
Publikationsdatum: 23.09.2022
Verlag: Springer US
Erschienen in: Immunologic Research / Ausgabe 6/2022
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-022-09313-9

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Long-term use of broad-spectrum antibiotics affects Ly6C^hi monocyte recruitment and IL-17A and IL-22 production through the gut microbiota in tumor-bearing mice treated with chemotherapy

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