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European Radiology

Erschienen in:

20.12.2023 | Commentary

Looking at the rim in multiple sclerosis: new MRI-based biomarkers may open our eyes to the disease’s evolution

verfasst von: Jean-Christophe Brisset, François Cotton

Erschienen in: European Radiology | Ausgabe 2/2024

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Excerpt

The identification of new prognostic biomarkers for progressive multiple sclerosis (MS) is crucial for the development of new therapeutic interventions targeting this phase of the disease [1]. The study entitled “Deeply 3D-T1-TFE hypointense voxels are characteristic of phase-rim lesions in multiple sclerosis” in this current issue of European Radiology investigates the use of a derived metric from 3D T1-weighted turbo field echo (3DT1TFE) MRI to identify phase-rim lesions (PRLs), which have been proposed as possible markers of progressive MS [2]. …

Ontaneda D, Chitnis T, Rammohan K, Obeidat AZ (2023) Identification and management of subclinical disease activity in early multiple sclerosis: a review. J Neurol. https://doi.org/10.1007/s00415-023-12021-5CrossRefPubMed

Naval-Baudin P, Pons-Escoda A, Camins À et al (2023) Deeply 3D-T1-TFE hypointense voxels are characteristic of phase-rim lesions in multiple sclerosis. Eur Radiol https://doi.org/10.1007/s00330-023-09784-w

Meaton I, Altokhis A, Allen CM et al (2022) Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis. Mult Scler 28:2212–2220. https://doi.org/10.1177/13524585221118677CrossRefPubMedPubMedCentral

Maggi P, Sati P, Nair G et al (2020) Paramagnetic rim lesions are specific to multiple sclerosis: an international multicenter 3T MRI study. Ann Neurol 88:1034–1042. https://doi.org/10.1002/ana.25877CrossRefPubMedPubMedCentral

Martire MS, Moiola L, Rocca MA et al (2022) What is the potential of paramagnetic rim lesions as diagnostic indicators in multiple sclerosis? Expert Rev Neurother 22:829–837. https://doi.org/10.1080/14737175.2022.2143265CrossRefPubMed

Caruana G, Auger C, Pessini LM et al (2022) SWI as an alternative to contrast-enhanced imaging to detect acute MS lesions. AJNR Am J Neuroradiol 43:534–539. https://doi.org/10.3174/ajnr.A7474CrossRefPubMedPubMedCentral

Absinta M, Sati P, Masuzzo F et al (2019) Association of chronic active multiple sclerosis lesions with disability in vivo. JAMA Neurol 76:1474. https://doi.org/10.1001/jamaneurol.2019.2399CrossRefPubMedPubMedCentral

Hemond CC, Reich DS, Dundamadappa SK (2022) Paramagnetic rim lesions in multiple sclerosis: comparison of visualization at 1.5-T and 3-T MRI. AJR Am J Roentgenol 219:120–131. https://doi.org/10.2214/AJR.21.26777CrossRefPubMed

Brisset J-C, Vukusic S, Cotton F (2021) Update on brain MRI for the diagnosis and follow-up of MS patients. Presse Med 50:104067. https://doi.org/10.1016/j.lpm.2021.104067CrossRefPubMed

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Cacciaguerra L, Storelli L, Rocca MA, Filippi M (2022) Current and future applications of artificial intelligence in multiple sclerosis. In: Augmenting neurological disorder prediction and rehabilitation using artificial intelligence. Elsevier, pp 107–144

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Bonacchi R, Filippi M, Rocca MA (2022) Role of artificial intelligence in MS clinical practice. Neuroimage Clin 35:103065. https://doi.org/10.1016/j.nicl.2022.103065CrossRefPubMedPubMedCentral

12.

La Rosa F, Wynen M, Al-Louzi O et al (2022) Cortical lesions, central vein sign, and paramagnetic rim lesions in multiple sclerosis: Emerging machine learning techniques and future avenues. Neuroimage Clin 36:103205. https://doi.org/10.1016/j.nicl.2022.103205CrossRefPubMedPubMedCentral

13.

Calvi A, Clarke MA, Prados F et al (2023) Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis. Mult Scler 29:352–362. https://doi.org/10.1177/13524585221141964CrossRefPubMed

14.

Wattjes MP, Ciccarelli O, Reich DS et al (2021) 2021 MAGNIMS–CMSC–NAIMS consensus recommendations on the use of MRI in patients with multiple sclerosis. Lancet Neurol 20:653–670. https://doi.org/10.1016/S1474-4422(21)00095-8CrossRefPubMed

Titel: Looking at the rim in multiple sclerosis: new MRI-based biomarkers may open our eyes to the disease’s evolution
verfasst von: Jean-Christophe Brisset
François Cotton
Publikationsdatum: 20.12.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 2/2024
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-023-10482-w

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Looking at the rim in multiple sclerosis: new MRI-based biomarkers may open our eyes to the disease’s evolution

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