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Erschienen in: Der Onkologe 5/2017

16.01.2017 | Magnetresonanztomografie | CME

Früherkennung bei Brustkrebs

verfasst von: M. R. Noftz, J. Hübner, Prof. Dr. med. A. Katalinic

Erschienen in: Die Onkologie | Ausgabe 5/2017

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Zusammenfassung

Brustkrebs ist die häufigste Krebserkrankung und auch die häufigste krebsbedingte Todesursache von Frauen in Deutschland. Die Früherkennung für Frauen mit normalem Brustkrebsrisiko beginnt in Deutschland mit dem 30. Lebensjahr. Seit 2004 können Frauen zwischen 50 und 69 Jahren im Rahmen der Früherkennung an einem systematischen und bevölkerungsbezogenen Mammografiescreening teilnehmen. Dessen Nutzen und Schaden werden aktuell kontrovers diskutiert. Ergebnisse zur Mortalitätsreduktion aus dem deutschen Screeningprogramm sind erst ab 2018 zu erwarten. Zukünftig ist als Weiterentwicklung der Mammografie v. a. mit der Anwendung der Tomosynthese zu rechnen. Für Frauen mit erhöhtem Brustkrebsrisiko aufgrund entsprechender Genveränderungen (Mutationen in den BRCA1- und BRCA2-Genen) stehen ab dem 25. Lebensjahr oder 5 Jahre vor dem frühesten Erkrankungsalter der betroffenen Angehörigen intensivierte Früherkennungsmaßnahmen (Sonografie, Magnetresonanztomografie, Mammografie) zur Verfügung.
Literatur
1.
Zurück zum Zitat Koch-Institut (2015) Krebs in Deutschland 2011/2012. Robert Koch-Institut und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e. V., Berlin Koch-Institut (2015) Krebs in Deutschland 2011/2012. Robert Koch-Institut und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e. V., Berlin
7.
Zurück zum Zitat Collaborative Group on Hormonal Factors in Breast Cancer (2001) Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Lancet 358:1389–1399CrossRef Collaborative Group on Hormonal Factors in Breast Cancer (2001) Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Lancet 358:1389–1399CrossRef
9.
Zurück zum Zitat McCormack VA, dos Santos Silva I (2006) Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 15:1159–1169CrossRefPubMed McCormack VA, dos Santos Silva I (2006) Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 15:1159–1169CrossRefPubMed
10.
Zurück zum Zitat Dyrstad SW, Yan Y, Fowler AM, Colditz GA (2015) Breast cancer risk associated with benign breast disease: systematic review and meta-analysis. Breast Cancer Res Treat 149:569–575CrossRefPubMed Dyrstad SW, Yan Y, Fowler AM, Colditz GA (2015) Breast cancer risk associated with benign breast disease: systematic review and meta-analysis. Breast Cancer Res Treat 149:569–575CrossRefPubMed
11.
Zurück zum Zitat Hankinson S, Tamini R, Hunter D (2008) Breast cancer. In: Adami HO, Hunter D, Trichopoulos D (Hrsg) Textbook of cancer epidemiology Hankinson S, Tamini R, Hunter D (2008) Breast cancer. In: Adami HO, Hunter D, Trichopoulos D (Hrsg) Textbook of cancer epidemiology
12.
Zurück zum Zitat Kemp Jacobsen K, O’Meara ES, Key D, Buist DSM, Kerlikowske K, Vejborg I, Sprague BL, Lynge E, von Euler-Chelpin M (2015) Comparing sensitivity and specificity of screening mammography in the United States and Denmark. Int J Cancer 137:2198–2207CrossRefPubMed Kemp Jacobsen K, O’Meara ES, Key D, Buist DSM, Kerlikowske K, Vejborg I, Sprague BL, Lynge E, von Euler-Chelpin M (2015) Comparing sensitivity and specificity of screening mammography in the United States and Denmark. Int J Cancer 137:2198–2207CrossRefPubMed
13.
Zurück zum Zitat Marmot MG, Altman DG, Cameron DA, Dewar JA, Thompson SG, Wilcox M (2013) The benefits and harms of breast cancer screening: an independent review. Br J Cancer 108:2205–2240CrossRefPubMedPubMedCentral Marmot MG, Altman DG, Cameron DA, Dewar JA, Thompson SG, Wilcox M (2013) The benefits and harms of breast cancer screening: an independent review. Br J Cancer 108:2205–2240CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Pace LE, Keating NL (2014) A systematic assessment of benefits and risks to guide breast cancer screening decisions. Jama 311:1327–1335 Pace LE, Keating NL (2014) A systematic assessment of benefits and risks to guide breast cancer screening decisions. Jama 311:1327–1335
15.
Zurück zum Zitat Perry N, Broeders M, de Wolf C, Tornberg S, Holland R, von Karsa L (2008) European guidelines for quality assurance in breast cancer screening and diagnosis. Fourth edition–summary document. Ann Oncol 19:614–622CrossRefPubMed Perry N, Broeders M, de Wolf C, Tornberg S, Holland R, von Karsa L (2008) European guidelines for quality assurance in breast cancer screening and diagnosis. Fourth edition–summary document. Ann Oncol 19:614–622CrossRefPubMed
18.
Zurück zum Zitat Malek D, Kaab-Sanyal V (2016) Implementation of the German Mammography Screening Program (German MSP) and first results for initial examinations, 2005–2009. Breast Care 11:183–187CrossRefPubMed Malek D, Kaab-Sanyal V (2016) Implementation of the German Mammography Screening Program (German MSP) and first results for initial examinations, 2005–2009. Breast Care 11:183–187CrossRefPubMed
20.
Zurück zum Zitat Schmutzler R, Dietz D, Jöckel K (2012) Präventive Gendiagnostik: Hoffnung und Fluch der Genanalyse. Dtsch Arztebl 109:A-1371/B-1183/C-1163 Schmutzler R, Dietz D, Jöckel K (2012) Präventive Gendiagnostik: Hoffnung und Fluch der Genanalyse. Dtsch Arztebl 109:A-1371/B-1183/C-1163
21.
Zurück zum Zitat Miller AB, Wall C, Baines CJ, Sun P, To T, Narod SA (2014) Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial. BMJ (Clinical research ed) 348:g366 Miller AB, Wall C, Baines CJ, Sun P, To T, Narod SA (2014) Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial. BMJ (Clinical research ed) 348:g366
22.
Zurück zum Zitat Tabar L, Vitak B, Chen TH, Yen AM, Cohen A, Tot T, Chiu SY, Chen SL, Fann JC, Rosell J, Fohlin H, Smith RA, Duffy SW (2011) Swedish two-county trial: impact of mammographic screening on breast cancer mortality during 3 decades. Radiology 260:658–663 Tabar L, Vitak B, Chen TH, Yen AM, Cohen A, Tot T, Chiu SY, Chen SL, Fann JC, Rosell J, Fohlin H, Smith RA, Duffy SW (2011) Swedish two-county trial: impact of mammographic screening on breast cancer mortality during 3 decades. Radiology 260:658–663
23.
Zurück zum Zitat Gotzsche PC, Jorgensen KJ (2013) Screening for breast cancer with mammography. Cochrane Database Syst Rev 6:CD001877 Gotzsche PC, Jorgensen KJ (2013) Screening for breast cancer with mammography. Cochrane Database Syst Rev 6:CD001877
24.
Zurück zum Zitat U.S. Preventive Task Force (2009) Screening for breast cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 151:716–726CrossRef U.S. Preventive Task Force (2009) Screening for breast cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 151:716–726CrossRef
25.
Zurück zum Zitat Fügemann H, Kääb-Sanyal V (2016) Mammographie-Screening: Nutzen-Schaden-Abwägung im internationalen Vergleich. Dtsch Arztebl 113:74–78 Fügemann H, Kääb-Sanyal V (2016) Mammographie-Screening: Nutzen-Schaden-Abwägung im internationalen Vergleich. Dtsch Arztebl 113:74–78
26.
Zurück zum Zitat IACR (2016) Breast cancer screening – IARC handbook of cancer prevention. IARC, Lyon, S 469 IACR (2016) Breast cancer screening – IARC handbook of cancer prevention. IARC, Lyon, S 469
27.
Zurück zum Zitat Lauby-Secretan B, Scoccianti C, Loomis D, Benbrahim-Tallaa L, Bouvard V, Bianchini F, Straif K, International Agency for Research on Cancer Handbook Working Group (2015) Breast-cancer screening – viewpoint of the IARC Working Group. N Engl J Med 372:2353–2358CrossRefPubMed Lauby-Secretan B, Scoccianti C, Loomis D, Benbrahim-Tallaa L, Bouvard V, Bianchini F, Straif K, International Agency for Research on Cancer Handbook Working Group (2015) Breast-cancer screening – viewpoint of the IARC Working Group. N Engl J Med 372:2353–2358CrossRefPubMed
29.
Zurück zum Zitat Weiss NS (2003) Breast cancer mortality in relation to clinical breast examination and breast self-examination. Breast J 9(Suppl 2):S86–S89CrossRefPubMed Weiss NS (2003) Breast cancer mortality in relation to clinical breast examination and breast self-examination. Breast J 9(Suppl 2):S86–S89CrossRefPubMed
30.
Zurück zum Zitat Kosters JP, Gotzsche PC (2003) Regular self-examination or clinical examination for early detection of breast cancer. Cochrane Database Syst Rev 2003:CD003373 Kosters JP, Gotzsche PC (2003) Regular self-examination or clinical examination for early detection of breast cancer. Cochrane Database Syst Rev 2003:CD003373
31.
Zurück zum Zitat Baxter N, Canadian Task Force on Preventive Health C (2001) Preventive health care, 2001 update: should women be routinely taught breast self-examination to screen for breast cancer? CMAJ 164:1837–1846PubMedPubMedCentral Baxter N, Canadian Task Force on Preventive Health C (2001) Preventive health care, 2001 update: should women be routinely taught breast self-examination to screen for breast cancer? CMAJ 164:1837–1846PubMedPubMedCentral
32.
Zurück zum Zitat Gartlehner G, Thaler K, Chapman A, Kaminski-Hartenthaler A, Berzaczy D, Van Noord MG, Helbich TH (2013) Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk. Cochrane Database Syst Rev 2013:CD009632 Gartlehner G, Thaler K, Chapman A, Kaminski-Hartenthaler A, Berzaczy D, Van Noord MG, Helbich TH (2013) Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk. Cochrane Database Syst Rev 2013:CD009632
34.
Zurück zum Zitat Nothacker M, Duda V, Hahn M, Warm M, Degenhardt F, Madjar H, Weinbrenner S, Albert US (2009) Early detection of breast cancer: benefits and risks of supplemental breast ultrasound in asymptomatic women with mammographically dense breast tissue. A systematic review. BMC Cancer 9:335CrossRefPubMedPubMedCentral Nothacker M, Duda V, Hahn M, Warm M, Degenhardt F, Madjar H, Weinbrenner S, Albert US (2009) Early detection of breast cancer: benefits and risks of supplemental breast ultrasound in asymptomatic women with mammographically dense breast tissue. A systematic review. BMC Cancer 9:335CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat Morrow M, Waters J, Morris E (2011) MRI for breast cancer screening, diagnosis, and treatment. Lancet 378:1804–1811CrossRefPubMed Morrow M, Waters J, Morris E (2011) MRI for breast cancer screening, diagnosis, and treatment. Lancet 378:1804–1811CrossRefPubMed
36.
Zurück zum Zitat Kriege M, Brekelmans CT, Boetes C, Besnard PE, Zonderland HM, Obdeijn IM, Manoliu RA, Kok T, Peterse H, Tilanus-Linthorst MM, Muller SH, Meijer S, Oosterwijk JC, Beex LV, Tollenaar RA, de Koning HJ, Rutgers EJ, Klijn JG, Magnetic Resonance Imaging Screening Study Group (2004) Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med 351:427–437CrossRefPubMed Kriege M, Brekelmans CT, Boetes C, Besnard PE, Zonderland HM, Obdeijn IM, Manoliu RA, Kok T, Peterse H, Tilanus-Linthorst MM, Muller SH, Meijer S, Oosterwijk JC, Beex LV, Tollenaar RA, de Koning HJ, Rutgers EJ, Klijn JG, Magnetic Resonance Imaging Screening Study Group (2004) Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med 351:427–437CrossRefPubMed
37.
Zurück zum Zitat Bernardi D, Macaskill P, Pellegrini M, Valentini M, Fanto C, Ostillio L, Tuttobene P, Luparia A, Houssami N (2016) Breast cancer screening with tomosynthesis (3D mammography) with acquired or synthetic 2D mammography compared with 2D mammography alone (STORM-2): a population-based prospective study. Lancet Oncol 17:1105–1113CrossRefPubMed Bernardi D, Macaskill P, Pellegrini M, Valentini M, Fanto C, Ostillio L, Tuttobene P, Luparia A, Houssami N (2016) Breast cancer screening with tomosynthesis (3D mammography) with acquired or synthetic 2D mammography compared with 2D mammography alone (STORM-2): a population-based prospective study. Lancet Oncol 17:1105–1113CrossRefPubMed
Metadaten
Titel
Früherkennung bei Brustkrebs
verfasst von
M. R. Noftz
J. Hübner
Prof. Dr. med. A. Katalinic
Publikationsdatum
16.01.2017
Verlag
Springer Medizin
Erschienen in
Die Onkologie / Ausgabe 5/2017
Print ISSN: 2731-7226
Elektronische ISSN: 2731-7234
DOI
https://doi.org/10.1007/s00761-016-0164-8

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