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Journal of Imaging Informatics in Medicine

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02.07.2019 | Magnetic Resonance Imaging

Fully Automated and Real-Time Volumetric Measurement of Infarct Core and Penumbra in Diffusion- and Perfusion-Weighted MRI of Patients with Hyper-Acute Stroke

verfasst von: Hyunna Lee, Kyesam Jung, Dong-Wha Kang, Namkug Kim

Erschienen in: Journal of Imaging Informatics in Medicine | Ausgabe 1/2020

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Abstract

Multimodal magnetic resonance imaging (MRI) has emerged as a promising tool for diagnosing ischemic stroke and for determining treatment strategies in the acute phase. The detection and quantification of the penumbra and the infarct core regions aid the assessment of the potential risks and benefits of thrombolysis by providing information on salvageable tissue or ischemic lesion age. In this study, we proposed a fully automated and real-time algorithm to compute parameter maps of perfusion-weighted images (PWIs) and to identify an infarct core from diffusion-weighted images (DWIs). DWI and PWI were obtained using a 1.5 Tesla MRI scanner for 15 patients with acute ischemic stroke. Parameter maps of PWI were computed using restricted gamma-variate curve fitting and Fourier-based deconvolution. The ischemic penumbra was identified using time-to-maximum (T_max) > 6 s as the mutual optimal threshold, while the infarct core was segmented using an adaptive thresholding on DWI. When the penumbra on PWI was compared with that generated using commercial software Pearson’s linear correlation coefficient between penumbra volumes was 0.601 (p = 0.030), and the Dice coefficient was 0.51 ± 0.15. The infarct core on DWI was compared with the manually segmented gold standard. Dice coefficient between the manually drawn and automated segmented infarct cores was 0.62 ± 0.18. The processing times for PWI and DWI were 222.9 ± 16.4 and 53.4 ± 4.8 s, respectively. In conclusion, we demonstrate a fully automated and real-time algorithm to segment the penumbra and the infarct core regions based on PWI and DWI.

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Titel: Fully Automated and Real-Time Volumetric Measurement of Infarct Core and Penumbra in Diffusion- and Perfusion-Weighted MRI of Patients with Hyper-Acute Stroke
verfasst von: Hyunna Lee
Kyesam Jung
Dong-Wha Kang
Namkug Kim
Publikationsdatum: 02.07.2019
Verlag: Springer International Publishing
Schlagwörter: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Stroke
Erschienen in: Journal of Imaging Informatics in Medicine / Ausgabe 1/2020
Print ISSN: 2948-2925
Elektronische ISSN: 2948-2933
DOI: https://doi.org/10.1007/s10278-019-00222-2

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Fully Automated and Real-Time Volumetric Measurement of Infarct Core and Penumbra in Diffusion- and Perfusion-Weighted MRI of Patients with Hyper-Acute Stroke

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