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Seminars in Immunopathology

Erschienen in:

12.05.2016 | Review

Macrophage-epithelial interactions in pulmonary alveoli

verfasst von: Jahar Bhattacharya, Kristin Westphalen

Erschienen in: Seminars in Immunopathology | Ausgabe 4/2016

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Abstract

Alveolar macrophages have been investigated for years by approaches involving macrophage extraction from the lung by bronchoalveolar lavage, or by cell removal from lung tissue. Since extracted macrophages are studied outside their natural milieu, there is little understanding of the extent to which alveolar macrophages interact with the epithelium, or with one another to generate the lung’s innate immune response to pathogen challenge. Here, we review new evidence of macrophage-epithelial interactions in the lung, and we address the emerging understanding that the alveolar epithelium plays an important role in orchestrating the macrophage-driven immune response.

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Titel: Macrophage-epithelial interactions in pulmonary alveoli
verfasst von: Jahar Bhattacharya
Kristin Westphalen
Publikationsdatum: 12.05.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Seminars in Immunopathology / Ausgabe 4/2016
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-016-0569-x

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